Patents Assigned to University of South Florida
  • Publication number: 20210369810
    Abstract: Described herein are cell-selective mRNA constructs that can contain a RNA of interest and one or more miRNA targets. The cell-selective mRNA constructs described herein can be used to express an RNA of interest to a cell in a cell-selective manner.
    Type: Application
    Filed: August 12, 2021
    Publication date: December 2, 2021
    Applicant: University of South Florida
    Inventor: Hana Totary-Jain
  • Patent number: 11185528
    Abstract: Methods of treating or preventing allergic or pulmonary diseases characterized by endothelial dysfunction with Alda-1 are presented. Treatment of pulmonary endothelial cells subjected to hyperoxia with Alda-1 showed an increase in ALDH2 activity and expression. Treatment with Alda-1 also illustrated a decrease in oxidative stress, a decrease in reactive oxygen species (ROS), a decrease in apoptosis, a decrease in inflammation and an enhancement of mitochondrial membrane potential.
    Type: Grant
    Filed: April 3, 2020
    Date of Patent: November 30, 2021
    Assignee: University of South Florida
    Inventors: Narasaiah Kolliputi, Richard F. Lockey, Lakshmi Galam
  • Patent number: 11185261
    Abstract: A system and method for continuous glucose monitoring (CGM) of blood in a blood vessel of a patient using a non-invasive sensor composed of a patch antenna operating in the Industrial, Scientific and Medical (ISM) Radio band (5.725 GHz-5.875 GHz). The device determines the blood glucose concentration of the blood in the blood vessel based on the measured shift of the resonant frequency of the non-invasive antenna patch sensor. A radio frequency (RF) synthesizer is used to drive the patch antenna with a fraction of its output coupled to both the antenna and receiver through a directional coupler. In this approach both the transmitted (FWD) and received (REV) power are processed, by demodulating logarithmic amplifiers, which convert the RF signals to corresponding voltages for downstream processing. The resulting voltages are then fed into a microcontroller and the measured shift in resonant frequency is converted to a real-time glucose concentration.
    Type: Grant
    Filed: January 30, 2019
    Date of Patent: November 30, 2021
    Assignee: University of South Florida
    Inventors: Stephen E. Saddow, Fabiola Araujo Cespedes, Gokhan Mumcu, Christopher Leroy Frewin
  • Patent number: 11181482
    Abstract: A mobile phone-based system for ELISA (MELISA). The MELISA system can perform all steps of ELISA procedure and output hormone concentration values. The system includes a heater that keeps the temperature required for sample incubation, illumination system for sample image capturing, and a digital camera system. All components are enclosed in a dark box to create optimal light conditions for image capturing. After sample images are captured, they are digitally processed, and hormone concentration values are reported based on colorimetric data from the samples. The system can be used to complete all steps of the assay, including incubation and reading. It is lightweight, can be fabricated at low cost, is portable, and can transfer test results via mobile phone. MELISA can be calibrated for accurate measurements of progesterone and has demonstrated successful measurements with the calibrated system.
    Type: Grant
    Filed: September 5, 2018
    Date of Patent: November 23, 2021
    Assignee: University of South Florida
    Inventors: Anna Pyayt, Arsenii Zhdanov, Jordan Keefe, Luis Franco-Waite
  • Patent number: 11176631
    Abstract: Disclosed are various embodiments for GPU-based parallel indexing for concurrent spatial queries. A number of nodes in a tree to be partitioned is determined. The tree is then iteratively partitioned with the GPU. Nodes are created with the GPU. Finally, a point insertion is performed using the GPU.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: November 16, 2021
    Assignee: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Yicheng Tu, Zhila Nouri Lewis
  • Patent number: 11173198
    Abstract: Described are immunogenic proteins against Clostridium difficile. Also described are compositions comprising the immunogenic proteins. Further described are methods of preventing or treating a Clostridium difficile infection in a subject in need thereof.
    Type: Grant
    Filed: February 10, 2020
    Date of Patent: November 16, 2021
    Assignee: UNIVERSITY OF SOUTH FLORIDA
    Inventor: Xingmin Sun
  • Patent number: 11173152
    Abstract: Nanoparticle based MKT formulation. MKT is encapsulated by poly(ethylene glycol)ylated (PEGylated) poly-(lactide-co-glycolide) (PLGA) to form nanoparticles (NPs). To induce trans-BBB permeability, glutathione (GSH) is coated on the resulting NPs. Newly generated MKT-NPs showed BBB permeability and tau reduction in experimental models. Specifically, brain-targeting MKT NPs were developed with a glutathione coating, characterized, and shown to permeate BBB permeation insert models as a therapeutic for Alzheimer's disease and related tauopathies.
