Abstract: The invention may provide, in part, compounds for use as antiproliferative, chemotherapeutic, antiviral, cell sensitising or adjuvant agents, and pharmaceutical compositions including the compounds. The compounds may be for use in treating diseases and disorders related to cell proliferation such as cancer, or in treating diseases and disorder which are linked to aberrant control of protein synthesis, such as cancer, viral infection, muscle wasting, autistic spectrum disorders, Alzheimer's disease, Huntingdon's disease and Parkinson's disease.

Abstract: The present disclosure relates to a method for producing metallurgical coke from non-coking coal. The method comprising, densifying, the non-coking coal to form pellets. The densified pellets will be placed in a microwave oven within plurality of bricks and are subjected for pyrolysis. For carrying our pyrolysis, the pellets are carried out by heating, the pellets in the microwave oven at a predetermined temperature under an inert atmosphere at atmospheric pressure, and then the pellets are cooled in the microwave oven under the inert atmosphere. This process coverts non-coking coal to the metallurgical coke in a quicker time, and without use of any susceptors.

Abstract: Methods of printing a three-dimensional object using co-reactive components are disclosed. Thermosetting compositions for three-dimensional printing are also disclosed.

Abstract: Novel compounds having antimicrobial activity, in particular against Pseudomonas aeruginosa, Burkholderia cepacia and/or Clostridium difficile, and a pharmaceutical composition containing the novel compound.

Abstract: A method (300) of fabricating an object by additive manufacturing comprises providing (310) a layer of polymeric material (100), said polymeric material (100) being in particulate form, and comprising linear polymer chains, selectively depositing (320) a reactive liquid (200) onto the layer of particulate polymeric material (100), said reactive liquid (200) comprising reactive units (210a) which are monomeric units, linear oligomeric units, linear polymeric units, or combinations thereof, wherein said reactive units (210a) have two or fewer reactive groups, and allowing (330) linear polymeric chains in said layer of polymeric material (100) to react with reactive units in said reactive liquid (200) so as to form extended polymeric chains that are linear, so as to provide a shaped layer of linear polymer. These steps (310, 320, 330) are repeated as required to form the object from successive shaped layers of linear polymer.

Abstract: A photoplethysmograph device includes a light source for illuminating a target object. A modulator drives the light source such that the output intensity varies as a function of a modulation signal at a modulation frequency. A detector receives light from the target object and generates an electrical output as a function of the intensity of received light. A demodulator with a local oscillator receives the detector output and produces a demodulated output, insensitive to any phase difference between the modulation signal and the oscillator, indicative of blood volume as a function of time and/or blood composition. A number of demodulators may be provided to derive signals from multiple light sources of different wavelengths, or from an array of detectors. The plethysmograph may operate in a transmission mode or a reflectance mode. When in a reflectance mode, the device may use the green part of the optical spectrum and may use polarising filters.

Abstract: The present disclosure relates to a method for producing metallurgical coke from non-coking coal. The method comprising, densifying, the non-coking coal to form pellets. The densified pellets will be placed in a microwave oven within plurality of bricks and are subjected for pyrolysis. For carrying our pyrolysis, the pellets are carried out by heating, the pellets in the microwave oven at a predetermined temperature under an inert atmosphere at atmospheric pressure, and then the pellets are cooled in the microwave oven under the inert atmosphere. This process coverts non-coking coal to the metallurgical coke in a quicker time, and without use of any susceptors.

Abstract: The present invention provides a method for diagnosing in a subject Acute Kidney Injury or a related or analogous disease state. The method comprises the steps of a) providing a sample taken from the subject: b) analysing the sample from the subject to determine the level of a biomarker selected from certain atomic species; and c) comparing the level of the biomarker in the sample to a reference level of the biomarker that is characteristic of a healthy subject, eg a subject having normal renal function. An elevated level of the biomarker in the sample relative to the reference level is indicative of Acute Kidney Injury or a related or analogous disease state. The invention also relates to the use of an atomic species selected from those in Table 1 as a biomarker for Acute Kidney Injury or a related or analogous disease state, and test kits comprising an analytical element sensitive to those biomarkers.

Abstract: Provided are methods for preparing non-gelling, solubilized extracellular matrix (ECM) materials useful as cell growth substrates. Also provided are compositions prepared according to the methods as well as uses for the compositions. In one embodiment a device, such as a prosthesis, is provided which comprises an inorganic matrix into which the non-gelling, solubilized ECM composition is dispersed to facilitate in-growth of cells into the ECM and thus adaptation and/or attachment of the device to a patient. In another embodiment, the composition is delivered intraarticularly, intrathecally, intraoccularly, intracranially, and into pleural space.

Abstract: This invention related to compounds that are inhibitors of the CDK12 kinase. The compounds are useful in the treatment of disorders mediated by the CDK12 kinase including myotonic dystrophy type 1 (DM1) and other disorders caused by the generation of RNA repeat expansion transcripts. In particular, the invention relates to compounds of the formula (I), or a pharmaceutically acceptable salts or N-oxides thereof, wherein R1a, R2, R3, R4a, R4b and R4c are as defined herein.

