Abstract: The invention provides a solution based process based on high molecular weight block copolymer (BCP) nanolithography for fabrication of periodic structures on large areas of optical surfaces. In one embodiment there is provided method of fabricating a nano-patterned surface for application in a photonic, optical or other related device, said method comprising the steps of: providing a substrate material; depositing a block copolymer (BCP) material on the substrate material; and phase separating the BCPs using at least one solvent selected to facilitate polymer chain mobilisation and lead to phase separation to fabricate said nano-patterned surface; wherein the nano-patterned surface comprises an ordered array of structures and having a domain or diameter of 100 nm or greater. A new photonic device and optical device is also described.

Abstract: A lung perfusion solution comprises a base solution comprising a physiological mixture of electrolytes and buffers, 3.5-5.5% (w/v) a first macromolecule having a molecular weight of 40-100 KDa, and an amount of a second, high molecular weight, macromolecule sufficient to adjust the relative viscosity of the solution to 2.0-3.0.

Abstract: Inhibitors of MAPK3 (ERK1 MAP kinase), in particular polypeptides having the ability to stimulate the global ERK signalling pathway in the brain and their use as neuroprotective and/or cognitive enhancing agents, are disclosed. Related polynucleotides, vectors, host cells and pharmaceutical compositions able to inhibit MAPK3, causing the stimulation of the global ERK signalling pathway, are also disclosed. Additionally, use of the afore inhibitors or stimulators in the treatment of neurodegenerative or neuropsychiatric disorders and cognitive impairment is also disclosed.

Abstract: Aspects of the subject disclosure may include, for example, a method in which a processing system identifies a plurality of performance indicators comprising device performance indicators for a plurality of communication devices on a cellular network and network performance indicators for the cellular network. The method also includes obtaining historical data regarding the plurality of performance indicators for each of a series of time points during a past time period; the historical data for each of the plurality of performance indicators form an array of values for that performance indicator. The method further includes generating from each array a set of inputs to an algorithm for predicting a throughput of the cellular network during a future time period; the set of inputs comprises quantiles of the array, and the algorithm comprises a machine learning algorithm. Other embodiments are disclosed.

Abstract: In one example embodiment, a method includes obtaining sets of input data and an objective, the sets of input data including values of wireless network communication parameters, generating sets of output data for the sets of input data in accordance with the objective, generating a mapping of the sets of input data to the sets of output data and training a network controller using the mapping.

Abstract: At least one embodiment of the invention provides a photonic subsystem for integrating onto a photonic platform. The subsystem comprises a laser source and a plurality of optical components for focusing and directing a laser beam emitted from the laser source into a photonic platform. The laser source and plurality of optical components are mounted to a substrate and encapsulated.

Abstract: The invention provides a method of preparing a silica-protein sub-micron particle, the method comprising contacting, in an aqueous medium having a pH in the range of about 7.5 to 10 and having an ionic strength in the range of about 1.2 to 60 mM, (i) protein sub-micron particle cores comprising 0.2 to 3 ?moles, per mg of the protein sub-micron particle cores, of a basic compound of formula (I) or an ester and/or amide thereof wherein n is an integer selected from 1 to 10, and p is an integer selected from 1 to 3, with (ii) orthosilicic acid or an ester thereof, in an amount equivalent to 5 to 60% (w/w) orthosilicic acid per mg of the protein sub-micron particle cores, to form the silica-protein sub-micron particle. The invention also provides a method of making a GLP-1 receptor agonist sub-micron particle core, by a. contacting a peptide in an aqueous medium at a pH of about 5.0-8.0 and comprising about 0.3-1.

Abstract: A surgical system for penetrating and determining a characteristic of tissue. An instrument generates rotational torque, and a drill bit tool body extends along an axis between a distal end to engage tissue and a proximal end to couple to the instrument. An emitter operatively coupled to the instrument emits light. A detector operatively coupled to the instrument detects light. An emission lightguide within the tool body transmits light emitted by the emitter toward the tissue as the instrument rotates the tool body. A detection lightguide within the tool body is spaced from the emission lightguide and transmit light reflected by the tissue toward the detector as the instrument rotates the tool body. The emitter emits light into the emission lightguide along the axis, and the detector detects light reflected from the tissue exiting the detection lightguide transverse to the axis when the tool body is coupled to the instrument.

Abstract: The invention relates to a sensor molecule for detecting a target molecule comprising: (a) a rod-like molecule L and a rod-like molecule R connected to each other by a joint molecule C to form a hinge; (b) a target binding molecule A bonded to the end of rod-like molecule L opposite to the joint molecule C; (c) a binding molecule A? bonded to the end of rod-like molecule R opposite the joint molecule C; wherein the target binding molecule A is arranged to bind to an epitope or nucleic acid sequence of the target molecule to be detected, and binding molecule A? is arranged to bind to the same epitope or same nucleic acid sequence, or portion thereof of the target molecule as target binding molecule A; and wherein the hinge is biased into an open position, such that target binding molecule A and binding molecule A? are biased apart by the hinge. The invention also relates to analyte dependent activation of pharmaceuticals and chemo-toxins.

