Abstract: Provided is a method for determining an effect of a potential active agent on a sample comprising a co-culture comprising a target cellular object, TCO, and one or more further cell types, FCT, wherein the TCO has been labelled with a flourescent live-cell marker having a first emission/excitation profile, and with a luminescent cell-death marker, and optionally the FCT has been labelled with a fluorescent live-cell marker having a second emission/excitation profile different from the first emission/excitation profile, comprising capturing, during an acquisition event using a microscope, a first fluorescent image from the fluorescent live-cell marker having the first emission/excitation profile, and optionally a second fluorescent image from the fluorescent live-cell marker having the second emission/excitation profile, and a luminescence measurement of the sample, and comparing fluorescent images and luminescent measurements between sample contacted with the potential active agent and sample not contacted wi

Abstract: A method for estimating movements of a crowd between a first and second subregion in an area are monitored by a wireless sensor network. The wireless sensor network includes nodes configured to exchange a radio frequency signal through a first respective second link. The first respective second link crosses the first respective second subregion. The method includes the steps of exchanging radio frequency signals over the first and second link; and measuring respective first and second attenuations of the exchanged radio frequency signals over the first respective second link; and estimating based on a change in the attenuations a flow of the crowd between the first and second subregion. The estimating further includes estimating based on the first and second attenuations a density of the crowd in the first respective second subregion; and estimating based thereon a flux of the crowd between the first and second subregion.

Abstract: A method is provided for inspection of an item comprising acquiring a projection image of the item using a radiation imaging system and obtaining a plurality of simulated projection images of the item or a component thereof, based on a simulation of a numerical three-dimensional model. A relative orientation of the item with respect to the imaging system is determined by comparing the projection image to the plurality of simulated images, and at least one angle of rotation is determined by taking into account a viewing angle and the relative orientation. The method further comprises moving the item and/or the imaging system in accordance with the at least one angle of rotation and acquiring a further projection image of the item.

Abstract: A system and method with improved water management for the electrochemical conversion of a gaseous compound, in particular CO2, in a zero-gap electrolyzer comprises the direct injection of a liquid, such as water, in the gaseous feed comprising the gaseous compound (CO2) and providing the gas/liquid mixture to the membrane electrode assembly of the zero-gap electrolyser via an interdigitated flow channel. This way, the gas and the liquid are forced through the porous electrode structures, thus ensuring that both the liquid and the gaseous compound (CO2) are in close contact with the electrode, resulting in an improved hydration of the electrode and an efficient conversion of the gaseous compound (CO2).

Abstract: A method and system for inspection of an item, and a use thereof, are presented. The method comprises acquiring a plurality of projection images of an item at a plurality of projection angles for performing a tomographic reconstruction of the item. A plurality of objects are detected in the tomographic reconstruction and each object has a generic shape described by a parametric three-dimensional numerical model. Said detection comprises determining initial estimates of position and/or orientation of each object and at least one geometrical parameter of the three-dimensional model for each object. The initial estimates are iteratively refining by using a projection-matching approach, in which forward projection images are simulated for the objects according to operating parameters of the radiation imaging device and a difference metric between acquired projection images and simulated forward projection images is reduced at each iteration step.

Abstract: The present disclosure relates to a method for producing lanthanide doped layered double hydroxides (Ln-doped LDHs). The method includes the steps of preparing a carbonate free alkaline solution; preparing a solution of metal salts comprising a salt of a lanthanide; co-precipitating the alkaline solution and the solution of metal salts to form a mixture and Ln-doped LDH precipitate wherein the pH of the mixture is maintained at a constant value; aging the precipitate; and separating the precipitate from the solution. The alkaline solution is an aqueous ammonia solution. The present disclosure is also related to lanthanide-doped layered double hydroxides (La-doped LDHs) obtainable by such a method, as well as to the use of the lanthanide-doped layered double hydroxides obtainable by such a method.

Abstract: The application discloses methods of ensuring pelvic health and/or treating a disease or disorder characterized by a dysfunctional autonomous nervous system in a subject with neuromodulation. The methods are characterized by the application of a burst stimulation pattern comprising a plurality of groups of electric pulses of high frequencies to the subject.

Abstract: A method for determining a narcotic in a mixture comprising at least one interferant. The method comprises: (a) determining a voltage at which, in absence of the interferant, a voltammetric signal of the narcotic can be detected; (b) contacting an electrode with the mixture comprising the at least one interferant and potentially comprising the narcotic; (c) applying a pretreatment potential to the electrode for a duration of at least 5 seconds, the pretreatment potential measuring between ?0.4 V and ?2 V versus Ag/AgCl; (d) measuring a voltammetric response of the mixture, the measurement comprising at least the determined voltage; and (e) determining whether the narcotic is present in the mixture by analyzing whether the voltammetric signal of the narcotic, resolved from a voltammetric signal of the interferant, can be detected in the measured voltammetric response.

Abstract: The present invention relates to a compound of formula (I) or a stereoisomer, or tautomer, for use in the prevention or treatment of a disease associated with the activation of receptor tyrosine-protein kinase (erbB4). In formula (I), wherein n, A1, A2, A3, A4, A5, R1, R2, R3, and R4 have the same meaning as that defined in the claims and the description. The present invention also relates uses of such compounds for the prevention and/or treatment of a disease associated with the activation of receptor tyrosine-protein kinase (erbB-4) such as heart failure, metabolic disorders, inflammatory disorders, fibrotic disorders, and cancer. The present invention also provides pharmaceutical compositions comprising such compounds, as well as the use of the compounds as a medicament.

