Patents Assigned to University Hospital of Cleveland
  • Patent number: 6564089
    Abstract: An Optical Coherence Tomography (OCT) device irradiates a biological tissue with low coherence light, obtains a high resolution tomogram of the inside of the tissue by low-coherent interference with scattered light from the tissue, and is provided with an optical probe which includes an optical fiber having a flexible and thin insertion part for introducing the low coherent light. When the optical probe is inserted into a blood vessel or a patient's body cavity, the OCT enables the doctor to observe a high resolution tomogram. In a optical probe, generally, a fluctuation of a birefringence occurs depending on a bend of the optical fiber, and this an interference contrast varies depending on the condition of the insertion. The OCT of the present invention is provided with polarization compensation means such as a Faraday rotator on the side of the light emission of the optical probe, so that the OCT can obtain the stabilized interference output regardless of the state of the bend.
    Type: Grant
    Filed: March 5, 2002
    Date of Patent: May 13, 2003
    Assignees: University Hospital of Cleveland, Olympus Optical Co., Ltd.
    Inventors: Joseph A. Izatt, Michael V. Sivak, Andrew Rollins, Akihiro Horii, Tadashi Hirata, Shuhei Iizuka
  • Patent number: 6495316
    Abstract: The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of a organisms to antimicrobial agents.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: December 17, 2002
    Assignees: Diagnostic Hybrids, Inc., University Hospitals of Cleveland
    Inventors: David R. Scholl, Yung T. Huang, Patricia Gail Ray Goodrum
  • Patent number: 6458577
    Abstract: This invention relates to a method for culturing a virus including the steps of: (A) providing cells from a cell line susceptible to infection by the virus and a specimen; (B) treating the cells with a compound of formula RC(O)Q, wherein Q is R, OR, OX or X, each R is independently hydrogen or a hydrocarbyl group containing 1 to about 10 carbon atoms and wherein X is hydrogen or a cation; © inoculating the treated cells with the specimen; and (D) incubating the inoculated cells to allow viral growth to proceed.
    Type: Grant
    Filed: August 28, 1997
    Date of Patent: October 1, 2002
    Assignee: University Hospital of Cleveland
    Inventor: Yung T. Huang
  • Patent number: 6406842
    Abstract: The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of a organisms to antimicrobial agents.
    Type: Grant
    Filed: May 1, 2001
    Date of Patent: June 18, 2002
    Assignees: Diagnostic Hybrids, Inc., University Hospitals of Cleveland
    Inventors: David R. Scholl, Yung T. Huang, Patricia Gail Ray Goodrum
  • Patent number: 6376172
    Abstract: The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of a organisms to antimicrobial agents.
    Type: Grant
    Filed: September 14, 2000
    Date of Patent: April 23, 2002
    Assignees: Diagnostic Hybrids, Inc., University Hospitals of Cleveland
    Inventors: David R. Scholl, Yung T. Huang, Patricia Gail Ray Goodrum
  • Patent number: 6306582
    Abstract: The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of a organisms to antimicrobial agents.
    Type: Grant
    Filed: April 19, 2000
    Date of Patent: October 23, 2001
    Assignees: Diagnostics Hybrids, Inc., University Hospitals of Cleveland
    Inventors: David R. Scholl, Yung T. Huang, Patricia Gail Ray Goodrum
  • Patent number: 6280928
    Abstract: The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of a organisms to antimicrobial agents.
    Type: Grant
    Filed: May 8, 2000
    Date of Patent: August 28, 2001
    Assignees: Diagnostic Hybrids, Inc., University Hospitals of Cleveland
    Inventors: David R. Scholl, Yung T. Huang, Patricia Gail Ray Goodrum
  • Patent number: 6168915
    Abstract: The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of a organisms to antimicrobial agents.
    Type: Grant
    Filed: April 24, 1998
    Date of Patent: January 2, 2001
    Assignees: Diagnostic Hybrids, Inc., University Hospitals of Cleveland
    Inventors: David R. Scholl, Yung T. Huang, Patricia Gail Ray Goodrum
  • Patent number: 5891624
    Abstract: This invention relates to a method for culturing a virus including the steps of (A) providing cells from a cell line susceptible to infection by the virus and a specimen; (B) treating the cells with a compound of formula RC(O)Q, wherein Q is R, OR, OX or X, each R is independently hydrogen or a hydrocarbyl group containing 1 to about 10 carbon atoms and wherein X is hydrogen or a cation; (C) inoculating the treated cells with the specimen; and (D) incubating the inoculated cells to allow viral growth to proceed.
    Type: Grant
    Filed: June 3, 1997
    Date of Patent: April 6, 1999
    Assignee: University Hospitals of Cleveland
    Inventor: Yung T. Huang
  • Patent number: 5484778
    Abstract: The present invention relates to a series of novel phthalocyanine compositions (or compounds) suitable for use as photosensitizers for photodynamic therapy. Specifically, the invention relates to a series of new aluminum (Al) germanium (Ge), gallium (Ga), tin (Sn) and/or silicon (Si) phthalocyanines having substituted amine or quaternary ammonium axial ligands attached to the central metal, and the use of these new phthalocyanine compositions for the treatment of cancer through photosensitization. Moreover, the present invention is directed to the methods of preparing these compositions for use in photodynamic therapy.
    Type: Grant
    Filed: September 2, 1993
    Date of Patent: January 16, 1996
    Assignee: University Hospitals of Cleveland
    Inventors: Malcolm E. Kenney, Nancy L. Oleinick, Boris D. Rihter, Ying-Syi Li
  • Patent number: 5021342
    Abstract: A cDNA clone (.lambda.RAL-1) that encodes a protein with an apparent molecular weight of 42,000 in vivo and which clone binds with O. volvulus antisera.A recombinant antigen produced by the aforementioned clone, which antigen stimulates T cells from infected individuals to proliferate.A DNA which codes for an O. volvulus peptide sequence, the sequence containing three repeats of the polypeptide sequence KKPEDWD.
    Type: Grant
    Filed: June 30, 1988
    Date of Patent: June 4, 1991
    Assignee: University Hospitals of Cleveland
    Inventors: Bruce M. Greene, Thomas R. Unnasch