Abstract: A compound of formula I wherein Ar1 is a bicyclic aryl or heteroaryl, which may be optionally substituted; X and Y are each independently a group of formula II: -L1-Ar2-L2-Ar3-Q-(CH2)n-NR1R2 L1 and L2 are each independently selected from NR3, C2H2, CH2, —O—, —S— and a bond; Ar2 and Ar3 are independently optionally substituted C5 or C6 aryl or heteroaryl; Q is selected from NH(C?O), NR3, S, O; n is an integer from 1 to 5; R1 and R2 are optionally substituted and are independently hydrogen, C1-7 alkyl, C3-20 heterocyclyl, or C5-20 aryl, or R1 and R2, taken together with the nitrogen atom to which they are attached, form a heterocyclic ring having from 3 to 8 ring atoms; R3 is H or C1-7 alkyl.

Abstract: The application relates to a bilateral hearing assistance system comprising first and second hearing assistance devices a processing unit, which in a NORMAL mode of operation processes an input audio signal based on configurable processing parameters and provides a processed electric stimulation signal. The system further includes one or more stimulation units for—in a TEST mode delivers first and second electric TEST stimulation signals to output units of said first and second devices respectively. The application further relates to a method of fitting a bilateral hearing assistance system to a particular user. The disclosure provides a measure allowing an improved fitting of bilaterally implanted Cochlear Implant users. The system further includes an evaluation unit configured to analyze the recorded physiological response of the user and to provide an objective measure of the user's perception of said TEST stimulation signals.

Abstract: A coherent anti-Stokes Raman spectroscopy (CARS) system comprises a laser light source for emitting pulsed light, a dichroic beam splitter for splitting a light pulse from the light source into a pump pulse and a Stokes pulse and directing these pulses along respective distinct paths, chirping means, e.g. dispersive glass blocks for chirping the pump and Stokes pulses, directing means for directing the chirped pump and Stokes samples to a sample in time overlap, and detecting means for detecting light stimulated from the sample by the interaction of the pump and Stokes pulses. The system may comprise a reflector connected to a linear motor, for adjusting the period between the arrival at the sample of the starts of the chirped pump and Stokes pulses. The system may further comprise a pulse replicating unit for converting a pulse from the light source into a plurality of pulses distributed in time.

Abstract: The current invention relates to the use of a bacterial species in the preparation of a composition adapted for oral administration for the delivery of an agent to a site in the body. The site in the body may be an organ or a tumour site. The bacterial species is a food grade, non-pathogenic, gram-positive bacteria capable of anaerobic growth.

Abstract: Silica core-shell microparticles are prepared by growing a porous silica shell from a silica precursor onto the surface of non-porous silica particle dispersed in a mixed surfactant solution under basic pH conditions. The particles are hydrothermally treating in an oil-in-water emulsion system and the particles are calcined to remove residual surfactants. Optionally, the particles of may be base etched to expand the size of the pores in the silica shell. Core-shell silica particles with an ordered mesoporous layer are produced.

Abstract: There is provided a method of producing microparticles using an emulsion based synthesis route including: Providing a first fluid phase and a second fluid phase, wherein the first fluid phase is a continuous phase and the second fluid phase is a dispersed phase comprising a dispersed material, wherein the continuous phase is immiscible with the dispersed phase; Mixing the first continuous phase and the second dispersed phase in the presence of a surfactant in a shear device to form an emulsion of droplets of controllable size and having a narrow drop size distribution; Drying the emulsion to form microparticles of controllable size and having narrow size distribution, and wherein the microparticles may comprise spherical, crumpled, dimpled, porous or hollow microparticles morphology. Also provided is a system including shear device and drying arrangement. Also provided are micro particles of controllable size and morphology formed by the method.

Abstract: The invention relates to the isolation and use of a novel progenitor cell population from the lamina propria of the oral mucosa. The novel progenitor cell population is highly proliferative and can be differentiated into a range of cell lineages. Further, these novel progenitor cells possess immunomodulatory activity and so can be used in the allogeneic transfer of tissue or to help combat immune disorders.

Abstract: A computing device determines a first table included in a plurality of tables, wherein the plurality of tables are included in the database. The computing device determines a dependency corresponding to the first table, wherein the dependency identifies a second table that is included in the plurality of tables. The computing device determines a distribution corresponding to the dependency, wherein the distribution identifies a correlation corresponding to the first table and to the second table. The computing device analyzes the correlation to determine a group of data values of the first table and the second table. The computing device selects a subset of data values from the group of data values. The computing device populates a sample with the subset.

