Abstract: Short bioactive sequences derived from the 2nd loop of the 7-transmembranal receptor of endothelial differentiation gene 3 (EDG3) useful in stimulation of angiogenesis, and peptide conjugates comprising a permeability enhancing moiety, are provided. Also provided are pharmaceutical compositions comprising the peptides and methods of use in conditions were insufficient blood-supply occurs, or which are associated with endothelia dysfunction such as peripheral vascular diseases, coronary artery diseases, cerebrovascular diseases, diabetes and delayed wound healing, pulmonary disease, eye diseases and pathological condition related to severe infection.
Type:
Grant
Filed:
December 17, 2014
Date of Patent:
January 23, 2018
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: The present invention provides compounds comprising fused tricyclic backbone structure and processes for their preparation. The invention further provides compounds and compositions useful in the treatment of pain and any type of disorder or symptom associated therewith.
Type:
Application
Filed:
January 28, 2016
Publication date:
January 18, 2018
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: Methods for treating individuals suffering from inflammation, specifically systemic inflammation including septic shock and inflammatory conditions affecting the gastrointestinal, myocardial and endocrine systems with ladostigil.
Type:
Grant
Filed:
August 6, 2014
Date of Patent:
January 16, 2018
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: Provided are hydrocolloid core-shell capsules including a liquid core including a non-crosslinked alginate solution and a solid or semi-solid shell including a hydrocolloid other than alginate crosslinked with metal ions, which do not crosslink alginate. Further provided is a method for the preparation of the liquid-core capsules including non-crosslinked alginate. The subject matter further provides the use of the capsules, inter alia, in the water treatment technology.
Type:
Application
Filed:
December 29, 2015
Publication date:
January 4, 2018
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: Provided is a nanoparticle including a water-soluble protein, a glucan and a hydrophilic active agent, the glucan being at least partially cross-linked by a metaphosphate.
Type:
Grant
Filed:
January 26, 2015
Date of Patent:
December 12, 2017
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventors:
Simon Benita, Taher Nassar, Liat Kochavi-Soudry
Abstract: Isolated polypeptides are disclosed comprising an amino acid sequence encoding a monomer of a fibrous polypeptide attached to a heterologous polysaccharide binding domain. Composites comprising same, methods of generating same and uses thereof are all disclosed.
Type:
Grant
Filed:
February 1, 2016
Date of Patent:
November 14, 2017
Assignees:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., CollPlantLtd.
Inventors:
Oded Shoseyov, Shaul Lapidot, Sigal Meirovitch, Daniel L. Siegel
Abstract: The invention provides compositions comprising rolling circle amplification sequences and hairpin sequences specifically designed for the accurate and highly sensitive detection of one or more analyte sequences. The invention further provides kits comprising them and methods for their use.
Type:
Grant
Filed:
December 30, 2014
Date of Patent:
November 7, 2017
Assignee:
Yissum Research Development Company of The Hebrew University Of Jerusalem Ltd.
Abstract: The invention disclosed herein generally provides implantable medical devices and implants that may be removed on-demand from a subject's body at any time after their implanting in the body, without necessitating invasive procedures.
Type:
Application
Filed:
October 7, 2015
Publication date:
November 2, 2017
Applicants:
Yissum Research Development company of the Hebrew University of Jerusalem Ltd., Rambam Med-Tech Ltd.
Abstract: An optically active structure and a display device are presented. The device utilized an optically active structure comprising liquid crystal material and a plurality of nanorods configured to emit light in one or more predetermined ranges in response to pumping light. Variation in orientation of the liquid crystal varies orientation of the nanorods and modulated light emission therefrom.
Type:
Application
Filed:
September 20, 2015
Publication date:
October 26, 2017
Applicants:
Yissum Research Development Company Of The Hebrew University of Jerusalem Ltd., QLight Nanotech Ltd., Merck Patent GmbH
Inventors:
Uri BANIN, Hagai ARBELL, Bernhard RIEGER, Ming-Chou WU
Abstract: An isolated polypeptide comprising an amino acid sequence at least 70% homologous to SEQ ID NO: 4 and an isolated polynucleotide encoding same are disclosed. A polynucleotide comprising a nucleic acid sequence capable of specifically hybridizing to the isolated polynucleotide and an isolated antibody comprising an antigen recognition domain which specifically binds the isolated polypeptide are also disclosed. Pharmaceutical compositions, methods of diagnosing and treating comprising same are also disclosed.
Type:
Grant
Filed:
June 15, 2014
Date of Patent:
October 24, 2017
Assignees:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Hadasit Medical Research Services and Development Ltd.
