Patents Assigned to University of Rochester
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Publication number: 20240231007Abstract: A tunable waveguide element includes a waveguide core and a waveguide cladding. A high k dielectric layer is between the waveguide core and the waveguide cladding. An electrode is disposed between the high k dielectric layer and the waveguide core. The electrode can be made of a two-dimensional material and/or monolayer.Type: ApplicationFiled: March 27, 2024Publication date: July 11, 2024Applicant: University of RochesterInventors: Jaime Cardenas Gonzalez, Yi Zhang, Marissa Granados-Baez
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Publication number: 20240229030Abstract: The invention relates to nucleic acid molecules for pseudouridylation of a target uridine in a target RNA in a mammalian cell, wherein the nucleic acid molecule comprises a guide region capable of forming a partially double stranded nucleic acid complex with the target RNA comprising the target uridine, wherein the partially double stranded nucleic acid complex is capable of engaging a mammalian pseudouridylation enzyme, wherein the guide region assists in positioning the target uridine in the partially double stranded nucleic acid complex for it to be converted to a pseudouridine by the mammalian pseudouridylation enzyme.Type: ApplicationFiled: September 28, 2023Publication date: July 11, 2024Applicants: University of Rochester, ProQR Therapeutics II B.V.Inventors: Bart KLEIN, Janne Juha TURUNEN, Lenka VAN SINT FIET, Pedro Duarte Morais Fernandes Arantes DA SILVA, Julien Auguste Germain BOUDET, Yi-Tao YU, Hironori ADACHI, Meemanage De ZOYSA
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Patent number: 12029525Abstract: A reverberant shear wave field in an object such as a patient's body or organ causes deformations in one or more selected directions measured with an imaging modality such as ultrasound or MR equipment or other imaging equipment, to estimate displacements in one or more selected directions over time increments and then viscoelastic properties such as stiffness or other parameters of the ROI.Type: GrantFiled: November 3, 2017Date of Patent: July 9, 2024Assignee: University of RochesterInventor: Kevin Parker
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Patent number: 12023875Abstract: Disclosed are methods of using reaction injection molding to mold stimuli-responsive thermosets such as urethane linked poly(caprolactone) networks from polyols and polyisocyanates, as well as polymers prepared by such methods.Type: GrantFiled: July 13, 2018Date of Patent: July 2, 2024Assignee: THE UNIVERSITY OF ROCHESTERInventor: Mitchell Anthamatten
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Publication number: 20240204471Abstract: Optical soliton pulses are generated using a drive unit to provide pump light at a drive power, a passive optical waveguide ring resonator, a spectral filter in the passive optical waveguide ring resonator, and an output to optically couple optical solitons from the passive optical waveguide ring resonator. The drive power, a net group velocity dispersion (GVD) of the passive optical waveguide ring resonator, a frequency detuning parameter of the passive optical waveguide ring resonator, and the spectral filter are configured to generate one or more optical solitons.Type: ApplicationFiled: November 27, 2023Publication date: June 20, 2024Applicant: University of RochesterInventor: William Renninger
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Patent number: 12007552Abstract: The invention provides apparatuses and systems for cutting off electromagnetic radiation (ER) beams, such as laser beams. The apparatuses and systems employ gravitational force on a shutter to close off the path of the ER beam if power is cut to an electromagnet holding the shutter out of the beam path. Power to the electromagnet is typically connected to a safety interlock connected to a door or other entry point to an enclosure in which the ER beam is being used. Additionally, the invention provides add-on devices that allow the ER beam to be blocked to change lenses or targets.Type: GrantFiled: April 26, 2021Date of Patent: June 11, 2024Assignee: University of RochesterInventors: Astrid M. Mueller, Jeffery W. Lefler
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Patent number: 11995829Abstract: Within the field of elastography, a new approach analyzes the limiting case of shear waves established as a reverberant field. In this framework, it is assumed that a distribution of shear waves exists, oriented across all directions in 3D (e.g. 2D space+time). The simultaneous multi-frequency application of reverberant shear wave fields can be accomplished by applying an array of external sources that can be excited by multiple frequencies within a bandwidth, for example 50, 100, 150, . . . 500 Hz, all contributing to the shear wave field produced in the liver or other target organ. This enables the analysis of the dispersion of shear wave speed as it increases with frequency, indicating the viscoelastic and lossy nature of the tissue under study. Furthermore, dispersion images can be created and displayed alongside the shear wave speed images.Type: GrantFiled: January 6, 2023Date of Patent: May 28, 2024Assignee: UNIVERSITY OF ROCHESTERInventors: Juvenal Ormachea Quispe, Kevin J. Parker, Jose Fernando Zvietcovich Zegarra
