Patents Assigned to Universite Pierre et Marie Curie (Paris 6)
  • DEVICE FOR ANALYSING AN OXIDISABLE MOLTEN METAL USING A LIBS TECHNIQUE
    Publication number: 20170074800
    Abstract: A device for analyzing at least one oxidizable molten metal using a LIBS technique, including: a LIBS analyzer; a mechanical rotary mechanism stirring a liquid bath of the at least one oxidizable molten metal, and including a central section, to be positioned above the liquid bath of the at least one oxidizable molten metal, including an internal cavity forming an analysis chamber, the central section including a first end connected to the LIBS analyzer, and a plurality of mechanical stirring paddles to be partially submerged in the liquid bath of the at least one oxidizable molten metal and that are connected to a second end of the central section opposite the first end of the central section, the LIBS analyzer configured to allow the surface of the at least one oxidizable molten metal located in the portion plumb with the internal cavity of the central portion to be analyzed.
    Type: Application
    Filed: May 20, 2015
    Publication date: March 16, 2017
    Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
    Inventors: Malek BENMANSOUR, Rafik BENRABBAH, Jean-Paul GARANDET, Daniel MORVAN
  • METHOD OF DNA SEQUENCING BY POLYMERISATION
    Publication number: 20170073749
    Abstract: The present invention relates to a method for the determination of a nucleic acid sequence by physical manipulation. The method is based on the precise determination of the localization of the replicating fork on the template by measuring the physical distance between one end of the molecule and the fork. This allows the determination of the physical location of the site where a pause or a blockage of the replication occurs, and deducing therefrom information on the sequence of the nucleic acid.
    Type: Application
    Filed: October 26, 2016
    Publication date: March 16, 2017
    Applicants: ECOLE NORMALE SUPERIEUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
    Inventors: David Bensimon, Vincent Croquette, Jean-Francois Allemand, Maria Manosas, Fang-Yuan Ding
  • Treatment of osteoarthritis with incretin hormones or analogues thereof
    Patent number: 9592272
    Abstract: The present invention relates to the use of the incretin hormones glucagon-like peptide-1 or GLP-1 and glucose-dependent insulinotropic polypeptide or GIP, or of analogs thereof, in particular the analogs resistant to dipeptidyl peptidase IV, in the treatment of osteoarthritis, in particular for inhibiting or slowing down cartilage destruction.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: March 14, 2017
    Assignees: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS
    Inventors: Francis Berenbaum, Carole Bougault, Claire Attali
  • CCR2 ANTAGONIST PEPTIDES
    Publication number: 20170051040
    Abstract: The invention relates to a peptide comprising the following amino acid sequence Thr-Phe-Leu-Lys or Thr-Phe-Leu-Lys-Cys, useful as a CCR2 non competitive antagonist peptide.
    Type: Application
    Filed: September 2, 2016
    Publication date: February 23, 2017
    Applicant: UNIVERSITE PIERRE ET MARIE CURIE (Paris 6)
    Inventors: Christophe Combadiere, Florian Sennlaub, Constance Auvynet, Sylvain Chemtob, Christiane Quiniou
  • SURFACE COATING METHOD AND DEVICE FOR CARRYING OUT SAID METHOD
    Publication number: 20170043369
    Abstract: A surface coating method includes the steps of preparing a solution containing a solvent and a material or its precursor, intended to cover a surface to be coated, which is non-volatile, film-forming and soluble or can be in suspension or dispersed in a solvent; and generating an aerosol of the solution. The method further includes generating an aerosol flow from a first end of a tube towards a second end of the tube, wherein the second end pre-determined cross-section (Se) and provided with a spray nozzle having an outlet with a cross-section (S) smaller than the cross-section (Se) of the second end of the tube, such that the ratio R1=F/S is greater than 4 metres per second. The method also includes the steps of directing the outlet of the nozzle towards the surface to be coated and spraying the aerosol onto the surface to be coated.
    Type: Application
    Filed: February 12, 2015
    Publication date: February 16, 2017
    Applicants: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: David Grosso, Benjamin Louis
  • METHOD OF DNA SEQUENCING BY HYBRIDISATION
    Publication number: 20170037466
    Abstract: The present invention relates to a method for the determination of a nucleic acid sequence by physical manipulation. In particular, the said method comprises the steps of denaturing a double-stranded nucleic acid molecule corresponding to the said nucleic acid sequence by applying a physical force to the said molecule; and detecting a blockage of the renaturation of the double-stranded nucleic acid molecule. More specifically, the method comprises the steps of denaturing a double-stranded nucleic acid molecule corresponding to the said nucleic acid sequence by applying a physical force to the said molecule; providing a single-stranded nucleic acid molecule; renaturing the said double stranded nucleic acid molecule in the presence of the said single-stranded nucleic acid molecule; and detecting a blockage of the renaturation of the double-stranded nucleic acid.
