Abstract: The present invention provides an immunogenic composition comprising one or more Streptococcus uberis sortase-anchored surface proteins, or an immunogenic part thereof, wherein the composition is capable of eliciting an immune response, when administered to a subject.

Abstract: The invention provides compositions comprising a polyamidoamine (PAA) polymer comprising a pendant disulphide, sulphydryl, or activated sulphydryl moiety, and methods for their manufacture. The invention extends to the use of such polyamidoamine polymers to form cross-linked compositions, and hydrogels comprising the same, and the use of such compositions in various biological and non-biological applications, such as the delivery of biomolecules to target sites, and for tracking fluid flows. The invention also provides carrier particles, which may be used to deliver biomolecules, and to methods of treatment. The invention also provides a fluid tracking system for monitoring fluid flow.

Abstract: A cellulose aerogel comprises a plurality of cellulose nanoparticles. The cellulose nanoparticles preferably comprise at least 50% or 80% cellulose nanocrystals by weight of cellulose nanoparticles, and the cellulose nanoparticle aerogel preferably has a density of from 0.001 to 0.2 g/cm3 or from 0.2 to 1.59 g/cm3 The cellulose nanoparticle aerogel typically has an average pore diameter of less than 100 nmm and the cellulose nanoparticles may comprise anionic and/or cationic surface groups.

Abstract: The invention provides an apparatus and methods for removing heavy metals and heavy metal-containing compounds from fluid streams. The invention also provides new uses and methods for removing heavy metals and heavy metal-containing compounds from a natural gas stream, or a gas stream produced during the combustion or gasification of a fossil fuel, such as coal or petroleum fuels or oil.

Abstract: One aspect of the present invention relates to a readily water-dispersible particulate composition comprising by weight of dry matter at least 10% of xanthan gum and not more than 60% of starch, said composition being characterized in that the xanthan gum present in the composition can be dispersed completely within 2 minutes in distilled water of 25° C. at a concentration of 0.7% based on the dry weight of xanthan. The particulate xanthan gum compositions of the present invention exhibit unique viscosity enhancing properties that are dependent on the electrolyte levels of the aqueous environment in which they are applied. The favorable properties of the xanthan compositions according to the invention can be realized without resorting to chemical modification of the xanthan gum. The xanthan compositions according to the present invention can be applied advantageously in e.g. food products and oil drilling fluids.

Abstract: A degradable composite comprising a degradable matrix, a first fiber type and a second fiber type, wherein the first fiber type has a different rate of degradation to that of the second fiber type.

Abstract: Non-leguminous crops, e.g. wheat, maize and rice, do not form nodules and are dependant for their nutrition on fixed nitrogen from the soil, or from chemical/nitrogenous fertilizers. The present invention provides non-leguminous plants and leguminous plants, including legumes that fail to nodulate with Rhizobia, with bacteria that enable them to fix nitrogen endophytically. Therefore, the plants contain nitrogen fixing bacteria the bacteria being located intracellularly in living plant cells.

Abstract: The present invention provides a solid-liquid composite material, a manufacturing method and an application of the same. Liquid-phase material, solid-phase material, and solvent are distributed to form a distributed system. The solid-phase material and liquid-phase material in the solvent can be suspensions, emulsions, microemulsions, colloids, or solutions. A portion or all of the solvent is removed to produce the solid-liquid composite material. The liquid-phase material is approximately equal to 1%˜80% of the total mass of the solid-liquid composite material. The porosity of the solid-phase material is approximately equal to 10%˜80% in the solid-liquid composite material. The specific surface area of the porous material is approximately equal to 50˜2000 cm2/cm3. The field-chromatic material is added to the solid-liquid composite material to form a field-chromatic device.

Abstract: The invention relates to degradable composites and their use in biomedical implants, in particular the repair of damaged bones and/or cartilage.

Abstract: We describe modified bacterial cells that are defective in gene expression and their use in the treatment of bacterial infections of animals and plants and the inhibition of bacterial biofilm formation.

