Abstract: Topical formulations of CoQ10 reduce the rate of tumor growth in an animal subject. In the experiments described herein, CoQ10 was shown to increase the rate of apoptosis in a culture of skin cancer cells but not normal cells. Moreover, treatment of tumor-bearing animals with a topical formulation of CoQ10 was shown to dramatically reduce the rate of tumor growth in the animals.
Type:
Grant
Filed:
February 3, 2012
Date of Patent:
October 22, 2013
Assignee:
University of Miami
Inventors:
Sung Lan Hsia, Niven Rajin Narain, Jie Li, Kathryn J. Russell, Karrune V. Woan, Indushekhar Persaud
Abstract: Provided is a cell culture apparatus for culturing cells, that provides enhanced oxygen delivery and supply to cells without the need for stirring or sparging. Oxygen diffusion occurs on both sides of the culture vessel, top and bottom. A gas-permeable membrane that includes perfluorocarbons in its composition allows for the rapid, enhanced and uniform transfer of oxygen between the environment of cells or tissues contained in the cell culture container apparatus and the atmosphere of the incubator in which the cell culture apparatus is incubated.
Type:
Grant
Filed:
July 9, 2007
Date of Patent:
October 8, 2013
Assignee:
University of Miami
Inventors:
Christopher A. Fraker, Juan Dominguez-Bendala, Ricordi Camillo, Luca Inverardi
Abstract: Agonists of growth hormone releasing hormone promote islet graft growth and proliferation in patients. Methods of treating patients comprise the use of these agonists.
Type:
Application
Filed:
September 16, 2011
Publication date:
October 3, 2013
Applicants:
University of Miami, U.S. Department of Veterans Affairs, National and Kapodistrian University of Athens
Inventors:
Andrew V. Schally, Hippokratis Kiaris, Norman L. Block
Abstract: A computer system having a processor, non-transitory memory and a communication system is described. The communication system is coupled to a network and communicates with one or more genetic databases using an internet protocol. The non-transitory memory stores processor executable code to cause the processor to (1) receive data indicative of genetic array data of a patient via the communication system, (2) conduct, via the communication system and the network, at least one query of one or more genetic databases of genotypic data and phenotypic data using the data indicative of patient genetic data and phenotypic data, and (3) provide results of the at least one query to provide a clinical synopsis of the patient.
Type:
Application
Filed:
January 24, 2013
Publication date:
August 15, 2013
Applicants:
The Board of Regents of the University of Oklahoma, University of Miami
Inventors:
University of Miami, The Board of Regents of the University of Oklahoma
Abstract: Whether the growth hormone (GH)/Insulin-like growth factor 1(IGF-I) axis exerts cardioprotective effects remains controversial; and the underlying mechanism(s) for such actions are unclear. Here we tested the hypothesis that growth-hormone releasing hormone (GHRH) directly activates cellular reparative mechanisms within the injured heart, in a GH/IGF-I independent fashion. Following experimental myocardial infarction (MI), rats were randomly assigned to receive, during a 4 week period, either placebo (n=14), rat recombinant GH (rrGH, n=8) or JI-38 (n=8; 50 ?g/Kg/day), a potent GHRH-agonist. JI-38 did not elevate serum levels of GH or IGF-I, but markedly attenuated the degree of cardiac functional decline and remodeling after injury. In contrast, GH administration markedly elevated body weight, heart weight, circulating GH and IGF-I, but did not offset the decline in cardiac structure and function.
Type:
Grant
Filed:
October 28, 2010
Date of Patent:
August 13, 2013
Assignees:
University of Miami, The United States of America, represented by the Deptartment of Veterans Affairs
Inventors:
Andrew V. Schally, Norman L Block, Joshua Hare, Rosemeire Miyuki Kanashiro Takeuchi
Abstract: The present invention provides an aircraft having one or more fixed wings in a flying wing configuration, where the aircraft further includes a high performance co-flow jet (CFJ) circulating about at least a portion of an aircraft surface to produce both lift and thrust.
Abstract: A method secures data in a network. The data includes a data message that has a first bit length. A random number is generated and transformed to create a first pseudo random number. The first pseudo random number is mixed with the data message to create an encrypted message. The encrypted message is transformed into a second pseudo random number. The second pseudo random number is mixed with the random number to produce a key. The encrypted message is placed side-by-side with the key to produce an output message. The output message is dispersed into a plurality of fragments. The plurality of fragments is stored in a plurality of data storage devices.
Abstract: Cell-based immunotherapy (e.g., immunization or vaccination) may be improved by frequent administration to a human subject of allogeneic cancer cells secreting a modified heat shock protein (e.g., gp96), depletion of B cells in the subject, or both. Antigen (e.g., epitope derived from neoantigen or tumor antigen of allogeneic or syngeneic cancer cells) may induce a specific immune response in the subject. For example, the epitope bound in an immunogenic complex with the secreted heat shock protein may be obtained from allogeneic cancer cells coexpressing both secreted gp96 and antigen, or from syngeneic cancer cells of the subject expressing only antigen.
Type:
Grant
Filed:
March 3, 2009
Date of Patent:
July 2, 2013
Assignee:
The University of Miami
Inventors:
Eckhard R. Podack, Joseph D. Rosenblatt, Nozomi Yamazaki
Abstract: A solid state energy storage device has two electrodes, a membrane separator and a solid electrolyte having a substantially solid solvent, a salt and a mediator. The energy storage device stores electric charge by both Faradaic and non-Faradaic systems. The energy storage device may include activated carbon mixed with the electrolyte and sonicated to provide connection between the activated carbon and the mediator. The energy storage device is hot pressed to increase conductivity. The two electrodes may be asymmetric in amount of reduced and oxidized species of mediator.
