Abstract: The present disclosure provides methods and compositions for treating a condition associated with impaired lymphatic drainage.

Abstract: An embodiment includes a method for use in managing a cluster comprising a plurality of computers, each computer comprising at least one hardware processor coupled to at least one memory. The method comprises a computer-implemented manager: collecting access pattern data for the plurality of computers; based at least in part on the access pattern data, determining that at least a first one of the plurality of computers is overutilized; and responsive to determining that the first computer is overutilized, moving stored data from the first computer to at least a second one of the plurality of computers.

Abstract: The methods and compositions described herein address the need in the art by providing peptides and polypeptides comprising a growth factor binding domain. In some embodiments, the peptides have an amino acid sequence that is at least 80% identical to one of SEQ ID NOS:1-7, 13-15, 49-50, or 66-70, or a fragment thereof; wherein the peptide is less than 300 amino acids in length.

Abstract: The invention relates to an anti-viral composition comprising at least one, and ideally a plurality of, monoclonal antibodies, or fragments thereof; an immunogenic agent, vaccine or pharmaceutical composition comprising the afore anti-viral composition; said anti-viral composition, immunogenic agent, vaccine or said pharmaceutical composition for use in the treatment of or prevention of a viral infection; use of said anti-viral composition in the manufacture of a medicament to treat or prevent a viral infection; a combination therapeutic for use in the treatment or prevention of a viral infection comprising said anti-viral composition, immunogenic agent, vaccine or pharmaceutical composition in combination with at least one other therapeutic agent; and a method of treating or preventing a viral infection comprising administering said anti-viral composition, immunogenic agent, vaccine or said pharmaceutical composition to an individual having, or suspected of having, a viral infection.

Abstract: The present invention relates to therapies and therapeutic agents for use in the treatment of cardiomyopathies. In particular, the invention is concerned with, but not limited to therapies and therapeutic agents for use in the treatment of hypertrophic cardiomyopathy. Such therapeutic agents comprise hypomethylating agents.

Abstract: Protein agglomeration is inhibited in a protein-containing liquid, within an industrial processing plant, using a microwave resonance cavity having an inlet conduit and an outlet conduit. The liquid is transported into and out of the cavity, and while within the cavity, it is exposed to a microwave electromagnetic field. This field exposure reduces the tendency of proteins within the liquid to agglomerate, and inhibits coagulation or protein deposition for an extended period of time after leaving the cavity.

Abstract: The present invention provides a method for performing optical image detection using a camera module comprising a Digital MicroMirror Device, a first point Photo Detector, a second point Photo Detector, a first lens and a second lens.

Abstract: A method for predicting risk of recurrence of cancer in an individual with cancer, the method comprising a step of assaying a cancer sample from the individual for positive expression of at least two genes or proteins encoded by those genes selected from the group consisting of FOXM1, UHRF1, PTTG1, E2F1, MYBL2, HMGB2, ATAD2, E2F8, ZNF367 and TCF19, wherein positive expression of the at least two genes correlates with increased risk of recurrence of cancer compared with an individual who does not exhibit positive expression of the at least two genes or proteins encoded by those genes.

Abstract: The present invention relates to the therapeutic uses of compositions containing antibody molecules and functional fragments thereof, e.g antibody molecules and functional fragments capable of binding to tumor necrosis factor alpha (TNF?), in the topical treatment of inflammatory bowel diseases, including Crohn's disease and ulcerative colitis.

Abstract: There is provided a method for distinguishing between sepsis and systemic inflammatory response syndrome (SIRS) in a patient, comprising: (i) determining the amount of one or more biomarker for sepsis, and one or more biomarker for SIRS in a sample obtained from a patient, wherein the one or more biomarker for sepsis is selected from the group consisting of: ITGB3, ITGA2B, MYL9, LCN2, TREML1, LCN15, CMTM5, PPBP, and PF4; and the one or more biomarker for SIRS is selected from the group consisting of: PLA2G7, ARHGEF10L, MYCL, TGFBI, and GPR124, (ii) comparing the amount of the one or more biomarker for sepsis determined in said sample in (i) to a corresponding reference value representative of a healthy individual, (iii) comparing the amount of the one or more biomarker for SIRS determined in said sample in (i) to a corresponding reference value representative of a healthy individual; wherein the patient is diagnosed as having sepsis, when an increase is observed in the one or more biomarker for sepsis, and no

Abstract: The present disclosure relates to a new T-cell receptor (TCR), in particular at least one complementarity-determining region (CDR) thereof; a T-cell expressing said TCR; a clone expressing said TCR; a vector encoding said TCR; a soluble version of said TCR; a pharmaceutical composition or immunogenic agent or bispecific or vaccine comprising said TCR, said cell, said clone or said vector; said TCR or said cell or said clone or said vector or said pharmaceutical composition or immunogenic agent or bispecific or vaccine for use in the treatment of cancer; a method of treating cancer using said TCR, said cell, said clone, said vector, said pharmaceutical composition, immunogenic agent, bispecific or vaccine comprising said TCR; and a ligand with which said TCR binds.