Abstract: There is provided a method of glycosylating an aminocoumarin compound comprising conjugating a sugar to the 4?-OH position of the core of the aminocoumarin compound. Also provided is an aminocoumarin compound glycosylated at the 4?-OH position of the core of the aminocoumarin compound. Further aspects of this invention provide this compound for use in therapy, more particularly for use as an antibiotic, or in anticancer treatment.

Abstract: A first instance of a reference video is stored. A primary video and a second instance of the reference video are simultaneously received. At least one quality of experience value that infers a perceptual quality of the primary video as received by a system is generated by comparing the first instance of the reference video to the second instance of the reference video on a pixel-by-pixel, frame-by-frame, basis and determining whether each pixel and each frame contained in the first instance of the reference video are contained in the second instance of the reference video.

Abstract: The invention relates to a method of diagnosis of vCJD in a diagnostic sample of a valid body tissue taken from a human subject, which comprises detecting an increased concentration of a protein in the diagnostic sample, compared with a sample of a control human subject, the protein being: beta-actin (SwissProt Acc. No. P60709), apolipoprotein A-IV precursor (SwissProt Acc. No. P06727); haptoglobin beta-chain consisting of residues 162-406 (SwissProt Acc. No. P00738); haemoglobin beta chain (SwissProt Acc. No. P02023); or alpha-1-antitrypsin (SwissProt Acc. No. P01009); or a decreased concentration of a protein in the diagnostic sample, compared with a sample of a control, normal human subject, the protein being plasma protease (C1) inhibitor precursor (SwissProt Acc. No. P05155); complement component 1, s sub-component (SwissProt Acc. No. P09871); butyrylcholinesterase precursor (SwissProt Acc. No. P06276); complement component C4B (SwissProt Acc. No. P01028); lumican (SwissProt Acc. No.

Abstract: The present invention relates to detectors for detecting fluorine-containing compounds and/or cyanide containing compounds, including hydrogen fluoride (HF) or HCN gas, hydrofluoric acid in solution, selected chemical warfare agents, selected industrial chemicals which may be hydrolyzed to release HF or HCN gas, compounds containing a cyanide group, and compounds that can release HF or HCN. The detectors comprise i) an organometallic component containing at least one bis-substituted boryl group of the formula —B(RB)(RB?) wherein each RB and each RB? is independently selected from H, halogen, C1-6 alkyl, OR6, N(R6)(R7), SR6, C3-20 aryl or heteroaryl, and C3-20 cycloalkyl or heterocycloalkyl groups, each of which may be optionally substituted, ii) a Lewis base component, and iii) a solid matrix component.

Abstract: A delayed release coating comprising a mixture of a first material selected from starch; amylose; amylopectin; chitosan; chondroitin sulfate; cyclodextrin; dextran; pullulan; carrageenan; scleroglucan; chitin; curdulan and levan, and a second material which has a pH threshold at about pH 5 or above, is used to target release of a drug from a core to the intestine, particularly the colon.

Abstract: The invention relates to novel variants that associate with Alzheimer's disease AD and their use in kits as a means for diagnosing AD; and also their use in nucleic acid molecules or cells/cell lines for identifying novel therapeutic, label of identification means.

Abstract: A method of forming a polymer is provided, the method comprising: Providing a first monomer comprising one or more aromatic moieties, the first monomer comprising at least two amino groups, each of the amino groups being attached to an aromatic moiety; and contacting said first monomer with formaldehyde or a source of methylene. Polymers made by such a method and uses of such polymers are also described.

Abstract: Described herein are nitrated lipids and methods of making and using the nitrated lipids.

Abstract: The invention concerns a screening method for the detection of Clostridium difficile in a sample, wherein said method comprises the detection of conserved target regions in the Clostridium genome through the binding of at least one oligonucleotide probe to said target site.

Abstract: A Nisin derivative or variant, comprising an amino acid substitution at amino acid position 29 in the amino acid sequence. The Nisin derivative exhibits enhanced antimicrobial activity when compared to wild type Nisin. The Nisin derivative has an application as a natural food additive and as a therapeutic agent.

Abstract: The present invention relates to a nisin derivative comprising amino acid substitutions in the peptide sequence encoding the hinge region of the protein, wherein the derivative exhibits an increased anti-microbial activity.

Abstract: The present invention relates to methods useful to monitor central and peripheral nervous system neuron/axon destruction resulting from an increase in acute phase inflammatory enzymes. The methods have applicability to monitoring the progress of neurological diseases, including multiple sclerosis and Alzheimer's disease, as well as neuroinflammatory damage that results from sports injuries, vigorous physical activity or any form of physical abuse. The invention further relates to methods of treating multiple sclerosis or other diseases with an inflammatory component related to phospholipase A2.