Abstract: Biological chemicals, potentially found in blood are measured by collecting sweat and determining the concentration or meaning of the selected chemical in sweat. The sweat can be collected using a time based, interval collector and analyzed using an external device. It can also be collected on a one time basis, using a flexible, chemical capacitor, or on a continuous basis using a chemical, field effect transducer.

Abstract: Devices and methods are described herein for directly and accurately measuring sweat flow rates using miniaturized thermal flow rate sensors. The devices (100, 200, 300, 400, 500, 600, 700, 800, 900, 1000, 1100, 1200, 1300, 1400, 1500) include the flow rate sensors (220, 320, 420, 520, 620, 720, 820, 920, 1020, 1120, 1220, 1320, 1420) in or adjacent to a microfluidic component (230, 330, 430, 530, 630, 730, 830, 930, 1030, 1130, 1230, 1330, 1430, 1530) of a wearable sweat sensing device. The devices and methods optimize the sensitivity of the flow rate sensors, while minimizing the presence of noise, in order to accurately and directly measure sweat flow rates.

Abstract: A kit for preparing a nucleic acid sample for analysis by liquid chromatography tandem mass spectrometry (LC-MS/MS) is provided, the kit comprising: a lyophilized enzyme composition comprising: micrococcal nuclease; nuclease P1; and bacterial alkaline phosphatase (BAP); and a digestion buffer. Also provided are enzyme compositions and methods of use for rapid, efficient preparation of a nucleic acid sample for analysis by LC-MS/MS, without the need for denaturation of the sample.

Abstract: Provided herein are photocatalytic carbon filters for the removal impurities such as microorganisms, organic compounds, algal toxins, and their degradation by-products from water and wastewater. The photolytic carbon filters comprise a porous titanium substrate comprising TiO2 nanotube arrays and multi-wall carbon nanotubes disposed on the TiO2 nanotube arrays. Also provided herein are methods of manufacture and methods of use of the disclosed photocatalytic carbon filters.

Abstract: A genetically modified strain of commensal bacteria Staphylococcus epidermidis is provided which produces a material with UV absorbing properties. The material with UV absorbing properties may be a mycosporine-like amino acid such as shinorine.

Abstract: An electrode includes an insulating surface layer and at least one aligned carbon nanotube fiber embedded in the insulating surface layer. Each of the at least one aligned carbon nanotube fiber has a first end and a second end opposite the first end, and the first end and the second end are separated by a body. Each of the at least one aligned carbon nanotube fiber is composed of a plurality of carbon nanotubes. The first end and the second end are free of the insulating surface layer. The second end is in contact with an electrical conductive material. A method of analyzing an analyte in a sample and a device for energy storage using the electrode are also described.

Abstract: Described are a device and method for detecting cerebral perfusion in a subject's head during a cardiac crisis. Embodiments of the device include a neurological status evaluation apparatus having a signal generator configured to generate an electromagnetic signal at one or more frequencies, a transmitting antenna coupled to the signal generator and configured to transmit the electromagnetic signal, and a receiving antenna positioned proximate to the transmitting antenna such that an evaluation space is defined between the transmitting antenna and the receiving antenna. In embodiments, the subject's head does not contact the transmitting antenna or the receiving antenna. The receiving antenna receives a modulated electromagnetic signal after propagating through the subject's head. The neurological status evaluation apparatus further includes a signal analyzer coupled to the receiving antenna, wherein the signal analyzer receives and samples the modulated electromagnetic signal.

Abstract: A method for pretreating lignocellulosic biomass to improve fermentability is disclosed. The method involves reacting lignocellulosic biomass with an acidic mixture while heating at a temperature from about 120° C. to about 200° C. to produce a prehydrolysate mixture. The acidic mixture includes a dilute acid and nucleophilic proteins, hydrolyzed amino acids or combinations thereof.

Abstract: A composition includes an aqueous solution including at least one fluorinated organic compound; and a reaction product of a source of iron(II) and a source of sulfite in the presence of water and molecular hydrogen. A method of making a catalyst includes reacting a source of iron(II) and a source of sulfite in the presence of water and molecular hydrogen. The water may include less than or equal to 1 weight percent dissolved molecular oxygen. The catalyst may be used for degrading fluorinated organic chemicals in aqueous media.

Abstract: Systems and methods of use and fabrication are described for a THx2 threshold gate cell for a programmable gate array including a mode-independent PMOS configuration and an NMOS configuration configured to operate in one of a TH12 mode and a TH22 mode, wherein x is set to a threshold of 1 for the TH12 mode and x is set to a threshold of 2 for the TH22 mode.

