Patents Assigned to University of Hawaii
  • Publication number: 20190249257
    Abstract: Certain embodiments of the invention provide a method for identifying a cancer cell, comprising detecting increased Sexpression of at least one lincRNA selected from the group consisting of PCAN-1, PCAN-2, PCAN-3, PCAN-5 and PCAN-6 and/or decreased expression of lincRNA PCAN-4 in a nucleic acid sample derived from the cell, wherein increased expression of at least one of PCAN-1, PCAN-2, PCAN-3, PCAN-5 and PCAN-6 and/or decreased expression of PCAN-4, as compared to expression from a control cell, indicates the cell is a cancer cell.
    Type: Application
    Filed: February 27, 2017
    Publication date: August 15, 2019
    Applicant: UNIVERSITY OF HAWAII
    Inventors: Travers CHING, Lana GARMIRE
  • Patent number: 10344333
    Abstract: Systems, methods, and computer readable media for diagnosing or characterizing a genetic predisposition to develop cancer are provided. Nucleic acids comprising a germline nucleic acid sequence encoding the BRCA1 associated protein 1 are sequenced or probed to determine if the nucleic acid sequence includes alterations that predispose a subject to develop cancer.
    Type: Grant
    Filed: February 17, 2012
    Date of Patent: July 9, 2019
    Assignees: Institute For Cancer Research, University of Hawaii
    Inventors: Joseph R. Testa, Michele Carbone, Mitchell Cheung, Jianming Pei
  • Patent number: 10266550
    Abstract: The present invention provides compounds as bacterial topoisomerase inhibitors with antibacterial activity. The present invention also provides pharmaceutical compositions comprising at least one of the compounds and methods of using the compounds and pharmaceutical compositions as antibacterial agents for treating infectious diseases.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: April 23, 2019
    Assignees: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES, UNIVERSITY OF HAWAII
    Inventors: Yuk-Ching Tse-Dinh, Dianqing Sun
  • Publication number: 20190048398
    Abstract: The present invention is a biosensor apparatus that includes a substrate, a source on one side of the substrate, a drain spaced from the source, a conducting channel between the source and the drain, an insulator region, and receptors on a gate region for receiving target material. The receptors are contacted for changing current flow between the source and the drain. The source and the drain are relatively wide compared to length between the source and the drain through the conducting channel.
    Type: Application
    Filed: August 28, 2018
    Publication date: February 14, 2019
    Applicant: University of Hawaii
    Inventor: James HOLM-KENNEDY
  • Publication number: 20180374024
    Abstract: Groups of architecturally connected files may incur and accumulate high maintenance costs as architectural debts. To quantify such debts, architectural debt, which is a term used herein, may be identified, quantified, measured, and modeled. A history coupling probability matrix for this purpose may search for architecture debts through the lens of 4 patterns of prototypical architectural flaws shown to correlate with reduced software quality. Further, a new architecture maintainability metric—Decoupling Level (DL)—measures how well the software can be decoupled into small and independently replaceable modules. The DL metric opens the possibility of quantitatively comparing maintainability between different projects, as well as monitoring architecture decay throughout software evolution.
    Type: Application
    Filed: June 22, 2017
    Publication date: December 27, 2018
    Applicants: Drexel University, University of Hawaii
    Inventors: Yuanfang CAI, Lu XIAO, Frederick KAZMAN, Ran MO
  • Patent number: 10137123
    Abstract: Methods are provided of treating cardiac hypertrophy in a mammalian subject comprising administering to the subject an anti-hypertrophic effective amount of an ion channel TR-PV1 inhibitor. The methods include treatment of a symptom of cardiac hypertrophy in the subject comprises cardiac remodeling, cardiac fibrosis, apoptosis, hypertension, or heart failure.
    Type: Grant
    Filed: May 1, 2017
    Date of Patent: November 27, 2018
    Assignee: University of Hawaii
    Inventor: Alexander Stokes
  • Patent number: 10111452
    Abstract: Perishable products, such as food products, can be preserved by cooling to temperatures below their freezing point without ice crystallization. In some embodiments, the perishable product is cooled to temperatures below the freezing point of water while a pulsed electric field and oscillating magnetic field are applied to the product. Apparatus for supercooling perishable products are also provided and include a pulsed electric field generator and an oscillating magnetic field generator.
