Abstract: This disclosure relates to a novel class of compounds having the structure of formula I as defined herein and pharmaceutical compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof. This disclosure also comprises methods of treating a subject by administering a therapeutically effective amount of a compound of formula I or a pharmaceutically acceptable salt thereof to the subject. These compounds are useful for the conditions disclosed herein. This disclosure further comprises methods for making the compounds of formula I and corresponding intermediates.

Abstract: A sonar based sensor for localization of a target in air is described. The sensor comprises a wide or ultra-wide band emitter for emitting a wide or ultra-wide band signal, and a set of spatially randomly or irregularly positioned receivers for receiving the wide or ultra-wide band signal after reflection at the target. A corresponding processor and method for localizing also is disclosed.

Abstract: Described are methods and kits for identifying a subject at risk of, or having, a sensory neuropathy related disease, such as sensory neuropathies. In particular, the disclosure is based on the determination of mutations in the SPTLC2 gene causing sensory neuropathies.

Abstract: This invention provides: —an aptamer-based electrochemical sensor, wherein said aptamer is covalently bonded to or chemisorbed on an electrode, said aptamer forming a complex with a target molecule and is encapsulated by a gelatin B matrix; —a method of manufacturing said aptamer-based electrochemical sensor; —the use of the aptamer-based electrochemical sensor for the electrochemical determination of a concentration of a target molecule; and —a composite electrode combining a polymeric material and electrically conducting particles for selective analyte detection, wherein said electrode is coated with gelatin type B.

Abstract: A computerized tomographic image exposure and reconstruction method wherein an object is subjected to irradiation during a relative movement of a source of radiation, saidthe object, and a radiation detector and wherein a digital representation of the radiation image of saidthe object is computed by applying a tomographic reconstruction algorithm to image data read out of the irradiated radiation detector. A number of projection images are generated, each of saidthe projection images being generated by integrating X-ray beams continuously emitted during saidthe relative movement through a predefined movement path, and the created projection images are modeled in a tomographic reconstruction algorithm.

Abstract: The present invention relates to the field of HIV-1 infections, and in particular provides novel compounds containing triazine rings and suitable spacers. The compounds according to this invention are very suitable for the prevention and/or treatment of HIV-1 infection and in particular show improved activity against NNRTI-resistant viruses of HIV-1.

Abstract: The present invention relates to novel compounds and probes which have a common chemical structure necessary to obtain potent inhibitory activity against KLK4 and/or may be used for the detection of KLK4 peptides and their activity. It further relates to the use of these compounds and methods for inhibiting and/or detecting KLK4 activity in vitro and in vivo by making use of said probes or inhibitors. The compounds of the invention differ from prior art compounds at least in the presence of phenyl guanidine (instead of e.g. benzyl guanidine) and/or the presence of a heteroatom in the tail group, their combined presence unexpectedly leading to potent and selective KLK4 inhibitory activity.

Abstract: A method for applying a filter component for an analytical tomographic reconstruction technique, e.g. filtered backprojection, used in tomographic comprises providing an algebraic reconstruction algorithm for reconstructing a spatial representation of a volume of interest from a projection data set. It thereby takes into account a geometry of the tomographic imaging. The method also comprises applying the algebraic reconstruction algorithm to a plurality of virtual projection data sets—corresponding with a basis vector of a basis for the projection space—to produce a plurality of reconstructed spatial representations and determining the filter component using the plurality of reconstructed spatial representations, and applying the filter. Applying the analytical reconstruction technique with the determined filter component may inherit beneficial properties from the algebraic reconstruction algorithm, e.g. versatility and robustness to noise, without incurring the associated computational cost.

Abstract: A method and device for dynamically altering the signal-space-to-physical-space mapping database of a set of access points for use in localizing of an object, by obtaining a location profile for the object and obtaining an estimated location of an object by measuring the signal parameter induced by at least one access point and using the signal-space-to-physical-space mapping database for deriving an estimated location from the measured signal parameter, and determining whether the obtained estimated location complies with the obtained location profile for the object. If the obtained estimated location does not comply with the location profile, the mapping database is dynamically adjusted to obtain an adjusted signal-space-to-physical-space mapping database based on a difference between the measured signal parameter and the signal parameter corresponding with the signal space for the location expected based on the location profile.

Abstract: A coated-wire potentiometric sensor comprising an electronically conducting substrate electrode coated with an ionically conductive sensing layer and an outermost surface consisting of or comprising in and/or on a first molecular species which is capable of reversibly adsorbing a second molecular species and a method for measuring the affinity between a first molecular species and a second molecular species comprising the steps of: providing a potentiometric sensor of the coated-wire type having an outermost surface; adapting said outermost surface so that consists of or comprises said first molecular species; placing said sensor in a system for the recording of sensorgrams; recording a sensorgram of the adsorption of a second molecular species on said first molecular species of or comprised in and/or on said adapted outermost surface.

