Patents Assigned to University of Rochester
  • Patent number: 11940445
    Abstract: The present invention provides point-of-care blood typing devices. The devices require only a small sample of blood and are able to provide results within minutes. The devices are capable of identifying A, B, AB, and O type blood. The devices are also capable of identifying blood that is positive (+) or negative (?) for the D antigen.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: March 26, 2024
    Assignee: UNIVERSITY OF ROCHESTER
    Inventor: Majed Refaai
  • Patent number: 11931739
    Abstract: Provided are methods, devices, and kits for the isolation and detection of one or more analytes of interest from a biological sample using microslit filter membranes. In various examples, the methods use capture particles and binding agents for specific recognition of one or more analytes of interest.
    Type: Grant
    Filed: August 16, 2018
    Date of Patent: March 19, 2024
    Assignees: SiMPore Inc., University of Rochester
    Inventors: James A. Roussie, James L. McGrath, Richard E. Waugh, Kilean S. Lucas, Joshua J. Miller
  • Publication number: 20240085330
    Abstract: Microscopy with Ultraviolet Surface Excitation (MUSE) for use in the classroom to enhance life sciences education and curricula, or for other applications, including without limitation the operating room, other medical environments, research environments, and low resource environments. MUSE's suitability is based on multiple key factors including its simplicity of use, the incorporation of inexpensive hardware including LED illumination, and very basic tissue preparation. The ultraviolet excitation acts as passive optical sectioning confining the generated fluorescence signal to only a few micrometers below the tissue surface thus eliminating the out of focus signals. This facilitates image capture of tissue microstructure and organization from specimens at the intact or sliced surface arising from varying fluorophore concentration within the different cellular compartments.
    Type: Application
    Filed: November 21, 2023
    Publication date: March 14, 2024
    Applicant: UNIVERSITY OF ROCHESTER
    Inventors: Stavros G. Demos, Chi Huang
  • Patent number: 11911261
    Abstract: Methods and systems wherein laser induced refractive index changes by focused femtosecond laser pulses in optical polymeric materials or optical tissues is performed to address various types of vision correction.
    Type: Grant
    Filed: March 1, 2021
    Date of Patent: February 27, 2024
    Assignee: University of Rochester
    Inventors: Leonard Zheleznyak, Scott Catlin
  • Patent number: 11909165
    Abstract: Optical pulse sources. In one example, the pulse source includes an optical fiber ring resonator with at least one normal dispersion fiber segment characterized by a positive group velocity dispersion (GVD) per unit length and at least one anomalous dispersion fiber segment characterized by a negative GVD per unit length. In another example, the pulse source includes an optical fiber ring resonator with one or more fiber segments having a positive net group velocity dispersion (GVD); and an intracavity spectral filter optically coupled to the one or more fiber segments. The pulse source is configured to generate one or more optical solitons in the optical fiber ring resonator.
    Type: Grant
    Filed: April 21, 2020
    Date of Patent: February 20, 2024
    Assignee: UNIVERSITY OF ROCHESTER
    Inventor: William Renninger
  • Patent number: 11904179
    Abstract: An individualized therapy session can be delivered to a patient using a virtual reality headset and system. In one example, the system can include an accelerometer and a processor. The processor can receive data detected by the accelerometer. The data can include head position data and head movement data. The processor can then determine a view direction of a user of the VR device using the head position data, determine a heart rate of the user by using the view direction of the user to process the head movement data, and output the heart rate of the user to a remote device. The processor can receive, from the remote device, a command to adjust a VR session presented by the VR device to the user. Based on the command, the processor can adjust one or more parameters of the VR session presented by the VR device.
    Type: Grant
    Filed: September 28, 2021
    Date of Patent: February 20, 2024
    Assignee: UNIVERSITY OF ROCHESTER
    Inventors: Michael J. Hasselberg, David John Mitten, Kostantinos Vasalos, Wendy Cross
  • Patent number: 11906812
    Abstract: Integrated active cooling of high-power reflective or diffractive optics uses substrates manufactured from low-expansion ceramics to flow coolant between the back surface of the substrate and chambers behind but adjacent a reflective front surface, in a direction transverse to the front surface, to thereby achieve much greater average power handling than known cooling techniques.
    Type: Grant
    Filed: February 4, 2021
    Date of Patent: February 20, 2024
    Assignee: University of Rochester
    Inventors: Erik P. Power, Jake Bromage, Jonathan D. Zuegel
  • Patent number: 11899026
    Abstract: The present invention provides point-of-care blood typing devices. The devices require only a small sample of blood and are able to provide results within minutes. The devices are capable of identifying A, B, AB, and O type blood. The devices are also capable of identifying blood that is positive (+) or negative (?) for the D antigen.
