Patents Assigned to University of South Florida
  • Patent number: 11896644
    Abstract: As disclosed herein, ?-arrestin1 and ?-arrestin2 levels are highly elevated in brains of FTLD-tau patients suggesting that both ?-arrestin1 and ?-arrestin2 are elevated in the brains of patients with AD and FLTD. The current work also shows that when ?-arrestin2 is overexpressed, tau levels become elevated. The data indicate that ?-arrestin2 reduces tau clearance by impairing p62-mediated autophagy, a role carried out by the oligomerized form of ?-arrestin2. Therefore, disclosed herein are ?-arrestin oligomerization inhibitors that can be used to prevent ?-arrestin oligomerization and therefore the accumulation of tau in cells, i.e. tauopathy. Also disclosed are methods of treating a tauopathy in a subject that involve administering to the subject a therapeutically effective amount of a ?-arrestin oligomerization inhibitor disclosed herein.
    Type: Grant
    Filed: February 8, 2021
    Date of Patent: February 13, 2024
    Assignee: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Jung A. Woo, Stephen Bryant Liggett, David E. Kang, Yu Chen, Eric Lewandowski
  • Patent number: 11896647
    Abstract: The subject invention concerns materials and methods for treating a person or animal having cognitive impairment. In one embodiment, the method comprises administering an effective amount of one or more inflammatory mediator(s), for example, fms-related tyrosine kinase 3 (Flt3) ligand, interleukin-6 (IL-6), macrophage migration inhibitory factor (MIF), interleukin-1 (IL-1), interleukin-3 (IL-3), erythropoietin (EPO), vascular endothelial growth factor A (VEGF-A), hypoxia-inducible transcription factor (HIF-1alpha), insulin like growth factor-1 (IGF-1), tumor necrosis factor (TNF), granulocyte colony-stimulating factor (G-CSF), granulocyte/macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF), Stem Cell Factor (SCF), Darbepoetin (ARANESP), and metalloproteinases, to an animal or person in need of treatment.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: February 13, 2024
    Assignee: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Huntington Potter, Gary W. Arendash, Steven Bennett, Timothy Boyd
  • Patent number: 11892294
    Abstract: Various examples are provided for systems and methods for geodesy in shallow water. In one example, a method includes obtaining, from a sensor module, a position of a superstructure of a moored device. At least one measurement corresponding to a heading, a pitch, or a roll of the superstructure can be obtained from the sensor module. An estimated position of an anchor, ballast, or other seafloor marker of the moored device can be determined based on the position of the superstructure and at least one corrected heading associated with the at least one measurement. The at least one corrected heading can be determined by applying a magnetic declination correction to the at least one measurement.
    Type: Grant
    Filed: October 29, 2020
    Date of Patent: February 6, 2024
    Assignee: UNIVERSITY OF SOUTH FLORIDA
    Inventor: Timothy Hugh Dixon
  • Patent number: 11891321
    Abstract: A modular system for waste treatment, water recycling, and resource recovery includes a buffer tank to receive and pre-treat raw organic waste, at least one reactor tank configured as an anaerobic bioreactor that receives and digests pre-treated waste from the buffer tank, a membrane module having a membrane configured to filter waste from the digested waste from the at least one reactor tank to produce a permeate, a permeate collection tank configured to collect and store the permeate generated by the membrane module, a pump system having a plurality of pumps, and a control system configured to monitor the flow of waste and to control the pump system to control the flow of waste between the buffer tank, the at least one reactor tank, the membrane module, and the permeate collection tank.
    Type: Grant
    Filed: June 21, 2021
    Date of Patent: February 6, 2024
    Assignees: UNIVERSITY OF SOUTH FLORIDA, UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATIOR OF NASA
    Inventors: Daniel H. Yeh, Luke Roberson, Talon Bullard, Melanie Pickett, Robert Bair, Ahmet Erkan Uman
  • Patent number: 11884906
    Abstract: A 4D-perfused tumoroid-on-a-chip platform used in personalized cancer treatment. The platform includes a plate with a plurality of bottomless wells that resides atop a microfluidic channel layer, which in turn resides atop a surface acoustic wave (SAW) based sensor layer that is capable of measuring potential pH values of fluids disposed within the platform. The microfluidic channel layer includes a plurality of bioreactors, with each bioreactor including an inlet well, a culture well, and an outlet well. The inlet well, culture well, and outlet well form a closed system via fluid conduits spanning from the inlet well to the culture well, as well as from the culture well to the outlet well. Due to the fluid flow from the plate to the chip, and from the inlet well to the outlet well on the chip through the culture well, target cell (tumoroid) growth is promoted within the culture well.