    Type: Grant
    Filed: December 9, 2014
    Date of Patent: October 30, 2018
    Assignee: UNIVERSITY OF HAWAII
    Inventors: Soojin Jun, Jin Hong Mok, Sung Hee Park
  • Patent number: 10072291
    Abstract: The present invention is a biosensor apparatus that includes a substrate, a source on one side of the substrate, a drain spaced from the source, a conducting channel between the source and the drain, an insulator region, and receptors on a gate region for receiving target material. The receptors are contacted for changing current flow between the source and the drain. The source and the drain are relatively wide compared to length between the source and the drain through the conducting channel.
    Type: Grant
    Filed: July 14, 2015
    Date of Patent: September 11, 2018
    Assignee: UNIVERSITY OF HAWAII
    Inventor: James Holm-Kennedy
  • Patent number: 9995282
    Abstract: A selectively perceptible wind turbine system provides illumination in a low intensity and wavelength invisible to the human eye, but visible to certain bats. This illumination deters bats and other flying animals from going near the turbine without becoming a nuisance. At least one ultraviolet (UV) illumination source produces at least one UV beam with a wavelength of approximately 200 nm to approximately 400 nm. This UV beam extends between the UV illumination source and at least one turbine blade surface of a turbine blade. Contact between the UV beam and the turbine blade surface forms an illumination interface with a power density of less than 100 ?W/cm2.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: June 12, 2018
    Assignees: The United States of America as Represented by the Secretary of the Department of the Interior, University of Hawaii, Bat Reseach and Consulting
    Inventors: Paul Michael Cryan, David Charles Dalton, Paulo Marcos Gorresen
  • Patent number: 9867549
    Abstract: This invention relates to a system that adaptively compensates for subject motion in real-time in an imaging system. An object orientation marker (30), preferably a retro-grate reflector (RGR), is placed on the head or other body organ of interest of a patient (P) during a scan, such as an MRI scan. The marker (30) makes it possible to measure the six degrees of freedom (x, y, and z-translations, and pitch, yaw, and roll), or “pose”, required to track motion of the organ of interest. A detector, preferably a camera (40), observes the marker (30) and continuously extracts its pose. The pose from the camera (40) is sent to the scanner (120) via an RGR processing computer (50) and a scanner control and processing computer (100), allowing for continuous correction of scan planes and position (in real-time) for motion of the patient (P).
    Type: Grant
    Filed: August 17, 2015
    Date of Patent: January 16, 2018
    Assignees: The Queen's Medical Center, The University of Hawaii, The Medical College of Wisconsin, Inc., UWM Research Foundation, Inc.
    Inventors: Thomas Michael Ernst, Thomas Edmund Prieto, Brian Stewart Randall Armstrong
  • Publication number: 20180011098
    Abstract: In accordance with some embodiments herein, methods of determining signatures of HMGB1 isoforms in a subject are provided. In some embodiments, antibodies that bind specifically to HMGB1 isoforms are provided. In some embodiments, immunoassay kits are provided.
    Type: Application
    Filed: January 19, 2016
    Publication date: January 11, 2018
    Applicant: University of Hawaii
    Inventors: Haining Yang, Michele Carbone
  • Patent number: 9802888
    Abstract: The present disclosure provides pharmaceutical compositions comprising Stat3 inhibitors and certain pharmaceutically acceptable salts thereof, and methods of use.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: October 31, 2017
    Assignee: UNIVERSITY OF HAWAII
    Inventors: James Turkson, Patrick Gunning, Sina Haftchenary
  • Patent number: 9801562
    Abstract: The disclosure herein provides cardiac monitoring and diagnostic system, methods, and devices. A cardiac diagnostic system for detecting potential indicators of cardiac disease comprises: a cardiac monitoring device comprising at least one electrode configured to detect an analog electrical cardiac signal of a user; a cardiac signal filter configured to convert the analog electrical cardiac signal to digital electrocardiogram data; an atypical cardiac sequence detector configured to detect atypical cardiac patterns in the electrocardiogram data that are potentially indicative of cardiac disease; and a notification transmitter configured to generate an alert when a detected atypical cardiac pattern is determined to be indicative of cardiac disease.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: October 31, 2017
    Assignee: UNIVERSITY OF HAWAII
    Inventor: Anders Host-Madsen
  • Patent number: 9782141
    Abstract: The disclosure herein provides methods, systems, and devices for tracking motion of a patient or object of interest during biomedical imaging and for compensating for that motion in the biomedical imaging scanner and/or the resulting images to reduce or eliminate motion artifacts. In an embodiment, a motion tracking system is configured to overlay tracking data over biomedical imaging data in order to display the tracking data along with its associated image data. In an embodiment, a motion tracking system is configured to overlay tracking data over biomedical imaging data in order to display the tracking data along with its associated image data. In an embodiment, one or more detectors are configured to detect images of a patient, and a detector processing interface is configured to analyze the images to estimate motion or movement of the patient and to generate tracking data describing the patient's motion.
