Patents Assigned to University of Iowa Research Foundation
  • METHODS FOR IDENTIFYING MYELOMA TUMOR-INITIATING CELLS AND TARGETED THERAPY
    Publication number: 20200209247
    Abstract: In certain embodiments, the present invention provides a method of treating cancer in a patient comprising administering an effective amount of a therapeutic agent to the patient, wherein the cancer was determined to contain cells comprising cell marker CD24+. In certain embodiments, the cancer cells also comprise cell markers CD38+ and/or CD45?.
    Type: Application
    Filed: September 17, 2018
    Publication date: July 2, 2020
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Ivana Frech, Fenghuang Zhan, Guido Tricot
  • EPIGENETIC INHIBITORS FOR SENSITIZING HEMATOLOGIC OR OTHER MALIGNANCIES TO GLUCOCORTICOID THERAPY
    Publication number: 20200181284
    Abstract: The present disclosure as disclosed in various embodiments is related to glueocorticoid compositions and glucocorticoid therapies for treating hematologic or other malignancies, methods and compositions for enhancing the chemotherapeutic effect of glucocorticoids, methods for determining early relapse of a hematologic or other malignancy in a subject, and methods for treating relapse of a hematologic or other malignancy in a subject.
    Type: Application
    Filed: May 18, 2018
    Publication date: June 11, 2020
    Applicants: UNIVERSITY OF SOUTHERN CALIFORNIA, UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Michael R. STALLCUP, Coralie POULARD, Miles A. PUFALL
  • IDENTIFICATION OF T-CELL TRAFFICKING GENES AND USES THEREOF FOR INCREASING INFILTRATION OF T-CELLS INTO SOLID TUMORS
    Publication number: 20200181574
    Abstract: Disclosed are compositions, kits, and methods for identifying genes that are involved in T-cell trafficking. In particular, the compositions, kits, and methods may be used to identify genes involved in T-cell trafficking and/or infiltration into tumors such as genes that encode immune checkpoint regulators and/or stimulatory agents. The disclosed compositions, kits, and methods utilize the Sleeping Beauty transposon system in a mouse tumor model to identify genes that are involved in T-cell trafficking and infiltration into tumors. The genes identified in the disclosed methods may provide immunotherapy targets in the tumor microenvironment. The identified genes may be utilized in order to develop therapies that enhance T-cell trafficking and infiltration into tumors and/or T-cell killing of tumors such as in chimeric antigen receptor (CAR) T cell therapies.
    Type: Application
    Filed: April 18, 2018
    Publication date: June 11, 2020
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Laura M. Rogers, George J. Weiner, Adam J. Dupuy
  • Botanical extracts and compounds from Castanea plants and methods of use
    Patent number: 10675321
    Abstract: This disclosure relates to extracts from chestnut plants and compositions comprising compounds contained therein. In certain embodiments, the extracts are derived from the leaves of a Castanea plant. In certain embodiments, the disclosure relates to methods of treating or preventing bacterial infections, acne, and other related uses.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: June 9, 2020
    Assignees: Emory University, University of Iowa Research Foundation
    Inventors: Cassandra L. Quave, James Lyles, Alexander R. Horswill
  • Vascular Prosthetic Assemblies
    Publication number: 20200170813
    Abstract: Vascular prosthetic assemblies (e.g., heart valves), such as those, for example, configured to be deployed percutaneously.
    Type: Application
    Filed: February 11, 2020
    Publication date: June 4, 2020
    Applicant: The University of Iowa Research Foundation
    Inventors: Benjamin Dickerhoff, Robert S. Farivar, Madhavan L. Raghavan, Vijay Kumar
  • Methods for inhibiting muscle atrophy
    Patent number: 10668087
    Abstract: In one aspect, the invention relates to methods for treating muscle atrophy by providing to an animal in need thereof an effective amount of a compound. The compound can modulate the expression levels of multiple mRNA of a muscle atrophy signature. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: October 11, 2018
    Date of Patent: June 2, 2020
    Assignees: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Christopher M. Adams, Steven D. Kunkel, Michael Welsh
  • Methods to prevent or treat periodontitis or peri-implantitis
    Patent number: 10669543
    Abstract: Compositions and methods to prevent, inhibit or treat aveolar or periodontal bone loss, enhance bone regeneration, prevent, inhibit or treat peri-implantitis or periodontitis, e.g., periodontitis or peri-implantitis associated with bone loss, or to prevent, inhibit or treat osteoarthritis are provided.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: June 2, 2020
    Assignee: University of Iowa Research Foundation
    Inventors: Liu Hong, Brad A. Amendt, Aliasger K. Salem, Satheesh Elangovan, Gustavo Avila Ortiz, Thad Sharp
  • GENES AND POLYMORPHISMS ASSOCIATED WITH AGE RELATED MACULAR DEGENERATION (AMD)
    Publication number: 20200165681
    Abstract: The invention relates to genes, gene polymorphisms, and genetic profiles associated with an elevated or a reduced risk of alternative complement cascade deregulation disease such as AMD. The invention provides methods and reagents for determination of risk, diagnosis and treatment of such diseases. In an embodiment, the present invention provides methods and reagents for determining sequence variants in the genome of a patient which facilitate assessment of risk for developing such diseases.
