Abstract: A method of tonally stabilizing a video sequence is provided herein. The method includes the following stages: automatically selecting one or more anchor frames from a sequence of frames; obtaining an anchor adjustment map for each selected anchor frame; applying an edge-preserving smoothing algorithm to the sequence of frames; generating for any given pair of smoothed frames, a robust set of pixels indicating pixels affected by external tonal fluctuation only; initializing an adjustment map for any given frame by applying the anchor adjustment map to accumulated color differences between pixels of the robust set of the given frame and the anchor frame; and completing the initialized adjustment map by predicting values of pixels in each adjustment map not included in the robust set by applying an interpolation at a color space for these pixels, wherein the adjustment maps are usable for tonally aligning the video sequence with the anchor frame.
Type:
Grant
Filed:
April 18, 2012
Date of Patent:
August 4, 2015
Assignee:
Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
Abstract: The present invention provides methods for desensitization for prevention or diminishing hypersensitivity reactions including C activation-related pseudoallergy (CARPA) and other reactions to particulate medicines. The desensitization is performed via pretreatment using a drug-free vehicle or carrier to eliminate or diminish the clinical symptoms of hypersensitivity.
Type:
Grant
Filed:
December 7, 2008
Date of Patent:
July 14, 2015
Assignees:
The Bay Zoltan Foundation for Applied Research, Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: Methods for the treatment and prevention of neural cell and neuro-pathological disorders are provided, comprising contacting the neural cells, or administering to a subject in need thereof, botanical raw material (BRM) or an extract obtainable from passion fruits. Compositions, as well as a nutraceutical composition comprising the same are also provided.
Type:
Application
Filed:
January 15, 2015
Publication date:
July 2, 2015
Applicants:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., The State of Israel, Ministry of Agriculture & Rural Dept, Agricultural Research Org. (ARO
Abstract: A system for qualifying cells of a cell sample labeled with a magnetic or magnetizable moiety is provided. The system includes a cell sample holder for holding a cell of the cells and a first cell analyzer which includes a magnetic field source for applying a magnetic field to the cell and a sensor for qualifying and/or quantifying an effect of the magnetic field on the cell.
Type:
Application
Filed:
January 6, 2015
Publication date:
June 11, 2015
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem
Inventors:
Dan GAZIT, Boris RUBINSKY, Gadi PELLED, Zulma GAZIT
Abstract: SP1 and modified SP1 variant polypeptides capable of forming reversible molecular associations with substances, compositions-of-matter comprising same, and uses thereof are provided.
Type:
Grant
Filed:
July 9, 2006
Date of Patent:
June 9, 2015
Assignees:
Fulcrum SP Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem
Inventors:
Amnon Wolf, Yehonathan Pouny, Ira Marton, Or Dgany, Arie Altman, Oded Shoseyov
Abstract: Provided are novel compositions exhibiting highly effective antiviral, antimicrobial and/or antifungal activity. The compositions of the invention can be used for sanitizing and/or disinfecting surfaces, e.g., inanimate and/or animate surfaces. Preferred compositions include a synergistic combination of an alcohol, docusate, geraniol and, optionally, menthol. The invention provides compositions that have high antimicrobial activity, yet are mild, non-irritating, quick drying, non-sticky and not drying to the skin. Processes for manufacturing and using the compositions and products containing such compositions are also disclosed.
Type:
Grant
Filed:
October 1, 2010
Date of Patent:
May 5, 2015
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: The present invention provides microspheres comprising a plurality of nanocapsules accommodated in a gel forming polymer, the plurality of nanocapsules comprising an oil core carrying a non hydrophilic active agent and a shell of polymeric coating. The invention also provides a method for preparing the microspheres of the invention, pharmaceutical compositions comprising the same as well as methods of use of the microspheres, specifically, in therapeutic, cosmetic and diagnostic applications.
Type:
Grant
Filed:
July 23, 2008
Date of Patent:
May 5, 2015
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem
Abstract: The present invention discloses a method of inhibiting an ethylene response in a plant, comprising step of applying to at least one portion of the plant an effective ethylene response-inhibiting amount of a H1-cyclopropene-1-propanoic acid salt (CPAS). A method of prolonging the life of a cut flower, comprising applying to the cut flower an effective life-prolonging amount of CPAS and a method for the production a CPAS, comprising steps of (i) preparing 4-bromo-4-pentenoic acid or derivatives thereof; (ii) producing 1-cyclopropene-1-propanoic acid; and (iii), converting this acid into its water soluble salt, especially its sodium salt are presented. Additionally, a new family of water soluble CPAS inhibitors for ethylene response in a plant is disclosed.
Type:
Grant
Filed:
July 17, 2008
Date of Patent:
May 5, 2015
Assignees:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., North Carolina State University
Inventors:
Raffi Goren, Akiva Apelbaum, Eliezer Goldschmidt, Moshe Huberman, Joseph Riov, Edward C. Sisler
Abstract: In one embodiment, the invention provides a method of suppressing, inhibiting, preventing, or treating conjunctivitis in a subject, comprising the step of administering an effective amount of a lipid or phospholipid moiety bound via an ester or amide bond to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof to a subject with conjunctivitis.
Type:
Grant
Filed:
January 9, 2013
Date of Patent:
April 21, 2015
Assignee:
Yissum Research Development Company of The Hebrew University of Jerusalem
Abstract: Isolated peptides comprising no more than ten amino acids and having anti-bacterial properties are disclosed. In one embodiment the peptides have a consensus amino acid sequence X1X2X3X4X5, wherein X1 and X5 comprise polar amino acids. In another embodiment, the peptides have a consensus amino acid sequence X1X2X3X4X5, wherein X2 and X4 are asparagine (N) residues and X3 is tryptophan (W). Compositions comprising same are also disclosed and uses thereof.