Abstract: A method for forming a self-cleaning coating, comprises providing a first dispersion comprising plasmonic nanoparticles by suspending plasmonic nanoparticles in an organic medium and providing a second dispersion comprising a precursor of a photocatalytic matrix in an organic medium. The method further comprises forming a mixture of the first and second dispersion and coating the mixture on a surface. The method also comprises calcining the coated mixture.

Abstract: Provided herein are compositions for topical use comprising an imidazole or a salt thereof, and domiphen bromide as active ingredients for use in treating or preventing a fungal infection, wherein said imidazole is chosen from ketoconazole and clotrimazole as active ingredients for use in treating or preventing a fungal infection.

Abstract: The present invention is directed to a novel isolated bacterial strain of the Streptococcus salivahus (S. salivahus) species. More in particular, a strain of the S. salivahus species deposited at BCCM under accession number LMG P-31813. Further, the present invention relates to a composition comprising an isolated bacterial strain of the S. salivahus species. In another aspect, the present invention further relates to the isolated bacterial strain according to the present invention or the composition according to the present invention for use in immunomodulation and/or in the treatment and/or prevention of infections of diseases.

Abstract: A photocatalytic reactor for use in a heating, ventilation and/or air conditioning system, and comprises a longitudinal housing having a wall and allowing air or gas to pass through along the longitudinal direction of the longitudinal housing. A plurality of tubes are positioned in the longitudinal housing and arranged such that some outer tubes are positioned closer to the housing wall than some inner tubes. The tubes have their longitudinal axis parallel with the longitudinal axis of the longitudinal housing allowing the air or gas to pass along and through the tubes and the tubes comprise photocatalytic material in or on their tube walls. The system comprises an irradiation system for irradiating the photocatalytic material for inducing catalytic action. The irradiation system and plurality of tubes are configured so that upon irradiating by the irradiation system photocatalytic material of the outer tubes and inner tubes is irradiated.

Abstract: The present invention is directed to a novel isolated bacterial strain of the Lactobacillus casei (L. casei) species. More in particular, the strain of the Lactobacillus casei species deposited under accession number LMG P-30039. The present invention further relates to the novel L. casei strain for use in the treatment and/or prevention of infections and/or immune-related diseases. Also the use of the isolated novel L. casei strain or a composition comprising said strain as an adjuvant to promote an immune response during vaccination is disclosed. Further, the use of said novel L. casei strain or a composition comprising said strain in personal hygiene industry, cleaning industry, biomass production, air purification and food industry is disclosed. In another aspect of the present invention, the use of a L. casei species that has a whole genome G/C content of at least 47.5% and expresses one or more catalase genes or a composition comprising one or more of said L.

Abstract: Mucins and isoforms thereof are provided herein for use in the diagnosis, monitoring, prevention, and/or treatment of a disease characterized by barrier dysfunction, such as, but not limited to a gastrointestinal disorder (e.g. Inflammatory Bowel Disease (IBD), Irritable Bowel Syndrome (IBS), cancer, gastrointestinal infections, obesitas, non-alcoholic fatty liver disease (NAFLD)), neurodegenerative disorders, respiratory infections, and more in particular coronaviral infections. In a specific embodiment, said mucins and/or isoforms thereof are selected from the list comprising: MUC16, MUC21, MUC20, MUC2, MUC4, MUC5AC, MUC5B, MUC13, and MUC1, and isoforms thereof.

Abstract: The invention relates to compositions for topical use comprising miconazole or a salt thereof and domiphen bromide as active ingredients for use in treating or preventing a fungal infection.

Abstract: The invention provides in an electron microscopy grid, comprising: - a perforated substrate; - a support film on the perforated substrate; - a mixture of different linker molecules according to Structure (I), wherein AG is an anchoring group, for anchoring the linker molecule to the solid support; BU is a binding unit, for binding to the analyte; L1 is a first linear linker section; L2 is a second linear linker section; ? is the angle between the linear linker section L1 and the linear linker section L2; AS is an angled linker section, connecting the linear linker section L1 and the linear linker section L2. The invention further provides in method of structural determination of analytes, using such EM-grids.

Abstract: A device for measuring elasticity of a tissue of an object is disclosed. It comprises a base portion comprising contact means for contacting the tissue. It also comprises a palpation probe for pushing down on the tissue comprising a palpation pen for pushing down the tissue and a force measuring means for determining a palpation force applied to the palpation probe and/or a displacement measuring means for determining a displacement of the palpation pen being representative for a displacement of the tissue. The device also comprises a swiveling handle mounted pivotally to the base portion for positioning the device and for distributing a positioning force along the at least two contact points in a predetermined manner.

Abstract: Provided herein are in vitro methods for diagnosing an immediate hypersensitivity reaction (IHR) against a small compound or a drug in a subject, comprising the steps of (a) contacting mast cells with serum obtained from said subject; (b) contacting the mast cells obtained in step (a) with said small compound or said drug; (c) detecting mast cell activation and/or degranulation of the mast cells obtained in step (b); and (d) attributing the detection or no detection of mast cell activation and/or degranulation to a particular diagnosis of IHR.

Abstract: The present invention relates to compounds for use in the prevention and/or treatment of PAR-related diseases, such as for example: pain and ocular disorders. More in particular, the present invention provides bis(acetamidophenyl) guanidinophenylethylphosphonates for use in the prevention and/or treatment of pancreatitis-related pain, IBS (irritable bowel syndrome), IBD (inflammatory bowel disease), dry eye disease and conjunctivitis sicca. These inhibitors were found to have a different inhibitory profile compared to diphenyl guanidinophenylethylphosphonates leading to a more pronounced effect on these conditions.