Patents Assigned to University of Edinburgh
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Patent number: 9212261Abstract: A method for the manufacture of a polymer is provided, the method comprising: Providing a first monomer, the first monomer comprising a bicyclic diamine moiety, a first nucleophilic group provided on a carbon atom of an aromatic moiety, and a second nucleophilic group provided on a carbon atom of an aromatic moiety; Providing a bridging compound comprising at least two sites vulnerable to nucleophilic attack; and Contacting the first monomer with the bridging compound. Polymers made by said method and uses of such polymers are also disclosed.Type: GrantFiled: September 15, 2011Date of Patent: December 15, 2015Assignee: The University Court of the University of EdinburghInventors: Neil Bruce McKeown, Mariolino Carta
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Patent number: 9178100Abstract: A single photon avalanche diode for use in a CMOS integrated circuit includes a deep n-well region formed above a p-type substrate and an n-well region formed above and in contact with the deep n-well region. A cathode contact is connected to the n-well region via a heavily doped n-type implant. A lightly doped region forms a guard ring around the n-well and deep n-well regions. A p-well region is adjacent to the lightly doped region. An anode contact is connected to the p-well region via a heavily doped p-type implant. The junction between the bottom of the deep n-well region and the substrate forms a multiplication region when an appropriate bias voltage is applied between the anode and cathode and the guard ring breakdown voltage is controlled with appropriate control of the lateral doping concentration gradient such that the breakdown voltage is higher than that of the multiplication region.Type: GrantFiled: September 8, 2011Date of Patent: November 3, 2015Assignees: STMicroelectronics (Research & Development) Limited, The University Court of the University of EdinburghInventors: Eric Alexander Garner Webster, Robert Kerr Henderson
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Patent number: 9139849Abstract: Methods are described for construction of long synthetic arrays of DNA repeats, such as alphoid repeats or other repeat sequences. The methods include concatamerization of DNA into short repeats (for instance using rolling circle amplification or directional in vitro ligation), followed by assembling the short repeats into long arrays by homologous recombination during transformation into microbe cells. These methods can be described generally as Recombinational Amplification of Repeats (RAR). The long arrays are engineered centromere-like regions that allow one to construct mammalian artificial chromosomes with a predefined centromeric region structure. Artificial chromosomes, including human artificial chromosomes with a regulated centromere, and methods of their use are also provided.Type: GrantFiled: April 7, 2006Date of Patent: September 22, 2015Assignees: The United States of America as Represented by the Government of the Department of Health and Human Services, The University Court of the University of EdinburghInventors: Vladimir L. Larionov, William C. Earnshaw, Reto Gassman, Stefanie Kandels-Lewis, Hiroshi Masumoto, Megumi Nakano, Vladimir Noskov, Natalay Y. Kouprina, Carl J. Barrett, Stefano Cardinale
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Patent number: 9131677Abstract: The invention relates to the field of organ and biological tissue preservation and in particular to solutions for use in preserving organs and/or tissues prior to transplanting into a subject.Type: GrantFiled: June 28, 2007Date of Patent: September 15, 2015Assignee: University Court of the University of EdinburghInventor: Ian L. Megson
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Patent number: 9097654Abstract: The present invention relates to an electrode assembly having a laminate structure comprising: a first insulating capping layer; a first conducting layer capped by the first insulating capping layer and substantially sandwiched by at least the first insulating capping layer such as to leave exposed only an electrical contact lip of the first conducting layer; and an array of etched voids extending through at least the first insulating capping layer and the first conducting layer, wherein each void is partly bound by a surface of the first conducting layer which acts as an internal submicron electrode.Type: GrantFiled: November 30, 2009Date of Patent: August 4, 2015Assignee: Nanoflex Limited and The University Court Of The University of EdinburghInventors: Neville John Freeman, Andrew Raymond Mount, Anthony John Walton, Jonathan Gordon Terry
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Patent number: 9049676Abstract: A method of spatial modulation and associated transmission apparatus, receiver apparatus, computer program product and system for identifying a transmitter element within a transmission array of at least two transmitter elements, wherein a signal is transmitted by one active transmitter element at a time over a channel to a receiver. Power is allocated to the transmitter elements, wherein the power is allocated differently between at least two transmitter elements. The transmitted data is received at the receiver. The location of the active transmitter element is detected using knowledge of the power allocated to the transmitter elements.Type: GrantFiled: February 22, 2011Date of Patent: June 2, 2015Assignee: The University Court of the University of EdinburghInventors: Harald Haas, Marco Di Renzo
