Abstract: Compositions and methods for treating diseases or disorders associated with the metabolic syndrome using conjugates of bile acids with basic amino acids or a decarboxylated amino acid such as agmatine are provided. Further provided are bile acid-basic amino acid conjugates including chenodeoxycholic acid with an amino acid selected from arginine, lysine, histidine, ornithine or a decarboxylated amino acid such as agmatine.
Type:
Application
Filed:
June 5, 2014
Publication date:
May 5, 2016
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventors:
Oren TIROSH, Ira VOLOSHIN, Shlomo SASSON, Michal OBERCYGER, Zecharia MADAR
Abstract: A Geminivirus based expression construct being capable of systemic symptomeless spread in a plant host is provided as well as methods of utilizing same for plant gene expression, gene silencing and plant protection.
Type:
Grant
Filed:
June 7, 2007
Date of Patent:
April 19, 2016
Assignees:
Yissum Research Development Company of the Hebrew University of Jerusalem, Morflora Israel Ltd.
Inventors:
Ilan Sela, Rita Mozes-Koch, Yuval Peretz, Herve Huet
Abstract: Provided are thermo-sensitive and light-sensitive polymer compositions including poly(4-vinyl pyridine) and poly(4-vinyl pyridine-co-butyl methacrylate).
Type:
Grant
Filed:
June 21, 2012
Date of Patent:
April 5, 2016
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: A method of quantifying non-transferrin bound iron (NTBI) in a biological fluid is provided, the method comprising: (a) contacting a sample of the biological fluid with a reducing agent to obtain redox-active iron; (b) contacting the sample of the biological fluid with a nitrilotriacetate (NTA) at a concentration of 0.4-2 mM to mobilize non-transferrin bound iron including redox inactive and the redox active iron in the sample; (c) contacting the sample of the biological fluid of step (b) with an indicator including an iron binding moiety and fluorophore; and (d) detecting and quantifying a fluorescent signal of the fluorophore thereby quantifying the NTBI in the biological sample.
Type:
Grant
Filed:
October 4, 2012
Date of Patent:
March 22, 2016
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: Isolated polypeptides are disclosed comprising an amino acid sequence encoding a monomer of a fibrous polypeptide attached to a heterologous polysaccharide binding domain. Composites comprising same, methods of generating same and uses thereof are all disclosed.
Type:
Grant
Filed:
December 8, 2014
Date of Patent:
March 1, 2016
Assignees:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., CollPlant Ltd.
Inventors:
Oded Shoseyov, Shaul Lapidot, Sigal Meirovitch, Daniel L Siegel
Abstract: Among other findings, the subject matter is based on the identification that p14 peptide is expressed in mammary carcinoma cells harboring MMTV. Thus, provided are methods for diagnosing breast cancer in subjects comprising determining the levels of expression of the peptide or the levels of anti-p14 antibodies produced in the subject to the peptide. Further provided are screening methods of individuals with high probability of having breast cancer as well as to therapeutic methods; pharmaceutical compositions and vaccine making use of the anti-p14 antibodies or p14 peptides or produced thereby.
Type:
Application
Filed:
November 9, 2015
Publication date:
February 25, 2016
Applicant:
Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: A method and apparatus for enhancing a digital photographic image uses a combination of global and content-specific operations. Image data is analyzed to detect one or more content items in the image to be separately enhanced. Then a content-specific enhancement operation is performed on data representing at least one detected content item, separately from the remainder of the image data. Several such content-specific operations may be performed for different types of content item. The content-specific enhancement operation comprises manipulating data, and the manipulation applies different adjustments to different pixels in the detected content item and the determination of the adjustments is based solely on analysis of the image data. Then a different enhancement operation is performed on at least the remaining image data excluding said one or more detected content items.
Type:
Grant
Filed:
July 8, 2013
Date of Patent:
February 9, 2016
Assignee:
Yissum Research Development Companyof The Hebrew University of Jerusalem Ltd.
Inventors:
Daniel Lischinski, Michael Werman, Liad Kaufman
Abstract: The present invention discloses a system and method for generating a beam of fast ions. The system comprising: a target substrate having a patterned surface, a pattern comprising nanoscale pattern features oriented substantially uniformly along a common axis; and; a beam unit adapted for receiving a high power coherent electromagnetic radiation beam and providing an electromagnetic radiation beam having a main pulse and a pre-pulse and focusing it onto said patterned surface of the target substrate to cause interaction between said radiation beam and said substrate enabling creation of fast ions.
Type:
Grant
Filed:
January 29, 2013
Date of Patent:
January 12, 2016
Assignees:
HIL Applied Medical, Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem, LTD.
Abstract: The present application provides a family of highly resistant and water-stable Titanium and Vanadium complexes, which may be administered directly without a further hydrolysis step and which solubility and cell-penetration characteristics may be modifiable by reducing their particle size to the nanoscale.
Type:
Application
Filed:
August 15, 2013
Publication date:
November 19, 2015
Applicant:
Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd.
