Abstract: The presently-disclosed subject matter describes distorted gold (I) phosphine compounds. The presently-disclosed subject matter also describes a method for killing fungus comprising contacting fungus with distorted gold (I) phosphine compounds. The presently-disclosed subject matter further describes a method of preventing or disrupting a biofilm on a surface comprising contacting a surface with distorted gold (I) phosphine compounds.

Abstract: Disclosed herein are methods for inducing production of full-length progranulin (GRN) from a nucleotide encoding a GRN with a premature stop codon (GRN-PTC), comprising exposing the GRN-PTC to an aminoglycoside. Methods for inducing production of full-length progranulin (GRN) from a nucleotide encoding a GRN with a premature stop codon (GRN-PTC), comprising administering gentamicin or G418 is also disclosed.

Abstract: A concrete and asphalt repair coating formulation includes a cement component and an aggregate component. The cement component includes a calcium sulfoaluminate cement and a Portland cement. The aggregate component includes coarse aggregates between 125-500 microns in diameter and fine aggregates between 5-62.5 microns in diameter.

Abstract: The presently-disclosed subject matter generally relates to antimicrobial compounds, compositions, methods of making and methods of use thereof. The presently-disclosed subject matter further relates to compounds, compositions and methods for the control of Porphyromonas gingivalis.

Abstract: The presently-disclosed subject matter relates to compositions of dual layer encapsulated cells, dual layer encapsulated stem cells. The presently-disclosed subject matter further relates to methods for improving retention of cells in vivo at a site of injury.

Abstract: An apparatus for enhancing a yield and a transfer rate of a packed bed includes a packed bed, a vessel having a reaction chamber, a support frame and acoustic attenuator for holding the packed bed in the reaction chamber, at least one acoustic transducer adapted to transmit acoustic energy into the packed bed and an acoustic generator. The acoustic generator has impedance matching functionality.

Abstract: The presently-disclosed subject matter describes fusion proteins comprising butyrylcholinesterase (BChE) having an improved production yield and biological half-life and nucleotides encoding the same.

Abstract: Compounds described herein are mithramycin (MTM) oxide (OX) derivatives and MTM Hydrazine (HY) derivatives. These compounds are useful for treatment of cancers and neuro-diseases.

Abstract: A system for determination of intraocular pressure includes: an intraocular pressure sensor; a light source illuminating the sensor with one or more wavelengths of light; and a detector that measures emitted light from the sensor. The sensor includes a substrate member, a spacer member, and a flexible membrane, which define a sealed cavity. The flexible membrane moves in response to intraocular pressure changes. A device for measuring intraocular pressure includes: the sensor; an anchoring member attached to the sensor for immobilizing the sensor in an eye; and a protective member attached to the anchoring member and covering the sensor to prevent contact between the flexible membrane and the eye. A method for determination of intraocular pressure includes: placing the sensor in an eye; illuminating, with a light source, the sensor with one or more wavelengths of light; and detecting, with a detector, a resultant light that contains information about intraocular pressure.

Abstract: A method is provided for producing modified mutant yeast and the resulting yeast that can be used as a platform for terpene production. The method includes chemical mutagenesis to effect ergosterol dependent growth in yeast. Subsequently, these yeast are subjected to an erg9 knockout mutation to thereby produce ergosterol dependent growth/erg9 knockout mutation yeast cell lines. The resulting yeast are well suited for use in the production of terpenes.

Abstract: A method and apparatus are provided for removing EPA regulated chemical species from industrial wastewater using green rust. The apparatus includes a green rust generator having an iron anode and a carbon cathode.

Abstract: Combinations and methods for treating a subject experiencing or at risk of experiencing an undesired consequence of stimulant use are provided. The combinations include topiramate and phentermine. The methods include administering an effective dose of a combination of topiramate and phentermine to a subject. In some embodiments, the methods include administering an effective dose of a combination of topiramate and phentermine to a subject with cocaine use disorder.

Abstract: A DCN1/2-mediated cullin neddylation modulator; a method for treating disorders associated with dysfunctional DCN1 and/or UBC12, Alzheimer's disease, other neurodegenerative diseases, bacterial infections, or viral infections; and a method for treating cancers are provided. The DCN1/2-mediated cullin neddylation modulator includes a compound according to Formula I disclosed herein. The methods include administering to a mammal a therapeutically effective amount of a compound according to Formula I. Also provided herein is a pharmaceutical composition including a therapeutically effective amount of a compound according to Formula I, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

Abstract: Methods of reducing blood brain barrier dysfunction involve inhibiting 5-LOX and COX-2.

Abstract: Compositions and methods for reducing the level of nornicotine and N?-nitrosonornicotine (NNN) in Nicotiana plants and plant parts thereof are provided. The compositions comprise isolated polynucleotides and polypeptides for cytochrome P450s that are involved in the metabolic conversion of nicotine to nornicotine in these plants. Expression cassettes, vectors, plants, and plant parts thereof comprising inhibitory sequences that target expression or function of the disclosed cytochrome P450 polypeptides are also provided. Methods for the use of these novel sequences to inhibit expression or function of cytochrome P450 polypeptides involved in this metabolic conversion are also provided. The methods find use in the production of tobacco products that have reduced levels of nornicotine and its carcinogenic metabolite, NNN, and thus reduced carcinogenic potential for individuals consuming these tobacco products or exposed to secondary smoke derived from these products.

Abstract: A fuel pellet includes a pellet body made from a mixture of (a) hemp byproduct, kenaf byproduct or hemp and kenaf byproduct, (b) sawdust and, optionally, (c) coal fines. The fuel pellet may be made without adding a binder. A method of making the binderless fuel pellet is also described.

Abstract: Methods for enhancing recovery after an ischemic injury, including cerebral ischemia and stroke, by administration of therapeutic amounts of Domain V protein are described.

Abstract: Provided are methods and compositions for the treatment or prevention of ocular angiogenesis and neovascularization. Administration of inhibitors of the CCR3 receptor or its ligands eotaxin (CCL11), eotaxin-2 (CCL24) or eotaxin-3 (CCL26) inhibits ocular angiogenesis.

Abstract: An inertial vortex particle scrubber includes a housing having an inlet guide, twin vortex chambers and an outlet. A particle-laden air stream is accelerated as it passes through the inlet guide into the twin vortex chambers where particles are displaced by centrifugal forces toward a wall of the twin vortex chambers. A relatively particle-free air stream is then discharged from the outlet.

Abstract: Provided herein is a tissue culture device and a method of forming a tissue culture device. The tissue culture device includes a microfluidic layer including at least one hydrophobic microchannel and a reservoir portion over the at least one hydrophobic microchannel, the reservoir portion including an opening aligned with the at least one hydrophobic microchannel. The method of forming a tissue culture device includes providing a microfluidic layer mold, a reservoir layer mold, and a removable lid mold, filling each of the molds with a device material, curing the device material within the molds, removing the cured device material from the molds to provide a microfluidic layer, a reservoir layer, and a removable lid, and bonding the microfluidic layer to the reservoir layer. A method of culturing tissue with the tissue culture device is also provided herein.