Abstract: Isoorientin analogues and related compounds that inhibit glycogen synthase kinase-3? activity are provided as are methods of using these compounds in the treatment of cognitive, neurodegenerative or neurological diseases or conditions, as well as cancer, obesity, diabetes, inflammatory or autoimmune disease, cardiovascular disorder, metabolic syndrome X, hair loss, severe acute respiratory syndrome coronavirus, cocaine addiction, dental caries, bone loss and glaucoma.

Abstract: A steerable surgical device includes a flexible joint positioned between first and second tubular elements, with multiple shape memory alloy wire elements extending across or through the joint being circumferentially spaced relative to one another and independently actuatable to effectuate pivotal movement between the first and second tubular elements (e.g., along at least two or at least three nonparallel planes) to provide enhanced maneuverability relative to single degree of freedom steerable devices. Longitudinal guide structures (e.g., channels or bores) and/or anchor points for shape memory alloy wire elements may be circumferentially spaced in or on the tubular elements to receive the shape memory alloy wire elements.

Abstract: The present disclosure provides a method of purifying pharmaceutical compositions consisting essentially of STAT3 inhibitors from a mixture of compounds, pharmaceutical compositions comprising STAT3 inhibitors used to inhibit STAT3 in tumor cells, and certain pharmaceutically acceptable salts thereof, and methods of use.

Abstract: Methods, systems, and apparatus for fabricating a circuit board. The method includes fabricating, using an additive manufacturing device, a trace layer, a sacrificial layer, a rail layer and a lid. The method includes placing the sacrificial layer on the trace layer such that the raised traces protrude through corresponding openings of the sacrificial layer. The method includes depositing a conductive material on top of the sacrificial layer and the plurality of traces. The method includes removing the sacrificial layer from the trace layer and placing the rail layer on the trace layer such that the raised traces align with the corresponding openings of the rail layer. The method includes connecting one or more electrical components and melting a sealing sheet on top of the rail layer and the electrical components to reinforce connections and to provide protection. The method includes placing the lid on top of the sealing sheet.

Abstract: A spatial Fourier transform spectrometer is disclosed. The Fourier transform spectrometer includes a Fabry-Perot interferometer with first and second optical surfaces. The gap between the first and second optical surfaces spatially varies in a direction that is orthogonal to the optical axis of the Fourier transform spectrometer. The Fabry-Perot interferometer creates an interference pattern from input light. An image of the interference pattern is captured by a detector, which is communicatively coupled to a processor. The processor is configured to process the interference pattern image to determine information about the spectral content of the input light.

Abstract: The present invention provides compounds as bacterial topoisomerase inhibitors with antibacterial activity. The present invention also provides pharmaceutical compositions comprising at least one of the compounds and methods of using the compounds and pharmaceutical compositions as antibacterial agents for treating infectious diseases.

Abstract: The disclosure herein provides methods, systems, and devices for tracking motion of a patient or object of interest during biomedical imaging and for compensating for that motion in the biomedical imaging scanner and/or the resulting images to reduce or eliminate motion artifacts. In an embodiment, a motion tracking system is configured to overlay tracking data over biomedical imaging data in order to display the tracking data along with its associated image data. In an embodiment, a motion tracking system is configured to overlay tracking data over biomedical imaging data in order to display the tracking data along with its associated image data. In an embodiment, one or more detectors are configured to detect images of a patient, and a detector processing interface is configured to analyze the images to estimate motion or movement of the patient and to generate tracking data describing the patient's motion.

Abstract: Systems and methods are disclosed for detecting a presence of a person in an area of coverage using radar. A transmitter can transmit radio signals in a first direction in an area of coverage defined by a wall and a floor. A receiver can receive the transmitted radio signals reflected back from the area of coverage. A signal conditioning circuit can process the received radio signals. One or more hardware processors can be programmed to analyze the processed radio signals and detect a presence of a person in the area of coverage based on the analysis. The analysis of the processed signals can be performed in both time and frequency domain. In addition to radar, an input from an infrared sensor can also be used in conjunction with radar based detection.

Abstract: Perishable products, such as food products, can be preserved by cooling to temperatures below their freezing point without ice crystallization. In some embodiments, the perishable product is cooled to temperatures below the freezing point of water while a pulsed electric field and oscillating magnetic field are applied to the product. Apparatus for supercooling perishable products are also provided and include a pulsed electric field generator and an oscillating magnetic field generator.

Abstract: The present invention is a biosensor apparatus that includes a substrate, a source on one side of the substrate, a drain spaced from the source, a conducting channel between the source and the drain, an insulator region, and receptors on a gate region for receiving target material. The receptors are contacted for changing current flow between the source and the drain. The source and the drain are relatively wide compared to length between the source and the drain through the conducting channel.

Abstract: Certain embodiments of the invention provide a method for identifying a cancer cell, comprising detecting increased Sexpression of at least one lincRNA selected from the group consisting of PCAN-1, PCAN-2, PCAN-3, PCAN-5 and PCAN-6 and/or decreased expression of lincRNA PCAN-4 in a nucleic acid sample derived from the cell, wherein increased expression of at least one of PCAN-1, PCAN-2, PCAN-3, PCAN-5 and PCAN-6 and/or decreased expression of PCAN-4, as compared to expression from a control cell, indicates the cell is a cancer cell.

Abstract: Enabling quick feature delivery is essential for product success and is therefore a goal of software architecture design. But how may we determine if and to what extent an architecture is “good enough” to support feature addition and modification, or determine if a refactoring effort is successful in that features may be added more easily? The applications may use Feature Space and Feature Dependency, derived from a software project's revision history that capture the dependency relations among the features of a system in a feature dependency structure matrix (FDSM), using features as first-class design elements. The applications may also use a Feature Decoupling Level (FDL) metric that may be used to measure the level of independence among features.

Abstract: Systems, methods, and computer readable media for diagnosing or characterizing a genetic predisposition to develop cancer are provided. Nucleic acids comprising a germline nucleic acid sequence encoding the BRCA1 associated protein 1 are sequenced or probed to determine if the nucleic acid sequence includes alterations that predispose a subject to develop cancer.

Abstract: The present invention provides compounds as bacterial topoisomerase inhibitors with antibacterial activity. The present invention also provides pharmaceutical compositions comprising at least one of the compounds and methods of using the compounds and pharmaceutical compositions as antibacterial agents for treating infectious diseases.

Abstract: The present invention is a biosensor apparatus that includes a substrate, a source on one side of the substrate, a drain spaced from the source, a conducting channel between the source and the drain, an insulator region, and receptors on a gate region for receiving target material. The receptors are contacted for changing current flow between the source and the drain. The source and the drain are relatively wide compared to length between the source and the drain through the conducting channel.

Abstract: Groups of architecturally connected files may incur and accumulate high maintenance costs as architectural debts. To quantify such debts, architectural debt, which is a term used herein, may be identified, quantified, measured, and modeled. A history coupling probability matrix for this purpose may search for architecture debts through the lens of 4 patterns of prototypical architectural flaws shown to correlate with reduced software quality. Further, a new architecture maintainability metric—Decoupling Level (DL)—measures how well the software can be decoupled into small and independently replaceable modules. The DL metric opens the possibility of quantitatively comparing maintainability between different projects, as well as monitoring architecture decay throughout software evolution.

Abstract: Methods are provided of treating cardiac hypertrophy in a mammalian subject comprising administering to the subject an anti-hypertrophic effective amount of an ion channel TR-PV1 inhibitor. The methods include treatment of a symptom of cardiac hypertrophy in the subject comprises cardiac remodeling, cardiac fibrosis, apoptosis, hypertension, or heart failure.

Abstract: Perishable products, such as food products, can be preserved by cooling to temperatures below their freezing point without ice crystallization. In some embodiments, the perishable product is cooled to temperatures below the freezing point of water while a pulsed electric field and oscillating magnetic field are applied to the product. Apparatus for supercooling perishable products are also provided and include a pulsed electric field generator and an oscillating magnetic field generator.

Abstract: The present invention is a biosensor apparatus that includes a substrate, a source on one side of the substrate, a drain spaced from the source, a conducting channel between the source and the drain, an insulator region, and receptors on a gate region for receiving target material. The receptors are contacted for changing current flow between the source and the drain. The source and the drain are relatively wide compared to length between the source and the drain through the conducting channel.

Abstract: A new cultivar of Leucadendron plant named ‘Hawaii Sunrise’ that is distinguished by a very compact bushy plant habit with densely packed foliage and many current-season branches which are bright red in color and which bear terminal inflorescences whose bracts are yellow in color with contrasting bright orange-red coloration to their apex and margin. ‘Hawaii Sunrise’ bears only male flowers which are bright yellow in color.