Patents Assigned to University of Iowa Research Foundation
  • REPEATED ADMINISTRATION OF LENTIVIRAL VECTORS TO RESPIRATORY CELLS
    Publication number: 20180271783
    Abstract: The invention provides methods for administering lentiviral vectors to the respiratory system of a patient to treat a disease.
    Type: Application
    Filed: May 11, 2018
    Publication date: September 27, 2018
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Paul B. McCray, Patrick L. Sinn
  • Floating electrodes that engage and accommodate movement of the spinal cord
    Patent number: 10071240
    Abstract: This invention provides a device for implantation directly into the spinal cord for the purpose of treating back pain. Electrodes on a backing that conforms directly to the spinal cord are installed as a source of electrical stimulation and pain relief. The floating electrodes can be flexibly mounted to the substrate such that when the electrode array is implanted into the subject, individual electrodes float or move resiliently relative to the substrate to an extent sufficient to accommodate pulsations of the surface of the spinal cord within the dura.
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: September 11, 2018
    Assignees: University of Iowa Research Foundation, University of Virgina Patent Foundation
    Inventors: Matthew A. Howard, Hiroyuki Oya, Steve Viljoen, Chandan G. Reddy, George T. Gillies
  • RNA interference suppression of neurodegenerative diseases and methods of use
    Patent number: 10072264
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: September 11, 2018
    Assignee: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Haibin Xia, Qinwen Mao, Henry Paulson, Ryan Boudreau, Scott Harper
  • Methods of improving vaccine immunogenicity
    Patent number: 10059746
    Abstract: The present invention provides a process called “Immune Banking” that enhances vaccine efficacy by exploiting existing humoral responses. The process involves tagging new antigens with molecular markers recognized by an existing antibody response. This recognition of the tagged vaccine components enhances adaptive immune responses to the new vaccine.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: August 28, 2018
    Assignee: University of Iowa Research Foundation
    Inventors: Gail Bishop, Tony Vanden Bush
  • METHODS FOR TREATING NEURODEGENERATIVE DISEASES USING GENE THERAPY TO DELAY DISEASE ONSET AND PROGRESSION WHILE PROVIDING COGNITIVE PROTECTION
    Publication number: 20180236105
    Abstract: The present disclosure provides methods of treating a lysosomal storage disorder in a mammal which method comprises administering AAV particles encoding a polypeptide directly to the central nervous system of the mammal in conjunction with administering at least two immunosuppressive agents. AAV particles may be delivered by direct injection into the brain, spinal cord, cerebral spinal fluid or a portion thereof.
    Type: Application
    Filed: October 24, 2016
    Publication date: August 23, 2018
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Beverly L. Davidson, Yong Hong Chen, Luis Tecedor
  • Compositions and methods for cancer therapy
    Patent number: 10052304
    Abstract: The invention provides compositions and methods to treat a hyperproliferative disorder with ascorbate or a pharmaceutically acceptable salt thereof, at least one chelating agent that enhances ascorbate redox cycling (EDTA) to form H2O2, and one or more anti-cancer therapies.
    Type: Grant
    Filed: October 12, 2016
    Date of Patent: August 21, 2018
    Assignee: University of Iowa Research Foundation
    Inventors: Bryan G. Allen, Douglas R. Spitz, Garry R. Buettner, Joseph Cullen, Joshua Schoenfeld, Michael Schultz, Fenghuang Zhan
  • Clubfoot orthotic
    Patent number: 10045874
    Abstract: Kits, devices, and methods for treating clubfoot are provided. The devices have two platforms that are attached to a bar. The platforms define slots to allow therapeutically preferred orientations of the platforms when attached to the bar. The kits and devices are simple to use and adjust, with a limited amount of possible settings.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: August 14, 2018
    Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Nicole M. Grosland, Jose Morcuende, Thomas M. Cook
  • METHOD OF PURIFYING TUMOR CELLS USING SHEAR STRESS
    Publication number: 20180224359
    Abstract: Methods for isolating viable cancer cells from a sample that comprises a mixture of cancerous cells and normal (non-cancerous) cells are provided. In the methods, a fluid preparation comprising a mixture of cancerous and normal cells is repeatedly exposed to fluid shear stresses, whereby the repeated exposure to the fluid shear stresses preferentially imparts fluid shear stress-resistance to the cancerous cells.