Type:
Grant
Filed:
January 8, 2008
Date of Patent:
April 21, 2015
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem
Inventors:
Hanna Engelberg-Kulka, Ilana Kolodkin-Gal
Abstract: A method for deriving a blur kernel from a blurred image is provided herein. The method may include the following steps: obtaining a blurred image B, being a product of a blur kernel k applied to an original image I; calculating f?(x)=Rd*P?(B)(x) for every angle ?, wherein R denotes an autocorrelation operator, P? denotes a projection operator of based on angle ?, and d denotes a one dimensional differentiation filter; estimating spectral power of the blur kernel based on a given support parameter; estimating the blur kernel k using a phase retrieval algorithm, based on the estimated spectral power of the blur kernel; updating the support parameters; and repeating the estimating of the spectral power, the estimating of the kernel and the updating of the support parameters in an iterative, to yield the blur kernel.
Type:
Grant
Filed:
June 25, 2013
Date of Patent:
April 14, 2015
Assignee:
Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
Abstract: The present invention relates to novel metalloproteinase inhibitors having an aryloxybenzenesulfonamide moiety and a carbamoylphosphonic acid moiety, to pharmaceutical compositions comprising them, and to their uses in the prevention and/or treatment of disease or disorder associated with MMP.
Type:
Grant
Filed:
February 9, 2010
Date of Patent:
March 31, 2015
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd.
Inventors:
Eli Breuer, Reuven Reich, Julia Frant, Amnon Hoffman, Veerendhar Ainelly
Abstract: The invention relates to use of the natural cytotoxicity receptor NKp46 for preventing and treating diabetes, including type I diabetes (TID) and type 2 diabetes. In particular, the invention provides compositions comprising a fragment of the extracellular region of NKp46 for preventing the onset and progression of diabetes.
Type:
Grant
Filed:
April 15, 2013
Date of Patent:
March 17, 2015
Assignees:
Ben-Gurion University of the Negev Research and Development Authority, Hadasit Medical Research Services and Development Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd.
Inventors:
Ofer Mandelboim, Angel Porgador, Yaakov Naparstek, Chamutal Gur
Abstract: The present invention relates to novel peptide sequences, compositions and methods for controlling fish reproduction. More particularly, the invention provides novel Neurokinin B peptides NKF and NKB and analogues thereof that regulate reproduction in fish. The invention further provides preprohormone thereof comprising at least one of a first peptide fragment of the amino acid sequence X1-X2-X3-X4-X5-X6-Asp7-X8-Phe9-Val10-X11-Leu12-Met13 and a second peptide fragment of the amino acid sequence of Glu1-Met2-His3-Asp4-Ile5-Phe6-Val7-Gly8-Leu9-Met10 and variants thereof, nucleic acid sequences and novel fish NKB receptors.
Type:
Application
Filed:
August 1, 2012
Publication date:
March 12, 2015
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: Biocontrol agents are provided, which protect plant and plant material from pests and pathogens, and promote the growth of plants. Also provided are compositions comprising the same, methods for protecting plant and plant material and promoting growth in plants, and uses of said biocontrol agent in the preparation of a pesticidal composition and a growth-promoting composition.
Type:
Grant
Filed:
May 31, 2011
Date of Patent:
March 10, 2015
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: The present invention provides means and methods for simple and efficient introduction of foreign genetic material into the plant cell. Particularly, the present invention combines seed priming and virus-based DNA constructs for efficient introduction of heterologous DNA into plants.
Type:
Grant
Filed:
June 30, 2010
Date of Patent:
March 10, 2015
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventors:
Ilan Sela, Haim David Rabinowitch, Ofer Gover
Abstract: The present invention relates to methods kits and combined compositions using DFO-metal complexes, specifically, Zinc-desferrioxamine (Zn-DFO), gallium-desferrioxamine (Ga-DFO) complexes and any combinations thereof for preventing, treating, ameliorating or inhibiting an immune-related disorder, specifically, a skin-related inflammatory disorder such as psoriasis, an inflammatory respiratory condition such as asthma, and an autoimmune disease such as diabetes and any immune-related disorder.
Type:
Grant
Filed:
August 19, 2010
Date of Patent:
March 10, 2015
Assignees:
Hadasit Medical Research Services and Development Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventors:
Mordechai Chevion, Vladimir Vinokur, Eduard Berenshtein, Ron Eliashar, Baruch Bulvik
Abstract: Leptin muteins, in particular leptin antagonists, with increased binding affinity to leptin receptor are provided. These compounds as well as pharmaceutical composition comprising them are useful for the treatment of any disorder in which a non-desirable or deleterious activity of endogenous leptin or an altered innate immune response is implicated.
Type:
Grant
Filed:
April 17, 2011
Date of Patent:
March 3, 2015
Assignees:
The Medical Research, Infrastructure, and Health Services Fund of the Tel-Aviv Medical Center, Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventors:
Arieh Gertler, Eran Elinav, Zamir Halpern
Abstract: An isolated nucleic acid agent is disclosed comprising a nucleic acid sequence which downregulates expression of a gene product of a Varroa destructor mite. Compositions comprising same and uses thereof are also disclosed.
Type:
Grant
Filed:
April 13, 2012
Date of Patent:
February 24, 2015
Assignees:
Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd., Beeologics Inc.
Inventors:
Ilan Sela, Sharoni Shafir, Eyal Maori, Yael Garbian, Eyal Ben-Chanoch, Gal Yarden, Haim Kalev