Abstract: The present invention relates to a cell, wherein the cell is modified to: reduce O-GalNAc galactosylation activity in the cell by reduction of functional COSMC molecular chaperone in the cell and/or by reduction of functional T-synthase in the cell; and overexpress ?1,4-galactosyltransferase in the cell; and associated methods, kits and uses.

Abstract: A strain of Bifidobacterium longum APC 1472 is described. The strain has weight lowering effects in-vivo, achieved through inducing satiety via decreased internalisation of the Ghrelin receptor, and therefore, decreased constitutive activity. Moreover, the strain also showed a trend towards decreased ghrelin receptor hypothalamic expression in HFD-fed mice when compared with vehicle control group. The strain also improves glucose tolerance and decreased insulin plasma levels in mice, indicating the strain in the prevention and/or treatment of Type II diabetes, especially in obese individuals.

Abstract: The invention provides a monolithic integrated mesh device for atomization or pumping of a fluid or liquid comprising a plurality of apertures and a piezoelectric material. The piezoelectric material is bonded to the mesh device at an atomic scale. In one embodiment the monolithic micro-fabricated device of the invention includes piezoelectric material that eliminates the need for expensive assembly process and improves reliability. This also has advantage of requiring lower operating voltage and less complicated circuitry.

Abstract: Serious gaming for interrelated critical infrastructure (CI) resilience improvement includes receiving from a serious gaming participant a selection of an anomalous event for a geographic region for which a hierarchy of CI elements has been modeled, and a specified change in allocation of at least one resource in a corresponding one of the CI elements. A previously determined cascading impact upon the CI elements resulting from the anomalous event is then retrieved and compared to a hypothetical cascading impact produced by a simulation of the model with the specified change. A visualization of the comparison is transmitted to the serious gaming participant so as to show the result of the hypothetical change in resources upon the cascading impact of the event in the hierarchy of CI elements.

Abstract: Provided are an apparatus and system for directing power flow between multiple devices, the apparatus comprising: one or more inlet ports for connection to one or more devices; a plurality of outlet ports configured for supplying electrical power; and a computing device configured to route power from the one or more inlet ports to the outlet ports. The system comprises a plurality of the apparatus connected to each other.

Abstract: Embodiments of the present invention provide a method, system and computer program product for tiered data sharing privacy assurance in responding for requests to inspect investigative data. In an embodiment of the invention, a method for tiered data sharing privacy assurance in responding for requests to inspect investigative data includes receiving a request to access investigative data and applying a privacy test to the request to determine if the request is specific for an individual or generic to any individual. On condition that the privacy test is determined to be generic, the request may be denied. But otherwise, on condition the test is determined to be specific, a data sharing rule that defines a degree to which the investigative data is to be shared may be applied and the request responded to according to the defined degree.

Abstract: Multi jurisdictional data sharing includes ingesting data sharing regulations for respectively different political jurisdictions and parsing each of the regulations into a corpus of regulatory text with portions of the corpus having been normalized into different sets of uniform regulations for corresponding ones of the different political jurisdictions. Each of the uniform regulations for each of the political jurisdictions is then matched with one or more applicable data sharing rules and a reference for each of the data sharing rules can be written to a data sharing rules table in association with one or more of the political jurisdictions determined to have uniform regulations matched to the one or more data sharing rules. Consequently, data sharing requests can be restricted as between organizations of one or more implicated political jurisdictions according to each matched data sharing rule in the data sharing rules table that had been associated with the political jurisdictions.

Abstract: A surface preparation method (200) for a composite material (104) having an original surface (110), the material (104) comprising fibres (104a) within a matrix (104b), comprises removing (204) a surface portion of the matrix (104b) by plasma ablation so as to reveal and activate (206) a new surface (120) with at least a portion of a plurality of the fibres (104a) exposed thereon, without creating a residual heat-affected zone.

Abstract: A method for synthesizing mesoporous silica microparticles comprising the steps of: preparing a sol from an ammonium catalyzed hydrolysis and condensation reaction of a pre-sol solution comprising a silica precursor and a structure directing agent dissolved in a mixed solvent system comprising an alcohol and water to produce mesoporous particles of silica with an average diameter of up to about 50 ?m; hydrothermally treating the particles to increase the pore size; treating the particles to remove residual structure directing agent; and further increasing the pore size using controlled dissolution.