Abstract: This invention relates to a method of forming crystals of chemical molecules. The methods are effective even when only very small amounts of a compound are available and can be used to explore the experimental crystallisation space including screening for optimal crystallisation conditions such as for polymorphic phases, salts, solvates and co-crystals of chemical molecules and to provide single crystals for structural determination of unknown molecules by single crystal X-ray crystallography.

Abstract: Methods for treating ovarian cancer comprising: administering to a patient and effective amount of a cannabis extract comprising CBD, wherein preferably, the cannabis extract is administered via a mucosal formulation.

Abstract: A method for treating a noncancerous gynecological disorder comprising: administering to a patient and effective amount of composition comprising a cannabis extract comprising cannabidiol (CBD), wherein the composition is preferably administered in a mucosal form, such as intravaginally.

Abstract: An optogenetic system and method for preventing or halting seizures. The system and method use a sensor for monitoring the activity of a neural network containing a group of target neurons, and generating an input signal indicative of said activity, the target neurons being excitatory neurons. Excitatory stimulation is delivered in the form of an optical signal by an optical stimulator to the target neurons, the optical signal being determined based on the input signal, to reduce the overall activity of the target neurons.

Abstract: A method and apparatus are disclosed for simultaneously providing a plurality of probe response signals indicative of electrical activity at a respective plurality of locations in a patient. The apparatus comprises a rigid needle shaft element comprising a piercing tip and a substrate supporting a plurality of electrode tracks, secured to the needle shaft element and extending along the shaft element away from the piercing tip. Each electrode track extends from a sensing end region arranged for providing a respective probe response signal responsive to localised electrical activity, along the region of the substrate, to a respective bond pad connection region. Recording surface regions of the plurality of electrode tracks are spaced apart in a plurality of substantially linear spaced apart configurations along the substrate.

Abstract: A method of preparing a water in oil emulsion comprises forming a mixture of oil and emulsifying agent, progressively adding an aqueous salt solution to the mixture and dispersing the aqueous salt solution into the mixture. A concentrated water in oil emulsion is formed with drops of the aqueous salt solution (1) packed inside the oil solution phase (2). The emulsion is added to water and then mixed so that the emulsion absorbs the water. The salt concentration of the emulsion relative to the salt concentration of the water is controlled. Methods of agglomerating fine hydrophobic particles in a slurry using the water in oil emulsion are provided, where the emulsion is added to the slurry and then mixed so that the emulsion absorbs the water in the slurry. The salt concentration of the emulsion relative to the salt concentration of the slurry is controlled.

Abstract: This invention relates to a method of forming crystals of chemical molecules. The methods are effective even when only very small amounts of a compound are available and can be used to explore the experimental crystallisation space including screening for optimal crystallisation conditions such as for polymorphic phases, salts, solvates and co-crystals of chemical molecules and to provide single crystals for structural determination of unknown molecules by single crystal X-ray crystallography.

Abstract: Provided herein are methods of detecting or determining aging and/or oxidative damage in tissue, including placental tissue, skin, kidney and brain tissue. One embodiment provides a method for detecting or determining aging in body tissue, comprising measuring one or more markers of aldehyde oxidase 1 (AOX1) expression or activity in a biological sample, wherein the level of AOX1 expression or activity, or of the one or more markers, is indicative of aging in the tissue. Also provided herein are methods of treating a disease or condition associated with ageing or oxidative damage in one or more cells or tissues, comprising administering to a subject in need thereof an inhibitor of AOX1.

Abstract: A method of agglomerating fine particles such as ultrafine coal in a beneficiation process, uses a water in oil emulsion to significantly reduce the amount of oil needed compared with known oil in water emulsions. A solution of oil and emulsifying agent is provided to which water is progressively added forming a concentrated water in oil emulsion with stabilized water drops (1) packed inside the oil solution phase (2). Fine particles in a slurry are then added, causing the fine particles to collide and stick to the emulsion particles. An optional form of the invention coats tiny portions of the emulsion in a thin film of low viscosity oil (5) to achieve a higher level of selectivity.

Abstract: A vibration unit assembly for a belt conveyor has a vibration element, and vibration generator and a connection assembly. The vibration generator is operatively connected to the vibration element for inducing vibrations in the vibration element. The connection assembly connects the vibration element to the belt conveyor so that the vibration element may move relative to the belt conveyor. A contact surface of the vibration element engages a material to vibrate and compress the material as it is transported on the belt conveyor. The vibration element may include a plate or a roller. A method for treating a material involves applying a vibration force and applying a compressive force to compact the material. A method for drying a material involves applying a vibration force to the material to release fluid and applying a compressive force to compact the material.

