Patents Assigned to University College
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Patent number: 8628584Abstract: A transcutaneous prosthesis includes a first component shaped for implantation into a bone, the first component including flutes or grooves on a surface thereof for deterring rotation of the prosthesis within a bone; a second component adapted for location between the bone and the skin, the second component having a surface treatment for stimulation of fibroblastic cell proliferation and attachment of epithelial cells; and a third component adapted for location to extend from the skin surface and is adapted to extend directly from the skin surface in use, the third component having a coating of a non-stick material on an outer surface thereof, the coating having a surface energy that is lower than a surface energy of the first and second components and which is low enough to deter bacterial adhesion.Type: GrantFiled: January 3, 2006Date of Patent: January 14, 2014Assignee: University College LondonInventors: Gordon Blunn, Justin Cobb, Allen Goodship, Paul Unwin
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Patent number: 8603461Abstract: The invention provides a probiotic composition to alleviate Salmonella infection in farm animals. The composition may comprise at least one of Lactobacillus murinus, Lactobacillus pentosus, Lactobacillus salivarius sub-species salivarius, and Pediococcus pentosaceus. The composition maybe formulated as an animal feedstuff, or as a pharmaceutical composition.Type: GrantFiled: April 6, 2006Date of Patent: December 10, 2013Assignees: TEAGASC—The Agriculture and Food Development Authority, University College CorkInventors: Catherine Stanton, Colin Hill, Ger Fitzgerald, Paul Ross
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Publication number: 20130324761Abstract: A process for the complete or partial oxidation of hydrocarbons comprises contacting a C1-C8 hydrocarbon and hydrogen peroxide in the presence of a heterogeneous catalyst under conditions suitable to convert the C1-C8 hydrocarbon to at least one corresponding C1-C8 oxygenate product, wherein the heterogeneous catalyst provides confinement and contains both Brønsted-Lowry and Lewis acid centers. Examples include zeolites modified with selected metals or metal oxides. Including copper, either in the catalyst, in a second catalyst of similar description, or as a homogeneous salt, increases both selectivity and activity of the process, particularly where an iron-containing catalyst is used.Type: ApplicationFiled: February 2, 2011Publication date: December 5, 2013Applicant: University College Cardiff Consulltants LimitedInventors: Graham John Hutchings, Jose Antonio Lopez-Sanchez, Ceri Hammond, Nikolaos Dimitratos, Nicholas Fracois Dummer
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Patent number: 8598077Abstract: The objective of the current invention is the control of agricultural infestations based on alternative methods that are less aggressive to the environment and that are harmless to other invertebrates and to man; for instance biological control using bacterial strains belonging to species of the genera Bacillus, Brevibacillus and/or Paenibacillus. A first embodiment of the invention refers to compositions based on the systemic utilization of bacterial strains belonging to species of the genera Bacillus, Brevibacillus and/or Paenibacillus to protect plants by using the composition containing the above referred bacteria in wild-type, conjugated, mutant or transgenic forms and/or the substances produced by them. A second embodiment of the invention refers to a method of bioinsecticide application based on bacteria from the genera Bacillus, Brevibacillus and/or Paenibacillus.Type: GrantFiled: August 29, 2007Date of Patent: December 3, 2013Assignees: Empresa Brasileira de Pesquisa Agropecuaria—EMBRAPA, Bthek Biotechnologia Ltda., University College Cardiff Consultants LimitedInventors: Rose Gomes Monnerat Solon De Pontes, Carlos Marcelo Silveira Soares, Colin Berry
