Patents Assigned to University of Iowa Research Foundation
  • Real-time applicator position monitoring system
    Patent number: 10376712
    Abstract: A real-time applicator position monitoring system (RAPS) measures brachytherapy applicator displacement in real-time by computing the relative displacement between two infrared reflective targets, one attached to the applicator and the other to the patient's skin. In an aspect, RAPS can be used with any brachytherapy application. RAPS measures the applicator motion during HDR brachytherapy treatment, as well as during the transfer of the patient from the imaging room (e.g., where the CT and MR scanners are located) to the HDR BT operating/treatment room.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: August 13, 2019
    Assignee: University of Iowa Research Foundation
    Inventors: Junyi Xia, Yusung Kim, Timothy J. Waldron
  • Automated separation of binary overlapping trees
    Patent number: 10360672
    Abstract: Provided are systems and methods for analyzing images. An exemplary method can comprise receiving at least one image having one or more annotations indicating a feature. The method can comprise generating training images from the at least one image. Each training image can be based on a respective section of the at least one image. The training images can comprise positive images having the feature and negative images without the feature. The method can comprise generating a feature space based on the positive images and the negative images. The method can further comprise identifying the feature in one or more unclassified images based upon the feature space.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: July 23, 2019
    Assignees: University of Iowa Research Foundation, The United States of America, as Represented by the Department of Veterans Affairs
    Inventors: Michael D. Abramoff, Mona K. Garvin, Hu Qiao
  • Neuroprotective Compounds and Use Thereof
    Publication number: 20190218203
    Abstract: Provided herein is compositions and methods for reducing one or both of axonal degeneration and neuronal cell death associated with a disease.
    Type: Application
    Filed: February 12, 2018
    Publication date: July 18, 2019
    Applicant: University of Iowa Research Foundation
    Inventors: Steven L. McKnight, Joseph M. Ready, Andrew A. Pieper
  • COMPOSITIONS AND METHODS FOR CANCER THERAPY
    Publication number: 20190216771
    Abstract: The invention provides compositions and methods to treat a hyperproliferative disorder with ascorbate or a pharmaceutically acceptable salt thereof, and one or more anti-cancer therapies.
    Type: Application
    Filed: June 6, 2017
    Publication date: July 18, 2019
    Applicant: University Of Iowa Research Foundation
    Inventors: Fenghuang ZHAN, Ivana FRECH, Guido TRICOT
  • Automated assessment of glaucoma loss from optical coherence tomography
    Patent number: 10354384
    Abstract: Systems and methods for assessing glaucoma loss using optical coherence topography. One method according to an aspect comprises receiving optical coherence image data and assessing functional glaucoma damage from retinal optical coherence image data. In an aspect, the systems and methods can map regions and layers of the eye to determine structural characteristics to compare to functional characteristics.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: July 16, 2019
    Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Michael Abramoff, Milan Sonka
  • MAGNETICALLY-ACTIVATED COATING FOR TREATING BIOFILMS, AND ASSOCIATED SYSTEMS AND METHODS
    Publication number: 20190209743
    Abstract: A system for disrupting a biofilm on a medical device that comprises an implantable medical device; a magnetically-sensitive coating on the surface of the implantable device comprising a polymer and magnetic particles embedded within the polymer; and a coil element capable of generating an alternating magnetic field, wherein the coil element is constructed and arranged to be capable of applying an alternating magnetic field to induce heating of the surface of the implantable device.
    Type: Application
    Filed: June 27, 2017
    Publication date: July 11, 2019
    Applicant: University of Iowa Research Foundation
    Inventors: Eric NUXOLL, Joel COFFEL, Erica RICKER
  • Miniature grism system for astronomical spectroscopy
    Patent number: 10345496
    Abstract: The invention is directed at a miniature grism system. The miniature grism system is a single compact device that comprises a grism with collimating and focusing optics. In an aspect, the grism includes at least one prism and a grating. In an aspect, the miniature grism system, and more specifically the grism, includes at least one prism which is placed on either side of the grating. The focusing optics and the collimating optics are found on opposite sides of the grism system, sandwiching the prism and grating of the grism. In an aspect, the miniature grism system is configured to be retained within a filter wheel. The miniature grism system is configured to be used with telescopes having a small focal ratio.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: July 9, 2019
    Assignee: University of Iowa Research Foundation
    Inventors: Dominic Ludovici, Robert Mutel
  • Methods and systems for augmentative and alternative communication
    Patent number: 10339768
    Abstract: Methods and systems for augmentative and alternative communication are disclosed. An example method can comprise receiving a candidate input, classifying the candidate input as an intentional input, and generating a signal in response to the intentional input.