    Type: Application
    Filed: October 26, 2016
    Publication date: February 9, 2017
    Applicants: ECOLE NORMALE SUPERIEUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
    Inventors: David Bensimon, Vincent Croquette, Jean-Francois Allemand, Maria Manosas, Fang-Yuan Ding
  • PRODUCTION OF BORON PHOSPHIDE BY REDUCTION OF BORON PHOSPHATE WITH AN ALKALINE METAL
    Publication number: 20170022061
    Abstract: The present invention concerns a process for the production of boron phosphide BP comprising the reduction of boron phosphate BPO4 with at least one alkaline earth metal (EA) according to Equation (1): BPO4+4 EA?BP?4 EA(O)(1)
    Type: Application
    Filed: December 23, 2014
    Publication date: January 26, 2017
    Applicants: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIV PARIS XIII PARIS-NORD VILLETANEUSE
    Inventors: Yann LE GODEC, Vladimir MUKHANOV, Vladimir SOLOZHENKO, Petr SOKOLOV
  • CHIMERIC POLYPEPTIDE COMPRISING THE FRAGMENT B OF SHIGA TOXIN AND PEPTIDES OF THERAPEUTIC INTEREST
    Publication number: 20170015719
    Abstract: The invention pertains to methods for using chimeric polypeptides of the formula: B-X wherein B represents the B fragment of Shiga toxin or a functional equivalent thereof, and X represents one or more polypeptides of therapeutic significance. Compositions for therapeutic use comprising the polypeptide B-X are also included.
    Type: Application
    Filed: July 26, 2013
    Publication date: January 19, 2017
    Applicants: Inserm, Centre National de la Recherche Scientifique (CNRS), Institut Curie, Universite Pierre Et Marie Curie (Paris 6)
    Inventors: Bruno Goud, Ludger Johannes
  • TRANSPARENT METAL FLUORIDE CERAMIC
    Publication number: 20170015591
    Abstract: A method for producing a metal fluoride ceramic, comprising: providing a sedimented compound comprising metal fluoride particles having an average particle size lower than 30 nm and a solvent, partially drying the sedimented compound at a temperature lower than 65° C. until the partially dried compound comprises from 5 wt % to 45 wt % of the solvent, and sintering, for example in air, the partially dried and sedimented compound.
    Type: Application
    Filed: April 3, 2015
    Publication date: January 19, 2017
    Applicants: PARIS SCIENCES ET LETTRES - QUARTIER LATIN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
    Inventors: Michel Mortier, Pierre Aballea, Patrick Gredin, Akiko Suganuma
  • Methods of increasing efficiency of vector penetration of target tissue
    Patent number: 9546112
    Abstract: Methods for increasing the efficiency of target tissue penetration of an adeno-associated virus (AAV) vector in a patient are provided. In some aspects, the methods involve inhibiting the interaction of the serum protein galectin 3 binding protein (G3BP) with AAV vector. Further provided are methods for reducing tissue distribution of a virus or for neutralizing a virus harbored by an organ destined for transplant, or newly transplanted, by administering a composition comprising G3BP.
    Type: Grant
    Filed: March 22, 2011
    Date of Patent: January 17, 2017
    Assignees: ASSOCIATION INSTITUT DE MYOLOGIE, GÉNÉTHON, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6), INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
    Inventors: Thomas Voit, Luis Garcia, Jérôme Denard, Fedor Svinartchouk
  • Use of coumarin derivatives for the preparation of drugs for treating skin diseases
    Patent number: 9532973
    Abstract: A compound of formula (I-1) wherein n equals 0 or 1, Z represents O or S, R1 represents one group chosen among the group consisting of hydrogen, C1-C7 alkyl, substituted, or not, by a halogen, a hydroxyl or a —O—R12 group, wherein R12 is a C1-C7 alkyl, a group —CH2—O—CO—R5 wherein R5 is chosen among a hydrogen atom and a C1-C7 alkyl, substituted or not by at least one halogen, a group —O—R13, wherein R13 is chosen among hydrogen and a C1-C7 alkyl, an amine or a —CH2-amine, R?1 represents a group chosen among hydrogen and —O—R14, wherein R14 is chosen among hydrogen and a C1-C7 alkyl, and R2 is chosen among the group consisting of a C1-C7 alkyl, a C3-C6 cycloalkyl, an aryl group, and an heteroaryl group for the treatment of pathologies involving excess activity of at least one member of the kallikrein family.
