Abstract: The invention provides systems and methods for degrading compounds containing at least one carbon-halogen, carbon-nitrogen, or carbon-oxygen covalent bond, which covalent bond is a single bond, by electrocatalysis using a water oxidation electrocatalyst in a predominantly aqueous electrolyte. In some embodiments, the compounds are perfluoroalkyl and polyfluoroalkyl substances, or “PFAS.

Abstract: Methods and compositions are provided for the display of genetically encoded macrocyclic peptides on a biological surface. Also provided are nucleic acid molecules, polypeptides, and methods for generating combinatorial libraries of macrocyclic peptides displayed on a biological surface. These methods can be used to produce and screen vast libraries of conformationally constrained peptides in a high-throughput manner, from which macrocyclic peptides with a desired property can be selected and identified.

Abstract: The present invention provides compositions and methods related to equine live-attenuated influenza vaccines. In one aspect, the invention relates to a composition comprising a multivalent equine live-attenuated influenza vaccine comprising a first live-attenuated influenza virus expressing one or more antigens of a clade 1 H3N8 equine influenza virus; and a second live-attenuated influenza virus expressing one or more antigens of a clade 2 H3N8 equine influenza virus, wherein the second live-attenuated influenza virus expresses HA, NA, or a combination thereof of A/equine/Lancashire/1/2016 H3N8.

Abstract: The present disclosure provides molecular methods to improve the rapid diagnosis of respiratory infections. In general, the present disclosure provides method of detecting host gene signatures which aid in determining the etiology of a respiratory infection and thereby improve the treatment.

Abstract: Optical soliton pulses are generated using a drive unit to provide pump light at a drive power, a passive optical waveguide ring resonator, a spectral filter in the passive optical waveguide ring resonator, and an output to optically couple optical solitons from the passive optical waveguide ring resonator. The drive power, a net group velocity dispersion (GVD) of the passive optical waveguide ring resonator, a frequency detuning parameter of the passive optical waveguide ring resonator, and the spectral filter are configured to generate one or more optical solitons.

Abstract: An abstract heading is required. Please delete this heading section if it is not applicable to your application. For more information regarding the headings of the abstract, please see MPEP 608.01(b).

Abstract: Methods and compositions for generating novel proteins comprise a genetically encoded macrocyclic peptide fused to an immunoglobulin Fc region, referred to as “cyclopeptibodies.” Methods and compositions are provided for making cyclopeptide-Fc region fusion proteins from genetically encoded, ribosomally produced artificial polypeptides. These methods are based on the genetic fusion of an immunoglobulin Fc region to an artificial precursor polypeptide comprising a non-canonical amino acid residue carrying a thiol-reactive functional group; and a cysteine residue that is positioned either upstream or downstream of the non-canonical amino acid in the polypeptide sequence.

Abstract: Technology is provided to transform spatially variable arbitrary polarization states and wavefront of a high-fluence, large-aperture laser beam to prescribed spatially resolved polarization states and wavefront at a specific position, with minimal losses. Technology is also provided to transform spatially resolved polarization states and wavefront at a specific position to spatially variable arbitrary polarization states and wavefront.

Abstract: A lithium niobate (LN) external cavity includes a Vernier mirror structure which includes two or more microresonators where: one or more or all of the Vernier microresonators are tuned by the electro-optic Pockels effect of LN, with tuning electrodes integrated with the resonators, and one of the Vernier microresonators could be tuned by the thermo-optic effect, with a local heater integrated with the resonator. One or more or all of the Vernier microresonators include a section or the whole resonator that is periodically poled to achieve quasi-phase matching for nonlinear frequency conversion directly inside the laser cavity. The lithium niobate (LN) external cavity also includes a phase shifter whose phase is tuned by the electro-optic Pockels effect of LN. A Sagnac loop mirror is placed at the end of the device to function as the output end mirror of the laser cavity.

Abstract: This invention relates to improving delivery of agents to the central nervous system.

Abstract: The present disclosure is directed to a method of generating a population of neurons. This method involves providing a population of human glial progenitor cells: providing a recombinant genetic construct comprising (i) a promoter and/or enhancer for a gene which is selectively or specifically expressed by human glial progenitor cells, and (ii) a nucleic acid sequence encoding one or more neuronal reprogramming factors for producing neurons from glial progenitor cells, where the nucleic acid sequence is operably linked to the 3? end of said promoter and/or enhancer to achieve expression of the one or more neuronal reprogramming factors; transfecting cells of the glial progenitor cell population with the recombinant genetic construct; and culturing the population after said transfecting under conditions suitable for neuron production from the transfected glial progenitor cells of the population. Also disclosed are methods of inducing the production of neurons, as well as recombinant genetic constructs.

Abstract: The present disclosure relates to a method of treating a disease or disorder in a subject in need thereof. This method involves providing a recombinant genetic construct comprising: (i) a G-protein coupled receptor (GPR17) promoter-inclusive regulatory element sequence having a 5? and a 3? end and (ii) a nucleic acid sequence encoding a molecule of interest, wherein said nucleic acid sequence is heterologous to the GPR17 promoter-inclusive regulatory element and wherein said nucleic acid sequence is positioned 3? to the GPR17 promoter-inclusive regulatory element sequence; an expression vector comprising the recombinant genetic construct; a pharmaceutical composition comprising the recombinant genetic construct or the expression vector; or a preparation of cells comprising the recombinant genetic construct or the expression vector.

Abstract: This application relates to stem cell biology and regenerative medicine. Disclosed herein are methods for isolation of skeletal stem cells, related methods, related compositions, related products, and related uses.

Abstract: The present disclosure relates to nucleic acids, compositions, and methods for treating a disease or disorder associated with premature termination codon. Certain aspects of the disclosure relate to polynucleotides, vectors, and host cells, and uses thereof.

Abstract: The wave number and phase velocity (shear wave speed) of ultrasound energy within an organ of interest are calculated using a herein-disclosed phase gradient calculation method. This calculation method is less sensitive to imperfections in the reverberant field distribution and requires a smaller support window, relative to earlier calculation methods based on autocorrelation. Applications are shown in simulations, phantoms, and in vivo liver.

Abstract: A shape-memory polymer that is melt-recyclable with high processability and little performance loss, in contrast to known Crosslinked semicrystalline shape-memory networks that are capable of storing large amounts of elastic energy with negligible plastic deformation but as thermosets are not easily melt-processed or recycled. In examples herein, catalyst-free isocyanate chemistry is used to prepare two linear poly(caprolactone)s with bisurea hydrogen bonding groups periodically positioned along the main chain. Compared to an entangled poly(caprolactone) homopolymer of similar molecular weight, the segmented poly(bisurea)s exhibit minimal stress relaxation when elastically strained at identical conditions. Furthermore, the materials' single relaxation times indicate chain reptation, and at sufficient temperatures, disentanglement occurs rapidly enough to perform melt-processing.

Abstract: Materials are disclosed that superconduct at high temperatures and low pressures. Methods of making and measuring the materials are also disclosed. In a particular embodiment, a nitrogen-doped (or other lightweight-atom doped) rare earth metal hydride is disclosed. Also disclosed are thermodynamic pathways to recovering materials that superconduct at room temperature and room pressure and/or at other desirable operating temperatures and pressures to enable superconductivity at conditions that make a wider range of superconductive applications practical. These and other aspects of various embodiments are disclosed herein.

Abstract: The invention relates to novel compositions managing or inhibiting blood clotting and related uses.

Abstract: This disclosure relates compositions and methods to delivery of various agents to the inner ear of a subject.

Abstract: This invention relates to dermatology and to treatments of infectious skin disease.