Abstract: Disclosed herein transgene construct comprising (i) a first nucleotide sequence, wherein the activity of the protein encoded by said first nucleotide sequence causes death of germ cells in the presence of an exogenous induction agent and (ii) a second nucleotide sequence which targets said construct to avian germ cells, methods of using the same and a transgenic avian provided by such methods.

Abstract: A method of detecting the presence of alpha-synuclein aggregation in a biological sample is provided whereby a biological sample is mixed with a reaction sample comprising a population of beads, a fluorophore adapted to bind to protein aggregates and to increase fluorescence when bound to protein aggregates, and alpha-synuclein or a fragment or variant thereof to form a reaction mixture, wherein a significant increase in the fluorescence of the reaction mixture during incubation is indicative of the presence of aggregates of alpha-synuclein in the biological sample.

Abstract: A method of performing Raman spectroscopy comprising: generating wavelength shifted excitation light for exciting a Raman response from at least one sample, wherein the wavelength shifted excitation light comprises at least two excitation wavelengths; providing the wavelength shifted excitation light to the at least one sample and collecting signal light from the at least one sample; obtaining response signals from the collected signal light; processing the obtained response signals to determine a Raman response and a fluorescence response, wherein determining the Raman response uses at least one characteristic of an expected Raman response to the wavelength shifted excitation light and wherein determining the fluorescence response uses at least one characteristic of an expected fluorescence response to the shifted excitation light.

Abstract: The invention provides a compound of formula (I), and salts, solvates and radiolabelled forms thereof, together with complexes of the compound of formula (I) with TSPO, and methods for forming such complexes, and methods for detecting the compound of formula (I), such as in complex with TSPO.

Abstract: A medical image processing apparatus includes a memory storing training medical images, each annotated with respective weak supervision annotation information relating to at least one object represented in the training medical image, the at least one object comprising an anatomical object, a pathology, or a medical device; and processing circuitry configured to use the plurality of training medical images to train a deep learning network to perform a task, wherein the training of the deep learning network includes training a compositional latent representation comprising a plurality of kernels, wherein the training of the compositional latent network includes using the weak supervision annotation information to provide weak supervision of the training of the computational latent representation, thereby guiding the compositional latent representation towards a representation in which different ones of the kernels are representative of different objects, the different objects comprising at least one anatomical

Abstract: The present invention provides livestock animals and methods to create recipient animals for spermatogonial stem cell transplantation through modulation of the NANOS gene. In one embodiment genome editing issued to create animals with insertions or deletions (indels) that inactivate or otherwise modulate NANOS gene activity so that resulting males lack functional germ cells yet retain functional somatic cells, and females are fertile. These males can then be transplanted with donor spermatogonial stem cells and used for breeding.

Abstract: A method of detecting the presence of alpha-synuclein aggregation in a biological sample is provided whereby a biological sample is mixed with a reaction sample comprising a population of beads, a fluorophore adapted to bind to protein aggregates and to increase fluorescence when bound to protein aggregates, and alpha-synuclein or a fragment or variant thereof to form a reaction mixture, the reaction mixture is illuminated and at the same time incubated with intermittent agitation cycles, wherein a significant increase in the fluorescence of the reaction mixture during incubation is indicative of the presence of aggregates of alpha-synuclein in the biological sample. Method of diagnosing alpha-synucleinopathies such as Parkinson's disease or Dementia with Lewy Bodies.

Abstract: A system comprising: a nematic liquid crystal, and at least one interface in contact with the nematic liquid crystal, wherein the interface comprises a first interface region on one side of the nematic liquid crystal and a second interface region on another side of the nematic liquid crystal, the interface comprising nucleation sites to form defect lines in the nematic liquid crystal extending across the nematic liquid crystal from the first interface region to the second interface region.

Abstract: A method of forming an imaging fibre apparatus comprises: •arranging core rods 102 and cladding rods 104 to form at least one primary stack 100a, each primary stack 100a comprising a plurality of core rods 102 and cladding rods 104 arranged in a stack arrangement thereby to form a plurality of core regions within a cladding region; •performing a drawing process to form a plurality of drawn stacks from the at least one primary stack; •wherein the plurality of core rods and cladding rods are further arranged to have a selected shape such that the plurality of stacks stack together in a desired arrangement and wherein the stack arrangement comprises an at least partial outer layer of cladding rods thereby to provide separation between core regions of respective adjacent stacks when stacked in the desired arrangement, the method further comprising: •stacking the plurality of drawn stacks together in the desired arrangement to form a further stack; •drawing the further stack; and •using the drawn further stack to

Abstract: A sensor device (10) for photon-based imaging comprising one or more photon detectors configured to produce a plurality of photon detection signals in response to a plurality of photon detection events, wherein each photon detection event has a corresponding detection time and wherein the detection times of the plurality of photon detection events are distributed in accordance with a distribution over time; and processing circuitry configured to perform a sketching process using timing information of the plurality of photon detection events to obtain a compressed representation of the distribution over time, wherein the sketching process comprises: generating a plurality of feature values based on the timing information of the plurality of photon detection events using one or more feature functions; combining the generated plurality of feature values to obtain the compressed representation of the distribution over time, wherein the feature functions have one or more properties such that combining the pluralit

Abstract: A data processing apparatus comprises: a memory configured to store a trained model; and processing circuitry configured to: receive at least one dataset that comprises d variables and n samples; determine variances associated with the variables by processing the dataset using the model; determine an order of the variables based on the determined variances, including iteratively removing at least one node or variable represented by said at least one node thereby to determine the order.

