Patents Assigned to University of Iowa
  • Optimal, user-friendly, object background separation
    Patent number: 10140699
    Abstract: A method of identifying an object of interest can comprise obtaining first samples of an intensity distribution of one or more object of interest, obtaining second samples of an intensity distribution of confounder objects, transforming the first and second samples into an appropriate first space, performing dimension reduction on the transformed first and second samples, whereby the dimension reduction of the transformed first and second samples generates an object detector, transforming one or more of the digital images into the first space, performing dimension reduction on the transformed digital images, whereby the dimension reduction of the transformed digital images generates one or more reduced images, classifying one or more pixels of the one or more reduced images based on a comparison with the object detector, and identifying one ore more objects of interest from the classified pixels.
    Type: Grant
    Filed: December 6, 2011
    Date of Patent: November 27, 2018
    Assignee: University of Iowa Research Foundation
    Inventors: Michael Abramoff, Gwenole Quellec
  • Diagnostics and Therapeutics for Macular Degeneration-Related Disorders
    Publication number: 20180335436
    Abstract: The invention relates to methods for treating, preventing and diagnosing macular degeneration-related disorders.
    Type: Application
    Filed: February 15, 2018
    Publication date: November 22, 2018
    Applicant: University of Iowa Research Foundation
    Inventors: Gregory S. Hageman, Robert F. Mullins
  • Nucleic acid aptamers
    Patent number: 10113172
    Abstract: The present invention relates to optimized aptamers and methods of using these aptamers.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: October 30, 2018
    Assignee: University of Iowa Research Foundation
    Inventors: Paloma Giangrande, Francis Miller, William Thiel
  • Promoter compositions
    Patent number: 10105450
    Abstract: An isolated promoter sequence comprising a nucleic acid of between 600 and 1700 nucleotides in length having at least 90% identity to SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, or SEQ ID NO:7.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: October 23, 2018
    Assignee: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Edgardo Rodriguez, Alejandro Mas Monteys
  • Tumor vaccines and methods of use thereof
    Patent number: 10092635
    Abstract: The present invention provides a therapeutic agent comprising an antibody-recognition epitope (ARE) covalently bound to a tumor cell, wherein the ARE is bound to an antibody that is specific for the ARE, to form a tumor cell:ARE:antibody complex, and kits and methods of using these tumor cell:ARE:antibody complexes.
    Type: Grant
    Filed: January 30, 2014
    Date of Patent: October 9, 2018
    Assignee: University of Iowa Research Foundation
    Inventors: Tony Vanden Bush, Gail Bishop
  • Reduction of off-target RNA interference toxicity
    Patent number: 10093927
    Abstract: The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence, and methods of using these RNAi molecules to reduce off-target toxicity.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: October 9, 2018
    Assignee: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Alejandro Mas Monteys, Jodi McBride, Ryan Boudreau
  • RNA interference suppression of neurodegenerative diseases and methods of use
    Patent number: 10072264
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: September 11, 2018
    Assignee: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Haibin Xia, Qinwen Mao, Henry Paulson, Ryan Boudreau, Scott Harper
  • Floating electrodes that engage and accommodate movement of the spinal cord
    Patent number: 10071240
    Abstract: This invention provides a device for implantation directly into the spinal cord for the purpose of treating back pain. Electrodes on a backing that conforms directly to the spinal cord are installed as a source of electrical stimulation and pain relief. The floating electrodes can be flexibly mounted to the substrate such that when the electrode array is implanted into the subject, individual electrodes float or move resiliently relative to the substrate to an extent sufficient to accommodate pulsations of the surface of the spinal cord within the dura.