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Patent number: 9029145Abstract: The present invention provides an isolated population of chondrocyte precursor cells wherein 1% or less of the cells express Oct4, Nanog and/or TRA-1-60, 7% or less of the cells express no collagen II, collagen X, CD105 or Stro-1 and 85% or more of the cells express CBFA1, methods for preparing such cells and uses of chondrocyte cells derived from said precursor cells.Type: GrantFiled: April 8, 2011Date of Patent: May 12, 2015Assignee: The University Court of the University of EdinburghInventors: Brendon Stewart Noble, David Matthew Pier
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Patent number: 9005962Abstract: The present invention relates to the generation of anterior definitive endoderm (ADE) cells from embryonic stem cells and the differentiation of such cells to, for example, pancreatic or liver cells. The invention also relates to cell lines, cell culture methods, cells markers and the like and their potential uses in a variety of applications.Type: GrantFiled: August 25, 2008Date of Patent: April 14, 2015Assignee: The University Court of the University of EdinburghInventors: Gillian Mary Morrison, Joshua Mark Brickman, Ifigenia Oikonomopoulou
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Patent number: 8889374Abstract: The present invention relates to recombinant factor H and variants and conjugates thereof and methods of their production, as well as uses and methods of treatment involving the materials.Type: GrantFiled: December 23, 2010Date of Patent: November 18, 2014Assignee: University Court of the University of EdinburghInventors: Christoph Schmidt, Paul N. Barlow, Anna Richards
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Patent number: 8815820Abstract: The present invention provides a method of identifying host cell molecules which may be modulated to inhibit viral replication and method of testing antiviral compounds. In addition, the invention provides compositions, methods and medicaments for treating viral infections and/or diseases or conditions caused or contributed to by viruses.Type: GrantFiled: March 30, 2010Date of Patent: August 26, 2014Assignee: The University Court of the University of EdinburghInventor: Amy Buck
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Patent number: 8785187Abstract: A homogenous, symmetrically dividing population of adherent neural stem cells is obtained from ES cells or foetal or adult brain isolates, using an activator of a signalling pathway downstream of a receptor of the EGF receptor family, optionally in combination with an activator of a signalling pathway downstream of an FGF receptor. The neural stem cell population is highly pure and retains the ability to differentiate into neurons after in excess of 100 passages.Type: GrantFiled: June 9, 2005Date of Patent: July 22, 2014Assignee: The University Court of the University of EdinburghInventors: Luciano Conti, Steven Michael Pollard, Austin Gerard Smith
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Patent number: 8787389Abstract: A method of transmitting data from a transmitter to a receiver in an unsynchronized, ad-hoc, low-power, wireless network including: creating a packet including a header and data; and retransmitting the same created packet a plurality of times in succession.Type: GrantFiled: May 11, 2007Date of Patent: July 22, 2014Assignee: The University Court of the University of EdinburghInventors: Damal K. Arvind, Kai Juan Wong
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Patent number: 8759104Abstract: The invention provides a cationic lipid comprising: (i) one head group, comprising one or more amino acids, in which at least one amino acid has a side chain that comprises a cationic moiety or a cationic precursor; (ii) a linking moiety of formula (5): —(HNR5)2NC(O)R3C(O)—??(5), wherein: each R5 is independently an optionally substituted C1-4 alkylene moiety; and R3 is an optionally substituted alkylene or alkenylene moiety; and (iii) two lipophilic moieties, wherein the head group and each of the lipophilic moieties are connected to the linking moiety through amide linkages.Type: GrantFiled: May 17, 2011Date of Patent: June 24, 2014Assignee: The University Court of the University of EdinburghInventors: Asier Unciti-Broceta, Aleksandra Liberska, Mark Bradley
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Patent number: 8748355Abstract: The present invention relates to methods of detecting specific cell surface antigens present in a sample of cells being tested and in particular blood group antigens, which methods do not employ the addition of extrinsic labels to detect said cell surface antigens. Typically detection is carried out using an intrinsic fluorescence capability of the cells being tested.Type: GrantFiled: March 23, 2006Date of Patent: June 10, 2014Assignee: University Court of the University of EdinburghInventors: Colin Campbell, Peter Ghazal, Juraj Petrik, Janine Scott Robb