Inventors:
Eli Keshet, Shay Sela, Ahuva Itin, Simcha Yagel
Abstract: The present disclosure provides a composition of matter comprising liposomes encapsulating in their intraliposomal aqueous compartment at least one active agent, the liposomes having a diameter of at least 200 nm and being embedded in a water insoluble, water absorbed cross-linked polymeric matrix. In one embodiment, the composition of matter is held within an aqueous medium, preferably being in iso-osmotic equilibrium with the intraliposomal aqueous compartments of the liposomes.
Type:
Application
Filed:
June 19, 2017
Publication date:
October 5, 2017
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem, LTD.
Abstract: The present invention provides compounds acting as Insulin/IGF signaling modulators useful in the treatment of neurodegenerative diseases and disorders. The invention provides pharmaceutical compositions including such compounds, and methods of using these compounds and compositions for the treatment of neurodegenerative diseases, in particular neurodegenerative diseases caused by proteotoxicity such as Alzheimer's disease.
Type:
Grant
Filed:
July 13, 2014
Date of Patent:
September 26, 2017
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd.
Inventors:
Hadas Reuveni, Ehud Cohen, Alexander Levitzki, Shmuel Ben-Sasson
Abstract: Provided relates to a crop Lisianthus (Eustoma grandiflorum) plants that do not require cold treatment (vernalization) for the inductions of bolting and flowering, and to means and methods for producing same.
Type:
Application
Filed:
November 24, 2015
Publication date:
September 14, 2017
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: The invention relates to anode materials suitable for use in batteries, such as lithium ion batteries and sodium ion batteries. In particular, the anode material is a reduced graphene oxide/metal sulfide composite. Methods for forming the reduced graphene oxide/metal sulfide composite are also disclosed.
Type:
Grant
Filed:
November 15, 2013
Date of Patent:
September 5, 2017
Assignees:
Nanyang Technological University, Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventors:
Yau Wai Denis Yu, Sudip Kumar Batabyal, Ovadia Lev, Jenny Gun, Petr V. Prikhodchenko
Abstract: Provided are fortified beverages, in particular fruit or vegetable juices, enriched with fruit or vegetable fiber in a nutritionally effective amount, and methods of manufacture thereof. In particular, the provided are methods for increasing the percentage of dietary fiber in fruit or vegetable tissue mass added to fruit or vegetable juice, thereby providing a fruit or vegetable juice enriched with fruit or vegetable fiber, the methods including at least one step of washing followed by a step of centrifugation, and excluding steps of drying at elevated temperatures or exposure to any chemical treatment.
Type:
Application
Filed:
September 6, 2015
Publication date:
August 31, 2017
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: A method of determining a treatment for an inflammatory disorder in a subject, is disclosed. The method comprises determining an amount of SRSF6 in a sample from the subject, wherein an amount of the SRSF6 is indicative of the treatment. Methods of diagnosing inflammatory disorders and treating same are also disclosed.
Type:
Grant
Filed:
May 16, 2013
Date of Patent:
August 29, 2017
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventors:
Rotem Karni, Vered Ben Hur, Avraham Maimon
Abstract: Isolated peptides comprising sequences derived from the protein integrase of HIV-1, as well as their analogs, mixtures, conjugates with permeability enhancing moieties, and pharmaceutical compositions are disclosed. The peptides and compositions are capable of selectively killing HIV-1 infected cells and are used in treatment of HIV infection and AIDS.
Type:
Grant
Filed:
October 19, 2015
Date of Patent:
August 22, 2017
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventors:
Aviad Levin, Zvi Hayouka, Assaf Friedler, Abraham Loyter
Abstract: Provided is a composition and methods for reducing the weight loss and/or preserving the natural gloss of post-harvest edible plant matter. In particular, the methods including applying to the surface of the plant matter a composition including an edible wax having a melting temperature below 70° C.; a hydrocolloid; a fatty acid; an emulsifier; and water, wherein said edible wax is present in a weight percent ranging from about 10% to about 25% of the total weight of the composition.
Type:
Application
Filed:
April 5, 2017
Publication date:
August 3, 2017
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventors:
Amos NUSSINOVITCH, Tal MARMUR, Yonatan ELKIND
Abstract: The present disclosure provides a composition of matter comprising liposomes encapsulating in their intraliposomal aqueous compartment at least one active agent, the liposomes having a diameter of at least 200 nm and being embedded in a water insoluble, water absorbed cross-linked polymeric matrix. In one embodiment, the composition of matter is held within an aqueous medium, preferably being in iso-osmotic equilibrium with the intraliposomal aqueous compartments of the liposomes.
Type:
Grant
Filed:
October 11, 2009
Date of Patent:
July 25, 2017
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem, LTD.
Abstract: Provided are Peptide-based neurokinin antagonists of fish reproduction. Compositions including antagonists of fish neurokinin and methods of inhibiting or delaying puberty, fish maturation or reproduction processes using these compounds are also provided.
Type:
Application
Filed:
July 16, 2015
Publication date:
July 20, 2017
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.