    Type: Application
    Filed: November 27, 2019
    Publication date: May 28, 2020
    Applicant: University of Iowa Research Foundation
    Inventor: Gregory S. Hageman
  • Oligonucleotide-based probes for detection of bacterial nucleases
    Patent number: 10653800
    Abstract: The present invention relates to a rapid detection of microbial-associated nuclease activity with chemically modified nuclease (e.g., ribonuclease) substrates, and probes and compositions useful in detection assays.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: May 19, 2020
    Assignees: University of Iowa Research Foundation, Integrated DNA Technologies, Inc.
    Inventors: James O. McNamara, II, Katie R. Flenker, Lingyan Huang, Alexander R. Horswill, Mark A. Behlke, Frank J. Hernandez
  • COMPOSITIONS AND METHODS OF TREATING CANCER
    Publication number: 20200147060
    Abstract: The invention provides in certain embodiments a therapeutic regimen comprising (a) an anti-cancer combination of vemurafenib and cobimetinib, or a combination of trametinib and dabrafenib, and (b) a secondary agent comprising L-buthionine-[S,R]-sulfoximine (BSO), or phenyl butyric acid (PBA) or a pharmaceutically acceptable salt thereof, and chloroquine or hydrochloroquine (HCQ) for the therapeutic treatment of a hyperproliferative disorder.
    Type: Application
    Filed: October 30, 2019
    Publication date: May 14, 2020
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Michael K. Schultz, Somya Kapoor, Douglas R. Spitz, Andrean Burnett, Ling Yang
  • RESPIRATORY SYNCYTIAL VIRUS (RSV) POLYANHYDRIDE NANOPARTICLE VACCINE
    Publication number: 20200129446
    Abstract: Disclosed are compositions and methods for vaccinating susceptible individuals against infection by respiratory syncytial virus (RSV). The disclosed compositions include vaccine compositions comprising an effective amount of respiratory syncytial virus (RSV) F protein in a pre-fusion stabilized form and/or M protein incorporated into biodegradable polyanhydride polymer particles for inducing an immune response against RSV. The vaccine compositions also may include a suitable adjuvant.
    Type: Application
    Filed: October 28, 2019
    Publication date: April 30, 2020
    Applicant: University of Iowa Research Foundation
    Inventors: Steven M. Varga, Kevin L. Legge
  • Nucleic acid aptamers to treat histone-induced disease states
    Patent number: 10633410
    Abstract: The present invention relates to methods of using optimized aptamers. In certain embodiments, the present invention provides a method for treating a subject having or being disposed to having a histone-induced injury or disease comprising administering to the subject a pharmaceutical composition comprising a pharmaceutically acceptable carrier and (i) a nucleic acid molecule not more than 90 nucleotides in length comprising an aptamer KU1, KU2, KU3, KU4, KU5, KU6, KU&, KU8, or KU9, wherein the aptamer specifically targets extracellular histones, wherein the nucleotides are RNA; or (ii) a conjugate comprising a nucleic acid molecule not more than 90 nucleotides in length comprising an aptamer KU1, KU2, KU3, KU4, KU5, KU6, KU&, KU8, or KU9, wherein the aptamer specifically targets extracellular histones, wherein the nucleotides are RNA, wherein the nucleic acid molecule is linked to a therapeutic molecule.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: April 28, 2020
    Assignee: University of Iowa Research Foundation
    Inventors: Paloma H. Giangrande, Francis Miller, Kevin Urak
  • Oligonucleotide-based probes and methods for detection of microbes
    Patent number: 10619219
    Abstract: The present invention relates to a rapid detection of microbial-associated nuclease activity with chemically modified nuclease (e.g., endonuclease) substrates, and probes and compositions useful in detection assays.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: April 14, 2020
    Assignee: University of Iowa Research Foundation
    Inventors: James O. McNamara, Katie R. Flenker, Hyeon Kim, Alexander R. Horswill, Frank J. Hernandez, Mark Behlke, Lingyan Huang, Richard Owczarzy, Elliot Burghardt, Karen Clark
  • System and method for an intensity modulated radiation therapy device
    Patent number: 10617885
    Abstract: Systems and methods for low energy radiation x-ray radiation therapy system for use at a target within a cavity of a subject. In an aspect, the system uses an aperture shaping device used to shape the radiation beam from the low energy radiation source. In an aspect, the aperture shaping device includes a plurality of leaf assemblies which include leaves configured to form the aperture and engage the radiation beam. In an aspect, the present invention utilizes a geared mechanics approach to create an aperture using only one dial input. The design ensures that the field size of the collimator remains a constant shape as it is opened and closed. In an aspect, the overall size of the collimator may be scaled to accommodate various radiation therapy requirements.
