Abstract: The present disclosure relates to nucleic acids, compositions, and methods for treating a disease or disorder associated with premature termination codon. Certain aspects of the disclosure relate to polynucleotides, vectors, and host cells, and uses thereof.

Abstract: This application relates to stem cell biology and regenerative medicine. Disclosed herein are methods for isolation of skeletal stem cells, related methods, related compositions, related products, and related uses.

Abstract: A shape-memory polymer that is melt-recyclable with high processability and little performance loss, in contrast to known Crosslinked semicrystalline shape-memory networks that are capable of storing large amounts of elastic energy with negligible plastic deformation but as thermosets are not easily melt-processed or recycled. In examples herein, catalyst-free isocyanate chemistry is used to prepare two linear poly(caprolactone)s with bisurea hydrogen bonding groups periodically positioned along the main chain. Compared to an entangled poly(caprolactone) homopolymer of similar molecular weight, the segmented poly(bisurea)s exhibit minimal stress relaxation when elastically strained at identical conditions. Furthermore, the materials' single relaxation times indicate chain reptation, and at sufficient temperatures, disentanglement occurs rapidly enough to perform melt-processing.

Abstract: The wave number and phase velocity (shear wave speed) of ultrasound energy within an organ of interest are calculated using a herein-disclosed phase gradient calculation method. This calculation method is less sensitive to imperfections in the reverberant field distribution and requires a smaller support window, relative to earlier calculation methods based on autocorrelation. Applications are shown in simulations, phantoms, and in vivo liver.

Abstract: Materials are disclosed that superconduct at high temperatures and low pressures. Methods of making and measuring the materials are also disclosed. In a particular embodiment, a nitrogen-doped (or other lightweight-atom doped) rare earth metal hydride is disclosed. Also disclosed are thermodynamic pathways to recovering materials that superconduct at room temperature and room pressure and/or at other desirable operating temperatures and pressures to enable superconductivity at conditions that make a wider range of superconductive applications practical. These and other aspects of various embodiments are disclosed herein.

Abstract: The invention relates to novel compositions managing or inhibiting blood clotting and related uses.

Abstract: This disclosure relates compositions and methods to delivery of various agents to the inner ear of a subject.

Abstract: The invention provides systems and methods for improved simulation of surgical procedures, using models of anatomical organs. The models comprise models of internal components present in the anatomical organ. The models of the internal components are registered to the position which the internal component occupies in the anatomical organ, and in some embodiments the models of the anatomical organ can lose simulated physiological fluids during simulated surgery.

Abstract: This invention relates to dermatology and to treatments of infectious skin disease.

Abstract: An optical device comprising an optical hydrogel with select regions that have been irradiated with laser light having a pulse energy from 0.01 nJ to 50 nJ and a wavelength from 600 nm to 900 nm. The irradiated regions are characterized by a positive change in refractive index of from 0.01 to 0.06, and exhibit little or no scattering loss. The optical hydrogel is prepared with a hydrophilic monomer.

Abstract: A tunable waveguide element includes a waveguide core and a waveguide cladding. A high k dielectric layer is between the waveguide core and the waveguide cladding. An electrode is disposed between the high k dielectric layer and the waveguide core. The electrode can be made of a two-dimensional material and/or monolayer.

Abstract: This disclosure provides methods that render hydrophobic carbon fiber paper (CFP) hydrophilic for extended periods without damaging the carbon fibers that compose the CFP or the architecture of the network of those carbon fibers. The disclosure further provides hydrophilic CFP made by the inventive methods. The methods include sonicating the CFP in an aqueous surfactant solution followed by electrooxidizing the CFP in an aqueous electrolyte.

Abstract: This disclosure relates to delivery of various agents to the inner ear of a subject.

Abstract: This disclosure relates to the unexpected discovery that agents capable of inhibiting calcium channels, such as calcium channel blockers, are effective in treating or alleviating the symptoms of myotonic disorders. In patients who have been diagnosed with the condition, the methods of this disclosure can, e.g., reverse or inhibit the worsening of symptoms related to such condition and/or prevent development of new symptoms.

Abstract: The present disclosure relates to a preparation of CD140a/PDGFR? positive cells that comprises oligodendrocyte progenitor cells co-expressing OLIG2 and CD140a/PDGFR?. The preparation of cells is derived from pluripotent cells that were derived from skin cells, fibroblasts, umbilical cord blood, peripheral blood, bone marrow, or other somatic cells. The cell preparation has an in vivo myelination efficiency that is equal to or greater than the in vivo myelination efficiency of a preparation of A2B5+/PSA-NCAM? sorted fetal human tissue derived oligodendrocyte progenitor cells. Methods of making, isolating and using the disclosed cell preparation are also described.

Abstract: The disclosure relates to oligodendrocyte-biased glial progenitor cells and methods of making, isolating, and using such cells.

Abstract: A RollingCache system and methodology defends against contention side-channel cache attacks by dynamically changing the set of addresses contending for cache sets. Unlike prior defenses, RollingCache system does not rely on address encryption, decryption, data relocation, or cache partitioning. One or more levels of indirection are used to implement dynamic mapping controlled by the whole-cache runtime behavior. The RollingCache system does not depend on having defined security domains and can defend against an attacker running on the same or another core.

Abstract: The present disclosure relates to novel methods for detection of nucleic acid sequences.

Abstract: Various aspects and embodiments disclosed herein relate generally to the modelling, treatment, reducing resistence to the treatment, prevention, and diagnosis of diseases/symptoms induced by multiple myeloma. Embodiments include methods of treating a bone related disease, comprising the steps of: administering to a subject at least one therapeutically effective dose of a compound disclosed herein.

Abstract: A method of forming an image of a region of interest using a pulse-echo imaging device is described. The method includes the steps of generating a pulse using the pulse-echo imaging device, causing the pulse to be incident on the region of interest to generate a reflected echo, receiving the reflected echo in the pulse-echo imaging device, comparing a measure of frequency content of the reflected echo to the transmitted pulse, and frequency shifted replicas of the transmitted pulse, wherein each is associated with a unique label, selecting a label based on the comparison, and generating an image incorporating the selected label.