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: January 3, 2017
    Assignees: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), UNIVERSITE DE LIEGE
    Inventors: Michele Reboud-Ravaux, Chahrazade Yerroum-El Amri, Xiao Tan, Lixian Qin, Maurice Pagano, Alain Hovnanian, Laetitia Furio, Bernard Pirotte
  • Analogs of temporin-SHa and uses thereof
    Patent number: 9522942
    Abstract: The present invention relates to novel antimicrobial peptides, to pharmaceutical compositions comprising said peptides, and to the uses thereof, in particular as antimicrobial drugs, disinfectants, pesticides or preservatives. The present invention also relates to a transgenic plant expressing said novel peptides.
    Type: Grant
    Filed: March 18, 2010
    Date of Patent: December 20, 2016
    Assignees: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), INSTITUT DE RECHERCHE POUR LE DEVELOPMENT, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Ali Ladram, Denis Sereno, Feten Abbassi, Bruno Oury, Mohamed Amiche, Pierre Nicolas
  • Lentiviral-based vector and its use in directed evolution of genomic regions, genes and polynucleotides
    Patent number: 9518271
    Abstract: A method of directing evolution of a target polynucleotide of interest for obtaining variants of this target polynucleotide, a method to generate genetic variability by preparing a cell library, and a method to isolate or to screen variants of a polynucleotide or variants of a protein able to impact the phenotype of a cell or to confer a desired phenotype to target cells, and to identify theses polynucleotide variants or protein variants responsible for this phenotype are described.
    Type: Grant
    Filed: November 10, 2010
    Date of Patent: December 13, 2016
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
    Inventors: Matteo Negroni, Sarah Gallois-Montbrun, Paola Rossolillo, Vincenzo Di Bartolo, Gilles Uze, Etienne Simon-Loriere, Roland Marquet, Valérie Vivet-Boudou
  • Method of DNA sequencing by hybridisation
    Patent number: 9512476
    Abstract: Described herein is a method for determining a nucleic acid sequence, said method comprising: a) denaturing a double-stranded nucleic acid molecule corresponding to the said nucleic acid sequence by applying a physical force to the said molecule; b) providing a single-stranded nucleic acid molecule; c) renaturing the said double stranded nucleic acid molecule in the presence of the said single-stranded nucleic acid molecule; and d) detecting a blockage of the renaturation of the double-stranded nucleic acid.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: December 6, 2016
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NORMALE SUPERIEURE, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
    Inventors: David Bensimon, Jean-François Allemand, Maria Manosas, Fang-Yuan Ding, Vincent Croquette
  • Method and system for inspecting a zone
    Patent number: 9507036
    Abstract: A method is provided for inspecting a zone, termed the zone of interest, whose characteristics are known at least partially, to detect at least one element included in the zone of interest, the method including: a first detection providing, through a time reversal method, a first signal relating to the position of the element for a first emission point, and at least one second detection providing, through a time reversal method, at least one second signal relating to the position of the element for a second emission point different from the first emission point. The method furthermore includes a multiplication of the first detection signal with the second detection signal to provide a third detection signal which is more accurate than the first and the second detection signal. A system implementing this method is also provided.
