Abstract: A fluid communication device is configured to provide fluid flow between first and second chambers separated by tissue. The fluid communication device includes a member configured for insertion through and engagement of the tissue. The member includes a first opening near a first end of the member for fluidic communication with the first chamber and a second opening near a second end of the member for fluidic communication with the second chamber, the fluid member including a fluid passage that provides fluidic communication between the first and second chambers. The fluid communication device is configured to be positioned with the eye to provide fluid communication between an anterior chamber of the eye and Schlemm's canal.

Abstract: A head-mounted pointing device is disclosed, and can be used for example for surgical training. The pointing device includes a frame or harness assembly made from a circumferential headband and a cross strap that extends over the user's (i.e. trainers) head. A laser pointer is mounted on one side of the circumferential headband, and a battery pack is provided to power the laser pointer. An user-operated pneumatically controlled switch is used to toggle the laser pointer. By moving the user's head and by activating the switch to engage the laser pointer, the trainer can point to a given target, such as material to be surgically excised from the patient during a surgical procedure.

Abstract: A novel system for securing a material to tissue is disclosed. The system may include a body and a plurality of engagement members extending from the body. The engagement members may be adapted to at least partially traverse the material, and each engagement member may include a support at least partially traversing the material and at least one securing member extending from the support and adapted to engage the tissue. The system may be useful for facilitating wound healing by maintaining contact between tissue and a material, such as a skin graft, during healing.

Abstract: The present application is directed to a colonoscope closure device. The colonoscope closure device includes an inner tubular member that defines an entry way sized to accommodate a colonoscope, an intermediate tubular member surrounding the inner tubular member, and an expandable sealing member at least partially surrounding the intermediate tubular member. The colonoscope closure device serves to prevent the escape of air during a colonoscopy procedure.

Abstract: A system and method for the analysis of one or more patient encounters from one or more healthcare related information systems of a healthcare organization are disclosed. The system and method include a data processing system, which provides a graphical user interface which accepts a query regarding the patient encounters, which receives data in response to the query from the one or more healthcare related information systems about a plurality of pre-selected objects concerning the one or more patient encounters, and which arranges the data according to a data model which sets relations between the pre-selected objects. The system and method also employ the relations between the pre-selected objects to provide a report to the accepted query, and output the report.

Abstract: The claimed subject matter provides systems and/or methods that facilitate improving visualization associated with intubation. A dynamically articulating laryngoscope blade can be controlled to configure to normal anatomic variants and pathologic abnormalities to facilitate placing of an endotracheal tube into a patient's trachea. Further, cameras can be integrated into and/or mounted upon the dynamically articulating laryngoscope blade. The cameras can enable stereoscopic visualization of the laryngeal aperture allowing for depth perception. Moreover, the cameras can be moved independently of the blade allowing for optimal viewing of the laryngeal opening.

Abstract: The claimed subject matter provides systems and/or methods that facilitate improving visualization associated with intubation. A dynamical articulating laryngoscope can include a handle assembly and a blade assembly. The blade assembly can further include a main blade assembly, a proximal blade assembly, and a distal blade assembly. A medium control articulation point can couple the main blade assembly and the proximal blade assembly, and a fine control articulation point can couple the distal blade assembly and the proximal blade assembly. Further, the proximal blade assembly can pivot relative to the main blade assembly around the medium control articulation point and/or the distal blade assembly can pivot relative to the proximal blade assembly around the fine control articulation point. Pivoting about the medium control articulation point and/or the fine control articulation point can be effectuated by one or more blade control components.

Abstract: The invention contemplates a method for sterilizing protein or collagen-based hard and soft tissues, from animal and human donors or created synthetically by exposure to genipin, an active compound found in gardenia fruit extract. Genipin sterilizes the tissues through crosslinking the organic framework of microbes while maintaining or enhancing mechanical strength of the tissue graft by stabilizing the collagen backbone with crosslinks bone allografts experience significant and repetitive loads during their duty cycle, sterilizing bone allografts without causing a loss in biomechanical properties is quite important.

Abstract: A fluid communication device is configured to provide fluid flow between first and second chambers separated by tissue. The fluid communication device includes a member configured for insertion through and engagement of the tissue. The member includes a first opening near a first end of the member for fluidic communication with the first chamber and a second opening near a second end of the member for fluidic communication with the second chamber, the fluid member including a fluid passage that provides fluidic communication between the first and second chambers. The fluid communication device is configured to be positioned with the eye to provide fluid communication between an anterior chamber of the eye and Schlemm's canal.

Abstract: The claimed subject matter provides systems and/or methods that facilitate improving visualization associated with intubation. A dynamically articulating laryngoscope blade can be controlled to configure to normal anatomic variants and pathologic abnormalities to facilitate placing of an endotracheal tube into a patient's trachea. Further, cameras can be integrated into and/or mounted upon the dynamically articulating laryngoscope blade. The cameras can enable stereoscopic visualization of the laryngeal aperture allowing for depth perception. Moreover, the cameras can be moved independently of the blade allowing for optimal viewing of the laryngeal opening.

Abstract: A radiation shield for use in connection with computed tomography (CT) calcium scoring of a target area of a patient is provided. The shield is configured for placement over the target area and over one or more radiosensitive secondary areas adjacent to the target area such that x-rays are transmitted through the radiation shield and the target area for detection by an x-ray detector. The detected radiation can be processed for use in a calcium scoring procedure. The radiation shield is configured to reduce radiation exposure of the radiosensitive secondary areas during the calcium scoring procedure without substantially reducing the accuracy of the calcium score associated with the target area.

