Abstract: Disclosed herein transgene construct comprising (i) a first nucleotide sequence, wherein the activity of the protein encoded by said first nucleotide sequence causes death of germ cells in the presence of an exogenous induction agent and (ii) a second nucleotide sequence which targets said construct to avian germ cells, methods of using the same and a transgenic avian provided by such methods.

Abstract: To be able to adequately provide desired services over a 5G mobile service network, the 5G communication infrastructures requires a much-improved flexibility in resource management. Network operators are foreseen to deploy network slicing, by isolating dedicated resources and providing customised logical instances of the physical infrastructure to each service. A critical operation in performing management and orchestration of network resources is the anticipatory provisioning of isolated capacity to each network slice. Accordingly, it is necessary to obtain an estimate of service level demands. However, the estimation of such service level demands is typically obtained via deep packet inspection, which is a resource intensive and time-consuming process. Therefore, it is typically not possible to provide updated accurate estimates at a frequency suitable for use in accurate prediction of a future per-service traffic consumption, without an undesirable level of computational and time resources being required.

Abstract: There is described a method of producing a flexible structure and sensor devices incorporating the former, such as wireless LC sensors, that comprises a plurality of thin-film layers of elastomeric material and at least one layer of micro-wrinkled electrically conductive material. The method includes steps leading to 2D wrinkled metallised polydimethylsiloxane (PDMS) layers enabling considerable flexibility with negligible bending failure for angles up to 180 degrees.

Abstract: A method of detecting the presence of alpha-synuclein aggregation in a biological sample is provided whereby a biological sample is mixed with a reaction sample comprising a population of beads, a fluorophore adapted to bind to protein aggregates and to increase fluorescence when bound to protein aggregates, and alpha-synuclein or a fragment or variant thereof to form a reaction mixture, wherein a significant increase in the fluorescence of the reaction mixture during incubation is indicative of the presence of aggregates of alpha-synuclein in the biological sample.

Abstract: A method of performing Raman spectroscopy comprising: generating wavelength shifted excitation light for exciting a Raman response from at least one sample, wherein the wavelength shifted excitation light comprises at least two excitation wavelengths; providing the wavelength shifted excitation light to the at least one sample and collecting signal light from the at least one sample; obtaining response signals from the collected signal light; processing the obtained response signals to determine a Raman response and a fluorescence response, wherein determining the Raman response uses at least one characteristic of an expected Raman response to the wavelength shifted excitation light and wherein determining the fluorescence response uses at least one characteristic of an expected fluorescence response to the shifted excitation light.

Abstract: A method for training a first neural network to detect the viewpoint of an object visible on an image and belonging to a given category of object when this image is inputted to the first neural network, including: providing a dataset of pairs of images under different viewpoints, providing a second neural network configured to be able to deliver appearance information of an object, providing a third neural network configured to be able to deliver a synthetic image of an object of the category using appearance information and a viewpoint, jointly training the first neural network, the second neural network, and the third neural network.

Abstract: An endoscopic imaging apparatus comprises at least one light source (1, 2, 3) configured to provide excitation signals to an imaging region via a common transmission path. Each excitation signal has one of a plurality of different colours. A controller (100) is configured to control the at least one light source (1, 2, 3) to provide the excitation signals as a repeating time-interleaved sequence that comprises at least an excitation signal of a first one of the colours and a subsequent excitation signal of a second one of the colours. A monochrome detector (80) is configured, for each of at least some of the excitation signals, to receive at least part of a respective response signal emitted from the imaging region in response to the excitation signal and to generate image data based on the at least part of the response signal.

Abstract: The invention provides a compound of formula (I), and salts, solvates and radiolabelled forms thereof, together with complexes of the compound of formula (I) with TSPO, and methods for forming such complexes, and methods for detecting the compound of formula (I), such as in complex with TSPO.

Abstract: A medical image processing apparatus includes a memory storing training medical images, each annotated with respective weak supervision annotation information relating to at least one object represented in the training medical image, the at least one object comprising an anatomical object, a pathology, or a medical device; and processing circuitry configured to use the plurality of training medical images to train a deep learning network to perform a task, wherein the training of the deep learning network includes training a compositional latent representation comprising a plurality of kernels, wherein the training of the compositional latent network includes using the weak supervision annotation information to provide weak supervision of the training of the computational latent representation, thereby guiding the compositional latent representation towards a representation in which different ones of the kernels are representative of different objects, the different objects comprising at least one anatomical

Abstract: The present invention provides livestock animals and methods to create recipient animals for spermatogonial stem cell transplantation through modulation of the NANOS gene. In one embodiment genome editing issued to create animals with insertions or deletions (indels) that inactivate or otherwise modulate NANOS gene activity so that resulting males lack functional germ cells yet retain functional somatic cells, and females are fertile. These males can then be transplanted with donor spermatogonial stem cells and used for breeding.

Abstract: A method of detecting the presence of alpha-synuclein aggregation in a biological sample is provided whereby a biological sample is mixed with a reaction sample comprising a population of beads, a fluorophore adapted to bind to protein aggregates and to increase fluorescence when bound to protein aggregates, and alpha-synuclein or a fragment or variant thereof to form a reaction mixture, the reaction mixture is illuminated and at the same time incubated with intermittent agitation cycles, wherein a significant increase in the fluorescence of the reaction mixture during incubation is indicative of the presence of aggregates of alpha-synuclein in the biological sample. Method of diagnosing alpha-synucleinopathies such as Parkinson's disease or Dementia with Lewy Bodies.

