Patents Assigned to University of Miami
  • Dendrimer conjugates for coating cells
    Patent number: 10493163
    Abstract: The present invention provides dendrimer conjugates. The present invention provides a composition comprising a dendrimer conjugate and a cell, such as a cell covered with dendrimer conjugates, in which dendrimer conjugates home the cell to a target tissue.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: December 3, 2019
    Assignee: UNIVERSITY OF MIAMI
    Inventors: Omaida Velazquez, Sylvia Daunert, Pirouz Daftarian, Zhao-Jun Liu, Sapna Deo
  • Vision defect determination and enhancement using a prediction model
    Patent number: 10485421
    Abstract: In certain embodiments, enhancement of a vision of a user may be facilitated. In some embodiments, a visual test presentation including a set of stimuli may be provided to a user. Feedback related to the set of stimuli may be obtained during the visual test presentation. The feedback may be provided to a prediction model, and the prediction model may be configured based on the feedback. Subsequent to the configuring of the prediction model, live video stream data, eye characteristic information, or other information may be provided to the prediction model to obtain a set of modification parameters. A modified version of the live video stream data may be generated and displayed to the user based on the live video stream and the set of modification parameters.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: November 26, 2019
    Assignee: University of Miami
    Inventors: Mohamed Abou Shousha, Amr Elsawy, Ahmed Sayed, Ozgur Gundogan
  • Functional imaging of photoreceptors in the retina by rhodopsin mapping
    Patent number: 10485418
    Abstract: The subject invention provides novel apparatuses and methods for assessing the structure and function of photoreceptors in retina. In a specific embodiment, the assessment is accomplished by imaging rhodopsin, pigmented protein responsible for initiating vision acquisition of the eye, in living subjects. Advantageously, the technologies provided herein can be used for clinical evaluation of retinal photoreceptors for diagnosis, disease staging and follow-up, and outcome measurement for clinical trials of retinal degenerative disorders, including, for example, hereditary retinal degeneration and age-related macular degeneration.
    Type: Grant
    Filed: August 3, 2015
    Date of Patent: November 26, 2019
    Assignees: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES, UNIVERSITY OF MIAMI
    Inventors: Shuliang Jiao, Rong Wen, Byron L. Lam, Tan Liu
  • Field of view enhancement via dynamic display portions for a modified video stream
    Patent number: 10481402
    Abstract: In certain embodiments, enhancement of a field of view of a user may be facilitated via one or more dynamic display portions. In some embodiments, one or more changes related to one or more eyes of a user may be monitored. Based on the monitoring, one or more positions of one or more transparent display portions of wearable device may be adjusted, where the transparent display portions enable the user to see through the wearable device. A live video stream representing an environment of the user may be obtained via the wearable device. A modified video stream derived from the live video stream may be displayed on one or more other display portions of the wearable device.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: November 19, 2019
    Assignee: University of Miami
    Inventors: Mohamed Abou Shousha, Ahmed Sayed
  • Cell culture media
    Patent number: 10465166
    Abstract: A cell culture medium comprising adenosine triphosphate; a carrier protein; cholesterol, linoleic acid, and lipoic acid; glutathione; at least one nucleotide salvage pathway precursor base; phosphoethanolamine; selenium; transferrin; triiodothyronine; all-trans-retinoic acid (ATRA) and vitamin C; zinc, magnesium, and copper; an agent that increases intracellular cAMP; epidermal growth factor (EGF); hydrocortisone; insulin; and charcoal stripped fetal bovine serum, wherein said cell culture medium is substantially free, if not entirely free, of vitamin D, androgenic hormones, androgenic ligands, estrogenic hormones, estrogenic ligands, and/or androgenic receptors.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: November 5, 2019
    Assignee: UNIVERSITY OF MIAMI
    Inventor: Tan Ince
  • Artificial intelligence-based system and methods for corneal diagnosis
    Patent number: 10468142
    Abstract: A method of predicting a disease or condition of a cornea or an anterior segment of an eye includes inputting input data into an AI model, processing the input data, and generating a set of scores and outputting a prediction. The input data may be representative of a cornea or anterior segment of an eye. Processing the input data may include processing the data through the plurality of convolutional layers, the fully connected layer, and the output layer. Each score of the set of scores may be generated by a corresponding node in the output layer. The output prediction may be related to the cornea or anterior segment of the eye represented by the input data processed through the AI model. The prediction may be determined by at least one score of the set of scores.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: November 5, 2019