    Type: Application
    Filed: April 2, 2018
    Publication date: August 9, 2018
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Michael D. Henry, J. Matthew Barnes
  • COMPOSITIONS AND METHODS FOR TREATING CANCER
    Publication number: 20180214402
    Abstract: The invention provides compositions and methods to treat a hyperproliferative disorder with phenyl butyric acid (PBA) or a pharmaceutically acceptable salt thereof and an anti-cancer composition.
    Type: Application
    Filed: July 26, 2016
    Publication date: August 2, 2018
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Michael K. Schultz, Somya Kapoor, Andrean L. Simons-Burnett
  • SYSTEMS AND METHODS FOR CARDIOVASCULAR CONDITIONING
    Publication number: 20180214690
    Abstract: An example system has a pulse generator configured to deliver a first series of electrical signals to a right atrium of a heart. The first series of electrical signals can increase a first heart rate toward a target heart rate. The system can have a monitoring device configured to retrieve physiological data from a user of the system while the heart is receiving the first series of electrical signals. The system can have a controller configured to determine whether a physiological parameter has met a physiological threshold based on the physiological data. If the physiological threshold has been met, the controller can modify the first series of electrical signals to a second series of electrical signals that restores the physiological parameter to an acceptable level.
    Type: Application
    Filed: September 30, 2016
    Publication date: August 2, 2018
    Applicant: University of Iowa Research Foundation
    Inventors: Denice Marie Hodgson-Zingman, Leonid Vladimir Zingman
  • Close-proximity range shifting device for proton radiosurgery
    Patent number: 10035025
    Abstract: A range shifting device configured to be placed close to a portion of a body of a patient during radiation beam treatment. The radiation beam treatment can include stereotactic radiosurgery (SRS). The range shifting device can be incorporated into an existing SRS localization system during SRS treatment. The range shifting device is configured to be placed close to the head of a patient during SRS treatment. The range shifting device is comprised of range shifting material. The range shifting device can be a range shifting helmet. The range shifting helmet can include a hollow frame including a plurality of apertures in which inserts made of range shifting material can be inserted.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: July 31, 2018
    Assignee: University of Iowa Research Foundation
    Inventors: Dongxu Wang, Daniel Hyer, Blake Dirksen
  • Method of inducing a cross-reactive HIV-1 immune response by administering a composition comprising the GBV-C E2 protein
    Patent number: 10034936
    Abstract: GB virus C (GBV-C or hepatitis G virus) is a flavivirus that frequently leads to chronic viremia in humans. The invention provides compositions and methods involving an anti-GBV-C antibody or other GBV-C binding agent, or a GBV-C antigen, for inhibiting and treating HIV infections.
    Type: Grant
    Filed: August 15, 2014
    Date of Patent: July 31, 2018
    Assignees: The University of Iowa Research Foundation, The United States of America as represented by the Secretary of the Department of Veterans Affairs
    Inventors: Jack T. Stapleton, Jinhua Xiang, Donna Klinzman, James H. McLinden
  • HTS Assay for Identifying Small Molecule Inhibitors of RAD52 and Uses of Identified Small Molecule Inhibitors for Treatment and Prevention of BRCA-Deficient Malignancies
    Publication number: 20180209956
    Abstract: Disclosed are methods, compositions, kits, and systems for identifying small-molecule drugs for treating cancer in a subject. The disclosed methods, compositions, kits, and systems may be utilized to identify small-molecule inhibitors of radiation sensitive protein 52 (RAD52) in order to treat cancer in a subject, such as breast cancer in a subject having a BRCA1-deficient, BRCA2-deficient, and/or PALB2-deficient phenotype by administering the identified small-molecule inhibitors to the subject.
    Type: Application
    Filed: July 11, 2016
    Publication date: July 26, 2018
    Applicant: University of Iowa Research Foundation
    Inventors: Michael Ashley Spies, Maria Spies, Sarah R. Hengel
  • FLUORESCENT PRODRUGS
    Publication number: 20180207284
    Abstract: The invention provides a drug conjugate comprising: 1) a therapeutic agent that comprises a phosphate, phosphonate, carboxy, or phosphoramidate group, and 2) a fluorescent group linked to the phosphate, phosphonate, carboxy, or phosphoramidate group to form the corresponding ester and salts thereof. The conjugates are useful for therapy and as probes.