Abstract: The disclosure relates to the field of human genetics, particularly the field of peripheral neuropathy, particularly inherited peripheral neuropathy. Specifically, the disclosure relates to methods and materials to detect hereditary peripheral neuropathy, more particularly autosomal recessive Charcot-Marie-Tooth disease.

Abstract: A method for performing high resolution electron microscopy of a soft matter object is described. The method comprises irradiating a soft matter object using an electron microscope having a spherical aberration correction with a substantially constant transfer function in a frequency band of thermal diffuse scattered electrons scattered at the soft matter object. The method comprises detecting the thermal diffuse scattered (TDS) electrons scattered at the soft matter, and using the detected thermal diffuse scattered electrons for deriving therefrom an image of the soft matter object.

Abstract: A method for determining a projection angle for use in tomographic imaging comprises obtaining projection data including at least one projection view from at least one projection angle. The at least one projection view is generated by scanning a test object with a tomographic imaging device. Each projection view comprises at least one observation value obtained at least one detection location, providing a plurality of candidate projection angles, for each candidate projection angle, calculating a function value indicative of an amount of information that may be gained by adding to the projection data a further projection view generated by scanning of the test object with the tomographic imaging device from the candidate projection angle, and selecting a candidate projection angle from the plurality of candidate projection angles taking into account the function values. A corresponding system and computer program product also is provided.

Abstract: The present invention relates to a drug release formulation, in particular a sustained release formulation for ophthalmic applications and a method of preparing same. The method is based on the hydration of a given solid polymeric matrix material under mild conditions, allowing versatility with respect to the drug to be formulated. Both said solid polymeric matrix material as well the API hydrated formulation is an object of the present invention. The thus obtained material is particularly suitable for prolonged and sustained delivery of medication to the eye. Thus in a further aspect, the present invention provides the use of said solid polymeric matrix material as well the API hydrated formulation, in ophthalmic applications.

Abstract: A device is arranged for imparting an orbital angular momentum to a charged particle wave propagating along an axis in a charged particle beam generating apparatus. The device includes a first conductive element comprising a plurality of angularly spaced electrical conductors arranged around the axis, and a second conductive element. The first and second conductive elements are spaced apart along the direction of the axis, and are adapted for transmitting a charged particle wave propagating along the axis. A connecting means is adapted for supplying an electrical potential to the plurality of angularly spaced electrical conductors for inducing an angular gradient of the phase of the charged particle wave when transmitted along the axis, in which the projection along the axis of the electrical potential varies as a function of an angular position with respect to the axis.

Abstract: The present invention relates to the field of HIV-1 infections, and in particular provides novel compounds containing triazine rings and suitable spacers. The compounds according to this invention are very suitable for the prevention and/or treatment of HIV-1 infection and in particular show improved activity against NNRTI-resistant viruses of HIV-1.

Abstract: A device for imparting an orbital angular momentum to a charged particle wave propagating along a beam axis in a charged particle beam generating apparatus is described. The device comprises a support element having a target region adapted for transmitting a charged particle wave propagating along a beam axis and an induction means for inducing a magnetic flux along an elongated profile having a free end portion located in the target region and the induction means is adapted for providing a magnetic flux in the elongated profile in order to induce an angular gradient, relative to the beam axis, of the phase of the charged particle wave when transmitted through the target region. A corresponding method is also disclosed, as well as the use thereof in electron microscopy.

Abstract: The present invention relates to a method for the modification of metal hydroxide and/or metal oxide surfaces of an inorganic matrix with an organometallic reagent for obtaining an organic functionalized matrix suitable for filtration processes. The method involves the direct covalent binding of organic functional groups by allowing a pre-treated matrix to react with organometallic reagents in the present of a suitable solvent. The present invention further relates to an organic functionalized matrix obtainable or obtained by carrying out a method according to the invention. The invention also provides various uses of a surface-modified matrices as described herein in various industrial applications, including for instance in filtration and/or adsorption and/or separation processes, or as support, e.g. for catalyst systems or for enzyme systems.

Abstract: Methods of cylindrical surface parameterization, such as colon flattening are provided for parameterizing tubular surfaces onto a cylinder, wherein the length of the cylinder is modified so that parameterization distortion is reduced.

Abstract: A coated-wire potentiometric sensor comprising an electronically conducting substrate electrode coated with an ionically conductive sensing layer and an outermost surface consisting of or comprising in and/or on a first molecular species which is capable of reversibly adsorbing a second molecular species and a method for measuring the affinity between a first molecular species and a second molecular species comprising the steps of: providing a potentiometric sensor of the coated-wire type having an outermost surface; adapting said outermost surface so that consists of or comprises said first molecular species; placing said sensor in a system for the recording of sensorgrams; recording a sensorgram of the adsorption of a second molecular species on said first molecular species of or comprised in and/or on said adapted outermost surface.