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Publication number: 20140124653Abstract: A pixel circuit includes a single photon avalanche diode (SPAD) and a measurement circuit including a capacitance. The circuit is operable to discharge a known portion of the charge on the capacitance upon each detection of a SPAD event within a time period, such that the charge remaining on the capacitance at the end of the time period corresponds to the number of SPAD events detected within the time period. A time resolved imaging apparatus includes an array of such pixel circuits. A method of counting photon detection includes sensing photons with a SPAD device and discharging a known portion of the charge on a capacitance upon each detection of a SPAD event within a time period.Type: ApplicationFiled: October 30, 2013Publication date: May 8, 2014Applicants: The University Court of the University of Edinburgh, STMicroelectronics (Research & Development) LimitedInventors: Neale Dutton, Robert Kerr Henderson
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Publication number: 20140124652Abstract: A pixel circuit includes a single photon avalanche diode (SPAD) and a measurement circuit including a capacitance. The SPAD detects an incident photon and the measurement circuit discharges the capacitance at a known rate during a discharge time period. The length of the discharge time period is determined by the time of detection of the photon, such that the final amount of charge on the capacitance corresponds to the time of flight of the photon. The pixel circuit may be included in a time resolved imaging apparatus. A method of measuring the time of flight of a photon includes responding to an incident photon detection by discharging a capacitance at a known rate and correlating final capacitance charge to time of flight.Type: ApplicationFiled: October 30, 2013Publication date: May 8, 2014Applicants: The University Court of the University of Edinburgh, STMicroelectronics (Research & Development) LimitedInventors: Neale Dutton, Robert K. Henderson
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Patent number: 8716457Abstract: The present invention provides modified nucleobase compounds, modified nucleic acid mimetic compounds and various uses thereof. In addition, the invention provides methods for nucleobase characterisation, SNP characterisation and nucleic acid sequencing.Type: GrantFiled: September 19, 2008Date of Patent: May 6, 2014Assignee: The University Court of the University of EdinburghInventors: Mark Bradley, Juan J. Diaz-Mochon
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Patent number: 8642621Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain (4-phenyl-piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone compounds that, inter alia, inhibit 11?-hydroxysteroid dehydrogenase type 1 (11?-HSD1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit 11?-hydroxysteroid dehydrogenase type 1; to treat disorders that are ameliorated by the inhibition of 11?-hydroxysteroid dehydrogenase type 1; to treat the metabolic syndrome, which includes disorders such as type 2 diabetes and obesity, and associated disorders including insulin resistance, hypertension, lipid disorders and cardiovascular disorders such as ischaemic (coronary) heart disease; to treat CNS disorders such as mild cognitive impairment and early dementia, including Alzheimer's disease; etc.Type: GrantFiled: September 14, 2010Date of Patent: February 4, 2014Assignee: The University Of EdinburghInventors: Scott Peter Webster, Jonathan Robert Seckl, Brian Robert Walker, Peter Ward, Thomas David Pallin, Hazel Joan Dyke, Trevor Robert Perrior
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Patent number: 8614209Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-thiophene compounds that, inter alia, inhibit 11?-hydroxysteroid dehydrogenase type 1 (11?-HSD1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit 11?-hydroxysteroid dehydrogenase type 1; to treat disorders that are ameliorated by the inhibition of 11?-hydroxysteroid dehydrogenase type 1; to treat the metabolic syndrome, which includes disorders such as type 2 diabetes and obesity, and associated disorders including insulin resistance, hypertension, lipid disorders and cardiovascular disorders such as ischaemic (coronary) heart disease; to treat CNS disorders such as mild cognitive impairment and early dementia, including Alzheimer's disease; etc.Type: GrantFiled: September 13, 2012Date of Patent: December 24, 2013Assignee: The University of EdinburghInventors: Scott Peter Webster, Jonathan Robert Seckl, Brian Robert Walker, Peter Ward, Thomas David Pallin, Hazel Joan Dyke, Trevor Robert Perrior
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Publication number: 20130333058Abstract: Pluripotent cells are derived and maintained in a self-renewing state in serum-free culture medium comprising a MEK inhibitor, a GSK3 inhibitor and an antagonist of an FGF receptor.Type: ApplicationFiled: April 5, 2013Publication date: December 12, 2013Applicant: The University Court of The University of EdinburghInventors: Qi-Long Ying, Austin Gerard Smith