Abstract: A heat engine comprising compressor and expander displacement elements (210, 211) reciprocating in respective compression and expansion chambers (111, 111?, 102, 102?) and arranged in a linear, free piston configuration, a combustor (116) separate from the compression and expansion chambers (111, 111?, 102, 102?), and a linear energy conversion device (212, 213) providing conversion of solid, liquid, or gaseous fuel into hydraulic, electric, or pneumatic energy by means of subjecting a working fluid to a thermodynamic cycle with substantially constant pressure combustion. The inlet and outlet valves of the compression chamber (102, 102?) and the rate of fuel injection to the combustor (116) are actively controlled by an electronic controller to avoid engine damage, and to maintain thermodynamic efficiency over a wide range of loads.

Abstract: A linear-acting, free-piston internal combustion engine suitable for operation on a four-stroke engine cycle comprises a power piston (11a, 11b) reciprocating in a power chamber (18a, 18b) and a compression piston (23, 23a, 23b) reciprocating in a compression chamber (29a, 29b). The power piston (11a, 11b) and the compression piston (23, 23a, 23b) are rigidly connected by means of a rod (19). The compression piston (23, 23a, 23b) performs alternately an intake stroke and a compression stroke and the power piston (11a, 11b) performs alternately a power stroke and an exhaust stroke.

Abstract: A plant growth support medium is described to enhance soil characteristics and provide where required, improved water, or nutrient contents. La addition the medium can be inoculated with microorganisms to aid soil characteristics and provide interactions within micron-scale environment between plant roots, water, nutrients and where applicable, bacteria and root exudates. This micro-environment provides direct delivery of active ingredients to the plant roots. The medium comprises a polymeric material having a primary pore size of greater than 30 micron. The walls of the pores are elastic, enabling the pore to swell in size to retain water, solutes or other biologically useful components and allow root penetration through them. Sulphonation of the walls renders the walls more hydrophilic so attracting water into the pores and also increasing the wall elasticity. Capillaries can be provided to interconnect pores and allow root penetration into the medium.

Abstract: An ultrasound imaging apparatus including a processing unit configured to produce an ultrasound image of the target region by applying position/orientation data representative of the position and/or orientation of an ultrasound transducer on the first side of a surface during each collection cycle to echo data representative of reflected ultrasound energy received by the ultrasound transducer during each collection cycle so as to coherently focus the echo data at a plurality of points distributed within the target region.

Abstract: An image processing system is described which is arranged to highlight information in image displays by selectively blurring less important areas of an image. By generating such displays comprising areas which are in focus and areas which are out of focus, a viewer's attention is preferentially drawn towards those areas of an image which appear sharp. By having a display system which is arranged to generate such images a means is provided to direct a viewer's attention towards considering the sharp areas of the image display first. Further the selective blurring portions of an image reduces rather than increases the amount of information presented to a viewer and hence reduces the likelihood that a viewer will become overloaded with information. Display systems of this type are therefore especially applicable to complex control environments as means of directing viewer's attention.

Abstract: The present invention relates to the discovery of an epigenetic relay pathway that controls hepatic stellate cell activation and the wound-healing response in fibrogenesis, including fibrogenesis of the injured liver. Methods of inhibiting fibrogenesis, including liver fibrogenesis and secondary disease states and conditions thereof, and in treating liver damage, including cirrhosis of the liver (which may be caused by viruses or chemicals, including alcohol), are aspects of the present invention. The methods utilize certain nucleoside compounds and/or antibodies which are optionally conjugated. Pharmaceutical compositions represent additional aspects of the invention.

Abstract: The present invention relates to a self monitoring device for attachment to the body, which incorporates real-time and correlated measurement of body movement and physiological analytes of metabolism (e.g. glucose) that can be modulated by physical activity. The system enables real time and personalised modulation of the selected physiological analyte(s) through appropriately selected cued activities and other evidence based clinical guidance dependent on previous and current analyte levels correlated with previous and current patterns of movement. The system also allows for personalisation of the outputs with regular calibration to the user.

Abstract: The present invention relates to a variant archaeal DNA polymerase having a modified amino acid sequence of a wild-type amino acid sequence, the modified sequence being in the amino-terminal amino acids that comprise a uracil-binding pocket in the wild-type polymerase whereby the variant polymerase has reduced affinity for uracil than the wild-type polymerase. Such variant polymerases may be usefully employed in biological assay systems such as the polymerase chain reaction.

Abstract: A method of immobilising a biological molecule on a substrate comprises: (i) covalently attaching a substantially three-dimensional polysilane polymer to a substrate; and (ii) attaching a biological molecule onto and/or within the polymer. The method may additionally comprise the steps of coating the substrate (or the chemically protective layer) with a layer of radiation sensitive material, exposing the substrate to a source of radiation, and incubating the substrate in the presence of a first species of biological molecule.

Abstract: Apparatus for reducing dust emissions from particulate commodities such as wheat or coal using a curved loading spoon connected to the discharge from a loading spout. The curved loading spoon turns particulate commodities delivered at a rate above a predetermined delivery velocity against a curved outer wall causing dust arising from the particulate commodities to be re-entrained within the commodities as they are diverted from a straight path by the curvature. Also described are an optional flap designed to rest just above the surface of the commodities stream adjacent the outlet, and a converging duct located upstream of the curve loading spoon and arranged to direct commodities against the curved outer wall adjacent the inlet.

