Patents Assigned to University of Iowa
  • Modified polydicyclopentadienes
    Patent number: 8981012
    Abstract: The present invention provides novel, modified polydicyclopentadienes and methods to prepare modified polydicyclopentadienes. The modified polydicyclopentadienes prepared by the methods of the invention are useful in many applications including new and useful solid phases for chromatography.
    Type: Grant
    Filed: July 8, 2009
    Date of Patent: March 17, 2015
    Assignee: University of Iowa Research Foundation
    Inventors: Ned B. Bowden, Mathew Perring
  • Methods and Reagents for Treatment and Diagnosis of Vascular Disorders and Age-Related Macular Degeneration
    Publication number: 20150050646
    Abstract: Disclosed are screening methods for determining a human subject's propensity to develop a vascular disorder and/or age-related macular degeneration (AMD), therapeutic or prophylactic compounds for treating disease or inhibiting its development, and methods of treating patients to alleviate symptoms of the disease, prevent or delay its onset, or inhibit its progression. The inventions are based on the discovery that persons with a genome having a deletion of the CFHR-1 and/or CFHR-3 gene, which normally lie on human chromosome 1 between DNA encoding CFH and CFHR-4, are at reduced risk of developing AMD, and elevated risk of developing vascular disease such as aneurysm.
    Type: Application
    Filed: May 15, 2014
    Publication date: February 19, 2015
    Applicant: University of Iowa Research Foundation
    Inventor: Gregory S. Hageman
  • Synthesis of hierarchical nanocrystalline zeolites with controlled particle size and mesoporosity
    Patent number: 8951498
    Abstract: A one step synthesis of nanocrystalline zeolites ZSM-5 and Na? from a single template system in high yield has been discovered. The size of individual nanocrystals, as well as mesopore surface area and pore volume can be controlled by adjusting the pH of the reaction mixture, as well as the hydrothermal treatment temperature and duration. The mesopore volume and size distribution show a dependence on particle size such that smaller particles lead to higher mesopore volumes and narrower pore size distributions.
    Type: Grant
    Filed: July 28, 2011
    Date of Patent: February 10, 2015
    Assignee: University of Iowa Research Foundation
    Inventors: Sarah Larsen, Anton Petushkov
  • -demethyase genes and uses thereof
    Patent number: 8951752
    Abstract: The invention provides isolated nucleic acid encoding one or more gene products that allow for degradation of caffeine and related structures, and for preparation of intermediates in that catabolic pathway. Further provided are methods of using one or more of those gene products.
    Type: Grant
    Filed: October 18, 2012
    Date of Patent: February 10, 2015
    Assignee: University of Iowa Research Foundation
    Inventors: Venkiteswaran Subramanian, Michael Tai-Man Louie, Ryan Summers
  • Spray dried microbes and methods of preparation and use
    Patent number: 8940510
    Abstract: The invention provides spray-dried preparations of microbes and methods of using those microbes.
    Type: Grant
    Filed: November 16, 2007
    Date of Patent: January 27, 2015
    Assignee: University of Iowa Research Foundation
    Inventors: Venkiteswaran Subramanian, James H. Glenn, IV, Shuvendu Das
  • METHODS TO MODULATE RAC1 IMPORT AND TO TREAT PULMONARY FIBROSIS
    Publication number: 20150005261
    Abstract: The invention provides methods for treating fibrosis, as well as methods for modulating mitochondrial peroxide production in a cell, and methods for modulating the import of Rac1 into the mitochondria of a cell.
    Type: Application
    Filed: April 25, 2014
    Publication date: January 1, 2015
    Applicant: University of Iowa Research Foundation
    Inventors: Raymond J. Hohl, A. Brent Carter
  • Photo-enforced stratification of polymeric materials
    Patent number: 8921447
    Abstract: The invention provides a process for manufacturing a polymeric material having a compositional gradient, comprising: forming a mixture comprising a first photopolymerizable polymer precursor and a second photopolymerizable precursor, and subjecting said mixture to an intensity gradient of electromagnetic radiation, wherein said first precursor has a greater reactivity ratio than said second precursor, and/or said first precursor is mono-functional and said second precursor is di-functional, and/or said first precursor is less inhibited by oxygen than said second precursor.