Abstract: The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof useful as inhibitors of Cyclophilins and modulators of cyclophilin-like proteins. The invention also relates to uses of said compounds in the treatment of various disorders.

Abstract: The invention relates to small photosensitizers, their process of preparation and uses of the compounds in optical imaging and photodynamic therapy. The invention provides a compound of formula (I), a derivative or a salt thereof Wherein R1 is selected from the group consisting of amines, anilines, phenols, thiophenols, selenols and aryl groups; R2 and R3 independently are H or halogen; R4 is selected from the group consisting of H, nitro and cyano: and R5 and R6 independently are either absent or oxygen or methyl.

Abstract: A medical image data processing apparatus is provided and includes processing circuitry to receive medical image data in respect of at least one subject; receive non-image data; generate a filter based on the non-image data; and apply the filter to the medical image data, wherein the filter limits a region of the medical image data.

Abstract: A branch target buffer, BTB, is provided to store at least one BTB entry corresponding to a respective branch in a control flow in a sequence of machine-readable instructions of a computer program. The BTB has a tag field to compare with a program counter of a fetch address generator and at least one further field to store information characteristic of the branch instruction identified by the corresponding tag field and allowing a conditional branch to be distinguished from an unconditional branch instruction. The BTB has a predetermined storage capacity and is utilized such that unconditional branch instructions are preferentially allocated storage space in the BTB relative to conditional branch instructions.

Abstract: A method of detecting the presence of alpha-synuclein aggregation in a biological sample is provided whereby a biological sample is mixed with a reaction sample comprising a population of beads, a fluorophore adapted to bind to protein aggregates and to increase fluorescence when bound to protein aggregates, and alpha-synuclein or a fragment or variant thereof to form a reaction mixture, the reaction mixture is illuminated and at the same time incubated with intermittent agitation cycles, wherein a significant increase in the fluorescence of the reaction mixture during incubation is indicative of the presence of aggregates of alpha-synuclein in the biological sample. Method of diagnosing alpha-synucleinopathies such as Parkinson's disease or Dementia with Lewy Bodies.

Abstract: An image data processing apparatus comprises processing circuitry configured to: receive first medical image data; obtain a first image feature data set from the first medical image data; obtain a second image feature data set from second medical image data and/or from stored image feature data; obtain style data; and generate synthesized image data based on the first image feature data set, the second image feature data set, and the style data.

Abstract: There is a photovoltaic (PV) panel 10 including an array of photovoltaic (PV) elements (12). Each PV element (12) is stand alone and can be electronically addressed individually. The PV panel (10) also includes a number of spectral filters (14), in this example, a red filter (14r), a green filter (14g) and a blue filter (14b) arranged over some of the PV elements (12) to filter out the red, green and blue spectral components from white (combined red, green and blue) light emitted from a red-green-blue (RGB) transmitter. Data can be transmitted by modulating the spectral components of the RGB transmitter such that the data in each of the spectral components can be recovered from the electrical signal generated by the PV elements (12).

Abstract: A system and a method for training a neural network to deliver the viewpoint of objects, the method comprising minimizing distances between each training image of a first set of training images, the output of the neural network with the viewpoint of this training image, and each pair of a second set of training image pairs, the second image of each pair of the second set of training image pairs with the output of a decoder neural network when the first image of this pair is inputted to an encoder neural network, the second image of this pair is inputted to the neural network to obtain a viewpoint, the obtained encoded image is rotated according to the viewpoint, and the rotated encoded image is decoded.

Abstract: A method of detecting the presence of alpha-synuclein aggregation in a biological sample is provided whereby a biological sample is mixed with a reaction sample comprising a population of beads, a fluorophore adapted to bind to protein aggregates and to increase fluorescence when bound to protein aggregates, and alpha-synuclein or a fragment or variant thereof to form a reaction mixture, the reaction mixture is illuminated and at the same time incubated with intermittent agitation cycles, wherein a significant increase in the fluorescence of the reaction mixture during incubation is indicative of the presence of aggregates of alpha-synuclein in the biological sample. Method of diagnosing alpha-synucleinopathies such as Parkinson's disease or Dementia with Lewy Bodies.