Abstract: A method for synthesizing mesoporous silica microparticles comprising the steps of: preparing a sol from an ammonium catalyzed hydrolysis and condensation reaction of a pre-sol solution comprising a silica precursor and a structure directing agent dissolved in a mixed solvent system comprising an alcohol and water to produce mesoporous particles of silica with an average diameter of up to about 50 ?m; hydrothermally treating the particles to increase the pore size; treating the particles to remove residual structure directing agent; and further increasing the pore size using controlled dissolution.

Abstract: A method for multi-dimensional, relaxation-diffusion magnetic resonance fingerprinting (MRF) includes performing, using a magnetic resonance imaging (MRI) system, a pulse sequence that integrates free-waveform b-tensor diffusion encoding into a magnet resonance fingerprinting pulse sequence to perform a multi-dimensional, relaxation-diffusion encoding while acquiring MRF signal evolutions, processing, using a processor, the acquired MRF signal evolutions to determine at least one relaxation parameter and at least one diffusivity parameter, and generating, using the processor, a report including at least one of the at least one relaxation parameter and the at least diffusivity parameter.

Abstract: Provided are an apparatus and system for directing power flow between multiple devices, the apparatus comprising: one or more inlet ports for connection to one or more devices; a plurality of outlet ports configured for supplying electrical power; and a computing device configured to route power from the one or more inlet ports to the outlet ports. The system comprises a plurality of the apparatus connected to each other.

Abstract: The invention concerns a device for introducing microneedles into the skin of a subject; and a method for inserting microneedles into the skin of a subject comprising use of said device.

Abstract: The invention concerns a device for use in ligament surgery to locate the best graft attachment site, including parts thereof; a kit of parts for use in ligament surgery; and a method for performing ligament surgery.

Abstract: The present disclosure relates to a new T-cell receptor (TCR), in particular at least one complementarity-determining region (CDR) thereof; a T-cell expressing said TCR; a clone expressing said TCR; a vector encoding said TCR; a soluble version of said TCR; a pharmaceutical composition or bispecific comprising said TCR, said cell, said clone or said vector; use of said TCR or said cell or said clone or said vector or said pharmaceutical composition or bispecific to treat cancer; and a method of treating cancer using said TCR, said cell, said clone, said vector, said pharmaceutical composition or bispecific comprising said TCR.

Abstract: The present invention relates to the therapeutic uses of compositions containing antibody molecules and functional fragments thereof, e.g antibody molecules and functional fragments capable of binding to tumor necrosis factor alpha (TNF?), in the topical treatment of inflammatory bowel diseases, including Crohn's disease and ulcerative colitis.

Abstract: Processes for the preparation of phosphorylated heptose compounds are provided. Embodiments of the invention relate to the chemical synthesis of heptopyranose phosphate compounds. Also, embodiments of the invention relate to the use of compounds according to the invention in modulating an immune response in a subject.

Abstract: Disclosed herein, inter alia, are methods of using thiosaccharide compounds for treating coronavirus infection.

Abstract: Certain aspects of the present disclosure provide techniques for semantically contextualizing structured and unstructured data, extracting and making sense of domain knowledge, and performing semantic-driven optimization to provide generic, scalable, autonomous and real-time performance management within a built environment domain.

Abstract: A stabilisation system for securing a medical device such as a catheter to tissue, in particular skin, the stabilisation system comprising a main body having a first section and a second section displaceable relative to one another to translate the system between an undeployed state and a deployed state, each section including an array of microneedles extending from a tissue contacting surface of the body and which penetrate the skin in response to the above displacement, the stabilisation system further comprising a closure member displaceable between an open position exposing a retention zone on the body and a closed position at least partially occluding the retention zone, within which retention zone the catheter or other medical device may be captured.

Abstract: An oral appliance (100) comprising a sensing arrangement (101) disposed in proximity to at least one part of a facial muscle complex of a user. A method of controlling the oral appliance (100) comprising sensing, with the sensing arrangement (101), the at least one part of the facial muscle complex being brought towards the sensing arrangement; and in response to sensing the at least one part of the facial muscle complex being brought towards the sensing arrangement (101), controlling the oral appliance (100) to perform an action. An external processing unit (200) is arranged to interact with the oral appliance (100) in response to the oral appliance (100) performing the action.

