Abstract: The present invention relates to a pharmaceutical cocktail and methods of cancer treatment. In particular, one such cocktail comprises a combination of effective amounts of a lactate transporter inhibitor, a carbonic anhydrase inhibitor, a sodium potassium chloride cofactor (NKCC) transporter inhibitor, a member of the hydroxycinnamate class of drugs or a derivative thereof, and/or an angiogenesis inhibitor, including a vascular endothelial growth factor (VEGF) inhibitor such as bevacizumab in combination with blood vessel occlusion. As most cancers in an untreated state uses both aerobic and anaerobic/glycolytic pathways treatments contemplated herein can affect both metabolic pathways.

Abstract: A cerebral protection system generally includes an array of cold packs, an insulating cover, and optionally a set of trays. The cold pack contains two reactive materials separated by a rupturable membrane. When the first reactive material and the second reactive material are mixed, an endothermic reaction occurs. The system can be used to induce hypothermia in selected regions of the brain when used.

Abstract: Provided is a stent pusher assembly for positioning a ureteral stent, the stent pusher assembly having an inner and outer stent pusher. The stent pusher assembly positions the ureteral stent in a patient's kidney and bladder without a bladder fixing portion of the stent entering a ureteral passage-way, thereby minimizing irritation to the patient.

Abstract: An apparatus for diagnosing and/or quantifying the degree of strabismus is disclosed. The apparatus includes a beam that supports at least two targets, a video camera, a light source for generating Purkinje reflexes, and a computer. The patient gazes at the targets while the video camera captures the patient's eyes. The frames of the video are then analyzed as described herein to determine the location of the pupil and the first Purkinje reflex. With this information, strabismus can be diagnosed, as well as the angle of deviation, which is useful for surgically correcting the strabismus. Methods of analyzing the frames are also discussed herein.

Abstract: The present invention relates to a pharmaceutical cocktail and methods of treatment involving said cocktail, in particular, a combination of effective amounts of a carbonic anhydrase inhibitor, in combination with effective amounts of an angiogenesis inhibitor, including a vascular endothelial growth factor (VEGF) inhibitor such as bevacizumab for the treatment of cancer. In other embodiments, it relates to compositions and methods of treating cancer involving effective amounts of a carbonic anhydrase inhibitor. Pharmaceutical compositions and methods of treating cancer (eliminating the tumor, shrinking the tumor, prolonging the life of the patient, increasing quality of life by decreasing the grade of adverse events seen with other cancer treatments, and/or preventing/reducing the likelihood of the tumor's metastases) are additional aspects of the present invention.

Abstract: Provided is a ureteral stent (=50) including a bladder portion (=52) positioned in a bladder of a patient, a kidney portion (=54) positioned in a kidney and ureteral passageway of the patient, and one or more tethers (=56) coupling the bladder portion to the kidney portion. The ureteral stent allows urine to pass around a blockage, and allows a ureter orifice connecting the ureteral passageway to the bladder to move between a compressed state and an uncompressed state to prevent or minimize urinary reflux, flank pain, blood in the urine, etc., while allowing the bladder portion to move freely in the bladder to prevent the bladder portion from irritating the trigone muscle.

Abstract: The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of organisms to antimicrobial agents.

Abstract: The present application is directed to a colonoscope closure device. The colonoscope closure device includes an inner tubular member that defines an entry way sized to accommodate a colonoscope, an intermediate tubular member surrounding the inner tubular member, and an expandable sealing member at least partially surrounding the intermediate tubular member. The colonoscope closure device serves to prevent the escape of air during a colonoscopy procedure.

Abstract: Systems, methods, and devices for providing subcutaneous hydration are disclosed. A system for providing subcutaneous hydration may include an infusion bag including a hydration fluid, a tubing removably connected to the infusion bag, a squeezable bulb at least partially encompassing the tubing for at least one of flushing and priming the tubing, and a deployment device including an integrated needle which is operative provide subcutaneous hydration through the needle. A deployment device for subcutaneous hydration includes a base may include a needle aperture, a spring-loaded barrel attached the base and including a needle, and a firing mechanism within the barrel for deploying the needle from the barrel and further operative to project the needle through the aperture only when a tent of skin has been raised within the aperture for injection. A method for providing subcutaneous hydration may include steps necessary to operate the systems and devices for subcutaneous hydration.

Abstract: The present invention relates to a pharmaceutical cocktail and methods of treatment involving said cocktail, in particular, a combination of effective amounts of a carbonic anhydrase inhibitor, in combination with effective amounts of an angiogenesis inhibitor, including a vascular endothelial growth factor (VEGF) inhibitor such as bevacizumab for the treatment of cancer. In other embodiments, it relates to compositions and methods of treating cancer involving effective amounts of a carbonic anhydrase inhibitor. Pharmaceutical compositions and methods of treating cancer (eliminating the tumor, shrinking the tumor, prolonging the life of the patient, increasing quality of life by decreasing the grade of adverse events seen with other cancer treatments, and/or preventing/reducing the likelihood of the tumor's metastases) are additional aspects of the present invention.

Abstract: The claimed subject matter provides systems and/or methods that facilitate improving visualization associated with intubation. A dynamically articulating laryngoscope blade can be controlled to configure to normal anatomic variants and pathologic abnormalities to facilitate placing of an endotracheal tube into a patient's trachea. Further, cameras can be integrated into and/or mounted upon the dynamically articulating laryngoscope blade. The cameras can enable stereoscopic visualization of the laryngeal aperture allowing for depth perception. Moreover, the cameras can be moved independently of the blade allowing for optimal viewing of the laryngeal opening.