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: September 11, 2018
    Assignees: University of Iowa Research Foundation, University of Virgina Patent Foundation
    Inventors: Matthew A. Howard, Hiroyuki Oya, Steve Viljoen, Chandan G. Reddy, George T. Gillies
  • Methods of improving vaccine immunogenicity
    Patent number: 10059746
    Abstract: The present invention provides a process called “Immune Banking” that enhances vaccine efficacy by exploiting existing humoral responses. The process involves tagging new antigens with molecular markers recognized by an existing antibody response. This recognition of the tagged vaccine components enhances adaptive immune responses to the new vaccine.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: August 28, 2018
    Assignee: University of Iowa Research Foundation
    Inventors: Gail Bishop, Tony Vanden Bush
  • Compositions and methods for cancer therapy
    Patent number: 10052304
    Abstract: The invention provides compositions and methods to treat a hyperproliferative disorder with ascorbate or a pharmaceutically acceptable salt thereof, at least one chelating agent that enhances ascorbate redox cycling (EDTA) to form H2O2, and one or more anti-cancer therapies.
    Type: Grant
    Filed: October 12, 2016
    Date of Patent: August 21, 2018
    Assignee: University of Iowa Research Foundation
    Inventors: Bryan G. Allen, Douglas R. Spitz, Garry R. Buettner, Joseph Cullen, Joshua Schoenfeld, Michael Schultz, Fenghuang Zhan
  • SYSTEMS AND METHODS FOR CARDIOVASCULAR CONDITIONING
    Publication number: 20180214690
    Abstract: An example system has a pulse generator configured to deliver a first series of electrical signals to a right atrium of a heart. The first series of electrical signals can increase a first heart rate toward a target heart rate. The system can have a monitoring device configured to retrieve physiological data from a user of the system while the heart is receiving the first series of electrical signals. The system can have a controller configured to determine whether a physiological parameter has met a physiological threshold based on the physiological data. If the physiological threshold has been met, the controller can modify the first series of electrical signals to a second series of electrical signals that restores the physiological parameter to an acceptable level.
    Type: Application
    Filed: September 30, 2016
    Publication date: August 2, 2018
    Applicant: University of Iowa Research Foundation
    Inventors: Denice Marie Hodgson-Zingman, Leonid Vladimir Zingman
  • Method of inducing a cross-reactive HIV-1 immune response by administering a composition comprising the GBV-C E2 protein
    Patent number: 10034936
    Abstract: GB virus C (GBV-C or hepatitis G virus) is a flavivirus that frequently leads to chronic viremia in humans. The invention provides compositions and methods involving an anti-GBV-C antibody or other GBV-C binding agent, or a GBV-C antigen, for inhibiting and treating HIV infections.
    Type: Grant
    Filed: August 15, 2014
    Date of Patent: July 31, 2018
    Assignees: The University of Iowa Research Foundation, The United States of America as represented by the Secretary of the Department of Veterans Affairs
    Inventors: Jack T. Stapleton, Jinhua Xiang, Donna Klinzman, James H. McLinden
  • Close-proximity range shifting device for proton radiosurgery
    Patent number: 10035025
    Abstract: A range shifting device configured to be placed close to a portion of a body of a patient during radiation beam treatment. The radiation beam treatment can include stereotactic radiosurgery (SRS). The range shifting device can be incorporated into an existing SRS localization system during SRS treatment. The range shifting device is configured to be placed close to the head of a patient during SRS treatment. The range shifting device is comprised of range shifting material. The range shifting device can be a range shifting helmet. The range shifting helmet can include a hollow frame including a plurality of apertures in which inserts made of range shifting material can be inserted.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: July 31, 2018
    Assignee: University of Iowa Research Foundation
    Inventors: Dongxu Wang, Daniel Hyer, Blake Dirksen
  • HTS Assay for Identifying Small Molecule Inhibitors of RAD52 and Uses of Identified Small Molecule Inhibitors for Treatment and Prevention of BRCA-Deficient Malignancies
    Publication number: 20180209956
    Abstract: Disclosed are methods, compositions, kits, and systems for identifying small-molecule drugs for treating cancer in a subject. The disclosed methods, compositions, kits, and systems may be utilized to identify small-molecule inhibitors of radiation sensitive protein 52 (RAD52) in order to treat cancer in a subject, such as breast cancer in a subject having a BRCA1-deficient, BRCA2-deficient, and/or PALB2-deficient phenotype by administering the identified small-molecule inhibitors to the subject.
