Patents Assigned to University of Iowa
  • Publication number: 20120283424
    Abstract: The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence, and methods of using these RNAi molecules to reduce off-target toxicity.
    Type: Application
    Filed: July 18, 2012
    Publication date: November 8, 2012
    Applicant: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Alejandro Mas Monteys, Jodi L. McBride, Ryan Boudreau
  • Patent number: 8299215
    Abstract: The present disclosure provides targeting peptides and vectors containing a sequence that encodes targeting peptides that deliver agents to the brain.
    Type: Grant
    Filed: July 11, 2008
    Date of Patent: October 30, 2012
    Assignee: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Yong Hong Chen
  • Patent number: 8282918
    Abstract: Disclosed are polynucleotides and polypeptides that are useful for assessing and modulating cell proliferation. The polynucleotides may comprise coding regions for RPA4 and RPA4/RPA32 hybrid polypeptides. The polynucleotides may be used in gene vectors for modulating cell proliferation in a patient in need thereof. Diagnostic methods related to assaying RPA4 expression in test samples in order to detect proliferating or cancerous cells also are disclosed.
    Type: Grant
    Filed: July 29, 2008
    Date of Patent: October 9, 2012
    Assignee: University of Iowa Research Foundation
    Inventors: Marc S. Wold, Stuart J. Haring
  • Patent number: 8268778
    Abstract: GB virus C (GBV-C or hepatitis G virus) is a flavivirus that frequently leads to chronic viremia in humans. The invention provides compositions and methods involving a -GBV-C NS5A peptide or polypeptide for inhibiting and treating HIV infections.
    Type: Grant
    Filed: March 20, 2008
    Date of Patent: September 18, 2012
    Assignee: University of Iowa Research Foundation
    Inventors: James McLinden, Jinhua Xiang, Jack T. Stapleton
  • Patent number: 8258286
    Abstract: The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence, and methods of using these RNAi molecules to reduce off-target toxicity.
    Type: Grant
    Filed: May 29, 2008
    Date of Patent: September 4, 2012
    Assignee: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Alejandro Mas Monteys, Jodi L. McBride, Ryan Boudreau
  • Patent number: 8258106
    Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
    Type: Grant
    Filed: November 10, 2006
    Date of Patent: September 4, 2012
    Assignees: University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., The United States of America, as represented by the Department of Health and Human Services
    Inventors: Arthur M. Krieg, Joel N. Kline, Dennis Klinman, Alfred D. Steinberg
  • Patent number: 8251938
    Abstract: A device may include a first plate and a second plate, and a linkage system that attaches the first plate and the second plate to one another such that the plates are capable of translating relative to each other, and the plates are incapable of rotating relative to each other.
    Type: Grant
    Filed: April 30, 2009
    Date of Patent: August 28, 2012
    Assignee: University of Iowa Research Foundation
    Inventors: Jose Morcuende, Nicole M. Grosland, Kelly Jensen, Nicole Jensen, Robert Kruse
  • Patent number: 8241622
    Abstract: The invention provides recombinant AAV vectors, at least one of which has heterologous terminal palindromic sequences, and methods of using those vectors.
    Type: Grant
    Filed: April 30, 2004
    Date of Patent: August 14, 2012
    Assignee: University of Iowa Research Foundation
    Inventors: John F. Englehardt, Ziying Yan
  • Patent number: 8238457
    Abstract: This invention provides a method and system for determining the number of bits to assign to a frequency range in a signal. The present invention is capable of bit allocation, with B total bits, among a plurality of N frequency ranges in time a time O(N log N), which is independent of the size of B. Embodiments of the present invention have many practical applications, including allocating bits among sub-channels in a multi-carrier communication system, and allocating bits among sub-bands in a signal representing digital multimedia, such as in JPEG or MPEG compressed files.
