Patents Assigned to University of Jerusalem
  • Publication number: 20160120880
    Abstract: Compositions and methods for treating diseases or disorders associated with the metabolic syndrome using conjugates of bile acids with basic amino acids or a decarboxylated amino acid such as agmatine are provided. Further provided are bile acid-basic amino acid conjugates including chenodeoxycholic acid with an amino acid selected from arginine, lysine, histidine, ornithine or a decarboxylated amino acid such as agmatine.
    Type: Application
    Filed: June 5, 2014
    Publication date: May 5, 2016
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Oren TIROSH, Ira VOLOSHIN, Shlomo SASSON, Michal OBERCYGER, Zecharia MADAR
  • Patent number: 9315818
    Abstract: A Geminivirus based expression construct being capable of systemic symptomeless spread in a plant host is provided as well as methods of utilizing same for plant gene expression, gene silencing and plant protection.
    Type: Grant
    Filed: June 7, 2007
    Date of Patent: April 19, 2016
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem, Morflora Israel Ltd.
    Inventors: Ilan Sela, Rita Mozes-Koch, Yuval Peretz, Herve Huet
  • Patent number: 9306168
    Abstract: Provided are thermo-sensitive and light-sensitive polymer compositions including poly(4-vinyl pyridine) and poly(4-vinyl pyridine-co-butyl methacrylate).
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: April 5, 2016
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Evgenia Vaganova, Shlomo Yitzchaik
  • Patent number: 9291619
    Abstract: A method of quantifying non-transferrin bound iron (NTBI) in a biological fluid is provided, the method comprising: (a) contacting a sample of the biological fluid with a reducing agent to obtain redox-active iron; (b) contacting the sample of the biological fluid with a nitrilotriacetate (NTA) at a concentration of 0.4-2 mM to mobilize non-transferrin bound iron including redox inactive and the redox active iron in the sample; (c) contacting the sample of the biological fluid of step (b) with an indicator including an iron binding moiety and fluorophore; and (d) detecting and quantifying a fluorescent signal of the fluorophore thereby quantifying the NTBI in the biological sample.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: March 22, 2016
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Ioav Zvi Cabantchik, William Breuer
  • Patent number: 9273152
    Abstract: Isolated polypeptides are disclosed comprising an amino acid sequence encoding a monomer of a fibrous polypeptide attached to a heterologous polysaccharide binding domain. Composites comprising same, methods of generating same and uses thereof are all disclosed.
    Type: Grant
    Filed: December 8, 2014
    Date of Patent: March 1, 2016
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., CollPlant Ltd.
    Inventors: Oded Shoseyov, Shaul Lapidot, Sigal Meirovitch, Daniel L Siegel
  • Publication number: 20160053005
    Abstract: Among other findings, the subject matter is based on the identification that p14 peptide is expressed in mammary carcinoma cells harboring MMTV. Thus, provided are methods for diagnosing breast cancer in subjects comprising determining the levels of expression of the peptide or the levels of anti-p14 antibodies produced in the subject to the peptide. Further provided are screening methods of individuals with high probability of having breast cancer as well as to therapeutic methods; pharmaceutical compositions and vaccine making use of the anti-p14 antibodies or p14 peptides or produced thereby.
    Type: Application
    Filed: November 9, 2015
    Publication date: February 25, 2016
    Applicant: Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd.
    Inventor: Jacob HOCHMAN
  • Patent number: 9256927
    Abstract: A method and apparatus for enhancing a digital photographic image uses a combination of global and content-specific operations. Image data is analyzed to detect one or more content items in the image to be separately enhanced. Then a content-specific enhancement operation is performed on data representing at least one detected content item, separately from the remainder of the image data. Several such content-specific operations may be performed for different types of content item. The content-specific enhancement operation comprises manipulating data, and the manipulation applies different adjustments to different pixels in the detected content item and the determination of the adjustments is based solely on analysis of the image data. Then a different enhancement operation is performed on at least the remaining image data excluding said one or more detected content items.
    Type: Grant
    Filed: July 8, 2013
    Date of Patent: February 9, 2016
    Assignee: Yissum Research Development Companyof The Hebrew University of Jerusalem Ltd.
    Inventors: Daniel Lischinski, Michael Werman, Liad Kaufman
  • Patent number: 9236215
    Abstract: The present invention discloses a system and method for generating a beam of fast ions. The system comprising: a target substrate having a patterned surface, a pattern comprising nanoscale pattern features oriented substantially uniformly along a common axis; and; a beam unit adapted for receiving a high power coherent electromagnetic radiation beam and providing an electromagnetic radiation beam having a main pulse and a pre-pulse and focusing it onto said patterned surface of the target substrate to cause interaction between said radiation beam and said substrate enabling creation of fast ions.
    Type: Grant
    Filed: January 29, 2013
    Date of Patent: January 12, 2016
    Assignees: HIL Applied Medical, Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem, LTD.
    Inventors: Arie Zigler, Shmuel Eisenmann, Tala Palchan, Sagi Brink-Danan, Eyal Gad Nahum
  • Publication number: 20150329578
    Abstract: The present application provides a family of highly resistant and water-stable Titanium and Vanadium complexes, which may be administered directly without a further hydrolysis step and which solubility and cell-penetration characteristics may be modifiable by reducing their particle size to the nanoscale.
    Type: Application
    Filed: August 15, 2013
    Publication date: November 19, 2015
    Applicant: Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd.