Abstract: The present invention relates to methods for the separation of materials from heterogeneous fluids and provides a means of effecting stimulant-sensitive flocculation and consolidation of solid suspensions within a liquid medium. Specifically, the present invention provides a method of controlling the state of a suspension of solid particles in a liquid, including applying to the suspension a stimulus adapted to control inter-particle forces between the solid particles. The stimulus is reversibly operable to control attraction and/or repulsion. Means of consolidating a sediment bed and of separating the resultant liquids-rich and solids-rich phases are also within the ambit of the invention.

Abstract: The present invention provides a device (10) for detecting the frothing ability of a fluid, said device including: an inlet (11) for receiving a portion of said fluid; means (12) for entraining air into said fluid portion; a mixing chamber (13) for receiving said air entrained fluid portion, said mixing chamber (13) being adapted for mixing said fluid portion and said air; and a detector (15) for detecting the amount of froth (18) generated in said mixing chamber (13). The invention also provides a method for detecting the frothing ability of a fluid.

Abstract: The present invention relates to the discovery of an epigenetic relay pathway that controls hepatic stellate cell activation and the wound-healing response in fibrogenesis, including fibrogenesis of the injured liver. Methods of inhibiting fibrogenesis, including liver fibrogenesis and secondary disease states and conditions thereof, and in treating liver damage, including cirrhosis of the liver (which may be caused by viruses or chemicals, including alcohol), are aspects of the present invention. The methods utilize certain nucleoside compounds and/or antibodies which are optionally conjugated. Pharmaceutical compositions represent additional aspects of the invention.

Abstract: An iodonium compound of formula (I): where RAR1 is a C5-6 aryl group, bearing at least one substituent selected from formyl, thionoacyl, acylamidocarboxy, thionoester, azo, C2-20 alkenyl, C2-20 alkynyl, and (CH2)nRC, where RC is selected from ether, amino, azo and thioether; RAR2 is a C5-10 aryl group, optionally substituted by one or more groups selected from C1-12 alkyl, C5-12 aryl, C3-12 heterocyclyl, ether, thioether, nitro, cyano and halo, and may be linked to a solid support or fluorous tag; and X is a counteranion.

Abstract: A process for preparing functionalised microporous polymers (which are also known as micro-cellular polymers or polyHIPE polymers (PHPs)) using intensified internal heating (for example by microwave irradiation).

Abstract: A method of depositing or etching a micro- or nano-scale pattern on a work piece is disclosed, including the steps of: (a) placing the work piece in an electrochemical reactor in close proximity to a patterned tool; (b) connecting the work piece such that it is the anode if is to be etched or the cathode if it is to be deposited, and the patterned tool such that it is the counter electrode; (c) pumping electrolytic fluid necessary for the electrolytic operation of the cell formed between the two electrodes; and (d) applying a current across the electrodes to etch or deposit the work piece.

Abstract: A peak flow measurement device comprises a hollow body (1) having an inlet (8) for receiving fluid and an outlet (3), wherein the inlet (8) and outlet (3) are spaced apart from each other, the cross-sectional area of the body being greater than the cross-sectional area of the outlet and wherein in use the device is oriented such that the inlet is above the outlet and the measured peak flow is proportional to the maximum height (11) of fluid within the body.

Abstract: A scapula component (1) for a reverse shoulder prosthesis comprises a part spherical, convex, surface (3) which is less than a hemisphere. The part spherical surface does not have a rotational axis of symmetry, and may include a main circular surface portion and one or more subsidiary surface portions (5, 6, 7) depending from an edge of the main surface portion. A humerus component (200) for a reverse shoulder prosthesis comprises a cup member (202) having a part spherical, concave bearing surface (206) surrounded by an oval rim (208).

Abstract: Pesticidal compounds of general formula (I) Wherein ?represents a double bond; A— represents ?C(R5)—C(?O)—, wherein R represents hydrogen or halogen, R1 and R2 represent, independently, hydrogen, halogen, alkoxy, substituted alkoxy or an ester group; or R1 and R2, together with the carbon atoms to which they are attached, represent an oxirane ring; or R1 and R2, taken together, represent an alkylidenedioxy or substituted alkylidenedioxy group; and R3 represents —CH2R6, wherein R6 represents an ester group, oxiranyl, or a group of formula wherein R7 represents hydrogen or alkyl, R8 represents phenylsulfanyl, phenylselenyl, phenylsulfoxy or phenylselenoxy, and R9 represents hydrogen, ethoxycarbonyl or carbamoyl and R4 represents, independently, hydrogen, alkoxy or substituted alkoxy; and methods of making the compounds of formula (I) and methods for controlling pests wherein the pest dies as a result of contact with a compound of formula (I).

Abstract: A method of manufacturing thermosets such as epoxy resins includes adding expandable hollow microspheres, which expand with temperature as shown in the accompanying graph, to the base thermoset components in the liquid phase and applying heat treatment to the mixture so formed causing the micropsheres to expand during or after curing of the thermoset. This results in a toughening mechanism caused by compressive residual stress around the microspheres which significantly increases the specific fracture energy of the epoxy resin.