Abstract: A fuzzy logic gate comprising an input node configured to receive an analogue input signal. A complementary metal oxide semiconductor (CMOS) logic gate is connected to the input node. A tunable load is connected to the CMOS logic gate such that the tunable load is provided on a current path connected to an output node. The output node is configured to output an analogue output signal.

Abstract: This invention relates to a gel comprising a colloid dispersed in a lyotropic nematic liquid crystal, the lyotropic nematic liquid crystal comprising defect lines formed by the colloid. The invention also relates to a method for making the gel comprising the steps of: (a) mixing a nematogen with a liquid and the colloid to form a resulting dispersion, and (b) applying shear to the resulting dispersion at a temperature such that a lyotropic nematic liquid crystal phase is formed. In addition, the invention relates to an adhesive, lubricant, ceramic, film, spray, gel, lotion, foam, nanowire, yarn, medical implant, wearable, bone graft material, 3D printing material, ink, agrochemical formulation, topical formulation, paint, coating, composite, energy storage material, advanced material, responsive composite, cosmetic product, personal care product, pharmaceutical or foodstuff comprising the gel.

Abstract: A system comprising: a nematic liquid crystal, and at least one interface in contact with the nematic liquid crystal, wherein the interface comprises a first interface region on one side of the nematic liquid crystal and a second interface region on another side of the nematic liquid crystal, the interface comprising nucleation sites to form defect lines in the nematic liquid crystal extending across the nematic liquid crystal from the first interface region to the second interface region.

Abstract: The present invention concerns a structurally distinct immunosuppressive mimic of TGF-? that is a potent inducer of murine and human regulatory T cells and provides a therapeutic agent for the treatment of inflammatory disorders. Disclosed herein is a novel parasite TGF-? mimic which fully replicates the biological and functional properties of TGF-?, including binding to mammalian TGF-? receptors and inducing Foxp3+ Treg in both murine and human CD4+ T cells. This TGF-? mimic shares no homology to mammalian TGF-? or other members of the TGF-? family, but s distinctly related to the component control protein (CCP) superfamily.

Abstract: A method of forming an imaging fibre apparatus comprises: •arranging core rods 102 and cladding rods 104 to form at least one primary stack 100a, each primary stack 100a comprising a plurality of core rods 102 and cladding rods 104 arranged in a stack arrangement thereby to form a plurality of core regions within a cladding region; •performing a drawing process to form a plurality of drawn stacks from the at least one primary stack; •wherein the plurality of core rods and cladding rods are further arranged to have a selected shape such that the plurality of stacks stack together in a desired arrangement and wherein the stack arrangement comprises an at least partial outer layer of cladding rods thereby to provide separation between core regions of respective adjacent stacks when stacked in the desired arrangement, the method further comprising: •stacking the plurality of drawn stacks together in the desired arrangement to form a further stack; •drawing the further stack; and •using the drawn further stack to

Abstract: The present invention provides nucleic acid molecules comprising a MeCP2 expression cassette, the expression cassette comprising, in operable linkage from 5? to 3?: a 5? transcriptional control region comprising a promoter capable of driving transcription in neural cells; an open reading frame encoding a MeCP2 protein; translation control signals; a 3? untranslated region (3?UTR) comprising one or more of: (i) a binding site for mir-22; (ii) a binding site for mir-19; (iii) a binding site for miR-132; (iv) a binding site for miR124; and (v) an AU-rich element; and transcriptional termination signals; wherein the MeCP2 expression cassette is not more than about 5 kb in length. The invention further provides viral vectors, especially vectors derived from adeno-associated virus (AAV), for use in therapeutic delivery of such expression cassettes.

Abstract: A tunable CMOS circuit comprising a CMOS element and a tunable load. The CMOS element is configured to receive an analogue input signal. The tunable load is connected to the CMOS element and configured to set a switch point of the CMOS element. The CMOS element is configured to output an output current that is largest when the analogue input signal is equal to the switch point. The combination of a CMOS element with a tunable load may also provide a hardware implementation of fuzzy logic. A fuzzy logic gate comprises an input node, a CMOS logic gate, a tunable load, and an output node. The input node is configured to receive an analogue input signal. The CMOS logic gate is connected to the input node. The tunable load is connected to the CMOS logic gate such that the tunable load is provided on a current path connected to the output node. The output node is configured to output an analogue output signal.

Abstract: A sensor device (10) for photon-based imaging comprising one or more photon detectors configured to produce a plurality of photon detection signals in response to a plurality of photon detection events, wherein each photon detection event has a corresponding detection time and wherein the detection times of the plurality of photon detection events are distributed in accordance with a distribution over time; and processing circuitry configured to perform a sketching process using timing information of the plurality of photon detection events to obtain a compressed representation of the distribution over time, wherein the sketching process comprises: generating a plurality of feature values based on the timing information of the plurality of photon detection events using one or more feature functions; combining the generated plurality of feature values to obtain the compressed representation of the distribution over time, wherein the feature functions have one or more properties such that combining the pluralit

Abstract: A data processing apparatus comprises: a memory configured to store a trained model; and processing circuitry configured to: receive at least one dataset that comprises d variables and n samples; determine variances associated with the variables by processing the dataset using the model; determine an order of the variables based on the determined variances, including iteratively removing at least one node or variable represented by said at least one node thereby to determine the order.