    Type: Grant
    Filed: October 7, 2020
    Date of Patent: February 13, 2024
    Assignee: University of Rochester, Rochester Institute of Technology
    Inventors: Majed J. Refaai, Steven W. Day
  • Patent number: 11896478
    Abstract: Methods and systems wherein laser induced refractive index changes by focused femtosecond laser pulses in optical polymeric materials or optical tissues is performed to address various types of vision correction.
    Type: Grant
    Filed: March 1, 2021
    Date of Patent: February 13, 2024
    Assignee: University of Rochester
    Inventors: Leonard Zheleznyak, Scott Catlin
  • Patent number: 11899141
    Abstract: An ultrasound imaging system includes an array of ultrasound transducer elements chat send ultrasound energy into an object when energized for respective transmission time periods and provide responses to ultrasound energy emitted from the object for respective reception time periods, a reception modulation circuit modulating the responses with irregular sequences of modulation coefficients, a combiner circuit combining the modulated responses, and an image reconstruction processor configured to computer-process the combined modulated responses into one or more images of the object.
    Type: Grant
    Filed: July 7, 2021
    Date of Patent: February 13, 2024
    Assignee: UNIVERSITY OF ROCHESTER
    Inventors: Zeljko Ignjatovic, Michael Huang, Swetha George
  • Publication number: 20240043825
    Abstract: Methods and systems for creating patterns in tissue growth for tissue engineering are disclosed. In one embodiment, a method for arranging biological cells along predetermined patterns using an ultrasound includes: emitting the ultrasound by an ultrasound transducer; transmitting the ultrasound through a holographic lens toward a plurality of cells; and generating a pressure field in the predetermined patterns. The predetermined pattern includes a plurality of mutually parallel transverse planes. The parallel transverse planes are configured to entrap groups of cells of the plurality of cells. The axial pressure gradients within the parallel transverse planes are smaller than a first predetermined threshold. The lateral pressure gradients within the parallel transverse planes are larger than a second predetermined threshold. In response to generating the pressure field, the groups of entrapped cells are aligned within parallel transverse planes.
    Type: Application
    Filed: August 3, 2023
    Publication date: February 8, 2024
    Applicants: UNIVERSITY OF WASHINGTON, University of Rochester
    Inventors: Michael R. Bailey, Adam D. Maxwell, Mohamed Abdalla Ghanem, Diane Dalecki
  • Publication number: 20240029587
    Abstract: The invention provides systems and methods for improved simulation of surgical procedures, using models of anatomical organs. The models comprise models of internal components present in the anatomical organ. The models of the internal components are registered to the position which the internal component occupies in the anatomical organ, and in some embodiments the models of the anatomical organ can lose simulated physiological fluids during simulated surgery.
    Type: Application
    Filed: October 3, 2023
    Publication date: January 25, 2024
    Applicant: University of Rochester
    Inventors: Jonathan STONE, Ahmed E. GHAZI
  • Publication number: 20240009350
    Abstract: The present invention relates to enhancing mechanical properties of tissue such as collagenous or collagen-containing or elastin-containing tissue (e.g., tendons, ligaments, and cartilage) and treating related musculoskeletal and non-musculoskeletal conditions or injuries.
    Type: Application
    Filed: May 3, 2023
    Publication date: January 11, 2024
    Applicant: University of Rochester
    Inventor: Catherine K. Kuo
  • Patent number: 11867602
    Abstract: A device, system and method for the detection and screening of plastic microparticles in a sample is disclosed. A nanoporous silicon nitride membrane is used to entrap plastic microparticles contained in the sample. The sample may be a water sample, an air sample, or other liquid or gas sample. The entrapped plastic microparticles are then heated or otherwise processed on the nanoporous silicon nitride membrane. An imaging system observes the nanoporous silicon nitride membrane with the entrapped plastic microparticles to determine the type and quantity of the various plastic microparticles that are entrapped on the membrane.
    Type: Grant
    Filed: January 19, 2022
    Date of Patent: January 9, 2024
    Assignee: University of Rochester
    Inventors: Wayne H. Knox, Gregory Madejski, James Lionel McGrath
  • Patent number: 11866702
    Abstract: The invention relates to nucleic acid molecules for pseudouridylation of a target uridine in a target RNA in a mammalian cell, wherein the nucleic acid molecule comprises a guide region capable of forming a partially double stranded nucleic acid complex with the target RNA comprising the target uridine, wherein the partially double stranded nucleic acid complex is capable of engaging a mammalian pseudouridylation enzyme, wherein the guide region assists in positioning the target uridine in the partially double stranded nucleic acid complex for it to be converted to a pseudouridine by the mammalian pseudouridylation enzyme.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: January 9, 2024
    Assignees: University of Rochester, ProQR Therapeutics II B.V.