    Type: Grant
    Filed: January 18, 2017
    Date of Patent: July 2, 2019
    Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Richard Hurtig, Benjamin Berkowitz, Blake Earl Martinson, Zihan Zhu, Richard Rives Bird
  • RNA based biomaterial for tissue engineering applications
    Patent number: 10335498
    Abstract: The present disclosure provides compositions and methods useful for tissue engineering including a composition having chemically modified RNA (cmRNA) encapsulated in or complexed with a non-viral delivery vehicle and a biocompatible, bioresorbable scaffold and methods of using the composition to regenerate, for example, bone tissue.
    Type: Grant
    Filed: December 29, 2015
    Date of Patent: July 2, 2019
    Assignee: University of Iowa Research Foundation
    Inventors: Satheesh Elangovan, Sheetal Reginald R D'mello, Anh-Vu T Do, Liu Hong, Behnoush Khorsand-Sourkohi, Aliasger K Salem, Michael Kormann
  • Lung injury repair compositions and methods
    Patent number: 10328114
    Abstract: The present invention provides a pharmaceutical composition comprising Protein Kinase C Zeta (PKC-?) inhibitor and therapeutic methods for preventing or treating a pathological condition or symptom or for inducing proliferation of lung progenitor cells in a mammal by administering the PKC-? inhibitor.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: June 25, 2019
    Assignee: University of Iowa Research Foundation
    Inventors: Alejandro P. Comellas Freymond, Xiaopeng Li, Joseph Zabner, Luis Guillermo Vargas Buonfiglio
  • Precise, low-cost orthopaedic surgical simulator
    Patent number: 10325380
    Abstract: An orthopaedic surgical simulator includes a bone (a simulated bone or cadaver bone). The simulator further includes a base, wherein the bone is operatively connected to the base, an optical system mounted proximate the base, wherein the optical system comprises at least one camera and provides a first view and a second view of an incision area associated with the bone. There are fiducial markers on a surgical wire to represent depth of the surgical wire when a tip of the surgical wire is not visible. The simulator further includes a computing device in operative communication with the camera and configured to track position of a surgical wire by determining position of the surgical wire using the fiducial markers on the surgical wire and to generate imagery based on a three-dimensional model of the bone and position of the surgical wire relative to the bone.
    Type: Grant
    Filed: January 3, 2017
    Date of Patent: June 18, 2019
    Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Geb W. Thomas, Steven A. Long, Donald D. Anderson
  • Preventative therapy for post-traumatic osteoarthritis
    Patent number: 10314941
    Abstract: Compositions comprising a reverse-temperature sensitive hydrogel comprising a biopolymer such as a polysaccharide and a synthetic polymer, and a compound in an amount that reversibly inhibits respiratory enzyme complex I, and methods of using the composition, are provided.
    Type: Grant
    Filed: February 13, 2018
    Date of Patent: June 11, 2019
    Assignee: University of Iowa Research Foundation
    Inventors: Todd O. McKinley, James A. Martin, Mitchell Coleman, Tae-Hong Lim, Marc Brouillette
  • CRISPR-RELATED METHODS AND COMPOSITIONS WITH GOVERNING gRNAS
    Publication number: 20190169639
    Abstract: Disclosed herein are methods and compositions useful in targeting a payload to, or editing a target nucleic acid, where a governing gRNA molecule is used to target, optionally inactivate, a Cas9 molecule or a Cas9 molecule/gRNA complex.