    Type: Grant
    Filed: April 14, 2009
    Date of Patent: August 7, 2012
    Assignee: University of Iowa Research Foundation
    Inventors: Soura Dasgupta, Manish Vemulapalli, Ashish Pandharipande
  • Patent number: 8232257
    Abstract: Embodiments of the present invention provide methods for targeted inactivation of viral genomes. In one embodiment, zinc-finger proteins in which DNA binding sites are altered such that they recognize and bind different, desired DNA sequences contained in hepatitis B virus (HBV) and that include nuclease domains are used for inactivation. Other embodiments for targeted inactivation of viral genomes use small nucleic acid molecules, such as short micro-RNA molecules or short hairpin RNA molecules capable of mediating RNA interference (RNAi) against the hepatitis B virus.
    Type: Grant
    Filed: March 27, 2008
    Date of Patent: July 31, 2012
    Assignee: University of Iowa Research Foundation
    Inventors: Anton P. McCaffrey, Thomas J. Cradick
  • Patent number: 8231988
    Abstract: Battery electrodes with desirable discharge performance comprise manganese oxide and magnetic particles. Corresponding power cells have improved specific discharge capacities. Furthermore, magnetically modified manganese dioxide electrodes are found to have significantly improved cycling properties that suggest the possibility for improved performance in secondary batteries.
    Type: Grant
    Filed: February 8, 2006
    Date of Patent: July 31, 2012
    Assignee: University of Iowa Research Foundation
    Inventors: Johna Leddy, Joseph Tesene
  • Patent number: 8227134
    Abstract: Disclosed are self-hydrating membrane electrode assemblies (MEAs), including MEAs that have been magnetically modified, which comprises (i) a cathode comprising an electrically conducting material having a catalytic material on at least a portion of a first surface thereof, the catalytic material comprising an effective amount of at least one catalyst component and at least one ion conducting material; (ii) a separator adjacent to and in substantial contact with the first surface of the cathode and comprising an ion conducting material; and (iii) an anode adjacent to and in substantial contact with the surface of the separator opposite the cathode and comprising an electrically conducting material having a catalytic material on at least a portion of a surface thereof adjacent to the separator, the catalytic material comprising an effective amount of at least one catalyst component and at least one ion conducting material; wherein the separator permits water to pass from the first surface of the cathode to the
    Type: Grant
    Filed: October 15, 2003
    Date of Patent: July 24, 2012
    Assignee: University of Iowa Research Foundation
    Inventors: Johna Leddy, Wayne L. Gellett, Drew C. Dunwoody
  • Patent number: 8227635
    Abstract: The invention provides methods and an apparatus useful for site-isolating reagents or catalysts during chemical reactions. The methods and apparatus are useful for carrying out cascade or domino reactions.
    Type: Grant
    Filed: June 2, 2009
    Date of Patent: July 24, 2012
    Assignee: University of Iowa Research Foundation
    Inventors: Ned Bowden, Michael Brett Runge, Alan Lee Miller, III
  • Patent number: 8227592
    Abstract: The present invention is directed to nucleic acid molecules containing a loop sequence designed to circumvent exportin-5 mediated export, and methods using these novel molecules.
    Type: Grant
    Filed: November 28, 2007
    Date of Patent: July 24, 2012
    Assignee: University of Iowa Research Foundation
    Inventors: Scott Harper, Beverly L. Davidson
  • Patent number: 8204565
    Abstract: Disclosed is an implantable microspectrometer for the reagentless optical detection of an analyte in a sample fluid. The microspectrometer comprises an optical sampling cell having a cell housing defining a fluid inlet port and a fluid outlet port, the fluid inlet port configured to receive an optical sampling fluid from a test subject; an electromagnetic radiation source in communication with a first portion of the optical sampling cell housing and configured to irradiate at least a portion of the optical sampling fluid with electromagnetic radiation; and an electromagnetic radiation detector in communication with a second portion of the optical sampling cell housing and configured to detect electromagnetic radiation emanating from the optical sampling cell. In use, the implantable microspectrometer can optically detect at least one parameter of an analyte contained within the optical sampling fluid in the absence of an added reagent.
