Patents Assigned to University College
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Patent number: 8859512Abstract: A compound for use in the treatment or prophylaxis of viral infections such, for example as chicken pox or shingles caused by the Varicella Zoster virus, said compound having the general formula (II): wherein X is O, S, NH or CH2, Y is O, S or NH, Z is O, S or CH2, R1 is C1-6 alkyl, preferably n-alkyl, e.g., n-pentyl or n-hexyl, and one of R2 and R3 is OH, and the other of R3 and R2 is a neutral, non-polar amino acid moiety, or a pharmaceutically acceptable salt or hydrate thereof. Said neutral, non-polar amino acid moiety R2 or R3 may be (IV): in which R4, R5, R6 and R7 are each independently H or C1-2 alkyl. In preferred embodiments, one of R2 or R3 is valine, leucine, isoleucine or alanine, particularly valine.Type: GrantFiled: November 30, 2012Date of Patent: October 14, 2014Assignees: University College Cardiff Consultants Limited, K.U. Leuven Research and DevelopmentInventors: Christopher McGuigan, Jan Balzarini, Marco Migliore
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Patent number: 8852917Abstract: The present invention relates to a new bacteriocin, to microbial strains which can produce it and to uses of the bacteriocin and the strains. The bacteriocin is effective against Clostridium difficile and Listeria monocytogenes amongst other organisms.Type: GrantFiled: November 28, 2008Date of Patent: October 7, 2014Assignees: University College Cork, TEAGASC, The Agriculture and Food Development AuthorityInventors: Colin Hill, Mary Rea, Paul Ross
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Patent number: 8852895Abstract: The present invention is directed to a macrocyclic derivative which is formed by modification of a macrocycle. The invention further relates to assemblies formed by the self-assembly of such macrocyclic derivatives in aqueous solvent, and includes bilayer vesicles, micelles, monolayers, nanoparticles, colloidal assemblies and surface-coated assemblies.Type: GrantFiled: July 6, 2009Date of Patent: October 7, 2014Assignees: University College Dublin, National University of Ireland, University College Cork, National University of IrelandInventors: Raphael Darcy, Caitriona O'Driscoll
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Patent number: 8850467Abstract: A computer-implemented method, computer program product, and computing system for receiving one or more transmitted frame identifiers that are mathematical representations of one or more transmitted video frames included within a multi-frame video. One or more video frames included within the multi-frame video are received, thus defining one or more received video frames. A mathematical representation of each of the one or more received video frames is generated, thus defining one or more received frame identifiers. The one or more received frame identifiers are compared to the one or more transmitted frame identifiers to determine a level of similarity between the one or more received video frames and the one or more transmitted video frames.Type: GrantFiled: March 15, 2013Date of Patent: September 30, 2014Assignees: International Business Machines Corporation, University College DublinInventors: John Fitzpatrick, Paul B. French, James P. Galvin, Patrick W. McDonagh, Patrick J. O'Sullivan
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Publication number: 20140262984Abstract: A method of assessing biofilm thickness in a membrane supported biofilm reactor (MSBR) of the type comprising a lumen containing a gas phase, a liquid phase, and a gas permeable membrane providing an interface between the gas and liquid phases, the method comprising the steps of charging the lumen with an inert gas, closing the lumen to establish an initial elevated pressure in the lumen, measuring the rate of change of pressure within the lumen, and correlating the rate of change of pressure (dP/dt) with biofilm thickness. The step of correlating dP/dt with biofilm thickness involves correlating dP/dt with the rate of diffusion of the inert gas (dn/dt), correlating dn/dt with an overall mass transfer coefficient (K), correlating K with the mass transfer coefficient of the biofilm (ICB), and correlating k? with the biofilm thickness.Type: ApplicationFiled: February 24, 2014Publication date: September 18, 2014Applicant: University College Dublin, National University of Ireland, DublinInventors: Eoin Casey, Eoin Syron, Barry Heffernan
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Publication number: 20140267787Abstract: A computer-implemented method, computer program product, and computing system for receiving one or more transmitted frame identifiers that are mathematical representations of one or more transmitted video frames included within a multi-frame video. One or more video frames included within the multi-frame video are received, thus defining one or more received video frames. A mathematical representation of each of the one or more received video frames is generated, thus defining one or more received frame identifiers. The one or more received frame identifiers are compared to the one or more transmitted frame identifiers to determine a level of similarity between the one or more received video frames and the one or more transmitted video frames.Type: ApplicationFiled: March 15, 2013Publication date: September 18, 2014Applicants: University College Dublin, International Business Machines CorporationInventors: JOHN FITZPATRICK, Paul B. French, James P. Galvin, JR., Patrick W. McDonagh, Patrick J. O'Sullivan