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Publication number: 20240165269Abstract: The present disclosure relates to methods for inducing rejuvenation in a population of glial progenitor cells and methods for treating a subject having a glial cell-related disorder. Methods include administering, to the population of adult glial progenitor cells, an effective amount of an expression vector comprising a nucleotide sequence encoding B-cell lymphoma/leukemia 11A (BCL11A) and a regulatory element operably linked to the nucleotide sequence.Type: ApplicationFiled: October 16, 2023Publication date: May 23, 2024Applicant: UNIVERSITY OF ROCHESTERInventors: Steven A. GOLDMAN, John MARIANI, Abdellatif BENRAISS, Benjamin MANSKY
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Publication number: 20240133788Abstract: A device, system and method for the detection and screening of plastic microparticles in a sample is disclosed. A nanoporous silicon nitride membrane is used to entrap plastic microparticles contained in the sample. The sample may be a water sample, an air sample, or other liquid or gas sample. The entrapped plastic microparticles are then heated or otherwise processed on the nanoporous silicon nitride membrane. An imaging system observes the nanoporous silicon nitride membrane with the entrapped plastic microparticles to determine the type and quantity of the various plastic microparticles that are entrapped on the membrane.Type: ApplicationFiled: December 11, 2023Publication date: April 25, 2024Applicant: University of RochesterInventors: Wayne H. Knox, Gregory Madejski, James Lionel McGrath
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Publication number: 20240132890Abstract: The invention relates to nucleic acid molecules for pseudouridylation of a target uridine in a target RNA in a mammalian cell, wherein the nucleic acid molecule comprises a guide region capable of forming a partially double stranded nucleic acid complex with the target RNA comprising the target uridine, wherein the partially double stranded nucleic acid complex is capable of engaging a mammalian pseudouridylation enzyme, wherein the guide region assists in positioning the target uridine in the partially double stranded nucleic acid complex for it to be converted to a pseudouridine by the mammalian pseudouridylation enzyme.Type: ApplicationFiled: September 27, 2023Publication date: April 25, 2024Applicants: University of Rochester, ProQR Therapeutics II B.V.Inventors: Bart KLEIN, Janne Juha TURUNEN, Lenka VAN SINT FIET, Pedro Duarte Morais Fernandes Arantes DA SILVA, Julien Auguste Germain BOUDET, Yi-Tao YU, Hironori ADACHI, Meemanage De ZOYSA
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Patent number: 11966084Abstract: An integrated tunable waveguide element includes: a cladding. A high k dielectric layer is disposed within the cladding. At least one waveguide is disposed adjacent to the high k dielectric layer. At least one two dimensional monolayer pad is disposed on or in the high k dielectric layer adjacent to a portion of the at least one waveguide. An integrated 2×2 array element is also described.Type: GrantFiled: August 24, 2022Date of Patent: April 23, 2024Assignee: University of RochesterInventors: Jaime Cardenas Gonzalez, Yi Zhang, Marissa Granados-Baez
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Publication number: 20240124845Abstract: This application relates to stem cell biology and regenerative medicine. Disclosed herein methods for isolation of skeletal stem cells, related methods, related compositions, related products, and related uses.Type: ApplicationFiled: February 22, 2022Publication date: April 18, 2024Applicant: University of RochesterInventors: Wei Hsu, Takamitsu Maruyama
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Patent number: 11959841Abstract: A device and method for isolating extracellular vesicles from biofluids is disclosed. A nanoporous silicon nitride membrane is provided with a tangential flow of biofluid. A pressure gradient through the nanoporous silicon nitride membrane facilitates capture of extracellular vesicles from the tangential flow vector of biofluid. Reversal of the pressure gradient results in the release of the extracellular vesicles for subsequent collection.Type: GrantFiled: January 8, 2018Date of Patent: April 16, 2024Assignee: UNIVERSITY OF ROCHESTERInventors: James Lionel McGrath, Kilean Scott Lucas, Henry Hung Li Chung