    Type: Grant
    Filed: April 4, 2006
    Date of Patent: June 19, 2012
    Assignee: University of Iowa Research Foundation
    Inventors: Mark A. Arnold, Jonathon T. Olesberg, Chris Coretsopoulos
  • Patent number: 8202688
    Abstract: The present invention relates generally to adjuvants, and in particular to methods and products utilizing a synergistic combination of immunostimulatory oligonucleotides having at least one unmethylated CpG dinucleotide (CpG ODN) and a non-nucleic acid adjuvant. Such combinations of adjuvants may be used with an antigen or alone. The present invention also relates to methods and products utilizing immunostimulatory oligonucleotides having at least one unmethylated CpG dinucleotide (CpG ODN) for induction of cellular immunity in infants.
    Type: Grant
    Filed: November 20, 2002
    Date of Patent: June 19, 2012
    Assignees: University of Iowa Research Foundation, Coley Pharmaceutical GmbH, Ottawa Health Research Institute
    Inventors: Heather L. Davis, Joachim Schorr, Arthur M. Krieg
  • Patent number: 8197911
    Abstract: An object of complex three-dimensional configuration, such as an automotive vehicle body, is coated with a combination of a coating formulation and a photoactivated mixture containing active centers that have been produced prior to application. The two liquids can be intimately mixed prior to application to the object, or the coating formulation can be applied prior to the application of the photoactivated mixture. The coating formulation is cured by the active centers that have been produced prior to application.
    Type: Grant
    Filed: June 8, 2007
    Date of Patent: June 12, 2012
    Assignees: Toyota Motor Engineering & Manufacturing North America, Inc., University of Iowa Research Foundation
    Inventors: Cynthia G. Templeman, Eric M. Leonard, Beth Ann Ficek, Alec B. Scranton
  • Patent number: 8194936
    Abstract: Methods and systems for image registration implementing a feature-based strategy that uses a retinal vessel network to identify features, uses an affine registration model estimated using feature correspondences, and corrects radial distortion to minimize the overall registration error. Also provided are methods and systems for retinal atlas generation. Further provided are methods and systems for testing registration methods.
    Type: Grant
    Filed: April 27, 2009
    Date of Patent: June 5, 2012
    Assignee: University of Iowa Research Foundation
    Inventors: Michael Abramoff, Meindert Niemeijer, Sangyeol Lee, Joseph Reinhardt
  • Patent number: 8189885
    Abstract: The present invention is an apparatus and method for computing regional statistical distributions or characteristics of one or more quantitative measures over a mean anatomic space for one or more predefined populations and uses this statistical distributions/characteristics to study, research or understand the regional response of a disease or a treatment process and to regionally assess clinical status in patient data from an unknown population for diagnostic purposes.
    Type: Grant
    Filed: February 15, 2008
    Date of Patent: May 29, 2012
    Assignee: The University of Iowa Research Foundation
    Inventors: Punam Kumar Saha, Milan Sonka
  • Patent number: RE43472
    Abstract: A novel isoform of tropomyosin is disclosed. The isoform is closely related to epithelial human tropomyosin (hTM) and more particularly to hTM5 except the last coding exon. The novel isoform, is called TC22. Northern blot analysis with TC22-specific probe revealed that normal culture cell lines and normal epithelial tissues expressed very little, if at all, TC22 message, whereas their transformed counterparts and tumor tissues including dysfunction of the alimentary canal, significantly increased the expression of TC22. Assays directed at determining the level of TC22 are useful in diagnostics and therapeutics of dysfunction of the alimentary canal. Specific antibodies and mimics for TC22 are also disclosed for use in diagnostics and therapeutics of dysfunction of the alimentary canal.
    Type: Grant
    Filed: October 23, 2009
    Date of Patent: June 12, 2012
    Assignees: University of Medicine and Dentistry of New Jersey, University of Iowa Research Foundation
    Inventors: Kiron M. Das, Jim Jung-Ching Lin