Abstract: A method of cutting (e.g. micro-milling) brittle materials where a protective ductile layer is present on the brittle material during the cutting step. The method offers an improved edge quality of the machined profile relative to previous cutting (e.g. micro-milling) techniques. A machined product obtained by or obtainable by this method is disclosed.

Abstract: A heat engine including a compressor; an expander; a reactor in which first and second reactants in a working fluid can react with each other, the reactor arranged between the compressor and the expander; and a condenser for condensing a gas in the working fluid, the condenser arranged between the expander and the compressor. There is also provided a method of operating a heat engine.

Abstract: A method for treating endometrial cancer comprising: administering to a patient a cannabis extract (CE) wherein the cannabis extract comprises cannabidiol (CBD) at between 50% and 99% by weight of the CE.

Abstract: The present invention relates to organic thin film sensors and the preparation and use thereof in sensing applications, and in particular in glucose sensing. The sensor is characterised by a layered structure comprising a porous wicking layer whose surface is configured to receive a liquid sample. An enzyme is disposed on or within the porous layer for facilitating the generation of a charge carrier from an analyte. A polymer layer in contact with the porous layer is connected to an ohmic conductor for applying a gate voltage to the polymer layer, the polymer layer being conductive to the charge carrier; and an organic semiconducting layer is connected to a source electrode and a drain electrode.

Abstract: This invention relates to gels that undergo either oscillatory stepwise expansion or oscillatory expansion and contraction. An oscillatory reaction occurs within the gel, changing the conditions of the gel, and causing the gel to expand and optionally contract. The gels may be used for oscillatory release of a chemical agent.

Abstract: This invention relates to a method of increasing the size of particulates in a gas comprising particulates, e.g. a gas that is formed from the combustion of fuels. The method comprises mixing an ionised gas stream with the gas comprising particulates.

Abstract: Disclosed herein are methods for treating estrogen sensitive disease, specifically toward endometrial cancers, and compositions used to treat the estrogen sensitive disease. Methods for treating estrogen sensitive diseases comprise administering to a patient an effective amount of a cannabis extract in the presence of an elevated level of estrogen wherein the estrogen is endogenous estrogen or further comprises exogenous estrogen and wherein the methods may further comprise the addition of a chemotherapeutic agent.

Abstract: Provided herein are methods for diagnosing functional gastrointestinal disorders such as functional dyspepsia and irritable bowel syndrome, comprising detecting IgG antibodies in a sample obtained from a subject, wherein the IgG antibodies recognise one or more antigens from Streptococcus salivarius. Also provided are kits for detecting IgG antibodies for use in the diagnosis of functional gastrointestinal disorders, and methods for selecting subjects for treatment for functional gastrointestinal disorders.

Abstract: A printing apparatus and method. The printing apparatus is for impinging liquids from at least two liquid sources. The apparatus comprises a first jet actuator configured to dispense a first liquid from a first liquid source and a second jet actuator configured to dispense a second liquid from a second liquid source. The apparatus further comprises an adjustment element configured to adjust a trajectory of at least the first liquid dispensed from the first jet actuator such that the first liquid impinges the second liquid dispensed from the second jet actuator.

Abstract: Compositions and methods of use of treatment of one or more of ovarian cancer, endometrial cancer, head and neck cancer, noncancerous gynecological disorders, and estrogen sensitive cancers, the composition comprising an effective amount of a cannabinoid and a flavonoid wherein the method comprises administering to a patient in need thereof an effective amount of the composition and optionally administering the composition concomitantly with a chemotherapeutic agent.

Abstract: Provided herein are methods for detecting an estrogen-induced cancer in a subject, for identifying a subject at risk of developing an estrogen-induced cancer and for determining or predicting prognosis for a subject with an estrogen-induced cancer. The methods of the disclosure comprise determining the level of expression of ALPPL2 in a biological sample, typically a blood sample, obtained from a subject.

Abstract: A method for treating a noncancerous gynecological disorder comprising: administering to a patient and effective amount of composition comprising a cannabis extract comprising cannabidiol (CBD) wherein the composition is preferably administered in a mucosal form, such as intravaginally.

