Abstract: A cascaded interferometric system for Fourier domain optical coherence tomography (OCT) in which the output of one sub-system interferometer is directed through a second sub-system interferometer for performing the Fourier transform in hardware.

Abstract: An ultrasound imaging system includes an array of ultrasound transducer elements chat send ultrasound energy into an object when energized for respective transmission time periods and provide responses to ultrasound energy emitted from the object for respective reception time periods, a reception modulation circuit modulating the responses with irregular sequences of modulation coefficients, a combiner circuit combining the modulated responses, and an image reconstruction processor configured to computer-process the combined modulated responses into one or more images of the object.

Abstract: Optical coherence tomography metrology systems with two highly telecentric objective lenses wherein one or both telecentric objectives can be arranged in a pseudo-bistatic configuration. One featured telecentric objective has a large scanning field of view relevant for broadband laser scanning applications where low uncertainty measurements are desired. Another featured telecentric objective has a large image space NA relevant as a standalone microscope objective or as a probing objective for optical coordinate measurement machines.

Abstract: An optical fiber, such as in some instances a high-power, diode-pumped, dual-clad, ytterbium-doped fiber amplifier (YDFAs), having a fundamental mode and at least one higher order mode, wherein the higher order mode or modes have mode areas that are substantially larger than a mode area of the fundamental mode.

Abstract: The present disclosure provides molecular methods to improve the rapid diagnosis of respiratory infections. In general, the present disclosure provides method of detecting host gene signatures which aid in determining the etiology of a respiratory infection and thereby improve the treatment.

Abstract: Systems and methods of driving plate loudspeakers with different parameters based on frequency region in a way similar to typical cone driver crossover networks are described. These systems and methods may be implemented using arrays of independently controlled drivers which allow a designer to emphasize or de-emphasize certain modes in certain frequency bands. Tuning the characteristics of the plate's motion can also affect the acoustical properties in a larger space rather than just at a single location. The systems and methods described herein can grant a designer a degree of control over the characteristics and performance of the plate.

Abstract: The present invention relates to compositions and methods for the treatment and prevention of canine influenza virus (CIV) and CIV-related pathology. The present invention is based in part upon the discovery that various mutations in segment 1 and segment 2 of the CIV genome, thereby encoding mutant PB2 and PB1 protein, render the virus to be temperature-sensitive.

Abstract: The present invention features a composition comprising zinc pyrithione and silver sulfiadizine, a formulation thereof and a method of treating microbial infection using the composition.

Abstract: The present invention is directed to a monoclonal antibody that binds specifically to a Staphylococcus aureus glucosaminidase and inhibits in vivo growth of S. aureus. Also disclosed are monoclonal antibody binding portions, recombinant or hybridoma cell lines, pharmaceutical compositions containing the monoclonal antibody or binding portions thereof, and methods of treating S. aureus infection and osteomyelitis, and methods for introducing an orthopedic implant into a patient using the monoclonal antibody, binding portion, or pharmaceutical composition of the present invention.

Abstract: A distal biceps tendon repair device is disclosed. The device allows for anatomically correct biceps tendon repair using a single incision anterior approach without the risk associated with a double incision posterior approach. The distal biceps tendon repair device eliminates the necessity of cutting supinator muscle and greatly reduces the risk of contact or damage to vital structures such as arteries or nerves. The device has a bone drill guide mechanically coupled to a cannulated bone hook. A retrieval wire passes through the cannulated bone hook to grasp a suture or suture guide that has passed through a cannulated drill bit retained by the bone drill guide. The retrieval wire brings the suture through the cannulated bone hook, thus bringing the suture through and around the bone for subsequent anatomically correct attachment and placement of sutures used to reattach the distal biceps tendon to the bone.

Abstract: In one aspect, the invention provides a method of screening a human subject to determine if said subject has a genetic predisposition to develop, or is suffering from Facioscapulohumeral Dystrophy (FSHD), said method comprising: (a) providing a biological sample comprising genomic DNA from the subject; and (b) analyzing the portion of the genomic DNA in the sample corresponding to the distal D4Z4-pLAM region on chromosome 4 and determining the presence or absence of a polymorphism resulting in a functional polyadenylation sequence operationally linked to exon 3 of the DUX4 gene.

Abstract: A resonant cavity-enhanced infrared photodetector has an absorber layer disposed between a first transparent layer and a second transparent layer within an optical cavity. The first transparent layer and the second transparent layer have a bandgap which is larger by at least 0.1 eV compared to the absorber layer. Since the bandgaps of the first and second layer are increased relative to the bandgap of the absorber layer, generation of dark current is limited to the absorber layer. The band profiles of the layers had been designed in order to avoid carrier trapping. In one embodiment, the conduction and valence band offsets are configured to allow unimpeded flow of photogenerated charge carriers away from the absorber layer. The photodetector may be a photoconductor, or a photodiode having n-type and p-type layers. In some embodiments, an interface between the absorber layer and a transparent layer is compositionally graded.

Abstract: The present invention provides, in certain aspects, novel 7-dehydrocholesterol (7DHC) derivatives that are useful in treating or preventing cancer, as well as in treating or preventing uncontrolled angiogenesis, in a subject. In certain embodiments of the present invention, the subject is a human. In other aspects, the present invention provides a method of preparing compounds of the invention, or a salt or solvate thereof.

Abstract: The invention provides methods and materials related to a gene expression-based survival predictor for DLBCL patients.

Abstract: A mechanical coupling device and methods of use for concentrating dynamic force transmitted from a dynamic force actuator to a panel. The device comprises a concentrator surface that is coupled to an elastic panel. The concentrator surface is a continuous region with a surface area that may be smaller, larger, or the same surface area as a region in contact with a dynamic force actuator. The concentrator surface transmits a dynamic force to a region of the panel coupled to the concentrator surface.

Abstract: A method for determining gaze location includes: providing a gaze tracking device including an illumination source to illuminate an eye of an observer at an angle of about 20 degrees to 40 degrees relative to a resting eye position of the eye, a camera or an imager includes at least one focusing lens, the camera or imager to acquire sequences of digital images of the eye, and a processor to run a gaze tracking process; and running the gaze tracking process to locate at least two Purkinje reflections of the illuminating source from the eye in the images. A gaze tracking system and a gaze tracking device are also described.

Abstract: The present disclosure is generally related to capturing a scene and projecting a virtual window to one or more observers. A virtual window may mimic the experience a viewer has when looking through a real window. In some embodiments, for a single observer looking at a digital display or digital screen, a head-tracking camera on the same side of the screen as the observer can determine the position of the observer relative to the screen. The camera may be a 3D camera, stereoscopic camera, a wide angle lens camera, or an array of cameras (e.g., two or more). A camera on the other side of the screen can then image the view on the other side of the screen and software can determine the correct portion of the view that should be displayed on the screen to the observer.

Abstract: A base element for switching a magnetization state of a nanomagnet includes a heavy-metal nanostrip having a surface. A ferromagnetic nanomagnet is disposed adjacent to the surface. The ferromagnetic nanomagnet includes a shape having a long axis and a short axis. The ferromagnetic nanomagnet has both a perpendicular-to-the-plane anisotropy Hkz and an in-plane anisotropy Hkx and the ferromagnetic nanomagnet has a first magnetization equilibrium state and a second magnetization equilibrium state. The first magnetization equilibrium state or the second magnetization equilibrium state is settable by a flow of electrical charge through the heavy-metal nanostrip. A direction of flow of the electrical charge through the heavy-metal nanostrip includes an angle ? with respect to the short axis of the nanomagnet.

Abstract: The present invention features anti-HERV-K monoclonal antibodies or antigen-binding portions thereof. The present invention also features uses of the antibodies for treating HIV infection or HIV-associated conditions or diseases.

Abstract: Methods of scanning an object using a pendulum gravimeter are disclosed. The pendulum gravimeter may include an interferometer, such as a Sagnac interferometer, to determine a displacement on the pendulum by way of a mirror attached to the pendulum. Scanning of the object may be performed in 1D, 2D, or 3D, and may result in an image of the object. In another aspect, a mass may be tracked while in motion using a pendulum gravimeter to detect the gravitational attraction of the object.