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Patent number: 8586313Abstract: In particular aspects, stem-cell polycomb group (PcG) targets are more likely to have cancer-specific promoter DNA methylation than non-targets, indicating a stem-cell origin of cancer, where reversible gene repression is replaced by permanent silencing, locking the cell into a perpetual state of self-renewal and predisposition to subsequent malignant transformation. Exemplary aspects provide methods for identifying preferred DNA methylation markers for a cellular proliferative disorder and/or cancer and markers for developmental lineages and/or stages, based on identifying PcG protein or PcG repressive complex genomic target loci within a precursor cell (e.g., stem or progenitor cell) population, and determining, in cells of the proliferative disorder and/or cancer or cell of the particular developmental lineages and/or stages, a characteristic methylation status of the PcG target loci. Additional aspects provide methods for validating and/or monitoring a precursor cell (e.g., stem cell) population.Type: GrantFiled: December 27, 2007Date of Patent: November 19, 2013Assignees: The University of Southern California, University College LondonInventors: Peter W. Laird, Martin Widschwendter
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Publication number: 20130280751Abstract: The invention is based on the use of photoluminescent probes for intracellular sensing of oxygen, especially assaying intracellular oxygen concentration. The photoluminescent probe comprises a suspension of polymeric particles having an average diameter in the 20 nm to 100 nm range, formed from an amphiphilic cationic co-polymer which is oriented in the formed particle to provide a hydrophobic core and a hydrophilic shell. The probe includes a hydrophobic oxygen-sensitive photoluminescent dye such as Pt-tetrakis(pentafluorophenyl)porphine, PtPFPP embedded in the hydrophobic core of the particle, and the co-polymer includes quaternary ammonium groups which provide hydrophilic and cationic character to the particle shell. The photoluminescent probe, which in use is provided in the form of an aqueous suspension of probe, is incubated with live mammalian cells in a suitable growth medium for a period of time to allow the probe particles passively load into the cells.Type: ApplicationFiled: October 22, 2010Publication date: October 24, 2013Applicant: University College Cork, National University of Ir CorkInventors: Dmitri Papkovsky, Andreas Fercher, Ingo Klimant, Sergey Borisov, Alexander Zhdanov
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Publication number: 20130275049Abstract: A method of assessing the allergic status of a subject to a specific allergen, comprises the steps of determining a subject-specific numeric value for a plurality of variables comprising age, sex, SPT, IgE, (sIgE or tIgE minus sIgE) and allergic symptoms, applying an allergen-specific weighting to the numeric value for each variable, and correlating the weighted numeric values with allergic status for the subject. The weighted numeric values is correlated with allergenicity status using a deterministic probability function.Type: ApplicationFiled: May 18, 2011Publication date: October 17, 2013Applicant: University College Cork-National University of Ireland, CorkInventors: Audrey Dunn-Galvin, Jonathan B. O'Hourihane
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Publication number: 20130274178Abstract: The invention provides a peptide triazole conjugate and derivatives thereof, and methods of its use. The invention also provides an antibody to the peptide triazole conjugate. The invention further provides a method of identifying an HIV-1 entry inhibitor candidate.Type: ApplicationFiled: March 27, 2013Publication date: October 17, 2013Applicant: Philadelphia Health & Education Corporation d/b/a Drexel University College of MedicineInventor: Philadelphia Health & Education Corporation d/b/a Drexel University College of Medicine
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Publication number: 20130267616Abstract: A method of forming a polymer is provided, the method comprising: Providing a first monomer comprising one or more aromatic moieties, the first monomer comprising at least two amino groups, each of the amino groups being attached to an aromatic moiety; and contacting said first monomer with formaldehyde or a source of methylene. Polymers made by such a method and uses of such polymers are also described.Type: ApplicationFiled: September 12, 2011Publication date: October 10, 2013Applicant: University College Cardiff Consultants LimitedInventors: Neil Bruce McKeown, Mariolino Carta, Matthew James Croad