    Type: Grant
    Filed: April 8, 2011
    Date of Patent: December 30, 2014
    Assignee: The University of Iowa Research Foundation
    Inventors: Clinton J. Cook, C. Allan Guymon
  • MANAGING BACK PAIN BY APPLYING A HIGH FREQUENCY ELECTRICAL STIMULUS DIRECTLY TO THE SPINAL CORD
    Publication number: 20140379043
    Abstract: This invention provides a new technology for management of back pain by stimulating the spinal cord in a manner that renders it refractory to transmission of deleterious or undesirable sensory input. The electrical stimulus comprises high frequency pulses in a regular or complex pattern or that are stochastically produced under microprocessor control. The stimulus is applied directly to the surface of the spinal cord from within the spinal canal, which provides important benefits over previous technology. The stimulus alleviates symptoms and signs of back pain, while minimizing the risk of side effects such as paresthesia, and potentially minimizing the effects on motor neuron transmission and proprioception.
    Type: Application
    Filed: January 30, 2013
    Publication date: December 25, 2014
    Applicant: University of Iowa research Foundation
    Inventor: Matthew A. Howard
  • Transgenic pig model of cystic fibrosis
    Patent number: 8912386
    Abstract: The present invention provides transgenic, large non-human animal models of diseases and conditions, as well as methods of making and using such animal models in the identification and characterization of therapies for the diseases and conditions.
    Type: Grant
    Filed: November 3, 2011
    Date of Patent: December 16, 2014
    Assignees: University of Iowa Research Foundation, The Curators of the University of Missouri
    Inventors: Michael J. Welsh, Christopher S. Rogers, Randall S. Prather, John Engelhardt, Ziying Yan
  • COMPOUNDS AND METHODS TO TREAT ORGANOPHOSPHORUS POISONING
    Publication number: 20140323473
    Abstract: Organophosphate (OP) nerve agents and pesticides are potent inhibitors of acetylcholinesterase (AChE). Though oxime nucleophiles can reactivate an AChE-phosphyl adduct, the adduct can undergo a reaction called aging, leading to an aged-AChE adduct. The invention provides compounds and methods that can be used to reactivate an aged-AChE adduct. Such compounds and methods are useful to counteract organophosphorus poisoning.
    Type: Application
    Filed: January 24, 2014
    Publication date: October 30, 2014
    Applicant: University of Iowa Research Foundation
    Inventors: Daniel Quinn, Joseph John Topczewski
  • Method for inhibiting HIV-1 replication utilizing anti-GBV-C E2 antibodies
    Patent number: 8858946
    Abstract: GB virus C (GBV-C or hepatitis G virus) is a flavivirus that frequently leads to chronic viremia in humans. The invention provides compositions and methods involving an anti-GBV-C antibody or other GBV-C binding agent, or a GBV-C antigen, for inhibiting and treating HIV infections.
    Type: Grant
    Filed: July 24, 2008
    Date of Patent: October 14, 2014
    Assignees: The University of Iowa Research Foundation, The United States of America, as represented by the Secretary of the Department of Veterans Affairs
    Inventors: Jack T. Stapleton, Jinhua Xiang, Donna Klinzman, James H. McLinden
  • INHIBITORS OF RGS PROTEINS
    Publication number: 20140303199
    Abstract: G-protein coupled receptors are a diverse group that are the target of over 50% of marketed drugs. Activation of these receptors results in the exchange of bound GDP for GTP in the G? subunit of the heterotrimeric G-protein. The G? subunit dissociates from the ?/? subunits and both proceed to affect downstream signaling targets. The signal terminates by the hydrolysis of GTP to GDP and is regulated by Regulators of G-protein Signaling (RGS) proteins that act as GTPase Activating Proteins (GAPs). This makes RGS proteins potentially desirable targets for “tuning” the effects of current therapies as well as developing novel pharmacotherapies. The present invention provides a convenient assay for identifying modulators of RGS proteins that can be adapted for high throughput screening utilizing the colorimetric dye, malachite green, to detect free phosphate in the presence of a test compound.
    Type: Application
    Filed: April 4, 2014
    Publication date: October 9, 2014
    Applicant: University of Iowa Research Foundation
    Inventor: David Roman
  • REDUCTION OF OFF-TARGET RNA INTERFERENCE TOXICITY
    Publication number: 20140303362
    Abstract: The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence, and methods of using these RNAi molecules to reduce off-target toxicity.