    Assignee: University of Miami
    Inventors: Mohamed Abou Shousha, Amr Saad Mohamed Elsawy
  • Methods of treating diabetes and/or promoting survival of pancreatic islets after transplantation
    Patent number: 10443056
    Abstract: Disclosed herein are methods for treating/and or preventing diabetes using a specific inhibitor of SMAD7 expression or function. Also disclosed are methods of promoting organ and/or cell, e.g., pancreatic islet cell, survival after transplantation using a specific inhibitor of SMAD7 expression or function.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: October 15, 2019
    Assignees: Nogra Pharma Limited, University of Miami
    Inventors: Giovanni Monteleone, Peter Buchwald, Luca Inverardi, Antonello Pileggi, Camillo Ricordi, Alice Tomei
  • Biodegradable oceanic drifter tracking device
    Patent number: 10444403
    Abstract: A water body drifter device for tracking movement of a fluid is disclosed. The drifter may include a floater assembly having a toroid shaped buoy fixedly connected to a floater head disposed interiorly to the toroid shaped buoy, the floater head having a recess and a cap sealably attached to the recess for housing a network-enabled controller. The drifter may also include one or more sensors mounted to the floater assembly to capture physical, chemical or biological data from the water body and/or from the environment around the water body, a drogue formed of a plurality of blades each spaced from one another, and a flexible connector attached to the floater assembly at one end and the drogue at another end. The floater assembly, the drogue, and the flexible connector may each be formed of one or more biodegradable materials.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: October 15, 2019
    Assignee: UNIVERSITY OF MIAMI
    Inventors: Tamay Ozgokmen, Charles Cousin, Guillaume Novelli, Cedric Guigand
  • Field of view enhancement via dynamic display portions
    Patent number: 10444514
    Abstract: In certain embodiments, enhancement of a field of view of a user may be facilitated via one or more dynamic display portions. In some embodiments, one or more changes related to one or more eyes of a user may be monitored. Based on the monitoring, one or more positions of one or more transparent display portions of a screen of wearable device may be adjusted, where the transparent display portions enable the user to see through the screen of the wearable device. A live video stream representing an environment of the user may be obtained via the wearable device. An enhanced video stream derived from the live video stream may be displayed on one or more other display portions of the screen of the wearable device.
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: October 15, 2019
    Assignee: University of Miami
    Inventors: Mohamed Abou Shousha, Ahmed Sayed
  • Visual enhancement for dynamic vision defects
    Patent number: 10409071
    Abstract: In certain embodiments, live image data modifications may be facilitated for dynamic vision defects. In some embodiments, one or more eyes of a user may be monitored while a set of stimuli are displayed to the user. Feedback related to the set of stimuli may be obtained, where the feedback indicates (i) whether or how the user sees one or more stimuli of the set and (ii) one or more characteristics related to the eyes that occurred when such stimuli are displayed. A set of modification profiles associated with the user may be generated based on the feedback, where each modification profile of the set (i) is associated with eye-related characteristics and (ii) includes modification parameters to be applied to an image to modify the image for the user when eye-related characteristics of the user matches the associated eye-related characteristics.
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: September 10, 2019
    Assignee: University of Miami
    Inventors: Mohamed Abou Shousha, Ahmed Sayed, Ozgur Gundogan
  • Digital therapeutic corrective spectacles
    Patent number: 10386645
    Abstract: Devices for testing, identifying, and compensating for ocular pathologies affecting the vision of a patient are provided in the form of digital therapeutic corrective spectacles that provided personalized, customized visual field corrected/enhancement. The devices include wearable spectacles with one or more digital monitors that are used to recreate an entire visual field as a digitized corrected image or that include custom-reality glasses that can be used to overlay a visual scene with generated image to correct or enhance the visual field of the subject.
