Abstract: A new class of nucleoside phosphoramidites which are relatively stable to permit isolation thereof and storage at room temperature. The phosphoramidites are derivatives of saturated secondary amines.

Abstract: A method and apparatus for detecting concealment of hidden information in interrogative polygraphy is described which employs Event Related Brain Potentials (ERP). Various stimuli are presented to a subject and the P300 components of the subject's ERP's are monitored and analyzed. Three types of stimuli are presented, Probe which are relevant to the "crime", Irrelevant--having no bearing on the crime, and Target which require the subject to perform an act. If, and only if, the subject has guilty knowledge, the Probe stimuli, like the Target stimuli, elicit a large ERP and provide a guilty indication.

Abstract: Method for determining levels of sulfhydryl amino acids, particularly total homocysteine levels in samples of body tissue from warm-blooded animals, methods of detecting cobalamin and folic acid deficiency using an assay for total homocysteine levels, and methods for distinguishing cobalamin from folic acid deficiency using an assay for total homocysteine levels in conjunction with an assay for methylmalonic acid.

Abstract: Disclosed are novel methods and materials for generating in vitro cultured populations of human epidermal keratinocyte cells having a characteristic colony-forming efficiency of greater than 20%. Novel media preparations and procedures are disclosed that permit isolation, serum-free primary culture and serum-free serial subculture of human epidermal keratinocytes. Also disclosed are procedures and products employing keratinocyte cells grown in serum-free conditions for medical application. i.e., skin grafting.

Abstract: Purine analogs sinefungin, formycin B and 9-deazainosine or its pharmaceutically aceptable acid addition salts are usful in treating African human and veterinary trypanosomiases.

Abstract: Novel methods for treatment of neoplastic disease states in animals, which methods comprise administering a therapeutically effective amount of a compound of the formula IV, ##STR1## wherein: Y is hydrogen or lower alkyl; and Z is a radical of the formula --O--R, wherein R is:a substituted lower alkyl radical selected from the group consisting of mono- and di-hydroxy lower alkyl, cyano lower alkyl, halo lower alkyl, lower alkyl amino lower alkyl, hydroxy lower alkylthio lower alkyl, hydroxy lower alkyldithio lower alkyl, di-lower alkoxy lower alkyl, hydroxy or lower alkoxy substituted lower alkoxy lower alkyl, and cyclo lower alkyl substituted lower alkyl; ora lower alkenyl radical; ora lower alkynyl radical; ora substituted or unsubstituted oxygen-containing heterocyclic radical selected from the group consisting of tetrahydro furanyl or lower alkyl substituted derivatives thereof, lower alkyl substituted oxiranyl, lower alkyl substituted dioxolanyl, lower alkyl substituted pyranyl, or lower alkyl substitute

Abstract: Compounds of the formula, I, ##STR1## wherein: Y is hydrogen or lower alkyl; and X is a thiazolamino radical, a furfurylamino radical or a radical of the formula, ##STR2## in which R, R.sup.1, and R.sup.2 are the same or different and selected from the group consisting of hydrogen and lower alkyl, and R.sup.3 is selected from the group consisting of lower alkenyl, halo-lower alkenyl, lower alkynyl, lower akloxycarbonyl, thienyl, formamyl, tetrahydrofuryl and benzene sulfonamide.Also disclosed are novel methods for treatment of neoplastic disease states in animals, which methods comprise administering a therapeutically effective amount of a compound of the formula, Ia, ##STR3## wherein, Y is hydrogen or lower alkyl; and Z is a thiazolamino radical, a furfuryllamino radical, a cyclopropylamino radical, a pyridylamino radical, or a radical of the formula, ##STR4## in which R.sup.4, R.sup.5, and R.sup.6 are the same or different and selected from the group consisting of hydrogen and lower alkyl, and R.sup.

Abstract: This invention concerns conditional protoplasts of temperature-sensitive variants of the osmotic-1 mutant strain of Neurospora crassa, and method of making same.

Abstract: A method for stimulating integumental melanocytes by the topical application of alpha-MSH analogs, and compositions comprising said analogs for use in the method are described.

Abstract: The disclosure is directed to a method and apparatus for precisely controlling the frequency of a laser, and for precise control of distance. In a disclosed embodiment, a laser beam is split, modulated to obtain a frequency differential, and coupled to an interferometer which is designed to produce two processed beams having intensities that vary at the same ac frequency, but at a phase difference that is indicative of the laser frequency. The processed beams are converted to ac electrical signals which are coupled to phase control circuitry. The phase control circuitry determines the phase between the electrical signals and produces a control signal for controlling the laser frequency. Phase offset increments are introduced in the phase detection process, these phase offset increments resulting in controlled changes in the laser frequency. The laser frequency can be computed and read out as a function of the phase offset increments.

