Abstract: Devices and methods for sensing analytes in a solution sample are provided. The device includes a substrate, a conversion component configured to convert the analyte in the sample solution into a metabolite, and an aptamer sensor configured to measure a presence of the metabolite, the aptamer sensor located on the substrate.

Abstract: Provided herein are methods of potentiating an effect of an anti-cancer drug in a subject diagnosed with cancer, the method including administering to the subject a combination therapy including: an effective amount of 7-ethynyl-5-(2-fluorophenyl)-1-methyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one (BZD-1); and an anti-cancer drug.

Abstract: A savonius wind turbine including a rotational shaft and a compound blade operatively coupled to the rotational shaft is provided. The compound blade includes a primary blade portion and a secondary blade portion. The primary blade portion extends between a first end and a second end and defines a primary concave surface therebetween. The secondary blade portion is coupled to the primary blade portion between the first end and the second end. The secondary blade portion defines a secondary concave surface configured to generate a torque about the rotational shaft.

Abstract: A method of treating a subject suffering from a condition characterized by over-expression of Ten-eleven translocation 1 (TET1) is provided, the method including administering to the subject an effective amount of a compound, or a pharmaceutically acceptable salt thereof, having the Formula I: wherein: R1, R2, R3, R4, and R5 are each independently selected from the group consisting of H, hydroxyl, alkyl, alkoxy, amine, halo, and trifluoromethyl, and wherein any two adjacent moieties of R1, R2, R3, R4, and R5 may come together to form a heterocyclic ring; R6 is H or hydroxyl; and R7 is selected from H, wherein R8 is C or O. Also provided are methods for selectively suppressing transcription of TET1 and/or reducing a level of 5-hydroxymethylcytosine in a subject by administering an effective amount of a Formula I compound and pharmaceutical compositions comprising Formula I compounds.

Abstract: Naloxone variants that are both long lasting and responsive are disclosed. One version of the compound has a boron ester functional group and the antagonist compound is capable of a sustained release of antagonist based on reaction with hydrogen peroxide. In addition, a method of treating opioid overdose is disclosed. The method involves administering a therapeutically effective amount of the formulation described above to a patient in need thereof. Administration occurs either intranasally, sublingually or intranasally and sublingually, wherein if administration occurs intranasally and sublingually administration occurs simultaneously, sequentially or concomitantly.

Abstract: An apparatus may include a processor configured to synthesize a first configuration file associated with a target field-programmable gate array (FPGA), and a second configuration file associated with the target FPGA, wherein first look-up-table (LUT) bits of the first configuration file are the logical inverse of second LUT bits of the second configuration file, and first non-LUT bits of the first configuration file are the same as second non-LUT bits of the second configuration file, and generate a LUT mask indicating which bits of the first configuration file and the second configuration file correspond to the first LUT bits and the second LUT bits by performing a bit-wise exclusive OR operation between the first configuration file and the second configuration file.

Abstract: A device for measuring one or more analytes in a sample fluid is provided. The device includes at least one aptamer sensor comprising a plurality of aptamers. The sensor provides a measurement of at least one of the analytes. In addition, the measurement is affected by changes in temperature (“a temperature-dependent response”). The device also includes a means to establish fluid communication between the at least one aptamer sensor and the sample fluid. Further, the device includes at least one temperature sensor and a means for correcting a measurement error due to the temperature-dependent response.

Abstract: A device for measuring one or more analytes in a sample of interstitial fluid or blood is provided. The device comprises at least one EAB sensor using one or more attached redox couples that measure at least one of the analytes. It also includes at least one means to establish fluid communication between the sensor and the sample. The analytes are selected from the group consisting of progesterone, luteinizing hormone (LH), estrogen, follicle stimulating hormone (FSH), their metabolites, and combinations thereof.

Abstract: A novel composition is provided. The composition is a tetrameric reaction product of heterocyclic 3-thiophenecarboxaldehyde and an aromatic compound, the reaction product being a calix[4]arene. In one embodiment, the present invention is a thiophene functionalized calixarene selected from the group consisting of C-thiopheneresorcin[4]arene and C-thiophenepyrogallol[4]arene. In another embodiment, the thiophene functionalized calixarene further comprises silver nanoparticles.

Abstract: Provided herein is a vaccine adjuvant containing an N-terminal domain of osteopontin or a fragment thereof. Also provided are conjugates and fusion proteins containing the N-terminal domain of osteopontin conjugated to a pathogen or a protein derived therefrom. A method for potentiating an immune response to an immunizing antigen is also provided, the method including administering to a subject an effective amount of a vaccine adjuvant containing an N-terminal domain of osteopontin. Also provided is a method of vaccinating a subject against SARS-CoV-2, the method including administering to a subject a fusion protein containing the N-terminal domain of osteopontin and the receptor binding domain of SARS-CoV-2 spike glycoprotein. Cellular vaccines and methods of vaccinating a subject with a cellular vaccine are also provided herein.

