Patents Assigned to University of Nottingham
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Patent number: 10352984Abstract: A method of locating a fault on an electricity transmission line is disclosed. The transmission line has a known line impedance and is operable to transport electricity at one or more system frequencies. The method comprises using measurements of the current and voltage made on the line at one or more frequencies which are different to the system frequency and the known line impedance (Z) to determine a distance to the fault. The method may include monitoring the voltage and the current on the transmission line at the one or more non-system frequencies, and determining from the presence of signals at a non-system frequency on the transmission line that a fault has occurred.Type: GrantFiled: November 28, 2012Date of Patent: July 16, 2019Assignee: The University of NottinghamInventors: David Thomas, Mark Sumner, Jia Ke
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Patent number: 10301264Abstract: Anti-angiogenic treatments, treatments of hyperpermeability disorders, treatments of neuropathic and neurodegenerative disorders, pain treatments, methods of reducing the risk of pre-eclampsia and compounds for use in such methods are described.Type: GrantFiled: October 17, 2013Date of Patent: May 28, 2019Assignee: The University of NottinghamInventors: Steven James Harper, David Owen Bates, Melissa Gammons, Jonathan Morris
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Patent number: 10226537Abstract: This invention relates to transduction of cargo molecules into living cells, such as protein transduction, in particular a delivery molecule for transduction of a cargo into a cell comprising: a cargo-binding molecule and/or a cargo; a glycosaminoglycan (GAG) binding element, which is capable of binding to GAG on the surface of the cell; and a protein transduction domain. Methods of transduction, methods of producing or modifying cargo for transduction, delivery molecules for transduction and methods of treatment using transduction, or using transduced cells are also provided.Type: GrantFiled: December 18, 2014Date of Patent: March 12, 2019Assignee: The University of NottinghamInventors: James Dixon, Kevin Shakesheff, Chris Denning
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Patent number: 10139406Abstract: A method of determining the P. aeruginosa or related species infection status of a subject comprising: (i) providing a sample of material obtained from the subject; (ii) determining the level of one or more alkyl quinolones or metabolites thereof produced by P.Type: GrantFiled: May 13, 2014Date of Patent: November 27, 2018Assignee: The University of NottinghamInventors: Miguel Camara, Paul Williams, David Barrett, Nigel Halliday, Alan Knox, Alan Smyth, Andrew Fogarty, Helen Barr, Doug Forrester
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Patent number: 10125739Abstract: A system suitable for extracting power directly from the main shafts of slow-moving mechanical systems. The system has a closed gas circuit having a lower-pressure (LP) side and a higher-pressure (HP) side. The LP side is at a pressure substantially greater than atmospheric pressure. The system includes primary compressors coupled to the wind turbines, thermal stores coupled to heat-exchangers on both the LP and HP sides of the closed gas circuit, a secondary motor-compressor set and an expander-generator set. The system allows some degree of independence between the input power resource and the output power. When substantial wind power is present and the demand for electrical power is weak, this system can export a fraction of the energy captured and store the rest. When the wind resource is low, the system can export more power than is being collected by drawing energy from the thermal stores.Type: GrantFiled: August 1, 2014Date of Patent: November 13, 2018Assignee: The University of NottinghamInventor: Seamus Dominic Garvey
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Publication number: 20180296733Abstract: The invention provides a method for inhibiting bacterial attachment to a surface, the method comprising forming the surface from a polymer, or applying a polymer to the surface, wherein the polymer is a homopolymer formed from a (meth) acrylate or (meth) acrylamide monomer or a copolymer formed from one or more (meth) acrylate or (meth) acrylamide monomers, wherein the (meth) acrylate or (meth) acrylamide monomers are of formula (I) or (II): [H2C?CR?—C(=0)-0-]n, R (I) [H2C?CR?—C(=0)-NH—]n R (II) wherein n is 1, 2 or 3, R? is independently H or CH3, R is an organic group having a total of from 2 to 24 carbon atoms, wherein the organic group includes an aliphatic or aromatic hydrocarbon moiety and wherein the organic group does not include any hydroxyl groups.Type: ApplicationFiled: May 24, 2018Publication date: October 18, 2018Applicants: The University of Nottingham, Massachusetts Institute of TechnologyInventors: Paul Williams, Morgan Russell Alexander, Martyn Christopher Davies, Robert Langer, Daniel Griffith Anderson