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Patent number: 8835380Abstract: The invention concerns a novel antimicrobial peptide (AMP) polymer conjugate comprising at least one AMP, typically colistin, and a dextrin polymer wherein said dextrin polymer has a molecular weight between 5,000-60,000 g/mol and is modified by the additions of pendant groups which increase the stability of the conjugate and so delays its degradation thereby slowing the rate at which the AMP is released.Type: GrantFiled: June 1, 2011Date of Patent: September 16, 2014Assignee: University College Cardiff Consultants LimitedInventors: Elaine Ferguson, David Thomas, Timothy Walsh
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Publication number: 20140249210Abstract: The present invention encompasses a class of compounds known as splice modulating oligonucleotides (SMOs) that modulate pre-mRNA splicing, thereby affecting expression and functionality of a specific protein in a cell. The present invention further provides compositions and methods for modulating pre-mRNA splicing using a SMO of the invention to abrogate disease-causing mutations in a protein. Accordingly, the present invention provides compositions and methods of treating a subject at risk of, susceptible to, or having a disease, disorder, or condition associated with aberrant or unwanted target pre-mRNA expression or activity.Type: ApplicationFiled: February 24, 2014Publication date: September 4, 2014Applicant: Philadelphia Health & Education Corporation d/b/a Drexel University College of MedicineInventors: Gordon J. Lutz, Melanie K. Tallent, Nicole Michele Lykens
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Publication number: 20140242707Abstract: The present invention provides a method for diagnosing hypercoagulability associated with carbon monoxide exposure in a subject. The method comprises obtaining a plasma sample from the subject, dividing the sample into at least two portions, and determining the clot strength of the first portion. The method further comprises exposing the second portion to an organic reductant, determining the clot strength of the second portion after exposure to the organic reductant, and comparing the clot strength of the first portion with the clot strength of the second portion. A diagnosis of hypercogulability associated with carbon monoxide exposure is made when the clot strength of the second portion is decreased compared with the cloth strength of the first portion.Type: ApplicationFiled: July 19, 2012Publication date: August 28, 2014Applicant: Philadelphia Health & Education Corporation d/b/a Drexel University College of MedicineInventors: Vance G. Nielsen, Keith Vosseller
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Patent number: 8816724Abstract: Methods and systems are disclosed that provide a radio frequency synthesizer that generates precise frequencies over a large radio frequency range. The radio frequency synthesizer can provide a high resolution of frequency generation and still provide precise frequencies over a range of radio frequencies. The precision and resolution while maintaining a large operating range come from the ability of the frequency synthesizer to generate frequencies as a product of a plurality of moduli. For example, the frequency can be generated from a reference frequency using a first modulus and a second modulus. The plurality of modulo can be implemented using nested digital delta-sigma modulators in a fractional-N frequency synthesizer.Type: GrantFiled: December 14, 2012Date of Patent: August 26, 2014Assignee: University College Cork—National University of Ireland, CorkInventor: Michael Peter Kennedy
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Patent number: 8813566Abstract: A new analytical technique, instrument and method of testing a material utilizing same is provided. The method of analyzing a test material comprises the steps of (vii) inducing an acoustic emission from a vessel containing a solvent and measuring said emissions; (viii) dissolving a known amount of the test material in the solvent; measuring changes in resonance and absorbance frequencies before and after dissolution to produce a broadband acoustic resonant dissolution emission profile.Type: GrantFiled: April 21, 2009Date of Patent: August 26, 2014Assignee: University College Cork—National University of IrelandInventor: Dara Fitzpatrick
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Patent number: 8817261Abstract: Laser pulses are applied to surface plasmon resonant articles such as gold nanoparticles within a microscopy sample to generate a four-wave mixing signal that is detected as the output of the microscopy process.Type: GrantFiled: December 15, 2009Date of Patent: August 26, 2014Assignee: University College Cardiff Consultants Ltd.Inventors: Paola Borri, Wolfgang Langbein, Francesco Masia
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Patent number: 8815279Abstract: A method is provided for reducing the extent of or occurrence of long-term adverse health effects in human infants, comprising feeding to said infants when newborn a nutrient-containing-formula providing not more than 1 gram of protein per 100 ml of formula and/or not more than 50 kcal per 100 ml of formula. Also disclosed are methods of administering the infant formulas to reduce the occurrence or extent of insulin resistance in an individual later in life, to reduce the occurrence or extent of obesity or atherosclerosis in an individual later in life, or combinations thereof, by feeding newborn infants the newborn infant formula described herein.Type: GrantFiled: January 6, 2009Date of Patent: August 26, 2014Assignee: University College LondonInventors: Atul Singhal, Alan Lucas