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: August 20, 2019
    Assignee: UNIVERSITY OF MIAMI
    Inventor: Mohamed Abou Shousha
  • Vision defect determination and enhancement using a prediction model
    Patent number: 10389989
    Abstract: In certain embodiments, enhancement of a vision of a user may be facilitated. In some embodiments, a visual test presentation including a set of stimuli may be provided to a user. Feedback related to the set of stimuli may be obtained during the visual test presentation. The feedback may be provided to a prediction model, and the prediction model may be configured based on the feedback. Subsequent to the configuring of the prediction model, live video stream data, eye characteristic information, or other information may be provided to the prediction model to obtain a set of modification parameters. An enhanced image may be generated and displayed to the user based on the live video stream and the set of modification parameters.
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: August 20, 2019
    Assignee: University of Miami
    Inventors: Mohamed Abou Shousha, Amr Elsawy, Ahmed Sayed, Ozgur Gundogan
  • MATERIALS AND METHODS FOR TREATING OPHTHALMIC INFLAMMATION
    Publication number: 20190247302
    Abstract: The disclosure provides an ophthalmic formulation comprising a bromodomain inhibitor, a polar aprotic solvent (e.g., dimethyl sulfoxide (DMSO)), polysorbate, salt, and Captisol, as well as a method of treating or preventing ophthalmic inflammation in a subject in need thereof comprising locally administering the formulation to the eye of the subject.
    Type: Application
    Filed: October 20, 2017
    Publication date: August 15, 2019
    Applicant: University of Miami
    Inventors: Robert B. Levy, Victor L. Perez, Claes Wahlestedt, Casey O. Lightbourn, Sabrina Copsel, Henry Barreras, Stephanie Duffort
  • Method and system for three-dimensional thickness mapping of corneal micro-layers and corneal diagnoses
    Patent number: 10368735
    Abstract: Techniques for improved diagnosis, treatment, and monitoring of corneal pathologies use enhanced mapping of the cornea or corneal regions, to develop three-dimensional mapping of corneal thickness, while retaining particular corneal micro-layer thickness data. Anterior and posterior surface identifications, along with surface apex determinations, are used for registration of segmentation of these micro-layers. 3D heat maps and bull's-eye maps are generated from resulting thickness date. The maps provided enhanced evaluation and diagnosis of a corneal pathologies, such as keratoconus, pellucid marginal degeneration, post-refractive surgery ectasia, keratoglobus, corneal transplant rejection and corneal transplant failed grafts, Fuchs dystrophy, corneal limbal stem cell deficiency, dry eye syndrome, and post-corneal collagen crosslinking evaluation.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: August 6, 2019
    Assignee: University of Miami
    Inventors: Mohamed Abou Shousha, Amr Saad Mohamed Elsawy
  • VISUAL ENHANCEMENT FOR DYNAMIC VISION DEFECTS
    Publication number: 20190223716
    Abstract: In certain embodiments, live image data modifications may be facilitated for dynamic vision defects. In some embodiments, one or more eyes of a user may be monitored while a set of stimuli are displayed to the user. Feedback related to the set of stimuli may be obtained, where the feedback indicates (i) whether or how the user sees one or more stimuli of the set and (ii) one or more characteristics related to the eyes that occurred when such stimuli are displayed. A set of modification profiles associated with the user may be generated based on the feedback, where each modification profile of the set (i) is associated with eye-related characteristics and (ii) includes modification parameters to be applied to an image to modify the image for the user when eye-related characteristics of the user matches the associated eye-related characteristics.
    Type: Application
    Filed: March 28, 2019
    Publication date: July 25, 2019
    Applicant: UNIVERSITY OF MIAMI
    Inventors: Mohamed Abou Shousha, Ahmed Sayed, Ozgur Gundogan
  • FIELD OF VIEW ENHANCEMENT VIA DYNAMIC DISPLAY PORTIONS
    Publication number: 20190227327
    Abstract: In certain embodiments, enhancement of a field of view of a user may be facilitated via one or more dynamic display portions. In some embodiments, one or more changes related to one or more eyes of a user may be monitored. Based on the monitoring, one or more positions of one or more transparent display portions of a screen of wearable device may be adjusted, where the transparent display portions enable the user to see through the screen of the wearable device. A live video stream representing an environment of the user may be obtained via the wearable device. An enhanced video stream derived from the live video stream may be displayed on one or more other display portions of the screen of the wearable device.