Abstract: An apparatus and method for the dry separation of bulk particulate material, especially coarse particles, is provided. The apparatus comprises a chamber, a screen adjacent the chamber and a fluidising device fluidly connected to the chamber. The screen has a screen surface, a plurality of apertures and an opening larger in size than the aperture. A mixture of the coarse particles and a fine particulate medium is fed into the chamber. The fluidising device directs a fluidising fluid to fluidise a fine particulate medium and create a fluidised bed directed towards the screen. The fine particulate medium and the coarse particles pass from the chamber through the openings. The fine particulate medium passes back through the apertures to the chamber. Relatively high density coarse particles also pass back through the openings to the chamber. Relatively low density coarse particles are retained on the screen surface. Vibrations may also be used.

Abstract: There is provided a method for promoting epithelium repair in a subject, the method comprising administering to the subject a therapeutically effective amount of an activator of PI3K/Akt signalling.

Abstract: An optrode arrangement for delivering optical stimulation to target tissue in a patient, the optrode arrangement comprising an implantable optrode comprising at least one electrically powered light emitter and an electrical circuit and control lines for controlling the light emitter, whereby an associated controller has two modes of operation: a stimulation mode in which it is configured to control the light emitter to deliver optical stimulation to the target tissue and a diagnostic mode in which it is configured to determine a condition of the light emitter and/or the optrode.

Abstract: A temperature sensor comprising a light emitter, an electrical circuit for applying a reverse bias voltage across the light emitter and for measuring a reverse current, and means for calculating a temperature from the measured reverse current.

Abstract: An electrical sub-assembly comprises a stator having a plurality of coils and a cooling means attached to the stator. The electrical sub-assembly further comprises a plurality of pairs of diodes attached to the cooling means, each pair of diodes being in antiparallel configuration and having three electrical terminals. One of the three electrical terminals is a common terminal shared by both diodes in each pair of diodes. A plurality of busbars electrically connect each of the diodes to at least one of the plurality of coils via one or more of the electrical terminals. In use, the cooling means is configured to simultaneously cool the stator and the plurality of diodes. The electrical sub-assembly may have particular application as a part of a switched reluctance machine.

Abstract: Provided herein are methods and compositions for the targeted delivery to myometrial tissue of one or more agents capable of regulating contractility of myometrial tissue, wherein the one or more agents are contained or encapsulated within a polymeric delivery vehicle conjugated with one or more molecules that recognizes and/or is capable of binding, directly or indirectly, to the oxytocin receptor.

Abstract: Provided herein are methods for treating or preventing myopia, or for inhibiting the development of myopia, comprising administering to a subject in need thereof an effective amount of an agent capable of increasing nitric oxide levels in one or more ocular cells or an agent capable of promoting or increasing the expression and/or activity of nNOS in one or more ocular cells. Also provided are methods for inducing or promoting nNOS expression and/or activity in one or more ocular cells, comprising exposing said cells to an effective amount of L-arginine.

Abstract: This invention relates to a method of chemical looping using non-stoichiometric materials with a variable degree of non-stoichiometry. One application of these methods is in the water gas shift reaction for H2 production. The methods of the invention can overcome limitations, e.g. those associated with chemical equilibria, which prevent chemical processes from proceeding with complete conversion of starting materials to products.

Abstract: A method for preventing counterfeiting of an object includes capturing an image of at least a portion of the object that is at least partially transparent. The captured image includes features of the internal structure of the object. Based on the image, a code is generated that encodes features of the internal structure of the object. The code is recorded. Generating the code includes applying a filter to the image to obtain a filtered image, and processing the filtered image to obtain a binary code. A random key, k, is generated, and a codeword fp is obtained by applying an error-correction encoding scheme, ErrorCC, to the random key according to fp=ErrorCC(k), wherein fp has the same size as the binary code fa. An encrypted binary code, r, is computed according r=fa?fp, where ? denotes modulo-2 addition. A hash value, h, is computed according to h=H(k), where H is a one-way hash function. Recording the code comprises recording the encrypted binary code r and the hash value h.

Abstract: A method for preventing counterfeiting of an object includes capturing an image of at least a portion of the object that is at least partially transparent. The captured image includes features of the internal structure of the object. Based on the image, a code is generated that encodes features of the internal structure of the object. The code is recorded. Generating the code includes applying a filter to the image to obtain a filtered image, and processing the filtered image to obtain a binary code. A random key, k, is generated, and a codeword fp is obtained by applying an error-correction encoding scheme, ErrorCC, to the random key according to fp=ErrorCC(k), wherein fp has the same size as the binary code fa. An encrypted binary code, r, is computed according r=fa?fp, where ? denotes modulo-2 addition. A hash value, h, is computed according to h=H(k), where H is a one-way hash function. Recording the code comprises recording the encrypted binary code r and the hash value h.