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Patent number: 8551965Abstract: A compound of formula (I) wherein Ar can be one six-membered or two fused six-membered aromatic rings; R8 and R9 can be hydrogen, alkyl, cycloalkyl, halogens, amino, alkylamino, dialkylamino, nitro, cyano, alkyoxy, aryloxy, thiol, alkylthiol, arythiol, or aryl; Q can be O, S or CY2, where Y may be H, alkyl or halogens; X can be O, NH, S, N-alkyl, (CHR2)m where m is 1 to 10, and CY2; Z can be O, S, NH, or N-alkyl; U? is H and U? can be H or CH2; wherein: T can be OH, H, halogens, O-alkyl, O-acyl, O-aryl, CN, NH2. or N3; T? and T? can be H or halogen; and W can be H or a phosphate group. Compounds show anti-viral activity, for example with respect to varicella zoster virus.Type: GrantFiled: September 24, 2010Date of Patent: October 8, 2013Assignees: University College Cardiff Consultants Limited, Rega FoundationInventors: Christopher McGuigan, Jan Balzarini
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Patent number: 8551966Abstract: 3-(2?,3?-dideoxy-ribo-?-L-furanosyl)[2,3-d]pyrimidin-2(3H)-one derivatives comprising 6-substitutents on the base moiety are shown to have anti-viral properties, particularly with respect to vaccinia and measles. The compounds have unnatural L ribose stereochemistry.Type: GrantFiled: July 28, 2011Date of Patent: October 8, 2013Assignee: University College Cardiff Consultants LimitedInventors: Christopher McGuigan, Joachim J. Bugert, Arwyn T. Jones, Ranjith Pathirana, Laura E. Farleigh
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Patent number: 8545497Abstract: Apparatus (20) for carrying out a prophylactic or treatment procedure on tissue comprises a device (21) having a chamber (22) and at least one active element such as an electrode (23) within the chamber (22). The chamber (22) has an opening (26) through which tissue is drawn into the chamber (22). Means for drawing the tissue into the chamber may comprise a vacuum lumen with vacuum orifices (25) in the chamber (22). Treatment such as electroporation may be applied to tissue in the chamber (22).Type: GrantFiled: September 22, 2006Date of Patent: October 1, 2013Assignee: University College Cork—National University of Ireland, CorkInventors: Anthony Morrissey, Declan Soden, Gerald O'Sullivan, Christopher Collins, Colum Dunne, John Piggott, Denton A. M Prior, Andrew Watson, Peter McGeehin
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Patent number: 8518641Abstract: The invention relates to a method of for detecting DNA damage in a tissue sample. The method includes the steps of exposing sample DNA to a tagged DNA-damage binding factor and then shearing the DNA to produce fragments. After separating damaged from undamaged DNA, the two are amplified and differentially labeled. The labeled fragments can be immobilized on a microarray allowing the location and extent of any DNA damage to be determined.Type: GrantFiled: June 27, 2008Date of Patent: August 27, 2013Assignee: University College Cardiff Consultants LimitedInventors: Raymond Waters, Simon Huw Reed
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Publication number: 20130210917Abstract: Described herein are nitrated lipids and methods of making and using the nitrated lipids.Type: ApplicationFiled: October 8, 2012Publication date: August 15, 2013Applicants: THE UAB RESEARCH FOUNDATION, Morehouse School of Medicine, Inc., University College Cardiff Consultants Limited, State of Oregon Acting By and Through the Board of Education on Behalf of the University of OregonInventors: Bruce A. Freeman, Francisco Schopfer, Valerie O'Donnell, Paul Baker, Yuqing E. Chen, Bruce Branchaud
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Publication number: 20130209429Abstract: The current invention provides use of a CLA-producing bacterium for the in vivo conversion in the gut of polyunsaturated fatty acids to CLA. The CLA-producing bacterium is selected from one or more of the group consisting of propionibacteria, lactobacilli, lactococci and streptococci, and bifidobacteria.Type: ApplicationFiled: March 27, 2013Publication date: August 15, 2013Applicants: University College Cork, National University of Ireland, Cork, Alimentary Health Ltd., TEAGASC - The Agriculture and Food Development AuthorityInventors: University College Cork, National University of Ireland, Cork, TEAGASC - The Agriculture and Food Development Authority, Alimentary Health Ltd.
