Abstract: Systems and methods for determining bacterial load in targets are disclosed. An autofluorescence detection and collection device includes a light source configured to illuminate a target with excitation light causing at least one biomarker in the illuminated target to fluoresce. Bacterial autofluorescence data regarding the target is collected and analyzed to determine bacterial load the target. The autofluorescence data may be analyzed using pixel intensity.
Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula: (I) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.
Type:
Grant
Filed:
August 1, 2018
Date of Patent:
September 26, 2023
Assignee:
UNIVERSITY HEALTH NETWORK
Inventors:
Mark Robert Bray, Jacqueline M. Mason, Tak W. Mak, Graham Fletcher
Abstract: Disclosed herein are breathing disorder identification, characterization and diagnosis methods, devices and systems. In general the disclosed methods, devices and systems may rely on the characterization of breath sound amplitudes, periodic breath sounds and/or aperiodic breath sounds to characterize a breathing disorder as obstructive (e.g. obstructive sleep apnea—OSA) or non-obstructive (e.g. central sleep apnea—CSA).
Type:
Grant
Filed:
September 11, 2017
Date of Patent:
September 12, 2023
Assignee:
UNIVERSITY HEALTH NETWORK
Inventors:
T. Douglas Bradley, Geoffrey Roy Fernie, Hisham Alshaer, Ahmad Ziad Akl
Abstract: Methods and related systems and devices are described for performing various AR medical applications, including a method of guiding augmented reality (AR) intervention. In one aspect, a primary client device: receives model sets, an intervention plan having an intervention field, and session information about a session related to the AR intervention from a server; receives first real-time input data from a first input device; generates metrics by evaluating an execution of the intervention plan by comparing the intervention plan to the first real-time input data; displays real-time graphics, based at least in part on the metrics, spatially over the intervention field; receives real-time status data, from the server, about a replicate client device that joins the session; sends the first real-time input data, the metrics and the evaluation computed from the intervention plan, through the server, to the replicate client device.
Type:
Grant
Filed:
August 11, 2022
Date of Patent:
August 22, 2023
Assignee:
University Health Network
Inventors:
Zigang Jimmy Qiu, Stefan Hofer, Blake Murphy, Tomas J. Saun, Lukasz Brzozowski, Trinette Wright, Xun Lin
Abstract: Provided are methods for producing compositions comprising a population of cardiomyocytes enriched for or substantially devoid of sinoatrial node-like pacemaker cardiomyocytes (SANLCM) from human pluripotent stem cells (hPSCs), and methods of use thereof.
Abstract: Methods and systems for evaluating a proposed treatment plan for radiation therapy, for evaluating one or more delineated regions of interest for radiation therapy, and/or for generating a proposed treatment plan for radiation therapy. Machine learning based on historical data may be used.
Type:
Grant
Filed:
March 21, 2018
Date of Patent:
August 22, 2023
Assignee:
UNIVERSITY HEALTH NETWORK
Inventors:
Thomas G. Purdie, Christopher James McIntosh, Igor Svistoun
Abstract: An adaptor for configuring a mobile communication device for tissue imaging is disclosed. The adaptor includes a housing configured to be removably coupled to a mobile communication device, at least one excitation light source for fluorescent imaging, a white light source for white light imaging, and a power source for powering the adaptor. The excitation light source is configured to emit light in one of ultraviolet, visible, near-infrared, and infrared ranges.
Abstract: Methods of increasing T cell effector function in a T cell population are provided that involve inhibiting one or more genetic subunits of the SAGA (Spt-Ada-Gcn5-acetyltransferase) gene regulation complex in the T cell population. Also provided are methods of using such T cell populations in the treatment of cancer patients.
Type:
Application
Filed:
April 7, 2021
Publication date:
July 20, 2023
Applicant:
UNIVERSITY HEALTH NETWORK
Inventors:
Daniel DINIZ DE CARVALHO, Housheng HE, Ilias ETTAYEBI, Fraser SOARES, Helen LOO YAU
Abstract: Methods for quantifying fluorescence and optical properties in a turbid medium such as tissue. Devices and systems suitable for the methods are also disclosed.
Type:
Grant
Filed:
December 23, 2019
Date of Patent:
July 4, 2023
Assignee:
University Health Network
Inventors:
Anthony Taywon Kim, Brian Campbell Wilson
Abstract: There is provided herein, the use of mammalian derived HLA class I molecule for in vitro peptide exchange. For example, there is provided a method of producing an HLA class I molecule complexed to a pre-selected peptide comprising: (a) providing a mammalian derived HLA class I molecule complexed to an existing peptide; (b) incubating, in vitro, the HLA class I molecule complexed to the existing peptide with the pre-selected peptide, wherein the pre-selected peptide is at a concentration sufficient to replace the existing peptide to produce the HLA class I molecule complexed to the pre-selected peptide; and the HLA class I molecule comprises ?1, ?2, ?3 and ?2m domains.
Type:
Application
Filed:
July 22, 2022
Publication date:
June 22, 2023
Applicant:
University Health Network
Inventors:
Naoto HIRANO, Munehide NAKATSUGAWA, Muhammed Aashiq RAHMAN, Kenji MURATA
Abstract: A system and method for non-invasively detecting abnormal electrical propagation in the heart are disclosed. The system and method include an interface for receiving a pacing signal applied to a heart of a patient, the pacing signal comprising (i) a sequence of regular pacing stimuli shorter than the sinus-rate intervals, and (ii) one or more extra pacing stimuli at intervals that are shorter than the regular pacing stimuli, a processor to assess the envelope of a body-surface ECG component after the regular pacing stimuli, assess the envelope of a body surface ECG component after the one or more extra pacing stimuli, and compare the assessed component after the extra pacing stimuli to the assessed component after the regular pacing stimuli. The interface outputting the comparison as an indication of regions of arrhythmogenicity and ablation targets in the heart.