Abstract: An organosulfur compound is detected and/or quantified, optionally in admixture with one or more other compounds, by reacting the organosulfur compound with gaseous fluorine at sub-atmospheric pressure and observing the chemiluminescence which develops. Detections at ultra-trace levels are achieved. A special detector cell is provided in which the reaction is performed.

Abstract: A thin planar curved microstrip antenna is described which exhibits substantially constant input impedance characteristics over a wide frequency band. The impedance characteristic is achieved by shaping the ground surface such that the ratio of the width of the radiating element to its distance from the ground surface stays constant for a given curvature.

Abstract: Electrochemical cells including secondary batteries and fuel cells are provided employing polyanilines having improved reversibility, stability and electrochemical properties. In accordance with a preferred embodiment polyaniline is employed as a cathode active polymer in a secondary battery at a pH between about 1 and 11. In accordance with other embodiment, fuel cells employing polyaniline are provided as are batteries wherein polyanilines are used as anodes.

Abstract: In an interlaced pulse-echo and range-gated Doppler system, an ultrasound transmitter generates a train of constant repetition rate echo pulse interlaced with a Doppler pulse train of plural bursts. The time duration between each burst and the preceding range gate opening is held constant while the time to the successive range gate opening is automatically varied to provide a continuously variable PRF tracking of the console range gate depth setting. The power of the transmitted signal is internally varied in the same sense and the cutoff frequency of the receiver low pass tracking filters is varied in the opposite sense to optimize signal-to-noise ratio at various tissue inspection depths. Selectable turnable high pass filters normalized to low velocity roll-off eliminate artifact for peripheral or central vascular probes. The detection system operates in quadrature and includes a synchronous demodulator and a peak detector, and a level detector operative on peak detected signals.

Abstract: Conjugated polymers are doped with ionic dopant species to a preselected room temperature electrical conductivity ranging from that characteristic of semiconductor behavior to that characteristic of metallic behavior, by means of reversible electrochemical doping procedures. The doping procedures are carried out in an electrochemical cell wherein the polymer to be doped is employed as one or both of the electrodes, and the electrolyte is a compound which is ionizable into the ionic dopant species to a p-type material; or if used as the cathode, becomes doped with a cationic dopant species to an n-type material.

Abstract: A sterile body implant is derived from a body structure having as its major protein component collagens in the form of extracellular matrix. The body structure is treated to remove cellular membranes, nucleic acids, lipids and cytoplasmic components. Such structures are implanted internally in the body or externally on the body in a variety of medical uses.

Abstract: The preparation and properties of liquid crystal compounds having an achiral core and chiral tail units composed of the 1-cyanoalkoyl grouping (chiral cyanohydrin ethers) are described. The newly made compounds are shown to be useful as components of ferroelectric liquid crystal mixtures which exhibit high speed, multistate electro-optic switching properties making them ideally suited to certain electro-optic display device applications.

Abstract: Ferroelectric (chiral) smectic liquid crystal compounds having an achiral core and chiral tail units derived from (2,3)-epoxyalkyloxiranemethanols possess a high ferroelectric polarization density. These newly made compounds exhibit high speed, multistate electro-optic switching properties which make them ideally suited to certain electro-optic display device applications.

Abstract: Improved electrochemical sensors are provided through isostatic processing techniques. Improved electrochemical sensors, especially those suitable for use in metallurgical melts, having, at once, long-term stability, improved sensitivity, and improved physical properties including thermal shock resistance are provided. In accordance with a preferred embodiment, unitary bodies comprising the sensing electrolyte and a source of reference potential are fabricated through isostatic processing techniques. Methods for the preparation of these improved sensors together with methods for the improvement of sensing, especially of oxygen in metallurgical melts are also disclosed.

Abstract: Catalytic chemical and biochemical conversion reactions are carried out in a novel compartmentalized catalytic reactor which enables the energy-efficient coupling of the conversion reaction with various energy-consuming post-conversion operations. The catalytic reactor is compartmentalized by means of a multilayer composite membrane comprising a catalytic membrane layer and one or more permselective membrane layers. The arrangement and properties of the membrane layers are such as to enable the free energy change of the conversion reaction to be utilized as the required energy source for effecting various post-conversion operations, including product separation, recovery and enrichment, and second-stage catalytic conversions with unfavorable reaction equilibria.