Patents Assigned to University of Nottingham
  • Patent number: 10352984
    Abstract: A method of locating a fault on an electricity transmission line is disclosed. The transmission line has a known line impedance and is operable to transport electricity at one or more system frequencies. The method comprises using measurements of the current and voltage made on the line at one or more frequencies which are different to the system frequency and the known line impedance (Z) to determine a distance to the fault. The method may include monitoring the voltage and the current on the transmission line at the one or more non-system frequencies, and determining from the presence of signals at a non-system frequency on the transmission line that a fault has occurred.
    Type: Grant
    Filed: November 28, 2012
    Date of Patent: July 16, 2019
    Assignee: The University of Nottingham
    Inventors: David Thomas, Mark Sumner, Jia Ke
  • Patent number: 10301264
    Abstract: Anti-angiogenic treatments, treatments of hyperpermeability disorders, treatments of neuropathic and neurodegenerative disorders, pain treatments, methods of reducing the risk of pre-eclampsia and compounds for use in such methods are described.
    Type: Grant
    Filed: October 17, 2013
    Date of Patent: May 28, 2019
    Assignee: The University of Nottingham
    Inventors: Steven James Harper, David Owen Bates, Melissa Gammons, Jonathan Morris
  • Patent number: 10226537
    Abstract: This invention relates to transduction of cargo molecules into living cells, such as protein transduction, in particular a delivery molecule for transduction of a cargo into a cell comprising: a cargo-binding molecule and/or a cargo; a glycosaminoglycan (GAG) binding element, which is capable of binding to GAG on the surface of the cell; and a protein transduction domain. Methods of transduction, methods of producing or modifying cargo for transduction, delivery molecules for transduction and methods of treatment using transduction, or using transduced cells are also provided.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: March 12, 2019
    Assignee: The University of Nottingham
    Inventors: James Dixon, Kevin Shakesheff, Chris Denning
  • Patent number: 10139406
    Abstract: A method of determining the P. aeruginosa or related species infection status of a subject comprising: (i) providing a sample of material obtained from the subject; (ii) determining the level of one or more alkyl quinolones or metabolites thereof produced by P.
    Type: Grant
    Filed: May 13, 2014
    Date of Patent: November 27, 2018
    Assignee: The University of Nottingham
    Inventors: Miguel Camara, Paul Williams, David Barrett, Nigel Halliday, Alan Knox, Alan Smyth, Andrew Fogarty, Helen Barr, Doug Forrester
  • Patent number: 10125739
    Abstract: A system suitable for extracting power directly from the main shafts of slow-moving mechanical systems. The system has a closed gas circuit having a lower-pressure (LP) side and a higher-pressure (HP) side. The LP side is at a pressure substantially greater than atmospheric pressure. The system includes primary compressors coupled to the wind turbines, thermal stores coupled to heat-exchangers on both the LP and HP sides of the closed gas circuit, a secondary motor-compressor set and an expander-generator set. The system allows some degree of independence between the input power resource and the output power. When substantial wind power is present and the demand for electrical power is weak, this system can export a fraction of the energy captured and store the rest. When the wind resource is low, the system can export more power than is being collected by drawing energy from the thermal stores.
    Type: Grant
    Filed: August 1, 2014
    Date of Patent: November 13, 2018
    Assignee: The University of Nottingham
    Inventor: Seamus Dominic Garvey
  • Publication number: 20180296733
    Abstract: The invention provides a method for inhibiting bacterial attachment to a surface, the method comprising forming the surface from a polymer, or applying a polymer to the surface, wherein the polymer is a homopolymer formed from a (meth) acrylate or (meth) acrylamide monomer or a copolymer formed from one or more (meth) acrylate or (meth) acrylamide monomers, wherein the (meth) acrylate or (meth) acrylamide monomers are of formula (I) or (II): [H2C?CR?—C(=0)-0-]n, R (I) [H2C?CR?—C(=0)-NH—]n R (II) wherein n is 1, 2 or 3, R? is independently H or CH3, R is an organic group having a total of from 2 to 24 carbon atoms, wherein the organic group includes an aliphatic or aromatic hydrocarbon moiety and wherein the organic group does not include any hydroxyl groups.