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Publication number: 20180271987Abstract: The invention relates to apH mediated cell delivery vehicle comprising: a cargo or a cargo-binding molecule for binding to a cargo; a protein transduction domain; and a glycosaminoglycan (GAG) binding element, which is capable of binding to GAG on the surface of the cell, wherein the GAG binding element is a peptide which is modified to comprise one or more histidine residues which are capable of being protonated in an acidic environment. The invention further relates to the use of such a delivery vehicle including methods of treatment, such as treatment for cancer.Type: ApplicationFiled: June 23, 2016Publication date: September 27, 2018Applicant: The University of NottinghamInventor: James Dixon
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Patent number: 10072073Abstract: A glycan having the structure gal?1-3GLcNac?1-3Gal?1-4(Fuc?1-3)GlcNAc (LecLex) which is attached to a lipid or protein backbone, and isolated binding members capable of binding thereto.Type: GrantFiled: October 31, 2014Date of Patent: September 11, 2018Assignee: The University of NottinghamInventors: Lindy Gillian Durrant, Jiaxin Chua, Tina Rose Parsons
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Patent number: 10012591Abstract: The disclosure relates to measurement and classification of tissue structures in samples using a combination of light imaging and spectroscopy, in particular although not necessarily exclusively for detection of tumors such as basal cell carcinoma or breast tumors in tissue samples. Embodiments disclosed include a method of automatically identifying tissue structures in a sample, the method comprising the steps of: measuring (1702, 1703) a response of an area of the sample to illumination with light; identifying (1704) regions within the area having a measured response within a predetermined range; determining (1705) locations within the identified regions; performing (1706) spectroscopic analysis of the sample at the determined locations; and identifying (1707) a tissue structure for each region from the spectroscopic analysis performed on one or more locations therein.Type: GrantFiled: March 21, 2014Date of Patent: July 3, 2018Assignees: The University of Nottingham, Royal Holloway University of LondonInventors: Ioan Notingher, Kenny Kong, Christopher Rowlands, Hywel Williams, Iain Leach, Sandeep Varma, William Perkins, Alexey Koloydenko
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Patent number: 9981068Abstract: The invention provides a method for inhibiting bacterial attachment to a surface, the method comprising forming the surface from a polymer, or applying a polymer to the surface, wherein the polymer is a homopolymer formed from a (meth) acrylate or (meth) acrylamide monomer or a copolymer formed from one or more (meth) acrylate or (meth) acrylamide monomers, wherein the (meth) acrylate or (meth) acrylamide monomers are of formula (I) or (II): [H2C?CR?—C(?O)—O—]nR??(I) [H2C?CR?—C(?O)—NH—]nR??(II) wherein n is 1, 2 or 3, R? is independently H or CH3, R is an organic group having a total of from 2 to 24 carbon atoms, wherein the organic group includes an aliphatic or aromatic hydrocarbon moiety and wherein the organic group does not include any hydroxyl groups.Type: GrantFiled: May 4, 2012Date of Patent: May 29, 2018Assignees: The University of Nottingham, Massachusetts Institute of TechnologyInventors: Paul Williams, Morgan Russell Alexander, Martyn Christopher Davies, Robert Langer, Daniel Griffith Anderson
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Patent number: 9932330Abstract: Anti-angiogenic treatments, treatments of hyperpermeability disorders, treatments of neuropathic and neurodegenerative disorders, pain treatments, methods of reducing the risk of pre-eclampsia and compounds for use in such methods are described.Type: GrantFiled: September 19, 2017Date of Patent: April 3, 2018Assignees: The University of Nottingham, NewSouth Innovations PTY LimitedInventors: David Bates, Jonathan Morris
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Patent number: 9861662Abstract: Methods of manufacturing a bone-derived extracellular matrix (bECM) product are provided. Also provided are bECM products and methods of using those products.Type: GrantFiled: July 3, 2014Date of Patent: January 9, 2018Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, The University of NottinghamInventors: Stephen F. Badylak, Michael J. Sawkins, Kevin M. Shakesheff, Lisa J. White
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Patent number: 9796707Abstract: Anti-angiogenic treatments, treatments of hyperpermeability disorders, treatments of neuropathic and neurodegenerative disorders, pain treatments, methods of reducing the risk of pre-eclampsia and compounds for use in such methods are described.Type: GrantFiled: May 31, 2017Date of Patent: October 24, 2017Assignees: The University of Nottingham, NewSouth Innovations PTY LimitedInventors: David Bates, Jonathan Morris
