Abstract: Surface plasmon microscopy methods are described which comprise irradiating a sample with a beam of electromagnetic radiation, wherein at least some of the radiation is incident on the sample at an angle or angles which results in the excitation of surface plasmons in the sample, and wherein the beam of radiation comprises a longitudinal axis passing through a focus of the beam. Both radiation reradiated from the sample by one or more surface plasmons and radiation reflected from a location on the sample which does not lie on the longitudinal axis passing through the focusare received at a detector. The received reradiated radiation is then interfered with the received reflected radiation to provide information about the sample. Apparatus for performing the methods is also described.

Abstract: The present invention provides a method of treatment for cancer in a subject comprising the administration of a prodrug, wherein the subject is colonised with an obligate anaerobic microorganism capable of expressing a polypeptide having nitroreductase activity, wherein the polypeptide exhibits preferential reduction of CB1954 to a 4-hydroxylamine (4HX) derivative instead of a 2-hydroxylamine derivative; and is capable of reducing CB1954 to the 4HX derivative with a Km of less than 30 micromolar. The present invention further provides an isolated polypeptide, nucleic acids encoding said polypeptide, vectors and host cells comprising said nucleic acids and vectors and uses of the above in treating solid tumours.

Abstract: The present invention relates to compositions comprising an alpha-adrenoceptor ligand for use in the treatment of benign anorectal conditions, in particular haemorrhoids. In addition to an alpha-adrenoceptor ligand, the compositions of the inventions may additionally include a calcium channel activator. Compositions with guanfacine and S(?)BayK8644 are preferred.

Abstract: The disclosure relates to measurement and classification of tissue structures in samples using a combination of light imaging and spectroscopy, in particular although not necessarily exclusively for detection of tumours such as basal cell carcinoma or breast tumours in tissue samples. Embodiments disclosed include a method of automatically identifying tissue structures in a sample, the method comprising the steps of: measuring (1702, 1703) a response of an area of the sample to illumination with light; identifying (1704) regions within the area having a measured response within a predetermined range; determining (1705) locations within the identified regions; performing (1706) spectroscopic analysis of the sample at the determined locations; and identifying (1707) a tissue structure for each region from the spectroscopic analysis performed on one or more locations therein.

Abstract: A method of monitoring and/or characterising biological or chemical material arranged on a substrate comprises: • producing a first image of the biological or chemical material using total internal reflection microscopy (TIRM); and • producing a second image of the biological or chemical material using transmitted or reflected light microscopy.

Abstract: Surface plasmon microscopy methods are described which comprise irradiating a sample with a beam of electromagnetic radiation, wherein at least some of the radiation is incident on the sample at an angle or angles which results in the excitation of surface plasmons in the sample, and wherein the beam of radiation comprises a longitudinal axis passing through a focus of the beam. Both radiation reradiated from the sample by one or more surface plasmons and radiation reflected from a location on the sample which does not lie on the longitudinal axis passing through the focusare received at a detector. The received reradiated radiation is then interfered with the received reflected radiation to provide information about the sample. Apparatus for performing the methods is also described.

Abstract: An abrasive element comprises a body of crystalline abrasive material. The body has an array of cutting elements formed of crystalline abrasive material which projects from a surface of the body. The shape, size and form of the projections is controlled in the production process. The body may be a natural or synthetic crystal. The body may be a film formed by deposition. The body may be diamond or cubic boron nitride. The body may be monocrystalline or polycrystalline. The projections may be aligned along a crystallographic plane or planes.

Abstract: The invention provides polymer particles that are obtainable by a method selected from emulsion methods, diffusion methods and evaporation methods carried out in the presence of surface-engineering surfactant which is one or more polymer that displays a lower critical solution temperature, in aqueous media, that is between 10 to 90° C., this polymer being the polymerization product of one or more monomer selected from polymerisable alkyleneglycol acrylate monomers and polymerisable alkyleneglycol methacrylate monomers. The polymer particles can be used in controlled release applications, such as flavour release applications, fragrance release applications and biomedical applications. The invention also provides a cell support matrix comprising the polymer particles.

Abstract: This invention relates to a composite comprising carbon nanotubes coated with a polymer, wherein the polymer comprises at least one hydrophobic monomer unit. This invention also relates to a process for the production of a composite comprising a polymer and carbon nanotubes.

Abstract: An apparatus for separating a hydrocarbon content from a material matrix composes the hydrocarbon content and a water content, the apparatus comprising: a material feeder arranged to feed material through a treatment chamber, the treatment chamber comprising a window which is substantially transparent to microwaves; a microwave emitter arranged in use to expose feed material in the treatment chamber to microwaves via the window in order to cause rapid heating of at least part of the water content of the matrix to form steam, so as to remove at least part of the hydrocarbon content from the matrix; wherein the material feeder and treatment chamber are arranged so that in use, the treatment chamber is substantially tilted with material/matrix.