Abstract: Methods for treating ovarian cancer comprising: administering to a patient and effective amount of a cannabis extract comprising CBD wherein preferably the cannabis extract is administered via a mucosal formulation.

Abstract: A printing apparatus and method. The printing apparatus is for impinging liquids from at least two liquid sources. The apparatus comprises a first jet actuator configured to dispense a first liquid from a first liquid source and a second jet actuator configured to dispense a second liquid from a second liquid source. The apparatus further comprises an adjustment element configured to adjust a trajectory of at least the first liquid dispensed from the first jet actuator such that the first liquid impinges the second liquid dispensed from the second jet actuator.

Abstract: System, methods, and other embodiments described herein relate to estimating reachable states for a vehicle using a neural model. In one embodiment, a method includes generating an unverified command by a first controller and a safety command by a second controller for a projected path by an automated driving system (ADS) associated with a vehicle. The method also includes estimating reachable states by a neural network (NN) model that uses the unverified command and an initial condition for the vehicle, the reachable states representing positions and orientations for the vehicle within a bounded time and a state space associated with the initial condition and the projected path. The method also includes, upon determining that the reachable states satisfy collision criteria, executing by the vehicle a maneuver with the safety command for the projected path and generating subsequent commands using vehicle data from the first controller and the second controller.

Abstract: A wall shear stress sensor comprising first and second optical gratings, an incident light source and a photodetector. The second optical grating overlaps the first optical grating such that the first optical grating and second optical grating form a Moiré fringe pattern, wherein the second optical grating is displaceable relative to the first optical grating in response to a wall shear stress imparted on the sensor, and wherein displacement of the second optical grating correlates with a phase shift in the Moiré fringe pattern. The incident light source is configured to sequentially illuminate a plurality of discrete locations distributed across the Moiré fringe pattern. The photodetector is configured to detect light intensity reflected from each discrete location on the Moiré fringe pattern. A method of using the sensor and a two dimensional wall shear stress sensor system are also disclosed.

Abstract: Example implementations relate to gyroscopes comprising: a cyclic symmetric proof mass for bearing on a first surface degenerate, spatially orthogonal primary and secondary modes of vibration which become coupled in response to rotation about an axis of the proof mass; at least one actuator for inducing a primary surface acoustic wave of circumferential order n associated with the primary mode; and at least one sensor for sensing a secondary surface acoustic wave of circumferential order n associated with the secondary mode.

Abstract: A two-dimensional wall shear stress sensor comprising fixed and floating substrates, an incident light source and first and second photodetectors. The fixed substrate supports a first plurality of optical gratings. The floating substrate supports a second plurality of optical gratings superimposed over the first plurality of optical gratings to form a plurality of Moire fringe patterns comprising at least a first Moire fringe pattern extending in a first direction and a second Moire fringe pattern extending in a second direction different to the first direction. The floating substrate is displaceable relative to the fixed substrate in response to a wall shear stress imparted on the sensor, wherein displacement of the floating substrate correlates with a phase shift in at least one of the first and second Moire fringe patterns. An incident light source is configured to illuminate each of the plurality of Moire fringe patterns.

Abstract: A bone cement pressuriser (50) comprising a pressuriser head. The pressuriser head has a first side (51) coupled to or configured to couple to an end of a pressuriser handle and a second side (52) configured to transfer pressure to bone cement in a bone cavity. The second side of the pressuriser head is defined by a first, convex curved surface (53) and a second surface (54) forming a ring surrounding the first surface and extending radially beyond the first surface. A method of pressurising bone cement using the bone cement pressuriser is also disclosed. The first surface is configured to pressurise bone cement within a bone cavity and the second surface is configured to both pressurise bone cement within the bone cavity and to seal about the periphery of the bone cavity.

Abstract: A method for treating endometrial cancer comprising: administering to a patient a cannabis extract (CE) wherein the cannabis extract comprises cannabidiol (CBD) at between 50% and 99% by weight of the CE.