Abstract: The present invention in particular relates to the identification of novel Lactobacillus mudanjiangensis strains which are characterized in having a whole genome GC content of less than 43%. Moreover, these strains are characterized by the expression of a novel cellulase enzyme, which has numerous applications in the fields of for example agriculture, bioconversion, detergents, fermentation, food, paper industry, or textile industry.

Abstract: A device is configured to monitor a state of a rotatable handle of a valve when the device is attached to the rotatable handle. The device comprises a vector magnetometer configured to measure a magnetic field. The device comprises a processing unit configured to obtain from the vector magnetometer measurements of the magnetic field when the handle is rotated; calculate a change in the state of the rotatable handle based on a difference between the measurements of the magnetic field; and report the change in the state.

Abstract: The present invention relates to compounds for use in the prevention and/or treatment of PAR-related diseases, such as for example: pain and ocular disorders. More in particular, the present invention provides bis(acetamidophenyl) guanidinophenylethylphosphonates for use in the prevention and/or treatment of pancreatitis-related pain, IBS (irritable bowel syndrome), IBD (inflammatory bowel disease), dry eye disease and conjunctivitis sicca. These inhibitors were found to have a different inhibitory profile compared to diphenyl guanidinophenylethylphosphonates leading to a more pronounced effect on these conditions.

Abstract: A process for the production of a catalyst comprising the steps of: dissolving the requisite quantities of copper nitrate and nickel nitrate in de-ionised water to provide a sub-0.30 molar aqueous solution of copper nitrate and nickel nitrate together in the ratio required; providing an ammoniacal solution by adding concentrated aqueous solution of ammonia in a quantity equal to between six and ten times the quantity required to realise both a 1:6 molar ratio for Cu2+ to ammonia and a 1:6 molar ratio for Ni2+ to ammonia; loading gamma alumina with 1 to 30% w/w of copper and nickel in a weight ratio of nickel to copper of 1:5 to 2:1 by suspending the requisite quantity of gamma alumina in said ammoniacal solution to achieve the required loading of copper and nickel; stirring the resulting gamma alumina suspension for at least 4 h at room temperature; then the volatile components evaporate under ambient conditions leaving dry loaded gamma alumina, which is calcined at a temperature of at least 260° C.

Abstract: A catalytic composition is built up from a ceramic material including a catalytic material and a first inorganic binder and a second inorganic binder and a catalytic structure made thereof. Preferably, the structure is made by a colloidal ceramic shaping technique. The structure is usable for catalytic or ion exchange applications as well. It is demonstrated that the catalytic structures have excellent mechanical, physicochemical and catalytic properties.

Abstract: The present invention relates to compounds for use in the prevention and/or treatment of PAR-related diseases, such as for example: pain and ocular disorders. More in particular, the present invention provides bis(acetamidophenyl) guanidinophenylethylphosphonates for use in the prevention and/or treatment of pancreatitis-related pain, IBS (irritable bowel syndrome), IBD (inflammatory bowel disease), dry eye disease and conjunctivitis sicca. These inhibitors were found to have a different inhibitory profile compared to diphenyl guanidinophenylethylphosphonates leading to a more pronounced effect on these conditions.

Abstract: A method, system, use, and computer program product for inspection of an item are disclosed. The method (1) comprises acquiring (2) a projection image of the item using a radiation imaging system and obtaining (3) a plurality of simulated projection images of the item or a component thereof, based on a simulation of a numerical three-dimensional model, in which at least one geometric parameter relating to the relative orientation between the simulated item, a simulated radiation source, and a simulated detection plane varies over the plurality of simulated images. The method comprises determining (4) a relative orientation of the item with respect to the imaging system, said determining of the relative orientation comprises comparing (9) the projection image to the plurality of simulated images.

Abstract: The present invention relates to novel nucleoside analogues and compositions containing said nucleoside analogues. Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicine, in particular for the diagnosis, prevention and/or treatment of parasitic infections, more specifically for use in the diagnosis, prevention and/or treatment of a Trypanosoma infection.

Abstract: A device for locally manipulating a spatial phase distribution of a charged particle wave propagating along a beam axis comprises a support element having a target region for receiving the charged particle wave propagating along the beam axis and a plurality of phase adjusting elements, supported by the support element and located in the target region, for locally adjusting the phase of the charged particle wave when the charged particle wave impinges on the phase adjusting element. The device also comprises a plurality of control lines connected to the plurality of phase adjusting elements for individually controlling each phase adjusting element.

Abstract: The present invention in general relates to a method for the deacylation and/or dealkylation (both O-dealkylation as well as C-dealkylation) of compounds, more specifically of aromatic compounds. The method is characterized by contacting the compound with an acid-containing aqueous reaction mixture using high temperature and high pressure conditions. The invention also provides a method for preparing a compound suitable for further deacylation using the method of the invention.