Abstract: A method of diagnosing and treating a glioma or a breast cancer is disclosed. The method of diagnosing comprises analyzing an amount or activity of heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) in a brain or breast cell sample of the subject, wherein an up-regulation in an amount or activity of hnRNP A2/B1 beyond a predetermined threshold with respect to a control cell sample is indicative of the breast cancer or glioma. The method may also be used for staging the cancer and for predicting patient's prognosis of survival. The method of treating glioblastoma and metastatic breast cancer includes inhibiting the expression and/or activity of hnRNP A2/B1.
Type:
Grant
Filed:
June 16, 2011
Date of Patent:
November 17, 2015
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: The present invention relates to the field of cancer treatment, particularly to a novel constructs useful for treating tumors expressing H19 and/or IGF-II. More specifically, the invention provides compositions and methods utilizing a nucleic acid construct enabling expression of a cytotoxic gene product directed by more than one tumor specific promoter.
Type:
Grant
Filed:
October 23, 2008
Date of Patent:
November 3, 2015
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: Biocontrol agents are provided, which protect plant and plant material from pests and pathogens, and promote the growth of plants. Also provided are compositions comprising the same, methods for protecting plant and plant material and promoting growth in plants, and uses of said biocontrol agent in the preparation of a pesticidal composition and a growth-promoting composition.
Type:
Grant
Filed:
February 5, 2014
Date of Patent:
October 20, 2015
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: Isolated peptides comprising sequences derived from the protein integrase of HIV-1, as well as their analogs, mixtures, conjugates with permeability enhancing moieties, and pharmaceutical compositions are disclosed. The peptides and compositions are capable of selectively killing HIV-1 infected cells and are used in treatment of HIV infection and AIDS.
Type:
Grant
Filed:
October 1, 2009
Date of Patent:
October 20, 2015
Assignee:
Yissum Research Development Company of The Hebrew University of Jerusalem Ltd
Inventors:
Aviad Levin, Zvi Hayouka, Assaf Friedler, Abraham Loyter
Abstract: SP1 and modified SP1 variant polypeptides capable of forming reversible molecular associations with substances, compositions-of-matter comprising same, and uses thereof are provided.
Type:
Application
Filed:
June 7, 2015
Publication date:
October 1, 2015
Applicants:
Fulcrum SP Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem
Inventors:
Amnon WOLF, Yehonathan Pouny, Ira Marton, Or Dgany, Arie Altman, Oded Shoseyov
Abstract: Isolated polypeptides are disclosed comprising an amino acid sequence encoding a monomer of a fibrous polypeptide attached to a heterologous polysaccharide binding domain. Composites comprising same, methods of generating same and uses thereof are all disclosed.
Type:
Grant
Filed:
March 13, 2014
Date of Patent:
September 29, 2015
Assignees:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., CollPlant Ltd.
Inventors:
Oded Shoseyov, Shaul Lapidot, Sigal Meirovitch, Daniel L. Siegel
Abstract: Rel proteins as a novel therapeutic agent for treating bacterial threats. More specifically, a novel class of compounds of Formula (I) as disclosed herein which possess antibacterial activity and which inhibit RelA, RelSeq or RelSpo synthetic activity or bacterial spore formation. Also, pharmaceutical compositions of such compounds and a method of combating bacteria, or treating bacterial infections, by administering to a subject in need thereof such compounds or pharmaceutical compositions.
Type:
Grant
Filed:
August 3, 2011
Date of Patent:
September 15, 2015
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: The present invention provides means and methods for simple and efficient introduction of foreign genetic material into the plant cell. Particularly, the present invention combines seed priming and virus-based DNA constructs for efficient introduction of heterologous DNA into plants.
Type:
Application
Filed:
March 8, 2015
Publication date:
August 20, 2015
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventors:
Ilan SELA, Haim David Rabinowitch, Ofer Gover
Abstract: The present invention relates to methods for generation of high molecular ordered fibrilar structures. More particularly, the method of the invention utilizes CBD's (cellulose binding domain) ability to form dimers for directing ordered assembly of fibrous proteins such as silk proteins into super-molecular fibrilar structures. The invention further provides fibrilar structures such as fibers and articles comprising said fibrilar structures.
Type:
Grant
Filed:
February 2, 2012
Date of Patent:
August 18, 2015
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd
Abstract: The present invention relates to particles of glucans, particularly oxidized cellulosed for use in medicine. The invention further discloses pharmaceutical compositions for the treatment and/or prophylaxis of diseases or disorders associated with or mediated by allergens.
Type:
Grant
Filed:
April 10, 2007
Date of Patent:
August 4, 2015
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: The present invention provides a redispersible powder and aqueous dispersions of nanoparticles of water insoluble organic pesticides. The invention further provides methods for preparing the redispersible powder and the aqueous dispersion, wherein the methods include preparation of an oil-in-water nanoemulsion or microemulsion and solvent removal. The present invention also provides pesticidal compositions of the redispersible powder or aqueous dispersions, and their agricultural use in combating pests.
Type:
Grant
Filed:
September 16, 2007
Date of Patent:
August 4, 2015
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem