Abstract: The present disclosure relates to neutralizing anti-influenza monoclonal antibodies. The disclosure further relates to therapeutic uses of the isolated antibody. The antibodies are either directed against Hemagglutinin (HA) and Neuraminidase (NA) of Influenza H3N2.

Abstract: Methods and systems wherein laser induced refractive index changes by focused femtosecond laser pulses in optical polymeric materials or optical tissues is performed to address various types of vision correction.

Abstract: The present application relates to a non-human mammal model of a human neurodegenerative disorder, methods of producing the non-human mammal model, and methods of using the non-human mammal model to identify agents suitable for treating a neurodegenerative disorder. The present application also relates to methods of treating neurodegenerative disorders and restoring normal brain interstitial potassium levels.

Abstract: An integrated tunable waveguide element includes: a cladding. A high k dielectric layer is disposed within the cladding. At least one waveguide is disposed adjacent to the high k dielectric layer. At least one two dimensional monolayer pad is disposed on or in the high k dielectric layer adjacent to a portion of the at least one waveguide. An integrated 2×2 array element is also described.

Abstract: A mechanically tunable reflective metamirror optical device for a targeted design optical wavelength includes a dynamically deformable substrate and a sub-wavelength periodic arrangement of patterned isolated gap surface plasmon (GSP) resonators positioned in or on the dynamically deformable substrate. The patterned isolated GSP resonators are movable relative to each other and comprise a patterned optically thin metal layer for the design wavelength, a patterned optically thick metal layer for the design wavelength, and a patterned insulator layer between the patterned optically thin and optically thick metal layers.

Abstract: A base element for switching a magnetization state of a nanomagnet includes a heavy-metal nanostrip having a surface. The heavy-metal nanostrip includes at least a first layer including a heavy metal and a second layer which includes a different heavy-metal. A ferromagnetic nanomagnet is disposed adjacent to the surface. The ferromagnetic nanomagnet includes a shape having a long axis and a short axis, the ferromagnetic nanomagnet having both a perpendicular-to-the-plane anisotropy Hkz and an in-plane anisotropy Hkx and the ferromagnetic nanomagnet having a first magnetization equilibrium state and a second magnetization equilibrium state. The first magnetization equilibrium state or the second magnetization equilibrium state is settable by a flow of electrical charge through the heavy-metal nanostrip. A direction of the flow of electrical charge through the heavy-metal nanostrip includes an angle ? with respect to the short axis of the nanomagnet.

Abstract: The present invention provides compositions and methods related to equine live-attenuated influenza vaccines.

Abstract: A beam shaping system including an all-optical liquid crystal beam shaper, the beam shaper including a photoswitchable alignment material including at least one of a PESI-F, SPMA:MMA 1:5, SPMA:MMA 1:9, ora SOMA:SOMA-p:MMA 1:1:6 material, at least some of the liquid crystals of the beam shaper including at least one of a phenylcyclohexane, cyclo-cyclohexane, or a perfluorinated material.

Abstract: Refractive index writing system and methods employing a pulsed laser source for providing a pulsed laser output at a first wavelength; an objective lens for focusing the pulsed laser output to a focal spot in an optical material; a scanner for relatively moving the focal spot with respect to the optical material at a relative speed and direction along a scan region for writing one or more traces in the optical material defined by a change in refractive index; and a controller for controlling laser exposures along the one or more traces in accordance with a calibration function for the optical material to achieve a desired refractive index profile in the optical material. The refractive index writing system may be for writing traces in in vivo optical tissue, and the controller may be configured with a calibration function obtained by calibrating refractive index change induced in enucleated ocular globes.

Abstract: Subsurface optical elements are formed within an ophthalmic lens using modulation of depth to which refractive index change inducing laser pulses are focused within the ophthalmic lens. A system for forming one or more subsurface optical structures within an ophthalmic lens comprises a control unit operatively coupled with a laser pulse source and a focusing assembly. The control unit is configured to control operation of the focusing assembly to sequentially focus each of the sequence of laser pulses onto a respective sub-volume of a sequence of sub-volumes of the ophthalmic lens. The sub-volumes of the sequence of sub-volumes have modulated depths within the ophthalmic lens and varying transverse locations within the ophthalmic lens.

Abstract: Within the field of elastography, a new approach analyzes the limiting case of shear waves established as a reverberant field. In this framework, it is assumed that a distribution of shear waves exists, oriented across all directions in 3D (e.g. 2D space+time). The simultaneous multi-frequency application of reverberant shear wave fields can be accomplished by applying an array of external sources that can be excited by multiple frequencies within a bandwidth, for example 50, 100, 150, . . . 500 Hz, all contributing to the shear wave field produced in the liver or other target organ. This enables the analysis of the dispersion of shear wave speed as it increases with frequency, indicating the viscoelastic and lossy nature of the tissue under study. Furthermore, dispersion images can be created and displayed alongside the shear wave speed images.