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Patent number: 9733177Abstract: An optical detector comprises a plurality of pixels, each pixel comprising a photodiode operable to detect light incident on that pixel and to generate a signal indicative of an intensity of that light. The plurality of pixels comprises a plurality of pixel pairs, and for each pixel pair, in a configuration mode, the detector is arranged to compare the signal generated by a first pixel of the pair with the signal generated by a second pixel of the pair. A method of optical detection is also described, as is a system incorporating the described optical detector.Type: GrantFiled: November 30, 2012Date of Patent: August 15, 2017Assignee: University of NottinghamInventors: Stephen Sharples, Roger Light
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Patent number: 9695160Abstract: Anti-angiogenic treatments, treatments of hyperpermeability disorders, treatments of neuropathic and neurodegenerative disorders, pain treatments, methods of reducing the risk of pre-eclampsia and compounds for use in such methods are described.Type: GrantFiled: April 17, 2015Date of Patent: July 4, 2017Assignees: The University of Nottingham, NewSouth Innovations PTY LimitedInventors: David Bates, Jonathan Morris
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Patent number: 9662344Abstract: A composition for influencing carnitine retention in biological tissue is disclosed. The composition comprises a carnitine substance and an agent to increase sodium potassium ATPase pump activity in the tissue, and/or to increase the activity of a carnitine transport protein, and/or increase blood/plasma insulin concentration.Type: GrantFiled: March 22, 2004Date of Patent: May 30, 2017Assignees: The University of Nottingham, Lonza Sales LTD.Inventors: Paul Leonard Greenhaff, Dumitru Constantin-Teodosiu
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Publication number: 20170080101Abstract: This invention relates to transduction of cargo molecules into living cells, such as protein transduction, in particular a delivery molecule for transduction of a cargo into a cell comprising: a cargo-binding molecule and/or a cargo; a glycosaminoglycan (GAG) binding element, which is capable of binding to GAG on the surface of the cell; and a protein transduction domain. Methods of transduction, methods of producing or modifying cargo for transduction, delivery molecules for transduction and methods of treatment using transduction, or using transduced cells are also provided.Type: ApplicationFiled: December 18, 2014Publication date: March 23, 2017Applicant: The University of NottinghamInventors: James DIXON, Kevin SHAKESHEFF, Chris DENNING
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Patent number: 9593132Abstract: The present invention relates to a metal organic framework comprising of a metal ion (M) and an organic ligand wherein more than one hydroxy ligand are present about the metal ion. Also provided is a method for synthesizing the metal-organic frameworks and their application in areas including scrubbing exhaust gas streams of acidic gases, scrubbing natural gas of acidic gases by separation or sequestration and separating C2Ha or other VOC gases from other gas mixtures.Type: GrantFiled: March 27, 2013Date of Patent: March 14, 2017Assignee: The University of NottinghamInventors: Martin Schroder, Sihai Yang
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Publication number: 20170044282Abstract: The invention relates to a method for producing functionalised monomers, the method comprising: a) providing a starting material selected from terpenes and terpenoids; b) forming a derivative of the starting material by incorporation of a hydroxyl group; c) esterifying the hydroxyl group of the derivative to introduce a moiety containing a vinyl group, so as to produce a functionalised monomer. The functionalised monomer can be polymerised to obtain a bio-derived polymer.Type: ApplicationFiled: April 22, 2015Publication date: February 16, 2017Applicant: The University of NottinghamInventors: Steven Howdle, Robert Stockman, Marina Fuentes, Jose Souto, Dominika Regentova, Derek Irvine
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Patent number: 9470629Abstract: Surface plasmon microscopy methods are described which comprise irradiating a sample with a beam of electromagnetic radiation, wherein at least some of the radiation is incident on the sample at an angle or angles which results in the excitation of surface plasmons in the sample, and wherein the beam of radiation comprises a longitudinal axis passing through a focus of the beam. Both radiation reradiated from the sample by one or more surface plasmons and radiation reflected from a location on the sample which does not lie on the longitudinal axis passing through the focusare received at a detector. The received reradiated radiation is then interfered with the received reflected radiation to provide information about the sample. Apparatus for performing the methods is also described.Type: GrantFiled: September 18, 2013Date of Patent: October 18, 2016Assignee: The University of NottinghamInventors: Michael Geoffrey Somekh, Chung Wah See