    Type: Grant
    Filed: March 2, 2023
    Date of Patent: January 30, 2024
    Assignee: University of South Florida
    Inventors: Subhra Mohapatra, Shyam S. Mohapatra, Tao Wang
  • Patent number: 11887316
    Abstract: A method for motion recognition and embedding is disclosed. The method may include receiving a plurality of frames of an input video for extracting a feature vector of a motion in the plurality of frames, generating a plurality of sets of one or more motion component bits based on the feature vector and a plurality of classifiers, the plurality of sets corresponding to the plurality of classifiers, each set of one or more motion component bits representing a physical or mechanical attribute of the motion; and generating a motion code for a machine to execute the motion by combining the plurality of sets of one or more motion component bits. Other aspects, embodiments, and features are also claimed and described.
    Type: Grant
    Filed: July 12, 2021
    Date of Patent: January 30, 2024
    Assignee: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Yu Sun, David Andres Paulius, Maxat Alibayev
  • Patent number: 11878182
    Abstract: A method of modulating neural activity using a combination of electrical and optical stimulation transmitted via a gold nanoparticle covered nanoelectrode is presented. The combination of short-duration green visible light optical pulses with the complementary sub-threshold level electric current pulses are capable of producing action potentials in neurons. Cells were found to have a greater than a 5× survival rate using this hybrid stimulation method as compared to pure plasmonic/optical stimulation. The cell stimulation success rate was 3× greater with hybrid stimulation.
    Type: Grant
    Filed: April 23, 2021
    Date of Patent: January 23, 2024
    Assignee: University of South Florida
    Inventors: Ratka Damnjanovic, Parveen Bazard, Robert Dana Frisina, Venkat Rama Bhethanabotla
  • Patent number: 11865125
    Abstract: Provided herein are formulations effective for and methods of treating or preventing a neurodegenerative disorder in a subject in need thereof that can include administering an amount of an aPKC inhibitor to a subject in need thereof.
    Type: Grant
    Filed: December 17, 2021
    Date of Patent: January 9, 2024
    Assignees: UNIVERSITY OF SOUTH FLORIDA, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Robert Vito Farese, Mini Paliyath Sajan, Margaret Genevieve Higgs
  • Patent number: 11866474
    Abstract: Provided herein are novel VEGF mimics, pharmaceutical compositions thereof, and methods of their use in increasing or reducing angiogenesis.
    Type: Grant
    Filed: December 21, 2022
    Date of Patent: January 9, 2024
    Assignee: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Jianfeng Cai, Sami Abdulkadir
  • Patent number: 11857679
    Abstract: The subject invention pertains to polyacrylate homopolymers produced from acrylolated drug monomers. The homopolymers can be produced in the form of nanoparticles. The nanoparticles comprising the homopolymers can be produced via a free radical-induced emulsion polymerization of the acrylolated drug monomers to produce an aqueous emulsion of uniformly sized nanoparticles. The homopolymers of the invention containing acrylolated antibiotic monomers can be active against Gram-positive and Gram-negative bacteria, such as Staphylococcus aureus and Escherichia coli. Accordingly, methods are provided of treating a disease, for example, an infection, by administering to a subject the homopolymers, homopolymeric nanoparticles, or emulsions containing homopolymeric nanoparticles of the invention.
    Type: Grant
    Filed: September 13, 2021
    Date of Patent: January 2, 2024
    Assignee: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Edward Turos, Faeez Mahzamani
  • Patent number: 11861050
    Abstract: The present disclosure presents various systems and methods for implementing a physical unclonable function device. One such method comprises providing an integrated circuit having a plurality of set/reset flip flop logic circuits, wherein each of the set/reset flip flop logic circuits enters a metastable state for a particular input sequence. The method includes varying circuit parameters for each of the plurality of set/reset flip flop logic circuits to account for manufacturing variations in the set/reset flip flop logic circuits and enable generating a stable but random output in response to the particular input sequence. Thus, by applying the particular input sequence to the integrated circuit, a unique identifier for the integrated circuit can be derived from an output response of the plurality of set/reset flip flop logic circuits.