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Publication number: 20130211222Abstract: A single sensing probe comprising multiple, spatially separate, sensing sites is utilized to sense neural activity. The sensing probe includes multiple conductors each with multiple sensing sites in a fixed geometric arrangement. The sensing probe is configured to comprise multiple combined sensing sites in polytrode configuration. By appropriately combining the wire groupings at each combined sensing site, activity sensed from a single wire with multiple sensing sites, can be coupled with other wires to unmix signals from the spatially separate sites and leverage the power of combinatorics to maximize total recording bandwidth and single neuron/unit yield per wire and per probe.Type: ApplicationFiled: March 4, 2013Publication date: August 15, 2013Applicant: Philadelphia Health & Education Corporation d/b/a Drexel University College of MedicineInventor: Philadelphia Health & Education Corporation d/b/a Drexel University College of Medicine
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Publication number: 20130209487Abstract: The invention includes compositions and methods for regulating p110 delta in an avian species. The invention includes inhibiting p110 delta, a component of p110 delta signaling pathway, or any combination thereof in an avian species as an anti-viral therapeutic approach for treating virus infection.Type: ApplicationFiled: June 30, 2011Publication date: August 15, 2013Applicant: Philadelphia Health & Education Corporation d/b/a Drexel University College of MedicineInventor: Peter D. Katsikis
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Patent number: 8509627Abstract: A semiconductor optical amplifier (SOA) is used in a double pass configuration with one of the output ports followed by an attenuator, which is followed by a modulator with a reflective facet. The variable loss between the SOA and the modulator is optimised, so that the SOA can be operated in a highly saturated regime without distorting the modulated signal. The SOA is firstly saturated by the input carrier, (21) in FIG. 2, which has a constant power and hence does not introduce patterning of the SOA gain. On the contrary the saturation induced by the carrier creates a clamping effect that prevents patterning for signals with input put power comparable with or less than the input optical carrier power. The optical carrier amplified by the SOA (22) then travels through the attenuator section and it is attenuated (23). The carrier (23) then enters the modulator section where it is modulated with the data signal (24).Type: GrantFiled: May 27, 2009Date of Patent: August 13, 2013Assignee: University College Cork - National University of Ireland, CorkInventors: Giuseppe Talli, Paul Townsend, Eimear Machale
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Patent number: 8507230Abstract: A method for producing polyhydroxyalkanoate (PHA), comprising (i) culturing in a culture medium comprising terephthalic acid and/or a salt thereof and/or an ester thereof one or more bacterial strains which are capable of accumulating PHA from terephthalic acid or a salt or ester thereof and which are selected from Pseudomonas putida strain GO16 having the accession number NCIMB 41538, Pseudomonas putida strain GO19 having the accession number NCIMB 41537, and Pseudomonas frederiksbergensis strain GO23 having the accession number NCIMB 41539; and (ii) recovering the PHA produced from the culture medium. The invention also provides Pseudomonas putida strain GO16 having the accession number NCIMB 41538; Pseudomonas putida strain GO19 having the accession number NCIMB 41537; and Pseudomonas frederiksbergensis strain GO23 having the accession number NCIMB 41539.Type: GrantFiled: April 6, 2009Date of Patent: August 13, 2013Assignee: University College Dublin, National University of IrelandInventors: Kevin O'Connor, Shane Kenny, Jasmina Nikodinovic
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Patent number: 8501427Abstract: The invention relates to antibodies, including monoclonal and polyclonal, or fragments thereof, which discriminate between the histidine and tyrosine isoforms of Complement Factor H and to their use in diagnostic methods and therapeutic treatments relating to Complement Factor H mediated diseases.Type: GrantFiled: January 23, 2008Date of Patent: August 6, 2013Assignee: University College Cardiff Consultants LimitedInventors: Bryan Paul Morgan, Claire Louise Harris, Svellana Hakobyan