Abstract: The present invention relates to a method for determining whether an HLA allele is lost in a tumour in a subject, wherein said method comprises the step of determining the specific copy number of said HLA allele in said tumour. The invention also relates to a method for treating cancer in a subject, comprising targeting a neoantigen which is predicted to be presented by an HLA molecule encoded by an HLA allele which has been determined not to have been lost in a tumour in said subject.

Abstract: A photonic integrated circuit (PIC) assembly that includes a PIC, and a light source mounted on a first carrier substrate, and optically coupled and aligned with the PIC. The first carrier substrate includes a wrap-around metal, that enables the first carrier substrate to be bonded electrically with the PIC using solder bumps, and wherein the wrap-around metal enables the first carrier substrate to be electrically controlled by an external device for facilitating alignment and optical coupling process with the PIC.

Abstract: An on-diaper body fluid screening device (100), comprising a stack of the following sheets: a surface sheet (110) permeable to body fluid, a collection sheet (120) impervious to body fluid, a testing sheet (130), which is body fluid absorbent and provided with colorimetric assay reaction pads (131), and which is provided with a body fluid barrier network (132) forming body fluid channels (134) between an inlet section (135) and the colorimetric assay reaction pads (131), a protection sheet (140) impervious to body fluid, and a transparent readout sheet (150), through which the assay reaction pads (131) are visible. The protection sheet (140) comprises pad receiving openings (142). The collection sheet (120) comprises an inlet hole (125) which is arranged over the inlet section (135). A swelling component (702) is arranged in association with the inlet hole (125) and an inlet hole closing member (601).

Abstract: The present disclosure relates to a phase-locked loop (PLL) based on a charge-sharing locking technique, capable of both fractional-N and integer-N operation. The PLL comprises a voltage pre-setting stage; an oscillator: a shared capacitive load; and a switching network configured for selectively connecting the voltage pre-setting stage to the shared capacitive load during a voltage pre-setting stage for applying an expectant voltage to the capacitive load. The switching network is being further configured for selectively connecting the capacitive load to the oscillator during a charge-sharing locking stage for correcting a phase error in response to a difference between the expected voltage of the capacitor and the voltage of the oscillator. Frequency-tracking and waveform-learning stages are also provided for maintaining PVT (process, voltage, temperature) robustness and for suppressing fractional-N spur, respectively.

Abstract: Aspects of the subject disclosure may include, for example, a method in which a processing system identifies a plurality of performance indicators comprising device performance indicators for a plurality of communication devices on a cellular network and network performance indicators for the cellular network. The method also includes obtaining historical data regarding the plurality of performance indicators for each of a series of time points during a past time period; the historical data for each of the plurality of performance indicators form an array of values for that performance indicator. The method further includes generating from each array a set of inputs to an algorithm for predicting a throughput of the cellular network during a future time period; the set of inputs comprises quantiles of the array, and the algorithm comprises a machine learning algorithm. Other embodiments are disclosed.

Abstract: The invention relates to a method of determining the likelihood of an individual transitioning to a first episode of psychosis (FEP), the method comprising determining the level of selected markers in a bodily fluid sample from the individual, wherein the increase or decrease in the markers is predictive of the individual transitioning to a first episode of psychosis (FEP). The invention also relates to a method of predicting the functional outcome for an individual following a first episode of psychosis (FEP), the method comprising determining the level of selected markers in a bodily fluid sample from the individual, wherein the increase or decrease in the markers is predictive of an increased risk of functional disability outcome for the individual.

Abstract: The present invention provides a fractional-N frequency synthesizer comprising a divider controller comprising a multistage noise Shaping (MASH) digital delta-sigma modulator comprising L error feedback modulator (EFM) stages, wherein the jth EFM stage is configured to receive as an input the sum of the error of the preceding EFM stage and a high amplitude dither signal derived from the error of the kth EFM stage, where 1?j?k?L.

Abstract: The invention provides an optical system and method for outputting a modulated signal comprising a single multimode interference (MMI) device having at least two inputs configured with a fixed phase and an output, wherein the output modulated signal is controlled by modulating the input power of at 5 least one of the inputs. The invention only requires a single MMI device to operate as the relative phase between the two inputs are fixed relative each other and one of the inputs can be used to modulate the output by modulating the power at a single input. In further embodiments, the invention shows how correct phases can be set by a single MMI device. Thus, no more than two 10 MMIs are required in conjunction with phase or amplitude modulating elements to fully generate a BPSK or QPSK signal.