    Type: Application
    Filed: January 24, 2019
    Publication date: June 6, 2019
    Applicants: EDITAS MEDICINE, INC., THE BROAD INSTITUTE INC., THE UNIVERSITY OF IOWA RESEARCH FOUNDATION, MASSACHUSETTS INSTITUITE OF TECHNOLOGY
    Inventors: Feng Zhang, Deborah Palestrant, Beverly Davidson, Jordi Mata-Fink, Edgardo Rodriguez, Alexis Borisy
  • COMPOSITIONS AND METHODS OF USE OF CRISPR-CAS SYSTEMS IN NUCLEOTIDE REPEAT DISORDERS
    Publication number: 20190153412
    Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a SIN CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing SIN CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.
    Type: Application
    Filed: January 30, 2019
    Publication date: May 23, 2019
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology, University of Iowa Research Foundation
    Inventors: Feng ZHANG, Beverly Davidson, Chie-Yu Lin, Edgardo RODRIGUEZ
  • THERAPEUTIC COMPOUNDS
    Publication number: 20190153021
    Abstract: The invention provides compounds of formula (I): and salts thereof, wherein R1, R2, R3, B, X, Y, and Z have any of the values defined herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, processes for preparing compounds of formula (I) and salts thereof, intermediates useful for preparing compounds of formula (I) and salts thereof, and therapeutic methods for treating cancer using a compound of formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: December 6, 2016
    Publication date: May 23, 2019
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Zhendong Jin, Yan Mei, Lei Chen, Aashay Sha
  • METHODS TO PREVENT OR TREAT PERIODONTITIS OR PERI-IMPLANTITIS
    Publication number: 20190144856
    Abstract: Compositions and methods to prevent, inhibit or treat aveolar or periodontal bone loss, enhance bone regeneration, prevent, inhibit or treat peri-implantitis or periodontitis, e.g., periodontitis or peri-implantitis associated with bone loss, or to prevent, inhibit or treat osteoarthritis are provided.
    Type: Application
    Filed: January 15, 2016
    Publication date: May 16, 2019
    Applicant: University of Iowa Research Foundation
    Inventors: Liu HONG, Brad A. AMENDT, Aliasger K. SALEM, Satheesh ELANGOVAN, Gustavo Avila Ortiz, Thad SHARP
  • NUCLEIC ACID APTAMERS
    Publication number: 20190136240
    Abstract: Disclosed herein are compositions including an aptamer bound to a complex, wherein the complex comprises at least two polypeptides. Accordingly, methods of using the aptamers and making the aptamers are also disclosed.
    Type: Application
    Filed: August 20, 2018
    Publication date: May 9, 2019
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: George Weiner, William Thiel, Paloma Giangrande, Suresh Veeramani, Sue Blackwell
  • MicroRNA-200 based approaches for modulating bone formation inhibition and bone regeneration
    Patent number: 10273476
    Abstract: In certain embodiments, the present invention provides the use of microRNA (miR)-200a and/or miR-200c to inhibit ossification and bone formation. In certain embodiments, the present invention provides the use of miR-200a inhibitor to stimulate bone regeneration.
    Type: Grant
    Filed: May 1, 2017
    Date of Patent: April 30, 2019
    Assignee: University of Iowa Research Foundation
    Inventors: Liu Hong, Brad Amendt, Thad Sharp, Aliasger Salem
  • METHODS FOR INHIBITING MUSCLE ATROPHY
    Publication number: 20190105333
    Abstract: In one aspect, the invention relates to methods for treating muscle atrophy by providing to an animal in need thereof an effective amount of a compound. The compound can modulate the expression levels of multiple mRNA of a muscle atrophy signature. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: October 11, 2018
    Publication date: April 11, 2019
    Applicants: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Christopher M. ADAMS, Steven D. KUNKEL, Michael WELSH
  • THERAPEUTIC COMPOSITIONS AND METHODS
    Publication number: 20190099414
    Abstract: Therapeutic methods and compositions for treating fibrosis (e.g. scarring) are provided, as well as compositions comprising blebbistatin or a salt thereof and PLGA and nanoparticles comprising blebbistatin or a salt thereof and PLGA.
    Type: Application
    Filed: May 1, 2018
    Publication date: April 4, 2019
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Edward A. Sander, Aliasgar Salem, James A. Martin