Abstract: A general method of analyzing immune signaling networks for identification of potential therapeutic targets in complex, chronic medical disorders is described. The disclosure provides the CD3?/CD56+ natural killer (NK) cell population as a potential therapeutic target in the clinically-overlapping disorders Gulf War Illness (GWI) and Myalg Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The disclosure also provides a method for improving or restoring Natural Killer (NK) cell function by stimulating the NK cells with interleukin-15 (IL-15).
Type:
Grant
Filed:
October 14, 2014
Date of Patent:
September 15, 2020
Assignees:
Nova Southeastern University, University of Miami, University of Alberta, TEC Edmonton
Inventors:
Mary Ann Fletcher, Gordon Broderick, Nancy Klimas, Zachary Barnes
Abstract: In certain embodiments, double-vision-related vision defects determinations or modifications may be facilitated. In some embodiments, a stimulus may be to be presented at a first time at a position on a first display for a deviating eye of a user (e.g., without a stimulus being presented on a second display of for a reference eye of the user) to cause the deviating eye to fixate on the position on the first display. A deviation measurement for the deviating eye may be determined based on an amount of movement of the deviating eye occurring upon the presentation on the first display for the deviating eye at the first time. In some embodiments, a modification profile associated with the user may be determined based on the deviation measurement, where the modification profile includes one or more modification parameters to be applied to modify an image for the user.
Abstract: The compositions and methods described herein include agents that inhibit inflammasome signaling in the mammal such as antibodies directed against inflammasome components used alone or in combination with extracellular vesicle uptake inhibitor(s). Also described herein are compositions and methods of use thereof for treating multiple sclerosis.
Type:
Grant
Filed:
July 3, 2018
Date of Patent:
July 7, 2020
Assignee:
UNIVERSITY OF MIAMI
Inventors:
Robert W. Keane, W. Dalton Dietrich, Juan Pablo De Rivero Vaccari, Helen M. Bramlett, Roberta Brambilla
Abstract: Devices and methods of making and using the device for the non-invasive detection of volatile anesthetics are provided. The devices are capable of measuring the concentration of volatile anesthetics transdermally and in a non-invasive manner. The devices and methods can be applied in detection of volatile anesthetics in samples collected from human skin perspiration.
Type:
Grant
Filed:
May 12, 2017
Date of Patent:
June 2, 2020
Assignees:
The Florida International University Board of Trustees, University of Miami
Inventors:
Yogeswaran Umasankar, Shekhar Bhansali, Ernesto A. Pretto, Jr.
Abstract: In certain embodiments, a user's field of view may be increased and/or modified. In some embodiments, views of a scene may be obtained via a wearable device. A first region of the scene may be determined, where the first region is common to the views and represented in the views at proximate a center of each of the views. For each view of the views, a second region of the scene may be determined, where the second region is represented in the view and related to peripheral vision of the user. A modified view may be generated based on (i) a portion of at least one of the views that corresponds to the common first region and (ii) portions of the views that correspond to the second regions such that the modified view comprises a representation of the common first region and representations of the second regions.
Abstract: In certain embodiments, vision-related alerting may be facilitated based on a physical contact prediction. In some embodiments, a prediction indicating defective visual field portions of a user's visual field may be generated based on feedback related to a set of stimuli displayed to the user. The defective visual field portions may be visual field portions of the visual field that fail to satisfy one or more vision criteria. Based on the prediction of the defective visual field portions, a modified video stream derived from a live video stream to be presented via a wearable device. Activation of an alert may be caused via the wearable device based on (i) a prediction of physical contact (of an object with the user) and (ii) the object not being sufficiently in any image portion of the modified video stream that corresponds to at least one visual field portion satisfying the vision criteria.
Abstract: This document provides novel compositions and methods utilizing immunomodulating agents that can stimulate or indirectly augment the immune system, or can have an immunosuppressive effect. TNFR25 agonists disclosed herein have an anti-inflammatory and healing effect. They can be used, e.g., to treat disease caused by asthma and chronic inflammation, such as inflammatory bowel diseases including ulcerative colitis and Crohn's Disease. TNFR25 antagonists disclosed herein can inhibit CD8 T cell-mediated cellular immune responses and can, for example, mitigate organ or tissue rejection following a tissue transplantation. TNFR25 agonists disclosed herein represent biological response modifiers that alter the interaction between the body's cellular immune defenses and cancer cells to boost, direct, or restore the body's ability to fight the cancer when given with tumor vaccines.
Type:
Grant
Filed:
September 14, 2017
Date of Patent:
April 21, 2020
Assignee:
University of Miami
Inventors:
Eckhard R. Podack, Vadim Deyev, Robert Levy
Abstract: Sodium cellulose sulfate (NaCS) is employed as a novel GAG mimetic. Schwann cells (SCs) could be used in combination with a scaffold because the SCs can secrete neurotrophic factors stimulating neuron survival and extension of axons. Furthermore, the conduit may be used alone or combination with Schwann cells for spinal cord repair. In addition, the conduit also can be used for peripheral nerve repair. Also described herein are compositions and methods useful for promoting the growth and/or differentiation and/or repair of a cell and/or tissue in the peripheral nervous system, central nervous system, and specifically the spinal cord. In certain aspects, the present disclosure includes a scaffold supporting and promoting growth, differentiation, and/or regeneration and repair. The scaffold in one embodiment closely mimics the natural extracellular matrix (ECM) of the spinal cord.