Abstract: The present invention is directed to a novel isolated bacterial strain of the Lactobacillus casei (L. casei) species. More in particular, the strain of the Lactobacillus casei species deposited under accession number LMG P-30039. The present invention further relates to the novel L. casei strain for use in the treatment and/or prevention of infections and/or immune-related diseases. Also the use of the isolated novel L. casei strain or a composition comprising said strain as an adjuvant to promote an immune response during vaccination is disclosed. Further, the use of said novel L. casei strain or a composition comprising said strain in personal hygiene industry, cleaning industry, biomass production, air purification and food industry is disclosed. In another aspect of the present invention, the use of a L. casei species that has a whole genome G/C content of at least 47.5% and expresses one or more catalase genes or a composition comprising one or more of said L.

Abstract: A method and system for inspection of an item, and a use thereof, are presented. The method comprises acquiring a plurality of projection images of an item at a plurality of projection angles for performing a tomographic reconstruction of the item. A plurality of objects are detected in the tomographic reconstruction and each object has a generic shape described by a parametric three-dimensional numerical model. Said detection comprises determining initial estimates of position and/or orientation of each object and at least one geometrical parameter of the three-dimensional model for each object. The initial estimates are iteratively refining by using a projection-matching approach, in which forward projection images are simulated for the objects according to operating parameters of the radiation imaging device and a difference metric between acquired projection images and simulated forward projection images is reduced at each iteration step.

Abstract: The present invention relates to 3-(benzylamino)-4-(cyclohexylamino)-N-(2-(piperazin-1-yl)ethyl)benzenesulfonamide derivatives and related ferrostatin-1 (Fer-1) analogues as cell death inhibitors by inhibition of ferroptosis and/or oxytosis for the treatment of stroke, myocardial infarction, diabetes, sepsis, the prevention of transplant rejection, neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, Huntington's disease, dementia with Lewy bodies and Friedreich's ataxia. The present invention further relates to pharmaceutical compositions of these compounds and discloses methods for making the compounds and the corresponding intermediate.

Abstract: A wireless communication device comprises a control unit, an antenna interface, an active wireless transceiver operable together with the control unit and antenna interface, a passive wireless transceiver operable together with the antenna interface and operable by harvesting power from received radio messages. The device is further configured to deactivate the one or more active wireless transceivers and control unit to an inactive state and, subsequently, by the passive wireless transceiver, activate the control unit and an active wireless transceiver to an active state when the passive wireless transceiver receives a message from the antenna interface.

Abstract: The current invention relates to long ?-? di-functional linear molecules as building blocks closing the gap between small molecules and polymers, or in a polycondensated form, in the production of oligomers and/or polymers, surfactants, lubricants, coatings, colloidal stabilizing surface chains/molecules.

Abstract: Described are methods and kits for identifying a subject at risk of, or having, a sensory neuropathy related disease, such as sensory neuropathies. In particular, the disclosure is based on the determination of mutations in the SPTLC2 gene causing sensory neuropathies.

Abstract: A system for imaging a target object comprises a first unmanned vehicle including a source of penetrating radiation. The first vehicle positions the source such as to direct the radiation toward the target object. A second unmanned vehicle comprises an image detector for registering a spatial distribution of the radiation as an image, in which the second vehicle positions the detector to register the distribution of radiation when transmitted through the target object. These unmanned vehicles are autonomous vehicles adapted for independent propelled motion, and comprise a positioning unit for detecting a position of the vehicle. A processing unit controls the motion of the unmanned vehicles to acquire at least two images corresponding to at least two different projection directions of the radiation through the target object. The processing unit is adapted for generating data representative of an internal structure of the target object from the at least two images.

Abstract: A method of estimating an individualized head-related transfer function and an individualized interaural time difference function of a particular person, comprises the steps of: a) obtaining a plurality of data sets comprising a left and a right audio sample from in-ear microphones, and orientation information from an orientation unit, measured in a test-arrangement where an acoustic test signal is rendered via a loudspeaker and the person is moving the head; b) extracting interaural time difference values and/or spectral values, and corresponding orientation values; c) estimating a direction of the loudspeaker relative to the head using a predefined quality criterion; d) estimating an orientation of the orientation unit relative to the head; e) estimating the individualized ITDF and the individualized HRTF. A computer program product may be provided for performing the method, and a data carrier may contain the computer program.

Abstract: The present invention relates to compounds having a benzotropolone core, and compositions containing said compounds acting as ATG4B inhibitors, thereby inhibiting autophagy. Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicine, in particular for the treatment of cell proliferative disorders, such as cancer.

Abstract: The present invention is directed to an aerosol spray containing one or more bacterial species and at least one siloxane suitable for applying said one or more bacterial species to a surface or into the environment.