    Inventors: Bart Klein, Janne Juha Turunen, Lenka Van Sint Fiet, Pedro Duarte Morais Fernandes Arantes Da Silva, Julien Auguste Germain Boudet, Yi-Tao Yu, Hironori Adachi, Meemanage De Zoysa
  • Patent number: 11860100
    Abstract: Microscopy with Ultraviolet Surface Excitation (MUSE) for use in the classroom to enhance life sciences education and curricula, or for other applications, including without limtiation the operating room, other medical environments, research environments, and low resource environments. MUSE's suitability is based on multiple key factors including its simplicity of use, the incorporation of inexpensive hardware including LED illumination, and very basic tissue preparation. The ultraviolet excitation acts as passive optical sectioning confining the generated fluorescence signal to only a few micrometers below the tissue surface thus eliminating the out of focus signals. This facilitates image capture of tissue microstructure and organization from specimens at the intact or sliced surface arising from varying fluorophore concentration within the different cellular compartments.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: January 2, 2024
    Assignee: UNIVERSITY OF ROCHESTER
    Inventors: Stavros G. Demos, Chi Huang
  • Publication number: 20230414083
    Abstract: A surgical visualization and medical imaging device and related computer based imaging methods and systems are disclosed. The surgical devices of the present invention use indocyanine green dye combined with a plastic, and are used in enhanced surgical imaging in applications such as robotically assisted surgeries. A near infrared light source, such as an 805 nm laser, may be used to excite the surgical device so that the device emits 835 nm light. Both the excitation and emission wavelengths penetrate tissue and blood, and provide enhanced imaging of surgical procedures. The resulting fluorescence image allows a user to readily determine relative tissue depth, to identify tissue inhomogeneity, to detect masses or tissue irregularities, to pinpoint anatomical holes, and to visualize tears.
    Type: Application
    Filed: September 1, 2023
    Publication date: December 28, 2023
    Applicant: University of Rochester
    Inventors: Paula Jaye Doyle, Jay Evan Reeder, Ronald Wesley Wood
  • Patent number: 11845143
    Abstract: A pre-objective two-degree-of-freedom galvanometer scanning system including two galvo mirrors (111,112) with an optical relay (120) between the mirrors (111,112) and a microscope objective (130) with a curved image plane (140) is presented. The second galvo mirror (112) is located in the aperture stop before the objective. The optical system enables scanning in both directions over the full, curved field for creating custom refractive structures across the 6.5 mm optical zone of contact lenses using femtosecond micro-modification.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: December 19, 2023
    Assignee: University of Rochester
    Inventors: Daniel R. Brooks, Jonathan D. Ellis
  • Publication number: 20230393118
    Abstract: In some embodiments, the invention provides tissue-on-a-chip and organ-on-a-chip devices with integrated, on-board photonic integrated circuit optical sensors that allow real-time detection of analytes released from cells disposed on either side of a porous, ultrathin membrane within the device. The invention further provides modular devices for studying cells and interactions between and among cell types. The devices and methods using them are useful for, among other thing, modeling the biological and physiological interactions of cells of different tissue types, allowing high-throughput screening of drug candidates, and informing safety and efficacy in a virtual clinical trial.
    Type: Application
    Filed: November 8, 2021
    Publication date: December 7, 2023
    Applicant: University of Rochester
    Inventors: John S. COGNETTI, Benjamin L. MILLER, Hani A. AWAD, Raquel E. AJALIK
  • Publication number: 20230396031
    Abstract: At least one beam of pump pulses is combined in a nonlinear process with a plurality of monochromatic beams, each containing signal pulses of a unique wavelength. This produces an ensemble of beams of pulses having wavelengths of medium length. Then, all of the pulses in all of the beams in the ensemble are subject to second harmonic generation, optical parametric amplification, sum-frequency generation, or combinations to reduce the wavelengths of those pulses to ultraviolet wavelengths, thereby creating driver pulses. Driver beams made up of those reduced-wavelength driver pulses can then be focused upon a fuel pellet.
    Type: Application
    Filed: May 25, 2023
    Publication date: December 7, 2023
    Applicant: University of Rochester
    Inventors: Jonathan D. Zuegel, Christophe Dorrer