Abstract: An Optical Coherence Tomography (OCT) device irradiates a biological tissue with low coherence light, obtains a high resolution tomogram of the inside of the tissue by low-coherent interference with scattered light from the tissue, and is provided with an optical probe which includes an optical fiber having a flexible and thin insertion part for introducing the low coherent light. When the optical probe is inserted into a blood vessel or a patient's body cavity, the OCT enables the doctor to observe a high resolution tomogram. In a optical probe, generally, a fluctuation of a birefringence occurs depending on a bend of the optical fiber, and this an interference contrast varies depending on the condition of the insertion. The OCT of the present invention is provided with polarization compensation means such as a Faraday rotator on the side of the light emission of the optical probe, so that the OCT can obtain the stabilized interference output regardless of the state of the bend.
Type:
Grant
Filed:
March 5, 2002
Date of Patent:
May 13, 2003
Assignees:
University Hospital of Cleveland, Olympus Optical Co., Ltd.
Inventors:
Joseph A. Izatt, Michael V. Sivak, Andrew Rollins, Akihiro Horii, Tadashi Hirata, Shuhei Iizuka
Abstract: The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of a organisms to antimicrobial agents.
Type:
Grant
Filed:
August 10, 2001
Date of Patent:
December 17, 2002
Assignees:
Diagnostic Hybrids, Inc., University Hospitals of Cleveland
Inventors:
David R. Scholl, Yung T. Huang, Patricia Gail Ray Goodrum
Abstract: The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of a organisms to antimicrobial agents.
Type:
Grant
Filed:
May 1, 2001
Date of Patent:
June 18, 2002
Assignees:
Diagnostic Hybrids, Inc., University Hospitals of Cleveland
Inventors:
David R. Scholl, Yung T. Huang, Patricia Gail Ray Goodrum
Abstract: The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of a organisms to antimicrobial agents.
Type:
Grant
Filed:
September 14, 2000
Date of Patent:
April 23, 2002
Assignees:
Diagnostic Hybrids, Inc., University Hospitals of Cleveland
Inventors:
David R. Scholl, Yung T. Huang, Patricia Gail Ray Goodrum
Abstract: The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of a organisms to antimicrobial agents.
Type:
Grant
Filed:
April 19, 2000
Date of Patent:
October 23, 2001
Assignees:
Diagnostics Hybrids, Inc., University Hospitals of Cleveland
Inventors:
David R. Scholl, Yung T. Huang, Patricia Gail Ray Goodrum
Abstract: The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of a organisms to antimicrobial agents.
Type:
Grant
Filed:
May 8, 2000
Date of Patent:
August 28, 2001
Assignees:
Diagnostic Hybrids, Inc., University Hospitals of Cleveland
Inventors:
David R. Scholl, Yung T. Huang, Patricia Gail Ray Goodrum
Abstract: The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of a organisms to antimicrobial agents.
Type:
Grant
Filed:
April 24, 1998
Date of Patent:
January 2, 2001
Assignees:
Diagnostic Hybrids, Inc., University Hospitals of Cleveland
Inventors:
David R. Scholl, Yung T. Huang, Patricia Gail Ray Goodrum
Abstract: This invention relates to a method for culturing a virus including the steps of (A) providing cells from a cell line susceptible to infection by the virus and a specimen; (B) treating the cells with a compound of formula RC(O)Q, wherein Q is R, OR, OX or X, each R is independently hydrogen or a hydrocarbyl group containing 1 to about 10 carbon atoms and wherein X is hydrogen or a cation; (C) inoculating the treated cells with the specimen; and (D) incubating the inoculated cells to allow viral growth to proceed.
Abstract: The present invention relates to a series of novel phthalocyanine compositions (or compounds) suitable for use as photosensitizers for photodynamic therapy. Specifically, the invention relates to a series of new aluminum (Al) germanium (Ge), gallium (Ga), tin (Sn) and/or silicon (Si) phthalocyanines having substituted amine or quaternary ammonium axial ligands attached to the central metal, and the use of these new phthalocyanine compositions for the treatment of cancer through photosensitization. Moreover, the present invention is directed to the methods of preparing these compositions for use in photodynamic therapy.
Type:
Grant
Filed:
September 2, 1993
Date of Patent:
January 16, 1996
Assignee:
University Hospitals of Cleveland
Inventors:
Malcolm E. Kenney, Nancy L. Oleinick, Boris D. Rihter, Ying-Syi Li
Abstract: A cDNA clone (.lambda.RAL-1) that encodes a protein with an apparent molecular weight of 42,000 in vivo and which clone binds with O. volvulus antisera.A recombinant antigen produced by the aforementioned clone, which antigen stimulates T cells from infected individuals to proliferate.A DNA which codes for an O. volvulus peptide sequence, the sequence containing three repeats of the polypeptide sequence KKPEDWD.