Abstract: An intravascular ultrasound (IVUS) catheter-based device for targeted delivery of ultrasound-activated emulsions of oxygen-scavenging droplets into a bloodstream of patients suffering from a hypoxic condition and methods utilizing the device to protect the patients from reperfusion injury upon restoration of oxygenated blood to a hypoxic tissue.

Abstract: Provided herein are methods for treating diabetic cardiomyopathy in a patient in need thereof, such as a patient diagnosed with type 1 or type 2 diabetes. The methods generally include administering a therapeutically effective amount of one or more glucose transporter isoform 1 (GLUT1) inhibitors to the patient. Exemplary GLUT1 inhibitors include STF-31, WZB117, phloretin, and BAY-876.

Abstract: Provided herein are implantable biomaterials for promoting regeneration of an injured biological tissue, the biomaterials including piezoelectric materials and an extracellular matrix specific to the injured biological tissue, wherein the piezoelectric materials and the extracellular matrix are electrospun together to provide tissue-specific bioactive piezoelectric nanofiber scaffolds. Also provided herein are methods of fabricating a tissue-specific bioactive piezoelectric nanofiber scaffold and methods of promoting regeneration of injured biological tissue by implanting the disclosed bioactive piezoelectric scaffolds.

Abstract: The present disclosure concerns RNA aptamers that specifically inhibit the protein-protein interaction between MED1 and an estrogen receptor. As shown herein, the aptamers are specific for the LXXLL recognition motif between MED 1 and an estrogen receptor. The present disclosure further concerns pRNA nanoparticles of the RNA aptamers coupled with a further HER2 aptamer that show HER2 specific uptake and subsequent inhibition of cellular proliferation and metastasis in vitro and in vivo. Furthermore, the pRNA nanoparticles showed no adverse effects, signifying a safe and effective composition to specifically target and control HER2 expressing cells.

Abstract: Devices and methods are described herein for directly and accurately measuring sweat flow rates using miniaturized thermal flow rate sensors. The devices (100, 200, 300, 400, 500, 600, 700, 800, 900, 1000, 1100, 1200, 1300, 1400, 1500) include the flow rate sensors (220, 320, 420, 520, 620, 720, 820, 920, 1020, 1120, 1220, 1320, 1420) in or adjacent to a microfluidic component (230, 330, 430, 530, 630, 730, 830, 930, 1030, 1130, 1230, 1330, 1430, 1530) of a wearable sweat sensing device. The devices and methods optimize the sensitivity of the flow rate sensors, while minimizing the presence of noise, in order to accurately and directly measure sweat flow rates.

Abstract: The present invention involves a compartmentalized microfluidic device using one or more separators. Each separator has a plurality of microfluidic channels and the separators are oriented in a perpendicular direction to the substrate. The vertical integration of the microfluidic components enables realization of 3D device features with high aspect ratio.

Abstract: A method of forming a yellow grease is provided. The method includes delivering a FOG lipid extraction agent into a processing tank. The method further includes preheating a waste grease to a temperature of between 35° C. and 95° C. The method further includes mixing the preheated waste grease with the FOG lipid extraction agent in the processing tank to form the yellow grease.

Abstract: A savonius wind turbine including a rotational shaft and a compound blade operatively coupled to the rotational shaft is provided. The compound blade includes a primary blade portion and a secondary blade portion. The primary blade portion extends between a first end and a second end and defines a primary concave surface therebetween. The secondary blade portion is coupled to the primary blade portion between the first end and the second end. The secondary blade portion defines a secondary concave surface configured to generate a torque about the rotational shaft.

Abstract: The invention relates to biomimetic, biodegradable composites including a magnesium (Mg) alloy mesh and a polymer/extracellular matrix (ECM). These hybrid composites, more particularly, are useful for the fabrication of medical implant devices, e.g., scaffolds, and are effective for bone regeneration. The fabrication process includes creating the Mg alloy mesh, and concurrently electrospinning the polymer and electrospraying the ECM onto the mesh.

Abstract: A method of inducing cell death in a glioblastoma multiforme cancer cell is provided, the method comprising administering to the cell a combination of therapeutic agents comprising: saposin C and dioleoylphosphatidylserine (SapC-DOPS), and nucleolin aptamer AS1411, wherein cell death of the cancer cell is induced. Also provided are methods of treating glioblastoma multiforme, methods of inhibiting growth of a glioblastoma multiforme tumor, kits, and pharmaceutical compositions comprising SapC-DOPS and AS1411.