Type:
Application
Filed:
December 9, 2022
Publication date:
June 15, 2023
Applicants:
Biosense Webster (Israel) Ltd., UNIVERSITY HEALTH NETWORK
Inventors:
Tal Haim Bar-on, Meir Bar-Tal, Gal Hayam, Einat Shapira, Amir Ben-Dor, Kumaraswamy Nanthakumar, Stéphane Massé, Ahmed Niri
Abstract: Systems and methods for obtaining diagnostic data of a target are disclosed. The systems include an imaging device and a drape. The imaging device includes at least one excitation light source for fluorescent imaging, and an optical sensor configured to detect signals responsive to illumination of the target with the excitation light. The drape is configured to reduce ambient light surrounding the target during imaging.
Abstract: A fumarate salt and a maleate salt of compound (I) represented by the following structural formula, as well as their corresponding pharmaceutical compositions, are disclosed. Particular single crystalline forms of 1:1 compound (I) fumarate and 1:1 compound (I) maleate are characterized by a variety of properties and physical measurements. Methods of preparing specific crystalline forms of 1:1 compound (I) fumarate and 1:1 compound (I) maleate are also disclosed. The present invention also provides methods of treating a subject with a cancer.
Type:
Grant
Filed:
February 10, 2021
Date of Patent:
June 6, 2023
Assignee:
UNIVERSITY HEALTH NETWORK
Inventors:
Peter Brent Sampson, Miklos Feher, Heinz W. Pauls
Abstract: A method and device for determining the depth and fluorophore concentration of a fluorophore concentration below the surface of an optically absorbing and scattering medium suitable for use in fluorescence-based surgical guidance such as in tumor resection is described. Long-wavelength stimulus light us used to obtain deep tissue penetration. Recovery of depth is performed by fitting measured modulation amplitudes for each spatial frequency to precomputed modulation amplitudes in a table of modulation amplitudes indexed by optical parameters and depth.
Type:
Grant
Filed:
November 1, 2021
Date of Patent:
May 30, 2023
Assignees:
THE TRUSTEES OF DARTMOUTH COLLEGE, UNIVERSITY HEALTH NETWORK
Inventors:
Keith D. Paulsen, David W. Roberts, Dennis Wirth, Brian C. Wilson, Mira Sibai
Abstract: An organ perfusion solution includes a colloid component, a salt mixture, a buffer system, and a glutamine compound in a physiologically acceptable medium.
Abstract: There is provided herein a method for expanding human CD4?CD8? regulatory T cells (DN Tregs) from a population of cells comprising DN Tregs, comprising: culturing the population of cells with artificial antigen presenting cells (APCs), preferably the DN Tregs are ??-TCR+CD56? or alternatively ??-TCR+.
Type:
Application
Filed:
December 23, 2022
Publication date:
April 27, 2023
Applicant:
UNIVERSITY HEALTH NETWORK
Inventors:
Li ZHANG, Paulina ACHITA, Jongbok LEE, Dalam LY, Dzana DERVOVIC
Abstract: Embodiments described herein provide a platform, device and process for digital pathology that enable multi-level annotation and visualization of histopathologic slides using a modular arrangement of deep convolutional neural networks (CNNs). The CNNs can be trained using pathology images (e.g., in some cases increasing the base of data by breaking larger fields of view into smaller ones) to learn features consistent with certain pathologies. The platform can use the CNNs to visually annotate pathology slides at an interface tool of a display device. The platform can automate the process of selection, as well as provide an opportunity for the pathologist to see a depiction of predicted results. The platform can use the CNNs to identify regions of interest on pathology slides. The interface tool can enable a predicted region of interest (ROI) type to be visually presented on a surface map showing the basis of the prediction.
Type:
Grant
Filed:
November 6, 2018
Date of Patent:
April 25, 2023
Assignee:
UNIVERSITY HEALTH NETWORK
Inventors:
Kevin Faust, Zoya Volynskaya, Ugljesa Djuric, Phedias Diamandis
Abstract: The invention provides antibodies that specifically bind to transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis). The antibodies can also be used for diagnosing TTR amyloidosis and inhibiting or reducing aggregation of TTR, among other applications.
Type:
Grant
Filed:
December 18, 2020
Date of Patent:
April 18, 2023
Assignees:
NOVO NORDISK A/S, UNIVERSITY HEALTH NETWORK
Inventors:
Tarlochan S. Nijjar, Avijit Chakrabartty, Jeffrey N. Higaki
Abstract: Devices, materials, compounds, systems, and processes for Cherenkov-Activated Nuclear-Targeted Photodynamic Therapy that involves generating Cherenkov light within the tissue of a target volume and using this light to activate photosensitizing material that is located in the nucleus of cells of the target volume.
Abstract: The present invention is related to a dual promoter lentiviral vector and methods of use for the treatment of diseases and disorders, specifically lysosomal storage disorders.
Type:
Grant
Filed:
June 6, 2018
Date of Patent:
March 7, 2023
Assignees:
The Medical College of Wisconsin, Inc., University Health Network, Washington University in St. Louis
Inventors:
Jeffrey A. Medin, John F. Dipersio, Murtaza S. Nagree