Abstract: A method of treating a subject suffering from a condition characterized by over-expression of Ten-eleven translocation 1 (TET1) is provided, the method including administering to the subject an effective amount of a compound, or a pharmaceutically acceptable salt thereof, having the Formula I: wherein: R1, R2, R3, R4, and R5 are each independently selected from the group consisting of H, hydroxyl, alkyl, alkoxy, amine, halo, and trifluoromethyl, and wherein any two adjacent moieties of R1, R2, R3, R4, and R5 may come together to form a heterocyclic ring; R6 is H or hydroxyl; and R7 is selected from H, wherein R8 is C or O. Also provided are methods for selectively suppressing transcription of TET1 and/or reducing a level of 5-hydroxymethylcytosine in a subject by administering an effective amount of a Formula I compound and pharmaceutical compositions comprising Formula I compounds.

Abstract: Provided herein is a method of diagnosing and treating a subject suffering from atopic dermatitis (AD), the method comprising: (a) obtaining a skin biopsy from a subject suspected of suffering from AD; (b) determining a level of RNA expression in the skin biopsy of genes selected from the 89ADGES gene panel; (c) comparing the determined level of RNA expression of the selected genes to the level of RNA expression of the selected genes in a reference sample comprising RNA expression products from normal healthy skin cells; (d) diagnosing the subject as suffering from AD when specific genes are up-regulated compared to the reference sample and when specific genes are down-regulated compared to the reference sample; and (e) treating the subject with a therapy effective for the treatment of AD. Methods of managing treatment of a subject suffering from AD are also provided.

Abstract: Various aspects of the disclosure relate to a tracheal implant comprising (a) a trachea processed to comprise one or more incisions providing a helical configuration to the processed trachea; and (b) a subject-specific synthetic support.

Abstract: A method of characterizing nanovesicles is disclosed. The method involves entrapping nanovesicles such as exosomes and sensing the dielectric properties of the exosomes using an electrical impedance sensing device. The method can distinguish exosomes based on different membrane compositions, different cellular origins, different size distribution and/or different cytosolic compositions.

Abstract: A device (100) for sensing a first analyte in sweat on skin includes an analyte-specific sensor (120) for sensing the first analyte and an active sweat coupling component (130) for transporting at least one sweat sample inside the device (100) and into fluid communication with the analyte-specific sensor (120). A method of sensing a first analyte in sweat on skin includes actively transporting at least one sweat sample into fluid communication with an analyte-specific sensor (120) for sensing the first analyte using an active sweat coupling component (130) and sensing the first analyte using the analyte-specific sensor (120).

Abstract: Inhibitors of miRNA-128 capable of promoting cardiomyocyte mitotic cell proliferation and methods effective for regeneration of heart tissue.

Abstract: A method for motion correction of Magnetic Resonance (MR) images is provided. The method includes acquiring a k-space dataset for an object using an MR scanner, detecting or identifying corrupted k-space data from the acquired k-space dataset, extracting the corrupted k-space data from the acquired k-space dataset, recovering the corrupted k-space data, combining uncorrupted k-space data of the acquired k-space dataset with the recovered k-space data to form a full k-space dataset, and reconstructing an image for the object based on the full k-space dataset. A magnetic resonance imaging system for correcting corrupted k-space data of an entire k-space dataset is also provided.

Abstract: Systems, methods, and computer program products for remaining useful life prediction. Operational data is collected from a test machine until a component fails, and a training dataset generated from the operational data. The training dataset is used to define and validate a prediction model. Operational data received from one or more field machines is provided to the prediction model. The prediction model then predicts the remaining useful life of the component of the field machine. To reduce the time-to-failure of the component in the test machine, the component may be repeatedly subjected to an accelerated wear cycle. The prediction model may be defined by extracting features from the training dataset. Like features may be extracted from the field dataset and provided to the prediction model as part of the prediction process. The operational data received from the field machines may be used to generate an updated prediction model.

Abstract: A novel ROS-responsive prodrug is provided. The prodrug utilizes a unique modified oxalate linker conjugated to 4-aminophenol, which can enhance the reaction kinetics for intracellular ROS within tumor tissues while keeping the modified oxalate backbone stable with amide bond under very low ROS level.

Abstract: An augmented neuromuscular training system and method for providing feedback to a user in order to reduce movement deficits associated with injury risk, prior injury or disease pathology.