    Type: Grant
    Filed: July 10, 2013
    Date of Patent: November 29, 2016
    Assignees: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ARIEL—UNIVERSITY RESEARCH AND DEVELOPMENT COMPANY
    Inventors: Frederic Nataf, Franck Assous, Marie Kray
  • Method of DNA sequencing by polymerisation
    Patent number: 9493829
    Abstract: Described herein is a method for determining a nucleic acid sequence, said method comprising: a) denaturing a double-stranded nucleic acid molecule corresponding to the said nucleic acid sequence; b) hybridizing a single-stranded nucleic acid molecule, the primer, with the said denatured double-stranded nucleic acid molecule; c) applying a tension to the hybridized primer/double-stranded nucleic acid molecule obtained in b); d) incubating the hybridized primer/double-stranded nucleic acid molecule obtained in b) with a polymerase in conditions which will lead to at least one pause in replication; and e) determining a position of the said pause in replication with respect to one end of the double-stranded nucleic acid.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: November 15, 2016
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NORMALE SUPERIEURE, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
    Inventors: David Bensimon, Vincent Croquette, Jean-François Allemand, Maria Manosas, Fang-Yuan Ding
  • TET2 AS A DIAGNOSTIC AND PRONOSTIC MARKER IN HEMATOPOIETIC NEOPLASMS
    Publication number: 20160319370
    Abstract: The present invention concerns an in vitro method for diagnosing a myeloid tumour or a lymphoid tumour in a subject, which comprises the step of analyzing a biological sample from said subject by (i) detecting the presence of a mutation in the Ten Eleven Translocation protein family member 2 gene (TET2) coding for the polypeptide having the sequence SEQ ID NO: 2, and/or (ii) analyzing the expression of the TET2 gene; wherein the detection of such a TET2 mutation, of the absence of expression of TET2 or of the expression of a truncated TET2 is indicative of a subject developing or predisposed to develop a myeloid tumour or a lymphoid tumour.
    Type: Application
    Filed: June 8, 2016
    Publication date: November 3, 2016
    Applicants: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), INSTITUT GUSTAVE-ROUSSY, ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS, CENTRE HENRI BECQUEREL, UNIVERSITE PARIS DESCARTES, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), UNIVERSITE PARIS-SUD
    Inventors: Franck Viguie, Olivier Bernard, Michaela Fontenay, Christian Bastard, Francois Delhommeau, William Vainchenker
  • CCR2 antagonist peptides
    Patent number: 9434766
    Abstract: The invention relates to a peptide comprising the following amino acid sequence Thr-Phe-Leu-Lys (SEQ ID NO: 17) or Thr-Phe-Leu-Lys-Cys (SEQ ID NO: 1), useful as a CCR2 non-competitive antagonist peptide.
    Type: Grant
    Filed: June 26, 2012
    Date of Patent: September 6, 2016
    Assignee: Universite Pierre Et Marie Curie (Paris 6)
    Inventors: Christophe Combadiere, Florian Sennlaub, Constance Auvynet, Sylvian Chemtob, Christiane Quiniou
  • Device for electro-optical sampling of a microwave frequency signal
    Patent number: 9423568
    Abstract: A device for electro-optical sampling of a microwave frequency signal is disclosed. In one aspect, the device includes a microwave transmission line for transmitting a microwave signal, the microwave line including an interruption zone configured to be rendered conducting under the effect of an optical control signal so as to carry out a function of optically controlled interrupter switch. The device also includes, in the interruption zone, a layer of nanostructured semiconductor material, including a periodic or quasi-periodic tiling of nanostructures. The layer of nanostructured semiconductor material is placed, at the level of the interruption zone, in suspension or on a dielectric material of lower refractive index than the refractive index of the semiconductor material, the layer of nanostructured semiconductor material being able to carry out the function of optically controlled interrupter switch.
    Type: Grant
    Filed: April 10, 2015
    Date of Patent: August 23, 2016
    Assignees: THALES, Université Pierre et Marie Curie (Paris 6)
    Inventors: Sylvain Combrié, Alfredo De Rossi, Charlotte Tripon-Canseliet, Jean Chazelas
  • Method for Determining the Sizing of the Transistors of an Analog Circuit
    Publication number: 20160224700
    Abstract: A method for determining electrical parameter values of the transistors of an analog circuit of a system on chip includes breaking the circuit down into a set of blocks connected to one another; establishing the wiring diagram of said circuit; defining a set of electrical constraints that are specific to said circuit, blocks and transistors of each block; defining electrical parameters of the circuit, block and transistors; selecting for each transistor of the circuit an operator for calculating the electrical parameter values of said transistor; generating structured diagrams of each block of the circuit from the defined constraints and the chosen operators; assembling said structured diagrams of blocks into a general diagram of the circuit; identifying whether there is any conflict; and, if so, emitting an alarm signal.
    Type: Application
    Filed: July 28, 2014
    Publication date: August 4, 2016
    Applicants: Centre National de la Recherche Scientifique - CNRS, Universite Pierre et Marie Curie (Paris 6)
    Inventors: Farakh Javid, Ramy Iskander, Marie-Minerve Louerat