    Type: Application
    Filed: March 28, 2019
    Publication date: July 25, 2019
    Applicant: UNIVERSITY OF MIAMI
    Inventors: Mohamed Abou Shousha, Ahmed Sayed
  • VISION DEFECT DETERMINATION AND ENHANCEMENT
    Publication number: 20190222817
    Abstract: In certain embodiments, enhancement of a vision of a user may be facilitated. In some embodiments, a visual test presentation including a set of stimuli may be provided to a user. Feedback related to the set of stimuli may be obtained during the visual test presentation. The feedback may be provided to a prediction model, and the prediction model may be configured based on the feedback. Subsequent to the configuring of the prediction model, live video stream data, eye characteristic information, or other information may be provided to the prediction model to obtain a set of modification parameters. An enhanced image may be generated and displayed to the user based on the live video stream and the set of modification parameters.
    Type: Application
    Filed: March 28, 2019
    Publication date: July 18, 2019
    Applicant: UNIVERSITY OF MIAMI
    Inventors: Mohamed Abou Shousha, Amr Elsawy, Ahmed Sayed, Ozgur Gundogan
  • SEGMENTATION-BASED CORNEAL MAPPING
    Publication number: 20190209006
    Abstract: In some embodiments, images of a cornea may be obtained, and the images of the cornea may be segmented to detect a tear film layer of the cornea and an epithelium layer of the cornea. Thickness of the tear film layer and thickness of the epithelium layer may be determined based on the segmentation of the images of the cornea. A thickness map may be generated based on the thickness of the tear film layer and the thickness of the epithelium layer. As an example, the thickness map may comprise visual differences in thickness across the tear film layer and the epithelium layer. In some embodiments, the foregoing may be performed with respect to one or more other microlayers of the cornea in addition to or alternatively to the tear film layer or the epithelium layer.
    Type: Application
    Filed: February 6, 2019
    Publication date: July 11, 2019
    Applicant: University of Miami
    Inventors: Mohamed Abou Shousha, Amr Saad Mohamed Elsawy, Marco Ruggeri
  • Purification of carbon nanotubes via selective heating
    Patent number: 10333069
    Abstract: The present invention provides methods for purifying a layer of carbon nanotubes comprising providing a precursor layer of substantially aligned carbon nanotubes supported by a substrate, wherein the precursor layer comprises a mixture of first carbon nanotubes and second carbon nanotubes; selectively heating the first carbon nanotubes; and separating the first carbon nanotubes from the second carbon nanotubes, thereby generating a purified layer of carbon nanotubes. Devices benefiting from enhanced electrical properties enabled by the purified layer of carbon nanotubes are also described.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: June 25, 2019
    Assignees: The Board of Trustees of The University of Illinois, Northwestern University, University of Miami
    Inventors: John A. Rogers, William L. Wilson, Sung Hun Jin, Simon N. Dunham, Xu Xie, Ahmad Islam, Frank Du, Yonggang Huang, Jizhou Song
  • Fusion proteins for promoting an immune response, nucleic acids encoding same, and methods of making and use thereof
    Patent number: 10329329
    Abstract: Disclosed herein are compositions, cells, kits, and methods for inducing an immune response in a subject. The compositions can be used as vaccines or vaccine adjuvants against cancer (e.g., melanoma, glioma, prostate, breast) and infectious diseases (e.g., therapeutic and preventative vaccination for viruses), and can be used in cell-based therapies for preventing and treating disorders such as cancer and infection. The compositions, cells, kits and methods involve one or more nucleic acids that encode one or more LMPI fusion proteins (chimeric proteins), and in a typical embodiment, synergistic activation of immune responses by a combination of two or more LMPI fusion proteins.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: June 25, 2019
    Assignee: UNIVERSITY OF MIAMI
    Inventors: Geoffrey W. Stone, Sachin Gupta