Abstract: The invention relates to a haptic controller comprising a base (2), at least one maneuvering body (8) which is movably mounted on the base such that it can be moved under the action of a user, mechanical connection means (4, 15) comprising at least one deformable abutment consisting of an elastomer material between the maneuvering body and the base, and suitable for exerting a monotonous, non-linear resistive effort against an actuating effort of the maneuvering body, at least one sensor (12) placed in the haptic controller in such a way as to generate a signal representative of said actuating effort, and associated built-in or remote means (18) for processing the signal generated by the sensor, in order to supply an output signal for controlling at least one characteristic of a sound.

Abstract: A continuous-time sigma delta radio frequency modulator is provided, including at least two LC resonators coupled in parallel by a coupling capacitive element, producing an at least 4th-order bandpass filter, a frequency response of the bandpass filter presenting at least two poles that can be brought closer together or moved further apart depending on the capacitive element value; a feedback loop for shaping the quantization noise with a predetermined noise transfer function; and an adder for receiving: at one of its inputs an analogue signal; and at its other input a signal provided by the feedback loop; and the output of which is linked to the input of the bandpass filter, the feedback loop including a finite impulse response filter, the coefficients of which being calculated to obtain a noise transfer function which maximizes the signal-to-noise ratio in a signal bandwidth while ensuring the stability of the feedback loop.

Abstract: The invention relates to a method for generating, on the fly and on demand, at least one virtual network (402, 404, 406), adapted for a specific use, on a physical network (200), referred to as an infrastructure network, including physical nodes (204, 206, 208, 210), each of said physical nodes (204, 206, 208, 210) runs at least one network operating system, said method including the following steps: determining, on at least one computer device (202), referred to as a virtual network server, data related to said virtual network (402) to be generated in accordance with said particular use; transmitting, on the basis of said data and to at least a portion of said physical nodes (204, 206, 208, 210), referred to as active nodes, of said infrastructure network (200), a request for creating a virtual node; and creating a virtual node on each of said active nodes by installing a virtual device in each of said active nodes, said virtual network consisting of all of said virtual nodes thus created.

Abstract: A photovoltaic component that includes at least one first array of photovoltaic nano-cells is disclosed. Each photovoltaic component includes an optical nano-antenna exhibiting an electromagnetic resonance in a first resonant spectral band, at least one lateral dimension of the optical nano-antenna being subwavelength in size, and a spectral conversion layer allowing at least part of the solar spectrum to be converted to said first resonant spectral band.

Abstract: The present invention relates to interfering RNAs, in particular miRNAs, capable of specifically blocking the replication of a strain of the HIV virus that is resistant to an antiretroviral compound, and use thereof for treating infections by this type of virus.

Abstract: A probe including NE ultrasonic emitters and NR ultrasonic receivers is applied on the medium to be characterized. Each emitter is activated successively and each time signals are detected on the set of receivers during a time window. Each of the NE×NR signals detected is converted by temporal Fourier transformation to a sum of vibrational components each having its temporal frequency. For each frequency, a matrix NE×NR of complex amplitudes of vibrational components having this frequency is extracted. These matrices are decomposed into singular values, the smallest are eliminated, and the singular vectors associated with the singular values retained, a base of the space of the reception signals is formed, for each frequency. The contribution of each plane wave, characterized by its velocity, in this base is calculated. This contribution is represented in the form of a grey level in a frequency-propagation velocity reference system.

Abstract: The present invention relates to compositions and methods, in particular to methods based on systemic administration of scAAV, for delivering genes to cells of the retina of mammals, and in particular to photoreceptor cells, ganglion cells, glial cells, inner nuclear layer cells or cells of the retinal pigmented epithelium.

Abstract: A process for depositing a layer on at least part of the surface of a substrate by at least partially submerging the substrate in a solution having a solvent and at least one compound intended to form the layer, then drying the substrate, the drying being at least partially carried out in an atmosphere that is isolated from the solution. The submersion in the solution and the drying of the substrate are carried out in the same controlled-atmosphere enclosure.

Abstract: A measurement device for measuring activity of the spinal cord of a vertebrate. The device includes at least one main probe (1) shaped to be fastened to a spinous process (2) of a vertebra (3) and to hold in position on opposite sides of the vertebra at least one emitter (6) for emitting a wave capable of interacting with the spinal cord (7) and at least one associated receiver (8) for receiving the wave that has interacted with the spinal cord and for generating a signal representative of the activity of the spinal cord.

Abstract: The present invention relates to the use of the incretin hormones glucagon-like peptide-1 or GLP-1 and glucose-dependent insulinotropic polypeptide or GIP, or of analogues thereof, in particular the analogues resistant to dipeptidyl peptidase IV, in the treatment of osteoarthritis, in particular for inhibiting or slowing down cartilage destruction.