    Type: Grant
    Filed: April 15, 2020
    Date of Patent: November 16, 2021
    Assignee: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Vijaykumar Bhadabhai Sutariya, Umesh Kumar Jinwal
  • Patent number: 11169256
    Abstract: A new system and method for FWI of common-offset GPR data, particularly targeting the dimensions and infilling material of buried objects. The method is useful in situations where clear isolated diffraction hyperbolas indicate the presence of an underground object, but the object's dimensions and filling may be unknown. The present invention acquires GPR data and applies advanced numerical methods to get the depth and size of the underground object in a very accurate manner. An embodiment of the invention includes five main steps: GPR data processing, ray-based analysis to set a good initial model, 3D to 2D transformation of data, effective SW estimation, and FWI.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: November 9, 2021
    Assignee: University of South Florida
    Inventors: Sajad Jazayeri, Sarah Kruse
  • Patent number: 11170645
    Abstract: Systems and methods are described herein to automatically detect objects and other debris located in the road. The lateral movement of a vehicle is monitored to detect lane changes. When a lane change is detected, information about the lane change including geographic coordinates of the lane change are collected. The information collected from various vehicles is correlated to identify possible locations of debris and other objects in the road. The identified locations may be provided to other vehicles for use in one or more navigation or collision detection systems or provided to one or more authorities who may use the information to address the identified objects or debris.
    Type: Grant
    Filed: April 10, 2020
    Date of Patent: November 9, 2021
    Assignee: University of South Florida
    Inventors: Mohsen Kamrani, Sisinnio Concas, Achilleas Kourtellis
  • Patent number: 11170493
    Abstract: A Pulsed Thermography (PT) system and method is provided utilizing a long duration pulse in combination with a radiant heat shield as a non-destructive testing method for quantitatively measuring defect depths within a 3D printed part and for characterizing layer-by-layer surface defects in the 3D printed part.
    Type: Grant
    Filed: February 3, 2020
    Date of Patent: November 9, 2021
    Assignee: University of South Florida
    Inventors: Nathan Brad Crane, James Randall Pierce, III
  • Patent number: 11161095
    Abstract: The disclosure provides a decontaminant comprising MoO2. The disclosure also provides methods to produce a decontaminant comprising MoO2 and methods for decontamination of a fluid comprising us of a decontaminant comprising MoO2.
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: November 2, 2021
    Assignee: University of South Florida
    Inventors: Michael Scott McCrory, Manoj Kumar Ram
  • Patent number: 11162061
    Abstract: In one embodiment, a concentrically baffled reactor includes an outer housing that defines an interior space, an inlet through which material can be delivered into the interior space, an outlet through which material can be removed from the interior space, and multiple concentric baffles within the interior space that define multiple concentric reactor zones through which the material can sequentially flow to the outlet.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: November 2, 2021
    Assignee: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Daniel H. Yeh, Onur Y. Ozcan, Robert A. Bair
  • Patent number: 11160498
    Abstract: A device and method for measuring prosthetic or orthotic slip is presented. An optical sensor device is attached to the prosthesis or orthosis and measures the amount of relative motion between the prosthetic socket and the residual limb surface or between the orthosis and the affected body part. The sensor device is comprised of an optical sensor, a light source, a processing unit and a power source contained within a housing. A system for measuring multidirectional prosthetic or orthotic slip using the sensor device and automatically adjusting the fit of the prosthetic based on a determined threshold is also presented.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: November 2, 2021
    Assignee: University of South Florida
    Inventors: Matthew Michael Wernke, Samuel Lon Phillips, Derek James Lura, Stephanie Lutton Carey, Rajiv V. Dubey
  • Patent number: 11156613
    Abstract: The present invention relates to a method for the diagnosis, prognosis, and monitoring of cancer, such as early or late stage ovarian cancer, in a subject by detecting Bcl-2 in a biological sample from the subject, preferably a urine or blood sample. Bcl-2 may be measured using an agent that detects or binds to Bcl-2 protein or an agent that detects or binds to encoding nucleic acids, such as antibodies specifically reactive with Bcl-2 protein or a portion thereof. The invention further relates to kits for carrying out the methods of the invention. The invention further relates to a device for the rapid detection of Bcl-2 in a bodily fluid and methods for rapidly measuring Bcl-2 in a bodily fluid.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: October 26, 2021