Abstract: The claimed subject matter provides systems and/or methods that facilitate employing a universal handle that provides various functionality and communicates with various network(s), device(s), and the like. The universal handle can be a handheld device that is auto-configured to implement rich functionality. Further, the universal handle can support remote diagnostic, prognostic, and control capabilities. Moreover, the universal handle can mate with disparate device(s), network(s), instrument(s), node(s), universal handle(s), and so forth to communicate data there between. Applications of the universal handle can be medically related, industry related, military related, etc. The universal handle can collect data directly and/or by controlling managed external device(s); the collected data can thereafter be analyzed, aggregated, stored, transmitted, outputted, and so forth by the universal handle.

Abstract: A system for generating an interface that tracks information over the course of patient care is provided. The system includes an interface component configured to generate an interface that facilitates tracking a course of care of a patient, wherein the interface comprises a plurality of input compartments defined by a first axis comprising columns corresponding to sequential points in time over the course of the care and a second axis comprising rows respectively corresponding to patient care events or patient conditions associated with the course of the care. The system further includes a reception component configured to receive input regarding a patient care event or condition that occurred over the course of the care, and a logging component configured to fill one or more input compartments respectively corresponding to a point or period of time associated with occurrence of the patient care event or patient condition.

Abstract: The claimed subject matter provides systems and/or methods that facilitate improving visualization associated with intubation. A dynamical articulating laryngoscope can include a handle assembly and a blade assembly. The blade assembly can further include a main blade assembly, a proximal blade assembly, and a distal blade assembly. A medium control articulation point can couple the main blade assembly and the proximal blade assembly, and a fine control articulation point can couple the distal blade assembly and the proximal blade assembly. Further, the proximal blade assembly can pivot relative to the main blade assembly around the medium control articulation point and/or the distal blade assembly can pivot relative to the proximal blade assembly around the fine control articulation point. Pivoting about the medium control articulation point and/or the fine control articulation point can be effectuated by one or more blade control components.

Abstract: A head-mounted pointing device is disclosed, and can be used for example for surgical training. The pointing device includes a frame or harness assembly made from a circumferential headband and a cross strap that extends over the user's (i.e. trainer's) head. A laser pointer is mounted on one side of the circumferential headband, and a battery pack is provided to power the laser pointer. An user-operated pneumatically controlled switch is used to toggle the laser pointer. By moving the user's head and by activating the switch to engage the laser pointer, the trainer can point to a given target, such as material to be surgically excised from the patient during a surgical procedure.

Abstract: Systems and methods that facilitate extraction and analysis of patient encounters from one or more healthcare related information systems are provided. In an aspect, a system includes a reception component configured to receive information from a plurality of sources regarding courses of care of a plurality of patients, including information identifying activities associated with the courses of care, timing of the activities, resources associated with the activities, and caregiver personal associated with the activities. The system further includes an indexing component configured to generate an index that relates aspects of the information, a filter component configured to employ the index to identify a subset of the information related to a subset of the courses of care for patients associated with a similar medical condition, and an analysis component configured to compare aspects of the subset of the information to identify variance in the subset of the courses of care.

Abstract: A relationship between cancer and ribonucleic acid (RNA) regulation is described by determining intracellular levels of niRN A regulators. Generally, mRNA levels are decreased in cancer cells that may be a reflection of either reduced mRNA expression and/or increased mRNA degradation. miRNAs are identified that hybridize to an mRNA that are suspected to mediate intracellular mRNA steady state levels. Alternatively, ribonucleic acid binding protein (RBP) levels may also mediate intracellular mRNA steady state levels. In particular, this invention demonstrates an effective clinical management strategy for uterine cell cancers may be implemented by taking advantage of an exemplary relationship between P2X7 mRNA and miRNAs including, but not limited to, miR-186 and/or miR-150.

Abstract: The present invention demonstrates that P2X7 receptor induced apoptosis may be specific for cancerous cells. Treatment with the P2X7 ligand BzATP, increased cellular apoptosis with no associated inflammatory changes or abnormal skin or systemic effects. In mice treated with DMBA/TPA, BzATP decreased papilloma skin formation. BzATP also induced involution of developed papillomas and stimulated apoptosis in keratinocytes outgrowing at the base of developed papillomas. These data show that (a) P2X7 regulates apoptosis of epidermal cells; (b) in vivo, local administration of a drug that activates the P2X7 receptor can inhibit development and progression of epidermal premalignant lesions.

Abstract: The present invention generally relates to the field of diagnostic microbiology, and, more particularly; to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of organisms to antimicrobial agents.

Abstract: The invention relates to methods for the treatment of urinary incontinence (UI) and stress urinary incontinence (SUI) in both men and women by replacement of a damaged, absent or injured pubo-urethral ligament (PUL) via a simple injection of “Regenerative Glue.” For example, in the case of UI, the injection of “Regenerative Glue” at the PUL site will adhere the ventral surface of the urethra to the dorsal surface of the symphysis pubis (i.e. the space of Retzius), and further provide regenerative material for continuous replacement of deficient tissues and cells. “The Regenerative Glue” can be made from several commercially available materials including biocompatible glues, fibrin sealant or biocompatible gels; combined with Meschencymal stem cells (MSC) derived from bone marrow or adipose tissues.