Abstract: An imaging apparatus (1) for imaging a sample (7) comprising an array of electronically addressable pixels (6) wherein each pixel is arranged to support a surface plasmon resonance thereinto generate an evanescent electromagnetic field (8) which extends transversely from the pixel so as to be salient from plane of the array for illuminating the sample (7). An optical detector (12) is arranged for detecting optical radiation (9, 10, 11) scattered from the evanescent electromagnetic field (8) by the sample (7). A processing unit (4) arranged to associate the detected optical radiation (9, 10, 11) with the address of the pixel or pixels within the array at which the surface plasmon resonance was generated.

Abstract: The present disclosure provides a medical device (100) for inducing cell death in cancer cells. The device comprises a signal generator (102) arranged to generate a pulsed electrical signal, and a transmitter (116) arranged to receive the pulsed electrical signal and generate, in response to the electrical signal, an electric field in a treatment volume. The device (100) is arranged such that the pulsed electrical signal received by the transmitter (116) has a pulse width of 0.1 microsecond to 1 millisecond, and a signal frequency of 10 Megahertz to 20 Gigahertz. The present disclosure also provides a method of inducing cell death. The method comprising a step of generating, using a transmitter (116), a pulsed time varying electric field in a treatment volume comprising a volume of cells to be treated. The electric field has a pulse width of 0.1 microsecond to 1 millisecond, and a signal frequency of 10 Megahertz to 20 Gigahertz.

Abstract: The invention relates to an anti-mitotic agent comprising at least one antibody, or an epitope thereof, that selectively binds the extracellular domain of at least one ZIP (Zrt, Irt-like Proteins) transporter protein to inhibit its function, specifically mitosis; a composition comprising same; and the use of said anti-mitotic agent or composition to treat a hyper proliferative disorder including cancer.

Abstract: The invention concerns a novel acoustofluidic device to separate acoustically active particles from fluids comprising a novel device arrangement for improved acoustic pressure and particle velocity; and a method of separating particles from a fluid comprising use of same.

Abstract: The invention provides compounds of the formula (I): (I) wherein A1, A2, R2, R4, B1, B2, X, X1, n, a and b are as defined are defined in the specification, to pharmaceutical compositions comprising the compounds and the compounds for use as medicaments. The compounds potentiate AMPA receptor function and are expected to be useful in the treatment of central nervous system disorders, for example in the treatment of depressive disorders, mood disorders and cognitive dysfunction associated with neuropsychiatric disorders such as schizophrenia.

Abstract: Microwave resonance cavities and associated methods and apparatus are described. In one example, a cavity (100) comprises a first and a second input port (102, 104) for inputting microwave radiation at a first and a second frequency respectively. The microwave radiation at the first frequency may be to excite a sample in the cavity whereas the microwave radiation at the second frequency may be to interrogate a sample in the cavity for analysis. The cavity has dimensions such that it resonates at both the first and the second frequency.

Abstract: There is provided system and a separation substrate device for use with an NLM separator in separating and/or detecting at least one target analyte in a sample, the substrate comprising a micromagnet array of a plurality of micromagnets, the micromagnet array comprising a first capture region, a second focusing region, and, a third detection region, the focusing region comprising a converging and/or diverging micromagnet array region. Also provided is a method for separating and detecting at least one target analyte in a sample.

Abstract: A method for the enzymatic conversion of a phenol substrate into a corresponding catechol product comprises the step of incubating the phenol substrate with a Ralstonia solanacearum tyrosinase enzyme, or a functional derivative thereof, in a reaction mixture, for a period of time sufficient to allow the enzyme convert at least some of the phenol substrate into the catechol product.

Abstract: A device for monitoring adherence of a patient to a prescribed regimen is provided. The device has a pulmonary delivery device fluid, an adapter in communication with the delivery device and a dispenser in fluid communication with the adapter. A pressurized drug, contained in the pulmonary delivery device, can be delivered from the pulmonary delivery device to the patient through the adapter and the dispenser. A sensor is mounted to the adapter or the dispenser for detecting a temperature or pressure change caused by the movement of the drug from the pulmonary delivery device to the patient and generating a feedback signal based on the change. The feedback signal is further processed for generating a signal indicating a successful deliver of the drug to the patient.

Abstract: The present invention provides an inductor device comprising one or more interconnected columns of conductive material embedded in a supporting structure, wherein the one or more columns comprise an input terminal and an output terminal; and wherein each column is surrounded by a first magnetic layer.

Abstract: The present invention provides a probability mass redistributor device comprising an input port and an output port. The device comprises a mapping block configured to perform a selected mapping function from a plurality of mapping functions on a random bitstream to generate an output signal having a desired probability mass function, at least one difference block, wherein the input to the at least one difference block comprises the output from the mapping block, and the output of the at least one difference block produces a modulation term, and wherein the output of each difference block is the difference between a previous value of the input signal to the block and a current value of the input signal to the block, and a summing block for summing a signal received by the input port and the modulation term to form an output signal.