    Type: Grant
    Filed: January 29, 2014
    Date of Patent: October 10, 2017
    Assignees: KINETICOR, INC., THE UNIVERSITY OF HAWAII, THE QUEEN'S MEDICAL CENTER
    Inventors: Jeffrey N. Yu, Thomas Michael Ernst
  • Patent number: 9676788
    Abstract: Disclosed is a compound of formula (I) or formula (II): (Formulas should be inserted here) wherein R1-R6 are as defined herein. Also disclosed are a pharmaceutical composition comprising such a compound and a method of treating or preventing cancer in a mammal in need thereof, comprising administering to the mammal a compound of formula (I) or formula (II).
    Type: Grant
    Filed: February 5, 2015
    Date of Patent: June 13, 2017
    Assignees: The United States of America, as represented by the Secretary of Health and Human Services, University of Hawaii
    Inventors: William J. Chain, John A. Beutler, David Fash, William D. Figg, Zhenwu Li, Cody John Peer, Joe William Ramos, Florian J. Sulzmaier
  • Patent number: 9664563
    Abstract: A spatial Fourier transform spectrometer is disclosed. The Fourier transform spectrometer includes a Fabry-Perot interferometer with first and second optical surfaces. The gap between the first and second optical surfaces spatially varies in a direction that is orthogonal to the optical axis of the Fourier transform spectrometer. The Fabry-Perot interferometer creates an interference pattern from input light. An image of the interference pattern is captured by a detector, which is communicatively coupled to a processor. The processor is configured to process the interference pattern image to determine information about the spectral content of the input light.
    Type: Grant
    Filed: December 1, 2010
    Date of Patent: May 30, 2017
    Assignee: University of Hawaii
    Inventor: Paul Lucey
  • Patent number: 9567597
    Abstract: Embodiments provided herein generally relate to methods and materials for ultrasound-mediated introduction of exogenous substances into microorganisms. Some embodiments relate to methods of introducing an exogenous material into a microorganism such as an algae. The methods can include, for example, providing a microorganism (e.g., algae); providing a population of bubbles that comprise one or more nucleic acid molecules and/or one or more polypeptide or one or more protein molecules; contacting the population of bubbles with the algae; applying ultrasound to the bubbles and algae with sufficient energy to cavitate one or more of bubbles comprising the one or more nucleic acid molecules in proximity to the algae; and maintaining the algae and the one or more burst bubbles comprising the one or more nucleic acid molecules in contact for a period of time sufficient to permit entry of at least one nucleic acid molecule into the algae.
    Type: Grant
    Filed: May 11, 2013
    Date of Patent: February 14, 2017
    Assignee: UNIVERSITY OF HAWAII
    Inventors: Eric Liaw, Chad B. Walton, Ralph V. Shohet
  • Patent number: 9561274
    Abstract: Embodiments provided herewith relate to methods and compositions for treating or preventing cancer. More particularly, several embodiments are drawn to treating or preventing malignant mesothelioma with antagonists of high-mobility group box 1 (HMGB1).
    Type: Grant
    Filed: June 7, 2012
    Date of Patent: February 7, 2017
    Assignee: UNIVERSITY OF HAWAII
    Inventors: Haining Yang, Michele Carbone, Marco E. Bianchi
  • Patent number: PP28567
    Abstract: A new cultivar of Colocasia plant named ‘Tropical Storm’ that is characterized by very compact, prolific basal branching and leaves which are purple-black in color except for a prominent contrasting cream-yellow central streak.
    Type: Grant
    Filed: July 7, 2016
    Date of Patent: October 24, 2017
    Assignee: University of Hawaii
    Inventor: John J. Cho
  • Patent number: PP29636
    Abstract: A new cultivar of Leucadendron plant named ‘Hawaii Magic’ that is distinguished by compact bushy plant habit, foliage color which changes from olive green in summer months to orange-red in the fall and becoming plum colored in spring. The branch stems of ‘Hawaii Magic’ are bright red in color. ‘Hawaii Magic’ bears only male flowers which are yellow in color.
    Type: Grant
    Filed: March 29, 2017
    Date of Patent: September 4, 2018
    Assignee: University of Hawaii
    Inventor: John J. Cho