Abstract: The invention relates to a microfluidic system for controlling a concentration profile of molecules capable of stimulating a target, for example formed by an assembly of living cells, this system comprising: —a microfluidic device (1) comprising at least one microfluidic channel (4) equipped with at least one inlet orifice (21) and with at least one outlet orifice (22) for at least one fluid; —at least one means for supplying the microfluidic channel (4) with at least one fluid comprising molecules capable of stimulating the target; —at least one chamber (8) or another microfluidic channel comprising a base (6) intended to receive the target; and —at least one microporous membrane (5) separating the chamber (8) or the other microfluidic channel from the microfluidic channel (4), said microporous membrane (5) being positioned away from the base (6) so that when the supply means provides the microfludic channel (4) with said at least one fluid flowing in laminar flow in contact with the microporous membrane (5)

Abstract: The present invention concerns an in vitro method for diagnosing a myeloid tumor or a lymphoid tumor in a subject, which comprises the step of analyzing a biological sample from said subject by (i) detecting the presence of a mutation in the Ten Eleven Translocation protein family member 2 gene (TET2) coding for the polypeptide having the sequence SEQ ID NO:2, and/or (ii) analyzing the expression of the TET2 gene; wherein the detection of such a TET2 mutation, of the absence of expression of TET2 or of the expression of a truncated TET2 is indicative of a subject developing or predisposed to develop a myeloid tumor or a lymphoid tumor.

Abstract: A chimeric peptide construct having a cell penetrating peptide linked to a pro-apoptotic peptide. The construct can be used for treating a tumor in combination with an anti-tumor agent. Also disclosed is a method for treating a tumor with the chimeric peptide construct and a chemotherapeutic agent.

Abstract: Device for the representation, in a frequency-wave number reference frame f-k, of the propagation of an ultrasound wave in a dihedral guide (1), which comprises ultrasound emitters (2) referenced by “Ej” with j an integer varying between 1 and N, N a strictly positive integer and ultrasound receivers (3) referenced by “Ri” with i an integer varying between 1 and M, M a strictly positive integer, the receivers being disposed spatially over a first segment of a straight line according to a regular pitch “A”, which comprises means for processing the signal received by the receivers, originating from the emitters, and in which the processing means comprise means for calculating a modified discrete spatial Fourier transform, for a spatial integration variable “x”, centered in the middle of said first segment and running through the receivers in the direction of increasing x, and for a wave vector k(x) equal to a product k.

Abstract: The invention relates to the use of at least one chelating agent, including an iron chelating agent, in order to stimulate the growth of magnetotactic bacteria.

Abstract: A cell-penetrating peptide is described. Also described is a pro-apoptotic agent including the cell-penetrating peptide and a pro-apoptotic peptide linked thereto. The pro-apoptotic agent is useful for inhibition of in vitro cell proliferation and for treatment of tumors.

Abstract: An implant and guide are described, together with methods for configuring the same. The implant and guide are for maxillofacial osteosynthesis and may be provided as a kit. Three-dimensional models of the pre- and post-operative anatomy are used to define attachment points. These attachment points are used to define a structure for the implant and the guide.

Abstract: This method comprises bringing drops to be separated into contact with an interface (40) suitable for allowing an osmotic equilibrium between the content of each drop to be separated. The method comprises an osmotic flow between the drops (20A) of the first group of drops through the interface (40) in order to modify the density of each drop (20A) of the first group of drops and the separation of the drops (20A, 20B) according to the density thereof or a combination of the density and the volume in order to isolate the drops (20A) of the first group of drops from the drops (20B) of a second group of drops.

Abstract: The endovascular prosthesis includes a first expandable framework and a first jacket for the first framework, the first framework and the first jacket forming a first channel when the first framework is in the expanded state. The first framework and the first jacket each have at least one opening, which openings are arranged substantially opposite one another and through which a sleeve is received, the sleeve having a first end and a second end, the perimeter of the first end being attached to the perimeter of the opening of the first jacket, while the second end extends inside the first channel.

Abstract: The present invention relates to methods and devices for observing the cell division, in particular the cytokinetic ring, methods for preparing such devices, methods for studying modifications of cell division, and methods for screening compounds of interest which enhance or inhibit cell division.