Type:
Grant
Filed:
March 31, 2010
Date of Patent:
May 28, 2013
Assignee:
University of Miami
Inventors:
Xiangyang Zhou, Juanjuan Zhou, Azzam N. Mansour
Abstract: A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A manifold having a plurality of liquid inlets, control valves, and liquid outlets can be provided. A receptacle housing has a plurality of receptacles. A drive is connected to the receptacle housing for moving the receptacle housing. A programmable controller can be provided to control movement of the receptacle housing. The test liquid includes at least one stimuli for the cells. The liquid collected in the receptacles is analyzed to determine the response of the cells to the stimuli.
Type:
Application
Filed:
August 27, 2012
Publication date:
February 14, 2013
Applicants:
University of Miami, Biorep Technologies, Inc.
Inventors:
Ramon E. Poo, Camillo Ricordi, Felipe Echeverri, Over Cabrera, Per-Olof Berggren
Abstract: Novel molecules termed STING which include nucleic acids, polynucleotides, oligonucleotides, peptides, mutants, variants and active fragments thereof, modulate innate and adaptive immunity in a subject. STING compositions are useful for the treatment of an immune-related disorder, including treating and preventing infection by modulating immunity.
Abstract: Therapeutic agents for treatment of Galactosemia and disorders thereof, and other enzyme related disorders thereof are identified. The compounds inhibit galactokinase (GALK) and other kinase activity and are identified by a high throughput screening assay.
Type:
Grant
Filed:
August 14, 2008
Date of Patent:
January 22, 2013
Assignee:
University of Miami
Inventors:
Kent Lai, Klass Jan Wierenga, Manshu Tang
Abstract: The present invention provides novel chimeric peptides and novel methods for treating animals including humans by administering the novel chimeric peptides. In particular, the invention is useful for enhancing endogenous acetylcholinesterase expression in individuals exposed to organophosphate compounds, such as nerve gases and pesticides.
Abstract: A system for performing anastomosis includes a plurality of staples, an annular staple support having structure for holding the staples, and a staple closing device for closing the staples to secure the canal ends together. A method for performing anastomosis and staples for performing anastomosis are also disclosed.
Type:
Grant
Filed:
November 11, 2009
Date of Patent:
January 8, 2013
Assignees:
Biorep Technologies, Inc., University of Miami
Abstract: Disclosed is a method for regenerating articular cartilage in an animal comprising administering a therapeutically effective amount of a non-demineralized particulate articular cartilage having a distribution of particle sizes within the range of from about 60 microns to about 500 microns.
Abstract: Heterocyclic compounds incorporating a [1,3]oxazine ring may be used to make chromogenic materials. These molecules switch from a colorless state to a colored form upon addition of either acid or base. In both instances, the [1,3]oxazine ring opens in response to the pH change forming an indolium cation, after the addition of acid, or a phenolate anion, after the addition of base. Alternatively, the switch may occur in response to a change in electrical current or potential or a change in temperature. Chromophores absorb in the visible region of the electromagnetic spectrum. Hence, their formation translates into the appearance of color. These processes are fully reversible and the original colorless state can be regenerated by switching the pH back to neutral. Thus, these halochromic compounds can be used to develop displays, filters, indicators, lenses, sensors, switches, or windows able to switch their color in response to pH changes.
Type:
Grant
Filed:
October 17, 2008
Date of Patent:
November 6, 2012
Assignee:
The University of Miami
Inventors:
Massimiliano Tomasulo, Francisco M. Raymo
Abstract: Topical formulations of CoQ10 reduce the rate of tumor growth in an animal subject. In the experiments described herein, CoQ10 was shown to increase the rate of apoptosis in a culture of skin cancer cells but not normal cells. Moreover, treatment of tumor-bearing animals with a topical formulation of CoQ10 was shown to dramatically reduce the rate of tumor growth in the animals.
Type:
Grant
Filed:
March 1, 2012
Date of Patent:
October 23, 2012
Assignee:
University of Miami
Inventors:
Sung Lan Hsia, Niven Rajin Narain, Jie Li, Kathryn J. Russell, Karrune V. Woan, Indushekhar Persaud
Abstract: Improved systems and methods for tissue processing are described here. The chemical process and the construction of the apparatus are simplified by using only two different solutions in two separate reaction modules. They are compatible with processing of tissue specimens for genetic analysis, histology, in situ antibody binding and hybridization, archival preservation of morphology and nucleic acids, and combinations thereof.
Abstract: Compositions are directed to the treatment of kidney diseases in a cell-specific manner. Methods of treating kidney diseases comprise the use of the compositions. Assays for identification of further compounds are provided.
Abstract: The present invention provides an aircraft having one or more fixed wings in a flying wing configuration, where the aircraft further includes a high performance co-flow jet (CFJ) circulating about at least a portion of an aircraft surface to produce both lift and thrust.
Type:
Grant
Filed:
May 12, 2008
Date of Patent:
September 11, 2012
Assignee:
University of Miami
Inventors:
Gecheng Zha, Sebastian Aspe, Joseph John Dussling, Nicholas Ramsay Heinz, Daniel J. Martinez