Abstract: An implant system for the fusion of the occipitocervical (O-C1) joint is provided. The system has a plate including a horizontal panel, a right vertical panel and a left vertical panel. The horizontal panel has at least two openings. The right vertical panel has at least two openings. The left vertical panel has at least two openings. The system also includes at least four bone fixation fasteners to fix the panels to the occipital condyle and C1 lateral mass using the openings in the panels.

Abstract: A positive expiratory pressure-generating device for reducing breathlessness in a subject with one or more pulmonary disorders is disclosed. The device is rigid and hollow and can be held in the mouth of the subject. The device has at least one air chamber, at least one opening in the portion of the device that is held in the mouth and at least one additional airflow orifice. The device is configured to increase expiratory resistance and can be supported by the mouth of the subject without the need for additional support by hands, another device or other means.

Abstract: Avobenzone complexes are provided, including a complex of avobenzone-RsC5 and a complex of cucurbit[7]uril. Among other uses, the complexes can be used in sunscreen compositions. In one embodiment, the avobenzone complex is from about 0.5 to about 10 weight percent of the sunscreen composition.

Abstract: Disclosed herein is a method of epigenetic quantification using DNA hybridization-based single-molecule immunofluorescent imaging, an ultra-sensitive method of detecting epigenetic modifications in DNA. Via use of probe DNA to capture the DNA fragment of interest and the immunofluorescent imaging to detect modifications, the fluorescent response signal can be detected and quantified at the single-molecule level.

Abstract: A method of assessing gut health in a subject is provided. The method involves placing a device on or near the subject's skin and measuring a level of hydrogen gas emanating through the subject's skin. The device includes an electrochemical sensor capable of detecting hydrogen gas and a means of connecting the device to an apparatus having a central processing unit (CPU). The apparatus provides information on hydrogen gas level and the hydrogen gas level is used to assess gut health of the subject.

Abstract: Described herein are methods and devices of detecting a particulate analyte in a sample solution, using an electrochemical cell having an anodic compartment and a cathodic compartment, wherein the anodic and cathodic compartments are separated by a semi-permeable membrane. The sample solution is acidified by applying a positive current to the anodic compartment and maintaining the positive current to permit anions to flow from the cathodic compartment to the anodic compartment through the semi-permeable membrane. The analyte is deposited on an electrode disposed in the anodic compartment by applying a negative current. The deposited analyte is stripped from the electrode and an electrochemical voltammogram is generated by measuring the current as the analyte is stripped from the electrodes. The voltammogram is used to determine the concentration of the analytes in the sample solution based on the generated electrochemical voltammogram.

Abstract: An apparatus may include a processor configured to synthesize a first configuration file associated with a target field-programmable gate array (FPGA), and a second configuration file associated with the target FPGA, wherein first look-up-table (LUT) bits of the first configuration file are the logical inverse of second LUT bits of the second configuration file, and first non-LUT bits of the first configuration file are the same as second non-LUT bits of the second configuration file, and generate a LUT mask indicating which bits of the first configuration file and the second configuration file correspond to the first LUT bits and the second LUT bits by performing a bit-wise exclusive OR operation between the first configuration file and the second configuration file.

Abstract: The present disclosure concerns open-end carbon nanotubes assembled as a microelectrode array in electrode sets/micro-electrode sets (ES/micro-ES). The ES/micro-ES includes three electrodes that are made of highly densified multi-walled carbon nanotubes fibers (HD-CNTfs) sectioned into rods embedded in an inert polymer film with exposed open ends of CNTs at the electrode-electrolyte interface. The ES/micro-ES provide miniature electrochemical sensing devices in which all electrodes are based on carbon nanomaterials. The combination of dimensions and orientation provides for highly sensitive electrochemical determination (picomolar) of different electroactive analytes in different electrolyte mediums, where even a single drop of desired analyte solution will be enough for electrochemical characterization.

Abstract: A nanoparticle delivery system designed for sustained delivery of microRNA-150 (miR-150) to FLT3-overexpressing acute myeloid leukemia (AML) cells, the delivery system comprising poly(amidoamine) (PAMAM) dendrimers complexed with miR-150, wherein at least one dendrimer is surface-functionalized with a ligand specific for FLT3 receptor, and methods for treating AML characterized by FLT3-overexpression are provided.

Abstract: A positive expiratory pressure-generating device for reducing breathlessness in a subject with one or more pulmonary disorders is disclosed. The device is rigid and hollow and can be held in the mouth of the subject. The device has at least one air chamber, at least one opening in the portion of the device that is held in the mouth and at least one additional airflow orifice. The device is configured to increase expiratory resistance and can be supported by the mouth of the subject without the need for additional support by hands, another device or other means.