    Type: Grant
    Filed: January 18, 2017
    Date of Patent: April 14, 2020
    Assignee: University of Iowa Research Foundation
    Inventors: Ryan Flynn, Junyi Xia, Timothy J. Waldron, Yusung Kim, Bryan G. Allen, Brennen N. Wears, Hongtao Ding
  • APPARATUS AND METHOD FOR THREE-DIMENSIONAL PHOTO-ELECTRODIALYSIS
    Publication number: 20200070094
    Abstract: A three-dimensional photo/electrodialysis unit includes four compartments. A first compartment holds a three-dimensional electrode and a group of one or more electrochemically active redox species. A first electroactive cation selective membrane couples the first compartment to a second compartment that provides a first feedstock. An electroactive anion selective membrane couples the second compartment to a third compartment that provides a second feedstock.
    Type: Application
    Filed: December 21, 2017
    Publication date: March 5, 2020
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Syed Mubeen Jawahar HUSSAINI, David Cwiertny, Joun Lee, Tim Young, Abdulsattar Hashim Ghanim Al Saedi
  • Tomatidine, analogs thereof, compositions comprising same, and uses for same
    Patent number: 10576091
    Abstract: In one aspect, the invention relates to methods for promoting muscle hypertrophy or decreasing adiposity by providing to an animal in need thereof an effective amount of a compound. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: March 3, 2020
    Assignees: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Christopher M. Adams, Michael C. Dyle, Michael Welsh
  • High frequency stimulation of the spinal cord from inside the dura
    Patent number: 10576272
    Abstract: This invention provides a device for implantation directly into the spinal cord for the purpose of treating back pain. Electrodes on a backing that conforms directly to the spinal cord are installed as a source of electrical stimulation and pain relief. The floating electrodes can be flexibly mounted to the substrate such that when the electrode array is implanted into the subject, individual electrodes float or move resiliently relative to the substrate to an extent sufficient to accommodate pulsations of the surface of the spinal cord within the dura.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: March 3, 2020
    Assignee: University of Iowa Research Foundation
    Inventor: Matthew A. Howard
  • METHODS FOR INHIBITING MUSCLE ATROPHY
    Publication number: 20200061083
    Abstract: The invention provides a method for (a) increasing skeletal muscle mass; (b) reducing skeletal muscle atrophy; (c) increasing muscular strength; (d) promoting muscle growth; (e) decreasing muscle wasting; or (f) increasing strength per unit of muscle mass in an animal identified or having been identified to be in need of one or more of (a)-(f), the method comprising administering to the animal an effective amount of a compound of formula: or a stereoisomer, solvate, or pharmaceutically acceptable salt thereof, thereby accomplishing one or more of (a)-(f).
    Type: Application
    Filed: October 23, 2019
    Publication date: February 27, 2020
    Applicants: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Christopher M. ADAMS, Steven D. KUNKEL, Michael WELSH
  • METHODS AND COMPOSITIONS FOR TREATING BRAIN DISEASES
    Publication number: 20200009267
    Abstract: The present disclosure provides methods of treating a disease or delivering a therapeutic agent to a mammal comprising administering to the mammal's cisterna magna and/or ventricle an rAAV particle containing a vector comprising a nucleic acid encoding a therapeutic protein inserted between a pair of AAV inverted terminal repeats in a manner such that cells with access to the cerebrospinal fluid (CSF) express the therapeutic agent and in certain embodiments secretes the therapeutic agent into the CSF for distribution to the brain.
    Type: Application
    Filed: June 28, 2019
    Publication date: January 9, 2020
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Beverly L. Davidson, Luis Tecedor, Young Hong Chen
  • Microrna inhibitor system and methods of use thereof
    Patent number: 10519443
    Abstract: The present invention relates to plasmid-based miR inhibitory systems (PMIS), miR inhibitors and methods of use of these systems and inhibitors.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: December 31, 2019
    Assignee: University of Iowa Research Foundation
    Inventors: Brad A. Amendt, Huojun Cao