Abstract: Phase separator comprising a housing with a main inlet and a main outlet and one or more secondary outlets, the main inlet arranged for allowing the multiphase mixture to enter the phase separator and the main outlet arranged for allowing the treated multi-phase mixture to leave the phase separator, i.e. after separation of phase entities from the multi-phase mixture, the one or more secondary outlets arranged for allowing the separated phase entities to leave the phase separator, characterized in that the phase separator further comprises compartmentalization means.

Abstract: A method for applying a filter component for an analytical tomographic reconstruction technique, e.g. filtered backprojection, used in tomographic comprises providing an algebraic reconstruction algorithm for reconstructing a spatial representation of a volume of interest from a projection data set. It thereby takes into account a geometry of the tomographic imaging. The method also comprises applying the algebraic reconstruction algorithm to a plurality of virtual projection data sets—corresponding with a basis vector of a basis for the projection space—to produce a plurality of reconstructed spatial representations and determining the filter component using the plurality of reconstructed spatial representations, and applying the filter. Applying the analytical reconstruction technique with the determined filter component may inherit beneficial properties from the algebraic reconstruction algorithm, e.g. versatility and robustness to noise, without incurring the associated computational cost.

Abstract: The present invention relates to selective trypsine-like serine protease activity-based probes, in particular urokinase plasminogen activator-activity based probes, the use thereof and methods for detecting selective urokinase activity by making use of said probes.

Abstract: This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.

Abstract: The present disclosure provides a device for analyzing target molecules. The device comprises a substrate retention device for holding a substrate having a functionalized surface provided thereon. This functionalized surface is adapted for capturing a plurality of target molecules. The device also comprises a light source for illuminating the functionalized surface and an image sensor for recording interference patterns of magnetic particles present on the functionalized surface. The device further comprises a first magnetic field generator configured to generate a magnetic field to attract magnetic particles linked to the target molecules to the functionalized surface. The disclosure further relates to a method for analyzing target molecules.

Abstract: A computer-implemented method and system for ranking information in an information system comprising linked objects is disclosed. The computer-implemented method comprises computing a prior ranking of all objects in the linked database, obtaining at least one source object, determining the probability of reaching an object taking a step in random walk with restart in the at least one source object(s) based on the adjacency between objects in the information system, and determining a ranking of objects in the information system using the determined probability and applying a correction factor inversely proportional with the computed prior ranking of the objects. An output based on the determined ranking is provided. The present invention also relates to a computer-implemented method and system for providing probable functional relations between at least one source object and a target object, as well as computer-related products therefor.

Abstract: This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.

Abstract: The present invention is a method for determining during run-time an adaptation to a software architecture comprising a plurality of components. The method includes the steps of—evaluating constraints for the adaptation relating to a functional dependence of components of the software architecture,—determining during run-time a context for the software architecture taking into account information on the state of the architecture,—selecting among a plurality of context models a context model corresponding to the determined context,—evaluating constraints for the adaptation imposed by the selected context model,—taking a decision on performing the adaptation based on the outcome of the evaluation steps.

Abstract: Methods of cylindrical surface parameterization, such as colon flattening are provided for parameterizing tubular surfaces onto a cylinder, wherein the length of the cylinder is modified so that parameterization distortion is reduced.

Abstract: Phase separator comprising a housing with a main inlet and a main outlet and one or more secondary outlets, the main inlet arranged for allowing the multiphase mixture to enter the phase separator and the main outlet arranged for allowing the treated multi-phase mixture to leave the phase separator, i.e. after separation of phase entities from the multi-phase mixture, the one or more secondary outlets arranged for allowing the separated phase entities to leave the phase separator, characterized in that the phase separator further comprises compartmentalization means.

Abstract: The present invention relates to a method for the modification of metal hydroxide and/or metal oxide surfaces of an inorganic matrix with an organometallic reagent for obtaining an organic functionalized matrix suitable for filtration processes. The method involves the direct covalent binding of organic functional groups by allowing a pre-treated matrix to react with organometallic reagents in the present of a suitable solvent. The present invention further relates to an organic functionalized matrix obtainable or obtained by carrying out a method according to the invention. The invention also provides various uses of a surface-modified matrices as described herein in various industrial applications, including for instance in filtration and/or adsorption and/or separation processes, or as support, e.g. for catalyst systems or for enzyme systems.

Abstract: The present invention relates to novel compounds with inhibitory activity towards urokinase plasminogen activator (uPA); to methods for preparation of said uPA inhibitor compounds; to pharmaceutical compositions comprising said uPA inhibitor compounds; to the use of said uPA inhibitor compounds as a medicament and the use of said uPA inhibitor compounds for the preparation of a medicament for the treatment of conditions chosen from the group comprising cancer, tumour growth, tumour invasion, tumour metastasis, diabetic retinopathy, hemorrhagic atherosclerosis and inflammatory conditions, such as rheumatoid arthritis and psoriasis.

Abstract: The present invention relates to mutations in the amyloid precursor protein (APP) promoter region, whereby the mutations cause a significant increase in APP expression. The increase in APP expression is related to Alzheimer's disease, and the mutations can be used in Alzheimer's disease diagnosis, or in the construction of transgenic animal models for studying Alzheimer's disease.

Abstract: The present invention relates to the use of high dose of folic acid, or an equivalent dose one of its biological active derivatives to blunt myocardial dysfunction during ischemia and to ameliorate post-reperfusion injury. The invention specially relates to an early treatment by the application of a high dose of at least 200 mg folic acid, or an equivalent dose of a derivative during active ischemia, before the reperfusion.

Abstract: The present invention relates to a potentiometric electrode and gradient polymer, both comprising electrically conducting particles, which increase in concentration away from one surface, ionophore molecules, which increase in concentration towards the same surface surface, and an electrical connection which passes proximal to said electrically conducting particles. The invention further relates to devices incorporating said electrode or gradient polymer, and to a method for their preparation. The new materials are highly robust and reliable.

Abstract: The present invention provides a Vestibular Evoked Myogenic Potential monitoring system comprising an autonomous integrated system. The integrated system comprises an output being arranged for transferring a stimulation signal via an actuator to an equilibrium organ of a person, a processing and controlling block having an integrated radio and antenna, and an array of electrodes being attachable in the vicinity of at least one muscle of said person and being arranged for recording the responsive signal and for transferring this signal to the processing and controlling block. The processing and controlling block of the integrated system is arranged for generating a stimulus, for storing and processing the recorded signals, and for sending the processed data via a WL link to a processor.

Abstract: A method for modelling, i.a. analyzing and/or synthesizing, a windowed signal such as sound or speech signals, by computing the frequencies and complex amplitudes from the signal using a nonlinear least squares method is disclosed. The computations complexity is reduced by taking into account the bandlimited property of a window.

Abstract: Methods of diagnosis and treatment of sleep apnea by taking measurements from a subject suffering from sleep apnea are disclosed. The methods include modelling the air flow through the upper airway of a subject suffering from sleep apnea.

Abstract: The present invention relates to novel compounds with inhibitory activity towards urokinase plasminogen activator (uPA); to methods for preparation of said uPA inhibitor compounds; to pharmaceutical compositions comprising said uPA inhibitor compounds; to the use of said uPA inhibitor compounds as a medicament and the use of said uPA inhibitor compounds for the preparation of a medicament for the treatment of conditions chosen from the group comprising cancer, tumour growth, tumour invasion, tumour metastasis, diabetic retinopathy, hemorrhagic atherosclerosis and inflammatory conditions, such as rheumatoid arthritis and psoriasis.