    Type: Application
    Filed: May 24, 2018
    Publication date: October 18, 2018
    Applicants: The University of Nottingham, Massachusetts Institute of Technology
    Inventors: Paul Williams, Morgan Russell Alexander, Martyn Christopher Davies, Robert Langer, Daniel Griffith Anderson
  • Publication number: 20180271987
    Abstract: The invention relates to apH mediated cell delivery vehicle comprising: a cargo or a cargo-binding molecule for binding to a cargo; a protein transduction domain; and a glycosaminoglycan (GAG) binding element, which is capable of binding to GAG on the surface of the cell, wherein the GAG binding element is a peptide which is modified to comprise one or more histidine residues which are capable of being protonated in an acidic environment. The invention further relates to the use of such a delivery vehicle including methods of treatment, such as treatment for cancer.
    Type: Application
    Filed: June 23, 2016
    Publication date: September 27, 2018
    Applicant: The University of Nottingham
    Inventor: James Dixon
  • Patent number: 10072073
    Abstract: A glycan having the structure gal?1-3GLcNac?1-3Gal?1-4(Fuc?1-3)GlcNAc (LecLex) which is attached to a lipid or protein backbone, and isolated binding members capable of binding thereto.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: September 11, 2018
    Assignee: The University of Nottingham
    Inventors: Lindy Gillian Durrant, Jiaxin Chua, Tina Rose Parsons
  • Patent number: 10012591
    Abstract: The disclosure relates to measurement and classification of tissue structures in samples using a combination of light imaging and spectroscopy, in particular although not necessarily exclusively for detection of tumors such as basal cell carcinoma or breast tumors in tissue samples. Embodiments disclosed include a method of automatically identifying tissue structures in a sample, the method comprising the steps of: measuring (1702, 1703) a response of an area of the sample to illumination with light; identifying (1704) regions within the area having a measured response within a predetermined range; determining (1705) locations within the identified regions; performing (1706) spectroscopic analysis of the sample at the determined locations; and identifying (1707) a tissue structure for each region from the spectroscopic analysis performed on one or more locations therein.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: July 3, 2018
    Assignees: The University of Nottingham, Royal Holloway University of London
    Inventors: Ioan Notingher, Kenny Kong, Christopher Rowlands, Hywel Williams, Iain Leach, Sandeep Varma, William Perkins, Alexey Koloydenko
  • Patent number: 9981068
    Abstract: The invention provides a method for inhibiting bacterial attachment to a surface, the method comprising forming the surface from a polymer, or applying a polymer to the surface, wherein the polymer is a homopolymer formed from a (meth) acrylate or (meth) acrylamide monomer or a copolymer formed from one or more (meth) acrylate or (meth) acrylamide monomers, wherein the (meth) acrylate or (meth) acrylamide monomers are of formula (I) or (II): [H2C?CR?—C(?O)—O—]nR??(I) [H2C?CR?—C(?O)—NH—]nR??(II) wherein n is 1, 2 or 3, R? is independently H or CH3, R is an organic group having a total of from 2 to 24 carbon atoms, wherein the organic group includes an aliphatic or aromatic hydrocarbon moiety and wherein the organic group does not include any hydroxyl groups.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: May 29, 2018
    Assignees: The University of Nottingham, Massachusetts Institute of Technology
    Inventors: Paul Williams, Morgan Russell Alexander, Martyn Christopher Davies, Robert Langer, Daniel Griffith Anderson
  • Patent number: 9932330
    Abstract: Anti-angiogenic treatments, treatments of hyperpermeability disorders, treatments of neuropathic and neurodegenerative disorders, pain treatments, methods of reducing the risk of pre-eclampsia and compounds for use in such methods are described.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: April 3, 2018
    Assignees: The University of Nottingham, NewSouth Innovations PTY Limited
    Inventors: David Bates, Jonathan Morris
  • Patent number: 9861662
    Abstract: Methods of manufacturing a bone-derived extracellular matrix (bECM) product are provided. Also provided are bECM products and methods of using those products.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: January 9, 2018
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, The University of Nottingham
    Inventors: Stephen F. Badylak, Michael J. Sawkins, Kevin M. Shakesheff, Lisa J. White
  • Patent number: 9796707
    Abstract: Anti-angiogenic treatments, treatments of hyperpermeability disorders, treatments of neuropathic and neurodegenerative disorders, pain treatments, methods of reducing the risk of pre-eclampsia and compounds for use in such methods are described.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: October 24, 2017
    Assignees: The University of Nottingham, NewSouth Innovations PTY Limited
    Inventors: David Bates, Jonathan Morris
  • Patent number: 9733177
    Abstract: An optical detector comprises a plurality of pixels, each pixel comprising a photodiode operable to detect light incident on that pixel and to generate a signal indicative of an intensity of that light. The plurality of pixels comprises a plurality of pixel pairs, and for each pixel pair, in a configuration mode, the detector is arranged to compare the signal generated by a first pixel of the pair with the signal generated by a second pixel of the pair. A method of optical detection is also described, as is a system incorporating the described optical detector.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: August 15, 2017
    Assignee: University of Nottingham
    Inventors: Stephen Sharples, Roger Light
  • Patent number: 9695160
    Abstract: Anti-angiogenic treatments, treatments of hyperpermeability disorders, treatments of neuropathic and neurodegenerative disorders, pain treatments, methods of reducing the risk of pre-eclampsia and compounds for use in such methods are described.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: July 4, 2017
    Assignees: The University of Nottingham, NewSouth Innovations PTY Limited
    Inventors: David Bates, Jonathan Morris
  • Patent number: 9662344
    Abstract: A composition for influencing carnitine retention in biological tissue is disclosed. The composition comprises a carnitine substance and an agent to increase sodium potassium ATPase pump activity in the tissue, and/or to increase the activity of a carnitine transport protein, and/or increase blood/plasma insulin concentration.