    Type: Application
    Filed: July 11, 2016
    Publication date: July 26, 2018
    Applicant: University of Iowa Research Foundation
    Inventors: Michael Ashley Spies, Maria Spies, Sarah R. Hengel
  • Advanced rotating-shield brachytherapy and planning of the same
    Patent number: 10029118
    Abstract: Systems and methods for rotating shield brachytherapy. In an aspect, some of the systems and methods can be used to facilitate shield selection for use in rotating shield brachytherapy. In an aspect, the invention is a shielded needle or catheter system with a rotational controller for delivering radioisotope-based interstitial rotating shield brachytherapy (I-RSBT). In an aspect, the catheter system can utilize paddle-based RSBT. Further provided are methods and systems for helical RSBT.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: July 24, 2018
    Assignee: University of Iowa Research Foundation
    Inventors: Ryan Flynn, Hossein Dadkhah
  • BST-2 AS A THERAPEUTIC TARGET AND DIAGNOSTIC MARKER FOR BREAST CANCER GROWTH AND METASTASIS
    Publication number: 20180200331
    Abstract: Disclosed are compositions, kits, and methods for treating and/or diagnosing cancer in a subject in need thereof. The compositions, kits, and methods may be used to treat and/or diagnose cancers associated with BST-2 expression and/or BST-2 biological activity. Also disclosed are reagents that inhibit dimerization of BST-2 which may be administered as therapeutic agents for inhibiting BST-2 biological activity and treating cancers associated with BST-2 biological activity.
    Type: Application
    Filed: July 11, 2016
    Publication date: July 19, 2018
    Applicant: University of Iowa Research Foundation
    Inventors: Chioma M. Okeoma, Wadie D. Mahauad-Fernandez
  • Alternative export pathways for vector expressed RNA interference
    Patent number: 10006028
    Abstract: The present invention is directed to nucleic acid molecules containing a loop sequence designed to circumvent exportin-5 mediated export, and methods using these novel molecules.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: June 26, 2018
    Assignee: University of Iowa Research Foundation
    Inventors: Scott Harper, Beverly L. Davidson
  • Transgenic pig models of cystic fibrosis
    Patent number: 10004212
    Abstract: This invention relates to transgenic pig models of cystic fibrosis, cells that can be used to make such animals, and methods of making and using these pigs and cells.
    Type: Grant
    Filed: April 24, 2017
    Date of Patent: June 26, 2018
    Assignee: University of Iowa Research Foundation
    Inventors: Michael J. Welsh, David Stoltz
  • Methods of improving RNAi in well-differentiated airway epithelia
    Patent number: 9987299
    Abstract: The present invention relates to methods of reducing a level of a target mRNA in a well-differentiated airway epithelial cell by contacting the cell with a facilitating agent followed by contacting the cell with a therapeutic RNAi agent, wherein the facilitating agent comprises a Platelet-activating factor receptor (PAFR) ligand.
    Type: Grant
    Filed: May 4, 2015
    Date of Patent: June 5, 2018
    Assignee: University of Iowa Research Foundation
    Inventors: Paul B. McCray, Jr., Beverly L. Davidson, Michael A. Apicella, Sateesh Krishnamurthy
  • METHODS FOR TREATING TUMORS IN SITU INCLUDING INTRATUMOR INJECTION OF CYTOTOXIC PARTICLES AND IMMUNE CHECKPOINT BLOCKADE THERAPY
    Publication number: 20180147224
    Abstract: Disclosed are compositions, kits, and methods for treating cancer in a subject in need thereof. The compositions, kits, and methods may be used to treat a tumor in a subject in situ. The compositions, kits, and methods comprise or utilize cytotoxic particles, immune checkpoint inhibitors, and/or T-cell stimulatory agents.
    Type: Application
    Filed: May 16, 2016
    Publication date: May 31, 2018
    Applicant: University of Iowa Research Foundation
    Inventors: Aliasger K. Salem, Amani Makkouk, Vijaya B. Joshi, George Weiner