    Assignee: UNIVERSITY OF SOUTH FLORIDA
    Inventor: Patricia A. Kruk
  • Patent number: 11156891
    Abstract: In one embodiment, an electrochromic device includes a single unitary active layer including a dye having a nitrogen group and a conducting polymer having a nitrogen group, wherein the active layer has a first color in an oxidized state and a second color in a reduced state, and wherein the electrochromic device comprises no other active layer.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: October 26, 2021
    Assignee: UNIVERSITY OF SOUTH FLORIDA
    Inventor: Manoj Kumar Ram
  • Patent number: 11155880
    Abstract: Provided herein are methods of measuring C19MC miRNA amount and/or expression in a post-natal cell and/or tissue. Provided herein are methods of measuring CpG methylation of the upstream C19MC miRNA promoter region in a post-natal cell and/or tissue. Also provided herein are methods of treating a cell, population thereof, and/or a subject in need thereof by administering a C19MC miRNA inhibitor or CRISPR to suppress the expression of specific miRNA within the C19MC or the entire C19MC cluster, population thereof, and/or the subject in need thereof.
    Type: Grant
    Filed: October 7, 2019
    Date of Patent: October 26, 2021
    Assignee: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Hana Totary-Jain, Ezinne Francess Mong
  • Patent number: 11158939
    Abstract: System and method for determining a position of an antenna array for optimal wireless communication. The system includes a spatially adaptive and beam-steering antenna array configured to control a wireless communications path between a first element and a second element based on a determination of wireless channel gain.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: October 26, 2021
    Assignee: University of South Florida
    Inventors: Mustafa Harun Yilmaz, Ertugrul Guvenkaya, Gokhan Mumcu, Huseyin Arslan
  • Patent number: 11149065
    Abstract: A one-bead-two-compound combinatorial synthesis technique provides libraries of macrocyclic peptidomimetic compounds and compositions with use as ligands for the Ephrin type-A receptor 2 (EphA2). The one-bead-two-compound technique and libraries of macrocyclic compounds are useful as research tools in drug discovery and/or to treat or prevent a range of diseases or disorders.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: October 19, 2021
    Assignee: University of South Florida
    Inventors: Jianfeng Cai, Yan Shi
  • Patent number: 11138473
    Abstract: Systems and methods for expert-assisted classification are described herein. An example method for evaluating an expert-assisted classifier can include providing a cascade classifier including a plurality of classifier stages; and providing a simulated expert stage between at least two of the classifier stages. The simulated expert stage can be configured to validate or contradict an output of one of the at least two classifier stages. The method can also include classifying each of a plurality of records into one of a plurality of categories using the cascade classifier combined with the simulated expert stage; and determining whether the simulated expert stage improves performance of the cascade classifier.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: October 5, 2021
    Assignee: University of South Florida
    Inventors: Balaji Padmanabhan, Utkarsh Shrivastava, Vivek Kumar Singh
  • Patent number: 11134997
    Abstract: A method and system for performing bone fusion and/or securing one or more bones, such as adjacent vertebra, are disclosed. The screws include a threaded tip connected to a main shaft and a threaded outer sleeve that rotates relative to the outer shaft until locked down. Independent rotation of the threaded outer sleeve relative to the threaded distal tip allows compression or distraction to modify the gap between the vertebral bodies. The screws are passed from the inferior to superior vertebra or superior to inferior, for example, through a transpedicular route to avoid neurological compromise. At the same time, the path of screw insertion is oriented to reach superior or inferior vertebra. An intervertebral cage of the system is configured for lateral expansion from a nearly straight configuration to form a large footprint in the disc space. The screws and cage may be combined for improved fixation with minimal invasiveness.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: October 5, 2021
    Assignee: University of South Florida
    Inventors: Frank D. Vrionis, Kamran Aghayev, Sabrina A Gonzalez Blohm, James J. Doulgeris