    Type: Grant
    Filed: March 22, 2004
    Date of Patent: May 30, 2017
    Assignees: The University of Nottingham, Lonza Sales LTD.
    Inventors: Paul Leonard Greenhaff, Dumitru Constantin-Teodosiu
  • Publication number: 20170080101
    Abstract: This invention relates to transduction of cargo molecules into living cells, such as protein transduction, in particular a delivery molecule for transduction of a cargo into a cell comprising: a cargo-binding molecule and/or a cargo; a glycosaminoglycan (GAG) binding element, which is capable of binding to GAG on the surface of the cell; and a protein transduction domain. Methods of transduction, methods of producing or modifying cargo for transduction, delivery molecules for transduction and methods of treatment using transduction, or using transduced cells are also provided.
    Type: Application
    Filed: December 18, 2014
    Publication date: March 23, 2017
    Applicant: The University of Nottingham
    Inventors: James DIXON, Kevin SHAKESHEFF, Chris DENNING
  • Patent number: 9593132
    Abstract: The present invention relates to a metal organic framework comprising of a metal ion (M) and an organic ligand wherein more than one hydroxy ligand are present about the metal ion. Also provided is a method for synthesizing the metal-organic frameworks and their application in areas including scrubbing exhaust gas streams of acidic gases, scrubbing natural gas of acidic gases by separation or sequestration and separating C2Ha or other VOC gases from other gas mixtures.
    Type: Grant
    Filed: March 27, 2013
    Date of Patent: March 14, 2017
    Assignee: The University of Nottingham
    Inventors: Martin Schroder, Sihai Yang
  • Publication number: 20170044282
    Abstract: The invention relates to a method for producing functionalised monomers, the method comprising: a) providing a starting material selected from terpenes and terpenoids; b) forming a derivative of the starting material by incorporation of a hydroxyl group; c) esterifying the hydroxyl group of the derivative to introduce a moiety containing a vinyl group, so as to produce a functionalised monomer. The functionalised monomer can be polymerised to obtain a bio-derived polymer.
    Type: Application
    Filed: April 22, 2015
    Publication date: February 16, 2017
    Applicant: The University of Nottingham
    Inventors: Steven Howdle, Robert Stockman, Marina Fuentes, Jose Souto, Dominika Regentova, Derek Irvine
  • Patent number: 9470629
    Abstract: Surface plasmon microscopy methods are described which comprise irradiating a sample with a beam of electromagnetic radiation, wherein at least some of the radiation is incident on the sample at an angle or angles which results in the excitation of surface plasmons in the sample, and wherein the beam of radiation comprises a longitudinal axis passing through a focus of the beam. Both radiation reradiated from the sample by one or more surface plasmons and radiation reflected from a location on the sample which does not lie on the longitudinal axis passing through the focusare received at a detector. The received reradiated radiation is then interfered with the received reflected radiation to provide information about the sample. Apparatus for performing the methods is also described.
    Type: Grant
    Filed: September 18, 2013
    Date of Patent: October 18, 2016
    Assignee: The University of Nottingham
    Inventors: Michael Geoffrey Somekh, Chung Wah See