    Inventors: Edit TSHUVA, Jacob HOCHMAN
  • Patent number: 9187787
    Abstract: A method of diagnosing and treating a glioma or a breast cancer is disclosed. The method of diagnosing comprises analyzing an amount or activity of heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) in a brain or breast cell sample of the subject, wherein an up-regulation in an amount or activity of hnRNP A2/B1 beyond a predetermined threshold with respect to a control cell sample is indicative of the breast cancer or glioma. The method may also be used for staging the cancer and for predicting patient's prognosis of survival. The method of treating glioblastoma and metastatic breast cancer includes inhibiting the expression and/or activity of hnRNP A2/B1.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: November 17, 2015
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventor: Karni Rotem
  • Patent number: 9173964
    Abstract: The present invention relates to the field of cancer treatment, particularly to a novel constructs useful for treating tumors expressing H19 and/or IGF-II. More specifically, the invention provides compositions and methods utilizing a nucleic acid construct enabling expression of a cytotoxic gene product directed by more than one tumor specific promoter.
    Type: Grant
    Filed: October 23, 2008
    Date of Patent: November 3, 2015
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Avraham Hochberg, Doron Amit
  • Patent number: 9161545
    Abstract: Biocontrol agents are provided, which protect plant and plant material from pests and pathogens, and promote the growth of plants. Also provided are compositions comprising the same, methods for protecting plant and plant material and promoting growth in plants, and uses of said biocontrol agent in the preparation of a pesticidal composition and a growth-promoting composition.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: October 20, 2015
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Marganit Levy, Aviva Gafni
  • Patent number: 9163067
    Abstract: Isolated peptides comprising sequences derived from the protein integrase of HIV-1, as well as their analogs, mixtures, conjugates with permeability enhancing moieties, and pharmaceutical compositions are disclosed. The peptides and compositions are capable of selectively killing HIV-1 infected cells and are used in treatment of HIV infection and AIDS.
    Type: Grant
    Filed: October 1, 2009
    Date of Patent: October 20, 2015
    Assignee: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd
    Inventors: Aviad Levin, Zvi Hayouka, Assaf Friedler, Abraham Loyter
  • Publication number: 20150273076
    Abstract: SP1 and modified SP1 variant polypeptides capable of forming reversible molecular associations with substances, compositions-of-matter comprising same, and uses thereof are provided.
    Type: Application
    Filed: June 7, 2015
    Publication date: October 1, 2015
    Applicants: Fulcrum SP Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Amnon WOLF, Yehonathan Pouny, Ira Marton, Or Dgany, Arie Altman, Oded Shoseyov
  • Patent number: 9145463
    Abstract: Isolated polypeptides are disclosed comprising an amino acid sequence encoding a monomer of a fibrous polypeptide attached to a heterologous polysaccharide binding domain. Composites comprising same, methods of generating same and uses thereof are all disclosed.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: September 29, 2015
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., CollPlant Ltd.
    Inventors: Oded Shoseyov, Shaul Lapidot, Sigal Meirovitch, Daniel L. Siegel
  • Patent number: 9133231
    Abstract: Rel proteins as a novel therapeutic agent for treating bacterial threats. More specifically, a novel class of compounds of Formula (I) as disclosed herein which possess antibacterial activity and which inhibit RelA, RelSeq or RelSpo synthetic activity or bacterial spore formation. Also, pharmaceutical compositions of such compounds and a method of combating bacteria, or treating bacterial infections, by administering to a subject in need thereof such compounds or pharmaceutical compositions.
    Type: Grant
    Filed: August 3, 2011
    Date of Patent: September 15, 2015
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Ezequiel Wexselblatt, Joshua Katzhendler, Ilana Kaspy, Gad Glaser, Roee Vidavski, Hafiz Mawasi, Sigal Ben Yehuda, Yaara Oppenheimer-Shaanan
  • Publication number: 20150232875
    Abstract: The present invention provides means and methods for simple and efficient introduction of foreign genetic material into the plant cell. Particularly, the present invention combines seed priming and virus-based DNA constructs for efficient introduction of heterologous DNA into plants.
    Type: Application
    Filed: March 8, 2015
    Publication date: August 20, 2015
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Ilan SELA, Haim David Rabinowitch, Ofer Gover
  • Patent number: 9109047
    Abstract: The present invention relates to methods for generation of high molecular ordered fibrilar structures. More particularly, the method of the invention utilizes CBD's (cellulose binding domain) ability to form dimers for directing ordered assembly of fibrous proteins such as silk proteins into super-molecular fibrilar structures. The invention further provides fibrilar structures such as fibers and articles comprising said fibrilar structures.
    Type: Grant
    Filed: February 2, 2012
    Date of Patent: August 18, 2015
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd
    Inventors: Oded Shoseyov, Shaul Lapidot, Sigal Meirovitch
  • Patent number: 9095603
    Abstract: The present invention relates to particles of glucans, particularly oxidized cellulosed for use in medicine. The invention further discloses pharmaceutical compositions for the treatment and/or prophylaxis of diseases or disorders associated with or mediated by allergens.
    Type: Grant
    Filed: April 10, 2007
    Date of Patent: August 4, 2015
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventor: Oded Shoseyov
  • Patent number: 9095133
    Abstract: The present invention provides a redispersible powder and aqueous dispersions of nanoparticles of water insoluble organic pesticides. The invention further provides methods for preparing the redispersible powder and the aqueous dispersion, wherein the methods include preparation of an oil-in-water nanoemulsion or microemulsion and solvent removal. The present invention also provides pesticidal compositions of the redispersible powder or aqueous dispersions, and their agricultural use in combating pests.
    Type: Grant
    Filed: September 16, 2007
    Date of Patent: August 4, 2015
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Shlomo Magdassi, Benny Dayan, Ganit Levi-Ruso