Abstract: A power generating system 10 includes a drive arrangement 12 and a compressor 18 arranged to be driven by the drive arrangement 12 to compress gas, in particular air. The system 10 also includes an underwater storage arrangement 20 for storing compressed gas provided by the compressor 18 and an expander 22 for expanding compressed gas from the underwater storage arrangement 20 and/or the compressor 18 to thereby drive a generator 16 to generate electrical power.

Abstract: The invention relates to inhibitors of tissue transglutaminase II activity and their use as a tocolytic agent.

Abstract: A sample 10 is measured by generating ultrasound at 12, for example by using a laser 22 and spatial light modulator 26. The ultrasound is detected at 16, for example by optical beam deflection techniques. A characteristic of the generation at 12 is swept across a range of values to vary the efficiency of generation of ultrasound. The value of the characteristic, which corresponds with the peak amplitude detected at 16, is identified to provide a measure of the acoustic velocity at the region 12. The method is executed at a plurality of sites 12, 20 to provide a set of spatially resolved measurements of the sample 10. This allows an image of the sample to be created.

Abstract: An open porous matrix of particulate material for in vivo use in or on a target tissue in medicine, the matrix comprising particles cross-linked with one another so as to define pores there between and uses therefor are described.

Abstract: A coolant sub-assembly is provided for use in a DNP apparatus. The sub-assembly comprises a plurality of concentric jackets surrounding an inner bore tube having first and second opposed ends. The jackets are adapted to inhibit heat flow to the inner bore tube, a DNP working region being defined within the inner bore tube where a DNP process will be performed on a sample in the DNP working region. A coolant supply path extends adjacent an outer surface of the inner bore tube at the DNP working region in order to cool said outer surface, whereby a sample holder assembly can be inserted through the first end of the inner bore tube to bring a sample holder into the DNP working region and can be moved through the second end of the inner bore tube. An auxiliary coolant supply path supplies coolant to a sample, located in use in the sample holder at the DNP working region, through at least one aperture in the inner bore tube wall at the DNP working region.

Abstract: A duct (10) for transporting a two phase mixture has a length portion of circular cross-section (12) leading, via a transition zone (14) in which the duct cross-section changes from circular to lobed, to a zone in which its cross-section exhibits at least one lobe (16) extending helically around and along the duct. The duct has a cross-sectional area which is substantially constant, or which progressively increases, over the transition zone. The transition from circular to lobed cross-section is alternatively smooth and continuous, and the transition zone occupies a duct length in which the or each lobe becomes relocated by at least one position.

Abstract: A mixing reactor for mixing efficiently streams of fluids of differing densities. In a preferred embodiment, one of the fluids is supercritical water, and the other is an aqueous salt solution. Thus, the reactor enables the production of metal oxide nanoparticles as a continuous process, without any risk of the reactor blocking due to the inefficient mixing inherent in existing reactor designs.

Abstract: This application concerns the separation of fine granular mixtures that may occur when the grains are suitably vibrated within fluid. In particular, the present invention provides a method of separating a particulate mixture comprising different particle types, comprising subjecting a supported particle bed comprising a fluid and said particulate mixture to a vibration thereby to effect separation of the particulate mixture into strata each of which is preferentially rich in substantially one particle type. Apparatus for effecting the above method also provided.

Abstract: A method of disinfection of livestock is provided. The method comprises administering at least one bacteriophage in an effective amount to said livestock to reduce the number of Campylobacter spp present in the gastro-intestinal tract of said livestock. The bacteriophage are selected from CP8 (NCIMB Accession No. 41184) and CP34 (NCIMB Accession No. 41185).

Abstract: A method of microwave pre treatment of a multi-phase material (200) prior to a subsequent operation on the material (200). The material (200) having a first phase of material and a second phase of material. The method comprises heating the material electromagnetically, preferably with microwaves (202), to produce a power density of at least 109 Wm?3 in a continuous process in which the material (200) moves into and through an electromagnetic, preferably microwave, treatment area (212). The material (200) experiences exposure to microwaves (202), in the treatment area (212) for a time of the order of ½ second or less before the material (200) is passed out of the treatment area (212) for subsequent operation.