    Type: Application
    Filed: July 14, 2016
    Publication date: July 26, 2018
    Applicants: UNIVERSITY OF IOWA RESEARCH FOUNDATION, UNIVERISTY OF CONNECTICUT
    Inventors: David F. Wiemer, Rocky J. Barney, Andrew Wiemer
  • Advanced rotating-shield brachytherapy and planning of the same
    Patent number: 10029118
    Abstract: Systems and methods for rotating shield brachytherapy. In an aspect, some of the systems and methods can be used to facilitate shield selection for use in rotating shield brachytherapy. In an aspect, the invention is a shielded needle or catheter system with a rotational controller for delivering radioisotope-based interstitial rotating shield brachytherapy (I-RSBT). In an aspect, the catheter system can utilize paddle-based RSBT. Further provided are methods and systems for helical RSBT.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: July 24, 2018
    Assignee: University of Iowa Research Foundation
    Inventors: Ryan Flynn, Hossein Dadkhah
  • BST-2 AS A THERAPEUTIC TARGET AND DIAGNOSTIC MARKER FOR BREAST CANCER GROWTH AND METASTASIS
    Publication number: 20180200331
    Abstract: Disclosed are compositions, kits, and methods for treating and/or diagnosing cancer in a subject in need thereof. The compositions, kits, and methods may be used to treat and/or diagnose cancers associated with BST-2 expression and/or BST-2 biological activity. Also disclosed are reagents that inhibit dimerization of BST-2 which may be administered as therapeutic agents for inhibiting BST-2 biological activity and treating cancers associated with BST-2 biological activity.
    Type: Application
    Filed: July 11, 2016
    Publication date: July 19, 2018
    Applicant: University of Iowa Research Foundation
    Inventors: Chioma M. Okeoma, Wadie D. Mahauad-Fernandez
  • SYSTEM AND METHOD FOR AN INTENSITY MODULATED RADIATION THERAPY DEVICE
    Publication number: 20180200540
    Abstract: Systems and methods for low energy radiation x-ray radiation therapy system for use at a target within a cavity of a subject. In an aspect, the system uses an aperture shaping device used to shape the radiation beam from the low energy radiation source. In an aspect, the aperture shaping device includes a plurality of leaf assemblies which include leaves configured to form the aperture and engage the radiation beam. In an aspect, the present invention utilizes a geared mechanics approach to create an aperture using only one dial input. The design ensures that the field size of the collimator remains a constant shape as it is opened and closed. In an aspect, the overall size of the collimator may be scaled to accommodate various radiation therapy requirements.
    Type: Application
    Filed: January 18, 2017
    Publication date: July 19, 2018
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Ryan Flynn, Junyi Xia, Timothy J. Waldron, Yusung Kim, Bryan G. Allen, Brennen M. Wears, Hongtao Ding
  • Tomatidine, analogs thereof, compositions comprising same, and uses for same
    Patent number: 10022386
    Abstract: In one aspect, the invention relates to methods for promoting muscle hypertrophy or decreasing adiposity by providing to an animal in need thereof an effective amount of a compound. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: July 17, 2018
    Assignees: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Christopher M. Adams, Michael C. Dyle, Michael Welsh
  • MUSCLIN PEPTIDES AND METHODS OF USE THEREOF
    Publication number: 20180194824
    Abstract: In certain embodiments, the present invention provides a musclin peptide and methods of increasing muscle growth, performance, resistance to injury and/or preventing or reducing muscle atrophy and improving overall skeletal muscle, metabolic and cardiac health in an animal in need thereof by administering a musclin peptide.
    Type: Application
    Filed: December 14, 2017
    Publication date: July 12, 2018
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Leonid Zingman, Denice Hodgson-Zingman
  • Alternative export pathways for vector expressed RNA interference
    Patent number: 10006028
    Abstract: The present invention is directed to nucleic acid molecules containing a loop sequence designed to circumvent exportin-5 mediated export, and methods using these novel molecules.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: June 26, 2018
    Assignee: University of Iowa Research Foundation
    Inventors: Scott Harper, Beverly L. Davidson