Abstract: A wind energy converter 10 comprises a horizontal axis wind turbine 12 including a plurality of blade members 14 rotatable about a generally horizontal axis. A mass member 16 is movable along the or each blade member 14 under the action of radial forces induced by rotation of the blade members 14 and under the action of gravitational force, and movement of the or each mass member 16 is arranged to provide for conversion of the wind energy. Also described is a power generating system 200, 240 including a heat recovery arrangement 216, comprising a heat exchanger arrangement 218 and an expander 222.

Abstract: A photoplethysmograph device includes a light source for illuminating a target object. A modulator drives the light source such that the output intensity varies as a function of a modulation signal at a modulation frequency. A detector receives light from the target object and generates an electrical output as a function of the intensity of received light. A demodulator with a local oscillator receives the detector output and produces a demodulated output, insensitive to any phase difference between the modulation signal and the oscillator, indicative of blood volume as a function of time and/or blood composition. A number of demodulators may be provided to derive signals from multiple light sources of different wavelengths, or from an array of detectors. The plethysmograph may operate in a transmission mode or a reflectance mode. When in a reflectance mode, the device may use the green part of the optical spectrum and may use polarising filters.

Abstract: A method for separating hydrocarbon content from a hydrocarbon contaminated matrix. The method includes controlling water content of a feed material having the hydrocarbon contaminated matrix; continuously conveying the feed material into a treatment cavity; exposing the feed material in a treatment area of the treatment cavity to microwave radiation arranged to cause rapid heating of at least a portion of the water content to form steam, wherein the rapid steam formation results in thermal desorption of at least a portion of the hydrocarbon content from the matrix; and continuously removing the treated matrix from the treatment cavity.

Abstract: A photoplethysmograph device includes a light source for illuminating a target object. A modulator drives the light source such that the output intensity varies as a function of a modulation signal at a modulation frequency. A detector receives light from the target object and generates an electrical output as a function of the intensity of received light. A demodulator with a local oscillator receives the detector output and produces a demodulated output, insensitive to any phase difference between the modulation signal and the oscillator, indicative of blood volume as a function of time and/or blood composition. A number of demodulators may be provided to derive signals from multiple light sources of different wavelengths, or from an array of detectors. The plethysmograph may operate in a transmission mode or a reflectance mode. When in a reflectance mode, the device may use the green part of the optical spectrum and may use polarizing filters.

Abstract: A method of double crossover homologous recombination in a host cell comprising: a first homologous recombination event between a donor DNA molecule comprising a first element of a selectable allele and an acceptor DNA molecule comprising a second element of the selectable allele in the host cell, thereby to form a product of the first homologous recombination event in the host cell; and a second homologous recombination event within the product of the first homologous recombination event, thereby to form a product of the second homologous recombination event in the host cell which confers a selectable phenotype on the host cell, wherein the selectable phenotype arises following and in dependency on the formation of a selectable allele from the first and second elements of the selectable allele.

Abstract: Ways of applying microwaves to feedstock to be processed are disclosed. One embodiment relates to heating inter-layer water in vermiculite to expand the vermiculite. Another embodiment relates to heating water in oil-contaminated materials and waste products, such as drilling cuttings, contaminated soils and certain types of animal by-products, to drive out oil. In some embodiments a microwave tunnel applicator has the microwaves applied from beneath the feedstock.

Abstract: A generator structure has alternating linear regions which are respectively relatively absorbing and relatively non-absorbing. When the structure is illuminated, the spatial contrast in the absorption created by the characteristics of the regions gives rise to mechanical effects within the workpiece, such as localized heating. This results in ultrasound being created to propagate through the workpiece.

Abstract: A method for testing the mechanical properties of a specimen. The specimen is generally characterized by a first contact surface and a second contact surface spaced apart from and opposing the first contact surface. The method involves applying forces to the contact surfaces of the specimen to deform the specimen over a period of time. The response of the specimen to the forces is then measured over time. A spatial distance between the contact surfaces is defined such that the equivalent gauge length of the specimen is greater than the distance between the contact surfaces.

Abstract: The present invention provides an immunogenic composition comprising one or more Streptococcus uberis proteins, or an immunogenic part thereof, wherein the composition is capable of eliciting an immune response, when administered to a subject.

Abstract: Provided are methods and compositions for improving the growth characteristics of plants.