Type:
Application
Filed:
September 17, 2019
Publication date:
March 19, 2020
Applicants:
New Jersey Institute of Technology, University of Miami
Inventors:
Treena Lynne Arinzeh, Roseline Menezes, George Collins, Sharareh Hashemi, Martin Oudega
Abstract: Described herein are nanoparticle-based compositions, kits and methods and platforms for delivering one or more nucleic acids to a myeloid cell.
Type:
Grant
Filed:
March 3, 2016
Date of Patent:
February 18, 2020
Assignee:
UNIVERSITY OF MIAMI
Inventors:
Paolo Serafini, Jennifer Vella, Vincenzo Bronte, Pirouz Daftarian, Angel Kaifer, Serena Zilio
Abstract: Disclosed herein are inhibitors of TNF superfamily costimulatory interactions, and methods for their use in modulating TNF superfamily costimulatory interactions and treating immune system related disorders. In particular, disclosed herein are compounds of Formula (I), and pharmaceutically acceptable salts thereof: wherein the substituents are described herein.
Abstract: Disclosed herein are compositions of GHRH agonists and peptides, and methods to treat disorders, such as ischemia and reperfusion injury. In one embodiment, a method of treating a reperfusion injury in a subject in need may involve administering a therapeutically effective amount of at least one GHRH agonist peptide to the subject. In additional embodiment, a method of promoting vasculogenesis in a mammal may involve administering a therapeutically effective amount of at least one GHRH agonist peptide to the subject. In a further embodiment, a method of promoting differentiation of mesenchymal stem cells into endothelial cells may involve contacting mesenchymal stem cells with at least one GHRH agonist peptide.
Type:
Grant
Filed:
November 21, 2017
Date of Patent:
February 11, 2020
Assignees:
UNIVERSITY OF MIAMI, U.S.A., REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
Inventors:
Andrew Schally, Joshua M. Hare, Norman Block, Samirah Gomes, Rosemeire M. Kanashiro-Takeuchi
Abstract: In certain embodiments, vision defect information may be generated via a dynamic eye-characteristic-based fixation point. In some embodiments, a first stimulus may be displayed at a first location on a user interface based on a fixation point for a visual test presentation. The fixation point for the visual test presentation may be adjusted during the visual test presentation based on eye characteristic information related to a user. As an example, the eye characteristic information may indicate a characteristic of an eye of the user that occurred during the visual test presentation. A second stimulus may be displayed during the visual test presentation at a second interface location on the user interface based on the adjusted fixation point for the visual test presentation. Vision defect information associated with the user may be generated based on feedback information indicating feedback related to the first stimulus and feedback related to the second stimulus.
Abstract: In certain embodiments, enhancement of a field of view of a user may be facilitated via one or more dynamic display portions. In some embodiments, one or more changes related to one or more eyes of a user may be monitored. Based on the monitoring, one or more positions of one or more transparent display portions of wearable device may be adjusted, where the transparent display portions enable the user to see through the wearable device. A live video stream representing an environment of the user may be obtained via the wearable device. A modified video stream derived from the live video stream may be displayed on one or more other display portions of the wearable device.
Abstract: Disclosed herein are inhibitors of the Notch transcriptional activation complex, and methods for their use in treating or preventing diseases, such as cancer. The inhibitors described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: Formula (I), wherein the substituents are as described.
Type:
Grant
Filed:
March 23, 2016
Date of Patent:
December 10, 2019
Assignees:
UNIVERSITY OF MIAMI, UNIVERSITY OF MARYLAND, BALTIMORE
Inventors:
Anthony J. Capobianco, Alex Mackerell, Jr., Mark Spyvee
Abstract: The present invention relates to the fields of medicine, cell biology, molecular biology and genetics. In particular, the present invention provides methods to isolate and purify microvesicles from cell culture supernatants and biological fluids. The present invention also provides pharmaceutical compositions of microvesicles to promote or enhance wound healing, stimulate tissue regeneration, remodel scarred tissue, modulate immune reactions, alter neoplastic cell growth and/or mobility, or alter normal cell growth and/or mobility. The present invention also provides compositions of microvesicles to be used as diagnostic reagents, and methods to prepare the compositions of microvesicles.
Type:
Grant
Filed:
March 12, 2014
Date of Patent:
December 10, 2019
Assignee:
University of Miami
Inventors:
Evangelos V. Badiavas, Arsalan Q. Shabbir, Stephen C. Davis
Abstract: The present invention provides dendrimer conjugates. The present invention provides a composition comprising a dendrimer conjugate and a cell, such as a cell covered with dendrimer conjugates, in which dendrimer conjugates home the cell to a target tissue.
Abstract: In certain embodiments, enhancement of a vision of a user may be facilitated. In some embodiments, a visual test presentation including a set of stimuli may be provided to a user. Feedback related to the set of stimuli may be obtained during the visual test presentation. The feedback may be provided to a prediction model, and the prediction model may be configured based on the feedback. Subsequent to the configuring of the prediction model, live video stream data, eye characteristic information, or other information may be provided to the prediction model to obtain a set of modification parameters. A modified version of the live video stream data may be generated and displayed to the user based on the live video stream and the set of modification parameters.
Type:
Grant
Filed:
May 31, 2019
Date of Patent:
November 26, 2019
Assignee:
University of Miami
Inventors:
Mohamed Abou Shousha, Amr Elsawy, Ahmed Sayed, Ozgur Gundogan