    Type: Application
    Filed: August 27, 2013
    Publication date: October 9, 2014
    Applicant: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Alejandro Mas Monteys, Jodi L. McBride, Ryan Boudreau
  • Compounds and methods to enhance rAAV transduction
    Patent number: 8846030
    Abstract: Agents and methods to alter rAAV transduction are provided.
    Type: Grant
    Filed: December 13, 2005
    Date of Patent: September 30, 2014
    Assignee: University of Iowa Research Foundation
    Inventors: John F. Engelhardt, Dongsheng Duan
  • Zinc finger nuclease for the CFTR gene and methods of use thereof
    Patent number: 8846578
    Abstract: The present invention provides new zinc finger proteins and zinc finger nuclease (ZFNs) that find particular using in repairing the cystic fibrosis transmembrane conductance regulator (CFTR) gene.
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: September 30, 2014
    Assignees: The General Hospital Corporation, University of Iowa Research Foundation
    Inventors: Paul McCray, Morgan Maeder, Jae Keith Joung
  • RNA INTERFERENCE SUPPRESSION OF NEURODEGENERATIVE DISEASES AND METHODS OF USE THEREOF
    Publication number: 20140287492
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
    Type: Application
    Filed: June 18, 2013
    Publication date: September 25, 2014
    Applicant: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Haibin Xia, Qinwen Mao, Henry Paulson, Ryan Boudreau, Scott Harper
  • Monoclonal antibodies specific for oxidized calcium/calmodulin dependent protein kinase II
    Patent number: 8841423
    Abstract: Calcium/calmodulin dependent protein kinase II (CaMKII) has been found to be directly oxidized, and direct oxidation of CaMKII was observed to result in calcium independent activation of CaMKII. Antibodies that bind specifically to oxidized forms of CaMKII (oxCaMKII) were generated and were utilized to detect oxCaMKII in blood from: (1) mice with cancer; (2) mice with a knock out of the gene encoding methionine sulfoxide reductase; (3) mice injected with angiotensin II; (4) mice injected with bacterial endotoxin; (5) mice fed a pro-oxidant (ketogenic) diet; and (6) mice with cancer that had been treated with experimental therapy.
    Type: Grant
    Filed: April 27, 2009
    Date of Patent: September 23, 2014
    Assignee: University of Iowa Research Foundation
    Inventors: Mark E. Anderson, Peter J. Mohler, Douglas R. Spitz, Jr., Jeffrey Robert Erickson
  • MARKER-FLANGE FOR MRI-GUIDED BRACHYTHERAPY
    Publication number: 20140275964
    Abstract: Disclosed herein is a marker flange for use with a brachytherapy applicator, having a flange body with a first face, a second face, and a hollow chamber positioned between the first and second faces. A cavity extending through the flange body is dimensioned to receive a tandem in a brachytherapy applicator in a press-fit connection, so as to affix the flange-marker to an outside surface of the tandem. The hollow chamber includes an MR imaging responsive marker agent that provides strong signal intensities and a high geometric accuracy in MR imaging.
    Type: Application
    Filed: March 14, 2013
    Publication date: September 18, 2014
    Applicant: University of Iowa Research Foundation
    Inventor: University of Iowa Research Foundation
  • FLUORAPATITE GLASS-CERAMICS
    Publication number: 20140271565
    Abstract: The present invention provides a highly-sintered fluorapatite glass-ceramic comprising a high Ca/Al or Sr/Al mole-ratio, that possesses a microstructure that induces apatite/bone deposition.
    Type: Application
    Filed: November 8, 2013
    Publication date: September 18, 2014
    Applicant: University of Iowa Research Foundation
    Inventors: Isabelle Denry, Julie Holloway
  • Combination motif immune stimulatory oligonucleotides with improved activity
    Patent number: 8834900
    Abstract: A class of immunostimulatory nucleic acids having at least two functionally and structurally defined domains is provided. This class of combination motif immunostimulatory nucleic acids activates an immune response and is useful for treating a variety of immune related disorders such as cancer, infectious disease, and allergic disorders. The nucleic acids also stimulate activation of natural killer cells and production of type 1 interferon.
    Type: Grant
    Filed: August 19, 2002
    Date of Patent: September 16, 2014
    Assignees: University of Iowa Research Foundation, Coley Pharmaceutical GmbH
    Inventors: Arthur M. Krieg, Jorg Vollmer