Abstract: A vertical axis wind turbine including a nozzle is provided. The nozzle includes a first airfoil and a second airfoil. The first airfoil includes a first airfoil leading edge and a first airfoil trailing edge, and the second airfoil includes a second airfoil leading edge and a second airfoil trailing edge. The nozzle defines an inlet area disposed between the first airfoil leading edge and the second airfoil leading edge and an exit area disposed between the first airfoil trailing edge and the second airfoil trailing edge, wherein the exit area is smaller than the inlet area.

Abstract: Pharmaceutical compositions, kits and methods for treating tumors such as glioma and cancers such as leukemia with (R)-2-hydroxyglutarate (R-2HG) are provided, along with therapeutic regimens including treatment of a patient suffering from glioma or leukemia with a MYC-signaling inhibitor followed by or cotemporaneous with treatment with R-2HG, and optionally other chemotherapeutic agents.

Abstract: Systems and methods of use and fabrication are described for a THx2 threshold gate cell for a programmable gate array including a mode-independent PMOS configuration and an NMOS configuration configured to operate in one of a TH12 mode and a TH22 mode, wherein x is set to a threshold of 1 for the TH12 mode and x is set to a threshold of 2 for the TH22 mode.

Abstract: A system comprises an nMOS active resistor, nMOS transistors, a pMOS active resistor, and pMOS transistors, wherein a subset of the nMOS transistors a subset of the pMOS transistors are coupled to each other, respectively, according to a parallel OR configuration, a source terminal of the nMOS active resistor is coupled to respective drain terminals of the nMOS transistors, and a source terminal of the pMOS active resistor is coupled to respective drain terminals of the pMOS transistors. The transistor level delay based circuit further includes a write subcircuit component includes one of the nMOS transistors coupled to at least one of the pMOS transistors, wherein the write subcircuit is controlled by reverse logic signals, and a gate component includes an additional subset of the plurality of nMOS transistors coupled to an additional subset of the pMOS transistors, the gate component corresponding to a semistatic cross coupled inverter circuit.

Abstract: Methods and model equations are provided for predicting a risk of a subject who experiences adverse medical events associated with the weather, of experiencing a new-onset event.

Abstract: A method to treat pneumothorax or malignant pleural effusion by pleurodesis in a mammalian subject is disclosed. The method involves administering particles to the lungs, the pleural space or both. The particles comprise a crystalline material that is non-toxic and is cleared over time by biodegradation. In some embodiments, the biodegraded crystalline material is readily cleared by the kidneys. In one embodiment, the crystalline material is essentially cleared from the lungs a few months after treatment.

Abstract: A system 100, 200 for sensing one or more analytes in a first biofluid and a second biofluid and methods of using said system. The system 100, 200 may include a first subsystem 102, 200a, 200b with a first sensor 120, 122, 220, 222 for sensing a first analyte in the first biofluid and a second subsystem 104, 200b, 200c with a second sensor 124, 126, 222, 224 for sensing a second analyte in the second biofluid. The second analyte may be the same as or different from the first analyte and the second biofluid may be different from the first biofluid. In an embodiment, the first biofluid is a non-sweat biofluid and the second biofluid is sweat. The system 100, 200 may be used to detect lag time for measuring an analyte in one of the biofluids.

Abstract: A cocrystal complex of pirfenidone with a polyphenolic macrocycle host is disclosed. The composition is useful, in some embodiments, as an acne treatment. In one embodiment, the macrocycle is calixarene or a calixarene derivative. In another embodiment, the macrocycle is resorcin[4]arene. In one embodiment, the macrocycle is C-methylresorcin[4]arene (RsC1). In another embodiment, the macrocycle is C-butylresorcin[4]arene (RsC4).

Abstract: Methods, processing systems, and computer-readable mediums for automated designing of patient-specific cranial implants may include extracting pixel data from a DICOM file; generating a virtual skull model based on the pixel data; identifying a mid-sagittal plane of the virtual skull model; identifying a surgical hole in the virtual skull model; mirroring a reference side of the virtual skull model onto a surgical hole side of the virtual skull model; subtracting the surgical hole side from the mirrored reference side to generate a virtual cranial implant; and generating a virtual two-part mold based on the virtual cranial implant. A physical two-part mold can be 3D printed based on the virtual two-part mold, and a physical cranial implant can be constructed using the physical two-part mold.

Abstract: The method of covalently bonding carbon nanotubes to substrates is provided. The method comprises functionalizing a substrate and each open-end of a plurality of open-ended carbon nanotubes, embedding each of the plurality of open-ended carbon nanotubes within respective polymers, aligning, orthogonally, the plurality of open-ended carbon nanotubes relative to the substrate, and applying pressure on each of the plurality of open-ended carbon nanotubes relative to the substrate for enabling covalent bonding of each of the plurality of open-ended carbon nanotubes to the substrate.