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Patent number: 11957517Abstract: Specialized ultrasound imaging systems and methods provide metrics related to objective and consistent quantification of scar tissue volume that strongly correlate with tendon healing and range of motion. Automated acquisition of ultrasound images of fingers helps assess tendon healing in a non-invasive, quantitative fashion and can be used to guide clinical decision-making, management of post-operative tendon repair patients, and employment and insurance considerations.Type: GrantFiled: March 4, 2020Date of Patent: April 16, 2024Assignee: University of RochesterInventors: Constantinos Ketonis, Alayna E. Loiselle
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Patent number: 11957314Abstract: A surgical visualization and medical imaging device and related computer based imaging methods and systems are disclosed. The surgical devices of the present invention use indocyanine green dye combined with a plastic, and are used in enhanced surgical imaging in applications such as robotically assisted surgeries. A near infrared light source, such as an 805 nm laser, may be used to excite the surgical device so that the device emits 835 nm light. Both the excitation and emission wavelengths penetrate tissue and blood, and provide enhanced imaging of surgical procedures. The resulting fluorescence image allows a user to readily determine relative tissue depth, to identify tissue inhomogeneity, to detect masses or tissue irregularities, to pinpoint anatomical holes, and to visualize tears.Type: GrantFiled: February 16, 2018Date of Patent: April 16, 2024Assignee: University of RochesterInventors: Paula Jaye Doyle, Jay Evan Reeder, Ronald Wesley Wood
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Patent number: 11958895Abstract: The present invention relates to broadly neutralizing anti-influenza monoclonal antibodies or antigen-binding fragments thereof. The present invention further relates to therapeutic uses of the isolated antibody or the antigen-binding fragment thereof.Type: GrantFiled: May 2, 2019Date of Patent: April 16, 2024Assignee: University of RochesterInventors: James J. Kobie, Luis Martinez-Sobrido, Michael Piepenbrink, Aitor Nogales
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Patent number: 11940445Abstract: The present invention provides point-of-care blood typing devices. The devices require only a small sample of blood and are able to provide results within minutes. The devices are capable of identifying A, B, AB, and O type blood. The devices are also capable of identifying blood that is positive (+) or negative (?) for the D antigen.Type: GrantFiled: April 5, 2019Date of Patent: March 26, 2024Assignee: UNIVERSITY OF ROCHESTERInventor: Majed Refaai
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Patent number: 11931739Abstract: Provided are methods, devices, and kits for the isolation and detection of one or more analytes of interest from a biological sample using microslit filter membranes. In various examples, the methods use capture particles and binding agents for specific recognition of one or more analytes of interest.Type: GrantFiled: August 16, 2018Date of Patent: March 19, 2024Assignees: SiMPore Inc., University of RochesterInventors: James A. Roussie, James L. McGrath, Richard E. Waugh, Kilean S. Lucas, Joshua J. Miller
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Publication number: 20240085330Abstract: Microscopy with Ultraviolet Surface Excitation (MUSE) for use in the classroom to enhance life sciences education and curricula, or for other applications, including without limitation the operating room, other medical environments, research environments, and low resource environments. MUSE's suitability is based on multiple key factors including its simplicity of use, the incorporation of inexpensive hardware including LED illumination, and very basic tissue preparation. The ultraviolet excitation acts as passive optical sectioning confining the generated fluorescence signal to only a few micrometers below the tissue surface thus eliminating the out of focus signals. This facilitates image capture of tissue microstructure and organization from specimens at the intact or sliced surface arising from varying fluorophore concentration within the different cellular compartments.Type: ApplicationFiled: November 21, 2023Publication date: March 14, 2024Applicant: UNIVERSITY OF ROCHESTERInventors: Stavros G. Demos, Chi Huang
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Patent number: 11923101Abstract: An optical tweezer phonon laser system and method for modulating mechanical vibrations of an optically levitated mechanical oscillator to produce coherence is disclosed. A feedback loop is configured to simultaneously supply an electro-optic modulator with an amplification signal and a cooling signal representing an amplification force linear in the mechanical oscillator momentum and a cooling force nonlinear in the mechanical oscillator variable position and linear in the momentum, respectively controlling the intensity of a trap beam levitating the mechanical oscillator.Type: GrantFiled: May 14, 2021Date of Patent: March 5, 2024Assignees: Rochester Institute of Technology, University of RochesterInventors: Mishkatul Bhattacharya, Anthony Nickolas Vamivakas