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Publication number: 20140227679Abstract: There is provided a method of aggregating a plurality of beads in a magnetic bead aggregation assay for subsequent analysis comprising: —providing magnetic beads comprising a capture probe for binding with said target analyte; —reacting the magnetic beads with the sample including a target analyte in a reaction chamber aggregating the magnetic beads in the presence of a magnetic field with the target analyte to allow formation of magnetic bead aggregates having physical properties detectable to enable characterisation of the aggregates on an aggregate by aggregate basis using a detector to measure the physical properties of the aggregates. Further provided are a method and system for detecting analytes in a sample by characterising the magnetic bead aggregates on an aggregate by aggregate basis by measuring physical properties of the aggregates.Type: ApplicationFiled: July 9, 2012Publication date: August 14, 2014Applicant: University College Dublin, National University of Ireland, DublinInventors: Gil Lee, Peng Li, Mark Platt, Gemma Cannon
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Publication number: 20140228380Abstract: The present invention provides a method of inhibiting, suppressing or preventing levodopa-induced dyskinesia in a patient suffering from Parkinson's Disease, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of inhibiting, suppressing or preventing Parkinson's Disease in a patient, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention.Type: ApplicationFiled: August 2, 2013Publication date: August 14, 2014Applicants: University of Medicine and Dentistry New Jersey Medical School, Philadelphia Health & Education Corporation d/b/a Drexel University College of MedicineInventors: Sandhya Kortagere, Eldo V. Kuzhikandahil
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Publication number: 20140228355Abstract: The present invention provides a method of inhibiting, suppressing or preventing levodopa-induced dyskinesia in a patient suffering from Parkinson's Disease, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of inhibiting, suppressing or preventing Parkinson's Disease in a patient, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention.Type: ApplicationFiled: February 11, 2013Publication date: August 14, 2014Applicants: University of Medicine and Dentistry New Jersey Medical School, Philadelphia Health & Education Corporation d/b/a Drexel University College of MedicineInventors: Philadelphia Health & Education Corporation d/b/a Drexel University College of Medicine, University of Medicine and Dentistry New Jersey Medical School
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Patent number: 8796456Abstract: The invention relates to novel compounds which are naphthalene diimides of general formula (I). The compounds are used in therapy, particularly in cancer treatment.Type: GrantFiled: November 28, 2008Date of Patent: August 5, 2014Assignee: University College LondonInventors: Mekala Gunaratnam, Francisco Cuenca, Stephen Neidle
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Publication number: 20140213528Abstract: The invention relates to IHG-1 (induced by high glucose-1) a novel gene which encodes a protein that amplifies fibrotic responses in in vitro and in vivo models of fibrotic disorders and in human diabetic nephropathy. In particular the invention relates to modifications of the IHG-1 structure which are potential fibrosuppressant biotherapeutics and modify cellular invasiveness. The invention also relates to a method of screening a therapeutic agent for suitability for the treatment of fibrotic disease comprising testing a candidate therapeutic agent for the ability to reduce the expression of IHG-1 levels in a model system.Type: ApplicationFiled: January 30, 2014Publication date: July 31, 2014Applicant: University College Dublin, National University of IrelandInventors: Catherine Godson, Madeline Murphy, Finian Martin, Victoria McEaneney
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Publication number: 20140206666Abstract: Pharmaceutical compositions of the invention comprise sulfamoylbenzamide derivative useful as pregenomic RNA encapsidation inhibitors, useful for the treatment of Hepatitis B virus (HBV) infection.Type: ApplicationFiled: June 29, 2012Publication date: July 24, 2014Applicants: Philadelphia Helath & Education Corporation d/b/a Drexel University College of Medicine, Institute for Hepatitis and Virus ResearchInventors: Ju-Tao Guo, Xiaodong Xu, Timothy M. Block
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Patent number: 8784324Abstract: A sleep monitoring system includes an ECG device (2) and a respiration inductance plethysmogram (3) which monitor cardiac activity and physical (ribcage) respiration respectively and feed representative signals to a digital data processor. Operations (5-9) process the beat interval data, while in a second thread, operations (20-24) independently process the amplitude modulation of the ECG data caused by the respiratory motion of the subject. The inductance plethysmogram device (3) provides an input to the processor which represents respiration as directly monitored independently of the ECG. Operations (30-34) process this direct respiration data independently and in parallel, in a third thread. All extracted features are fed to a classifier which in step (10) combines selected combinations of features to make decisions in real time.Type: GrantFiled: November 2, 2005Date of Patent: July 22, 2014Assignee: University College Dublin, National University of IrelandInventors: Conor Heneghan, Stephen Redmond