Abstract: A mixing reactor for precipitating nanoparticles by mixing a precursor fluid with a second fluid at a higher temperature than the precursor fluid. The reactor comprises: a first fluid conduit with an inlet region configured to receive a flow of the precursor fluid, and an outlet region configured to output a mixed flow; and a second fluid conduit configured to receive a flow of the second fluid. The second fluid conduit extends into the first fluid conduit in a direction substantially perpendicular to the flow within the first fluid conduit, and has an opening for introducing the second fluid into the first fluid conduit. Related processes for producing nanoparticles are disclosed.

Abstract: Novel compounds having antimicrobial activity, in particular against Pseudomonas aeruginosa, Burkholderia cepacia and/or Clostridium difficile, and a pharmaceutical composition containing the novel compound.

Abstract: The invention relates to a preserved amniotic membrane, in particular a vacuum-dried amniotic membrane. It also relates to uses of vacuum-dried amniotic membrane and methods for making a vacuum-dried amniotic membrane. A method of processing an amniotic membrane to provide a vacuum-dried amniotic membrane, comprising the step of vacuum-drying the amniotic membrane Amniotic membrane (AM) is the inner most extraembryonic membrane that surrounds the foetus in a sac of amniotic fluid, functioning as a protective barrier to ascending infection and trauma during pregnancy.

Abstract: The present invention relates to polypeptides and uses thereof for reducing CD95-meditated cell motility. In particular, the present invention relates to a polypeptide having an amino acid sequence having at least 70% of identity with the amino acid sequence ranging from the amino-acid residue at position 175 to the amino-acid residue at position 191 in SEQ ID NO:1.

Abstract: The invention may provide, in part, compounds for use as antiproliferative, chemotherapeutic, antiviral, cell sensitising or adjuvant agents, and pharmaceutical compositions including the compounds. The compounds may be for use in treating diseases and disorders related to cell proliferation such as cancer, or in treating diseases and disorder which are linked to aberrant control of protein synthesis, such as cancer, viral infection, muscle wasting, autistic spectrum disorders, Alzheimer's disease, Huntingdon's disease and Parkinson's disease.

Abstract: A medical device material impregnated with a combination of antimicrobial agents, the combination of antimicrobial agents comprising a first antimicrobial agent, the first antimicrobial agent being triclosan and at least a second antimicrobial agent, wherein the combination of antimicrobial agents provides the device material with antimicrobial activity and inhibition of resistant microbial mutations for of the order of, or greater than, 80 days.

Abstract: The invention may provide, in part, compounds for use as antiproliferative, chemotherapeutic, antiviral, cell sensitizing or adjuvant agents, and pharmaceutical compositions including the compounds. The compounds may be for use in treating diseases and disorders related to cell proliferation such as cancer, or in treating diseases and disorders which are linked to aberrant control of protein synthesis, such as cancer, viral infection, muscle wasting, autistic spectrum disorders, Alzheimer's disease, Huntingdon's disease and Parkinson's disease.

Abstract: A mixing reactor (1), the reactor comprising a body (2) having a first inlet (3), a second inlet (5) and an outlet (4), in which there is an inner passage (6) through the body (2) from the first inlet (3) at a first end (12) of the body (2) to the outlet (4) at a second end of the body (2) along a length of the body (2), the inner passage (6) having a side wall (17) along the length, and an outer passage (7) closer to a surface (14) of the body (2) than the inner passage (6), the outer passage (7) running from the second inlet (5) at the second end, travelling through the body (2) along the length and meeting the inner passage (6) at a junction (11) at the first end, the outer passage (7) joining the inner passage (6) through the side wall (17) at the junction (11). Such a mixing reactor can be used for producing particles such as nanoparticles or Metal-Organic frameworks.

Abstract: A method of locating a fault on an electricity transmission line is disclosed. The transmission line has a known line impedance and is operable to transport electricity at one or more system frequencies. The method comprises using measurements of the current and voltage made on the line at one or more frequencies which are different to the system frequency and the known line impedance (Z) to determine a distance to the fault. The method may include monitoring the voltage and the current on the transmission line at the one or more non-system frequencies, and determining from the presence of signals at a non-system frequency on the transmission line that a fault has occurred.

Abstract: A method for testing for target Mycobacteria in a reaction mixture comprising the steps of: providing a reaction mixture; admixing a bacteriophage with the reaction mixture under conditions suitable to allow the bacteriophage to infect any target Mycobacteria present in the reaction mixture; allowing time for the bacteriophage to lyse infected live target Mycobacteria; and analysing in said reaction mixture DNA from the lysed Mycobacteria to identify a signature DNA sequence that occurs in the target Mycobacteriumspedes.