Abstract: The claimed subject matter provides systems and/or methods that facilitate improving visualization associated with intubation. A dynamical articulating laryngoscope can include a handle assembly and a blade assembly. The blade assembly can further include a main blade assembly, a proximal blade assembly, and a distal blade assembly. A medium control articulation point can couple the main blade assembly and the proximal blade assembly, and a fine control articulation point can couple the distal blade assembly and the proximal blade assembly. Further, the proximal blade assembly can pivot relative to the main blade assembly around the medium control articulation point and/or the distal blade assembly can pivot relative to the proximal blade assembly around the fine control articulation point. Pivoting about the medium control articulation point and/or the fine control articulation point can be effectuated by one or more blade control components.

Abstract: The present invention demonstrates that P2X7 receptor induced apoptosis may be specific for cancerous cells. Treatment with the P2X7 ligand BzATP, increased cellular apoptosis with no associated inflammatory changes or abnormal skin or systemic effects. In mice treated with DMBA/TPA, BzATP decreased papilloma skin formation. BzATP also induced involution of developed papillomas and stimulated apoptosis in keratinocytes outgrowing at the base of developed papillomas. These data show that (a) P2X7 regulates apoptosis of epidermal cells; (b) in vivo, local administration of a drug that activates the P2X7 receptor can inhibit development and progression of epidermal premalignant lesions.

Abstract: The invention provides cell lines which are useful for the rapid detection of enteroviruses. In particular, the invention provides transgenic African green monkey kidney cell lines and buffalo green monkey kidney cell lines. The invention provides cell lines which have increased sensitivity to infection by enteroviruses in single-cell type and mixed-cell type cultures compared to other cell types which are currently used for enterovirus detection. The cells of the invention also are permissive to infection by a larger number of enteroviruses as compared to the cell type from which they were derived.

Abstract: The claimed subject matter provides systems and/or methods that facilitate improving visualization associated with intubation. A dynamically articulating laryngoscope blade can be controlled to configure to normal anatomic variants and pathologic abnormalities to facilitate placing of an endotracheal tube into a patient's trachea. Further, cameras can be integrated into and/or mounted upon the dynamically articulating laryngoscope blade. The cameras can enable stereoscopic visualization of the laryngeal aperture allowing for depth perception. Moreover, the cameras can be moved independently of the blade allowing for optimal viewing of the laryngeal opening.

Abstract: The claimed subject matter provides systems and/or methods that facilitate improving visualization associated with intubation. A dynamical articulating laryngoscope can include a handle assembly and a blade assembly. The blade assembly can further include a main blade assembly, a proximal blade assembly, and a distal blade assembly. A medium control articulation point can couple the main blade assembly and the proximal blade assembly, and a fine control articulation point can couple the distal blade assembly and the proximal blade assembly. Further, the proximal blade assembly can pivot relative to the main blade assembly around the medium control articulation point and/or the distal blade assembly can pivot relative to the proximal blade assembly around the fine control articulation point. Pivoting about the medium control articulation point and/or the fine control articulation point can be effectuated by one or more blade control components.

Abstract: The invention provides cell lines that are useful for the rapid detection and production of influenza and parainfluenza viruses. In particular, the invention relates to transgenic cells with increased sensitivity to infection by influenza A, influenza B, or parainfluenza 3 viruses, or which are capable of enhanced productivity of infectious virions. The invention is suitable for use in culturing clinical influenza and parainfluenza virus isolates and for the production of influenza and parainfluenza virus for vaccine formulations, as antigen preparations for diagnostic applications, and for screening antiviral drugs.

Abstract: A monopolar neuromuscular electrical stimulation (NMES) apparatus is configured for use with a cannula and a remote electrode. The apparatus includes a longitudinally rigid rod that is movable in the cannula throughout a range of operative positions in which inner and outer end portions of the rod extend longitudinally outward from the inner and outer ends of the cannula. The apparatus further includes a single electrode configured to be supported as a solitary electrode on the inner end portion of the rod for movement with the rod through the cannula. In this manner, the electrode can be moved into and out of contact with internal test sites to apply NMES at the internal test sites in an electrical circuit with the remote electrode upon movement of the rod back and forth in the cannula. Additionally, the rod is a rigid tube and the electrode is a suction-tip electrode configured to communicate pneumatically with the rigid tube.

Abstract: The claimed subject matter provides systems and/or methods that facilitate employing a universal handle that provides various functionality and communicates with various network(s), device(s), and the like. The universal handle can be a handheld device that is auto-configured to implement rich functionality. Further, the universal handle can support remote diagnostic, prognostic, and control capabilities. Moreover, the universal handle can mate with disparate device(s), network(s), instrument(s), node(s), universal handle(s), and so forth to communicate data there between. Applications of the universal handle can be medically related, industry related, military related, etc. The universal handle can collect data directly and/or by controlling managed external device(s); the collected data can thereafter be analyzed, aggregated, stored, transmitted, outputted, and so forth by the universal handle.

Abstract: A system and method for autologous normovolemic hemodilution (ANH) are disclosed. The system can include a vacuum canister, which is sized to accept donor bags of a predetermined capacity. The vacuum canister is connected to a vacuum source which applies a suction to the donor bag within the canister. The system can include a canister having a self-generated vacuum, which includes compressible sidewalls that are spring-loaded to provide negative pressure needed to collect blood from a patient without the use of a gravity-induced siphon gradient. Also disclosed are ANH systems and kits that rely on a gravity-induced siphon gradient for blood collection.