Abstract: A method of fabricating an elongate structure having a steerable end, the structure including a flexible longitudinal body associated with at least one actuator member having at least one shape memory alloy wire or “SMAW” extending along the body and anchored thereto at its ends, and associated with a mechanism for heating it in controlled manner. The method includes the following steps: inserting at least one of the ends of the SMAW in tubes; crimping the tubes onto the ends of the SMAW; and securing the tubes to the body in such a manner that the wire extends along the body.

Abstract: The present invention relates to a novel bacterial strain isolated from groundwater. The invention also relates to bacterial extracts and to the use of same in the context of the treatment of inflammations. More particularly, the present invention relates to novel compositions of interest in the treatment and the prevention of inflammatory disorders, notably dermatological pathologies.

Abstract: The invention relates to a method for detecting a physiological state of a patient deviating from a reference physiological state, in which, after having determined, in each of Q frequency bands, R reference matrices PRq,r with qe[1 . . . Q] and r?[1 . . . R] which correspond to the reference physiological state, the following steps are repeated in a loop: carrying out measurements, in M time segments, of an electroencephalographic signal; filtering and centering the measurements in Q frequency bands to obtain and determine M×Q scaled matrices of spatial covariance; for each time segment m, calculating a deviation from the reference physiological state, and comparing each of the deviations from the reference physiological state to a predefined threshold. The invention also relates to a monitoring device applying said method.

Abstract: A compound of formula (I-1) wherein n equals 0 or 1, Z represents O or S, R1 represents one group chosen among the group consisting of hydrogen, C1-C7 alkyl, substituted, or not, by a halogen, a hydroxyl or a —O—R12 group, wherein R12 is a C1-C7 alkyl, a group —CH2—O—CO—R5 wherein R5 is chosen among a hydrogen atom and a C1-C7 alkyl, substituted or not by at least one halogen, a group —O—R13, wherein R13 is chosen among hydrogen and a C1-C7 alkyl, an amine or a —CH2— amine, R?1 represents a group chosen among hydrogen and —O—R14, wherein R14 is chosen among hydrogen and a C1-C7 alkyl, and R2 is chosen among the group consisting of a C1-C7 alkyl, a C3-C6 cycloalkyl, an aryl group, and an heteroaryl group for the treatment of pathologies involving excess activity of at least one member of the kallikrein family.

Abstract: The invention relates to peptides useful for inhibiting IGF-1 activity and their use as agents for inhibition of in vitrocell proliferation and for treatment of various diseases.

Abstract: The present invention relates to an apparatus for the treatment of a brain affection, which comprises at least one implantable generator (4) made of non-ferromagnetic material comprising a casing (7), an ultrasound generating treating device (11) positioned into said casing to induce brain affection treatment by emission of ultrasound waves, and means for fastening the implantable casing into the skull. The apparatus further comprises a power controller (PwC) to supply electricity to the treating device of the implantable generator and to set and control its working parameters, and connecting means (6) to connect the power controller and the treating device of the implantable generator. A method for treating a brain affection with such an apparatus is also disclosed.

Abstract: A surgical instrument having an elongated arm and a distal end mounted with a pivot joint on the elongated arm. A drive shaft substantially coaxial with the elongated arm forms a universal joint facing the pivot joint. A distal tool is securely fastened on the drive shaft and rotatively mounted on and in the extension of the distal end of the elongated arm, such that the distal tool has two rotational degree of freedom, distinct and independent of each other, one being around an axis substantially perpendicular to the longitudinal axis of the elongated arm and the other being around an axis substantially collinear to an own axis of the distal tool. The elongated arm includes a plurality of linking elements mounted in series to form the pivot joint. The universal joint is a Cardan joint.

Abstract: The present invention relates to a method of vaccination via hair follicles that makes it possible to target vaccine components to the antigen-presenting cells in order to induce a protective and effective immune response against pathogens.

Abstract: The percutaneous probe, made in MRI-compatible materials, comprises: a body percutaneously inserted into the tissue of a patient's body organ (8) having a region (10) to be analyzed, treated and monitored during a single medical procedure; at least one information collection sensing device (30,33,34); treatment application transducers (30) 360° disposed to emit focused or defocused therapeutic ultra-sound waves. The computerized system comprises a parametrizable command device (50) adapted to simulate then command a generation of the therapeutic ultra-sound waves, and to monitor the treatment by thermal MRI images.

Abstract: The invention relates to a titanium based polycarboxylate inorganic-organic hybrid solid material that has a pseudo-cubic crystalline structure, to a method for preparing the same using a solvo-thermal procedure, and to the uses thereof in particular for the storage of gases, the adsorption of liquids, the separation of liquids or gases, and the applications thereof in optics or catalysis, in the biomedical (controlled release drug), cosmetic fields, etc.