Abstract: A continuous-time sigma delta radio frequency modulator is provided, including at least two LC resonators coupled in parallel by a coupling capacitive element, producing an at least 4th-order bandpass filter, a frequency response of the bandpass filter presenting at least two poles that can be brought closer together or moved further apart depending on the capacitive element value; a feedback loop for shaping the quantization noise with a predetermined noise transfer function; and an adder for receiving: at one of its inputs an analog signal; and at its other input a signal provided by the feedback loop; and the output of which is linked to the input of the bandpass filter, the feedback loop including a finite impulse response filter, the coefficients of which being calculated to obtain a noise transfer function which maximizes the signal-to-noise ratio in a signal bandwidth while ensuring the stability of the feedback loop.

Abstract: The invention relates to a haptic controller comprising a base (2), at least one maneuvering body (8) which is movably mounted on the base such that it can be moved under the action of a user, mechanical connection means (4, 15) comprising at least one deformable abutment consisting of an elastomer material between the maneuvering body and the base, and suitable for exerting a monotonous, non-linear resistive effort against an actuating effort of the maneuvering body, at least one sensor (12) placed in the haptic controller in such a way as to generate a signal representative of said actuating effort, and associated built-in or remote means (18) for processing the signal generated by the sensor, in order to supply an output signal for controlling at least one characteristic of a sound.

Abstract: A method for employing certain cobalt complexes as electron donors and in combination with an electron acceptor is provided for preparing an active layer in a photovoltaic conversion cell, as well as to the photovoltaic conversion cell in which the electron donor of the active layer includes such cobalt complexes.

Abstract: A straight, branched or cross-linked polymer, including, per 100 mol %: a) a mole fraction from 75% to 99.95% of monomer units from an N,N-dialkyl acrylamide; b) a mole fraction from 0.05% to 1% of monomer units from a monomer of formula (I): CH2=C(Ri)-C(=0)-0-[(CH2-CH(R2)-0]n-R3 (I); c) optionally a mole fraction higher than 0% to 24% either of monomer units from a monomer including a free strong acid function, partially or totally salified, or of monomer units from a monomer of formula (II): CH2=C(R4)-C(=0)-Y-(CH2)m-N(R5)(R6) (II); d) optionally a mole fraction higher than 0% to 1% of a diethylene or polyethylene cross-linking monomer. Also, a method for treating a surface made of a hydrophobic material, using the polymer, and an aqueous, hydro-organic or organic solution including the polymer for modifying interactions between the species contained the solution and the hydrophobic surface.

Abstract: A method and a system is provided for configuring a device for correcting the effect of a medium on a light signal having propagated through the medium, the device including at least one optical element whose phase profiles are individually adjustable. The configuring system and method include propagating a reference signal and a disordered signal obtained at the output of the medium through the correcting device. An interference parameter is measured and optimized by modifying the phase profile of each of the optical elements of the correcting device. A method and a system is also provided for correcting the effect of a medium on a light signal having propagated through the medium.

Abstract: A new dual biomarker of neurodegeneration and of neuroregeneration

Abstract: A computer receives asynchronous information originating from a light sensor (10) having a pixel matrix disposed opposite a scene. The asynchronous information comprises, for each pixel of the matrix, successive events originating from this pixel and depending on variations in light in the scene. For a place of estimation (p) in the matrix of pixels and an estimation time (t), the computer selects a set (Sp t) of events originating from pixels included in a spatial neighborhood (??) of the place of estimation and which have occurred in a time interval (?) defined with respect to the estimation time, such that this set has at most one event per pixel of the spatial neighborhood. The computer quantifies the variations in the times of occurrence of the events of the set selected as a function of the positions, in the matrix, of the pixels from which these events originate.

Abstract: A biocompatible carbon based electrode, and its preparation process are described. The electrode is formed by first and second biocompatible chemically oxygen terminated or H-terminated carbon-based materials. The first material is configured to promote the growth or at least the direct interfacing of adult neurons on the first material without substantially promoting the growth and direct interfacing of glial cells on the first material. The second material presents a peptide coating to promote the growth and at least the direct interfacing of adult glial cells.

Abstract: The present invention relates to the use of interferent RNAs that silence PW1 expression in order to activate adult stem cells in vitro or in vivo, in particular in the context of regenerative medicine.

Abstract: The present invention describes the use of nucleoside analogs for the treatment of viral infections, in particular of an HIV infection, and also compositions comprising at least one of these analogs, and a method for evaluating the sensitivity to said treatment.