Abstract: A system and method for rehabilitation and recovery using adaptive surface electromyographic sensing and visualization is disclosed. The system uses surface electromyography (sEMG) sensors to identify signals of intent from patients with physical disabilities and then uses these signals to interact with a computer system designed to create repetitive practice in a manner that promotes neurological recovery. A machine teaming module analyses body signals picked up during patient movement attempts and converts these body signals to a visual representation of the intended movement by way of a virtual body or virtual body part displayed on a computer display, display glasses, or the like. The system thus allows for very early patient therapy, providing early benefits to rehabilitation therapy not heretofore possible. The virtual reality or augmented reality environment provides a patient with very early visual reinforcement of beneficial muscle activation patterns.

Abstract: Aspects and features of this disclosure relate to delivering individualized mental health therapies via networked computing devices. A mental-health-treatment-delivery server outputs a module with video content in connection with a mental health treatment protocol for a user. The mental-health-treatment-delivery server outputs a request for the user to respond to a question or to stimuli. The mental-health-treatment-delivery server receives a response from the user to the question or the stimuli. The mental-health-treatment-delivery server compares the response to stored data to determine information to present to the user. The mental-health-treatment-delivery server receives a command from the server device to present the information to the user. The mental-health-treatment-delivery server outputs the information to an interface of the user device.

Abstract: The wave number and phase velocity (shear wave speed) of ultrasound energy within an organ of interest are calculated using a herein-disclosed phase gradient calculation method. This calculation method is less sensitive to imperfections in the reverberant field distribution and requires a smaller support window, relative to earlier calculation methods based on autocorrelation. Applications are shown in simulations, phantoms, and in vivo liver.

Abstract: Methods and systems for manufacturing a wavefront-guided scleral lens prosthetic device customized for an eye of a patient include obtaining a first scleral lens prosthetic device with a central optic zone configured to vault over the eye's cornea and a peripheral haptic zone configured to align with the eye's sclera, collecting measurements of any offset and/or rotation of the first scleral lens prosthetic device relative to the eye's pupil and of any aberrations, particularly higher-order aberrations, generating a wavefront-guided profile from the measurements, and fabricating a second scleral lens prosthetic device with the profile on a surface of a central optic zone configured to vault over the eye's cornea and a peripheral haptic zone customized to align with the eye's sclera.

Abstract: A loudspeaker system with viscoelastic material affixed between two flexible panels is disclosed. The loudspeaker system dissipates the energy of motion, resulting in less pronounced resonant peaks. The effect may be especially evident at high frequencies, where energy is dissipated over many cycles in a shorter period of time. Also disclosed are the method of making the loudspeaker system and a method of using the loudspeaker system.

Abstract: A metal or metal alloy including a region with hierarchical micro-scale and nano-scale structure shapes, the surface region is super-hydrophobic and has a spectral reflectance of less than 30% for at least some wavelengths of electromagnetic radiation in the range of 0.1 ?m to 10 ?m. Methods for forming the hierarchical micro-scale and nano-scale structure shapes on the metal or metal alloy are also described.

Abstract: The invention provides compositions of oligofructose and specific digestive tract microbes useful for mitigating the negative effects of obesity and/or type 2 diabetes on osteoarthritis, bone fracture healing and immune system function, and methods of preparation and use thereof.

Abstract: A method is disclosed for determining the percent volume of fat in an organ (advantageously, the liver) of a living subject. Radiation (advantageously shear waves of known frequency and amplitude) is directed into the liver. The speed with which the radiation propagates within the liver, and the attenuation of the amplitude of the radiation caused by the liver, are measured. From these measured quantities, the percent volume of fat in the liver can be determined. The determination can be carried out by calculation, or by using a nomogram.

Abstract: A heat transfer device and method are disclosed. The device includes a working region (i.e., working substance) made from a first superconducting material having a superconducting state and a normal state when magnetized. The first superconducting material has a first energy gap while in the superconducting state. A substrate (i.e., cold reservoir) is connected to the working region at a first tunnel junction. The substrate may be a metallic substrate. A heat sink (i.e., hot reservoir) is connected to the working region at a second tunnel junction. The heat sink is made from a second superconducting material having a second energy gap that is larger than the first energy gap. In a particular example, the heat transfer device includes a metallic substrate is made from Copper, a working region made from Tantalum, a heat sink made from Niobium, and the first and second tunnel junctions are made from Tantalum Oxide.