    Type: Grant
    Filed: December 22, 2022
    Date of Patent: January 2, 2024
    Assignee: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Srinivas Katkoori, Rohith Prasad Challa, Sheikh Ariful Islam
  • Patent number: 11858096
    Abstract: A method for achieving a target joint preload includes identifying a thread pitch of a first fastener element used to secure two components together. The first fastener element is passed through the two components and a second fastener element is threaded onto the first fastener element. A tightening torque is applied to the second fastener element, which is measured as the trial tightening torque. A loosening torque is applied to the second fastener element, which is measured as the trial removal torque. A required tightening torque that is required to be applied to the second fastener element to achieve the target joint preload is calculated using only the thread pitch, the trial tightening torque, the trial removal torque, and the target joint preload.
    Type: Grant
    Filed: June 25, 2020
    Date of Patent: January 2, 2024
    Assignee: UNIVERSITY OF SOUTH FLORIDA
    Inventor: Daniel P. Hess
  • Patent number: 11857598
    Abstract: Described herein are cell-selective mRNA constructs that can contain a RNA of interest and one or more miRNA targets. The cell-selective mRNA constructs described herein can be used to express an RNA of interest to a cell in a cell-selective manner.
    Type: Grant
    Filed: August 12, 2021
    Date of Patent: January 2, 2024
    Assignee: UNIVERSITY OF SOUTH FLORIDA
    Inventor: Hana Totary-Jain
  • Patent number: 11851616
    Abstract: Structures of a particle containing a core and at least one shell, a metal oxide material of which is necessarily doped to ensure protection of a material of the core from photodegradation. The core can include any of a thermochromic material, a phase-change material, and a judiciously defined auxiliary material that in turn contains organic and/or polymeric material. Derivative products utilizing a plurality of such particles. Methodologies for producing such particles and derivative products.
    Type: Grant
    Filed: February 11, 2022
    Date of Patent: December 26, 2023
    Assignee: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Elias K. Stefanakos, Sesha S. Srinivasan
  • Patent number: 11851707
    Abstract: A method of predicting the development of chronic lung allograft dysfunction (CLAD) in lung transplant patients using N-myc-interactor (NMI) as a biomarker and associated treatment thereof is presented. Also presented is a method of reducing the risk of CLAD by administering a therapeutic agent capable of increasing NMI in the patient. NMI is a critical regulator of epithelial-to-mesenchymal transition (EMT) and an important precursor to development of CLAD. NMI expression is reduced in CLAD patients and can be used as an early diagnostic biomarker to predict the development of CLAD. NMI can also be used as a drug target for a therapeutic to increase expression of NMI and treat chronic lung disease such as CLAD. Therapeutics comprising NMI protein or NMI gene can be used as potential treatments for chronic lung diseases such as CLAD.
    Type: Grant
    Filed: March 29, 2021
    Date of Patent: December 26, 2023
    Assignee: University of South Florida
    Inventors: Nirmal S. Sharma, Mudassir Banday, Andreas Seyfang
  • Patent number: 11849984
    Abstract: A method and system for performing bone fusion and/or securing one or more bones, such as adjacent vertebra, are disclosed. The screws include a threaded tip connected to a main shaft and a threaded outer sleeve that rotates relative to the outer shaft until locked down. Independent rotation of the threaded outer sleeve relative to the threaded distal tip allows compression or distraction to modify the gap between the vertebral bodies. The screws are passed from the inferior to superior vertebra or superior to inferior, for example, through a trans-pedicular route to avoid neurological compromise. At the same time, the path of screw insertion is oriented to reach superior or inferior vertebra. An intervertebral cage of the system is configured for lateral expansion from a nearly straight configuration to form a large footprint in the disc space. The screws and cage may be combined for improved fixation with minimal invasiveness.
    Type: Grant
    Filed: June 18, 2020
    Date of Patent: December 26, 2023
    Assignees: H. Lee Moffitt Cancer Center and Research Institute, Inc., University of South Florida
    Inventors: Frank D. Vrionis, Kamran Aghayev, Sabrina A. Gonzalez Blohm, James J. Doulgeris
  • Patent number: 11844809
    Abstract: Disclosed herein are compositions and methods for inducing, promoting, or enhancing an immune response in a subject. For example, the disclosed compositions and methods can be used prophylactically to prevent viral/microbial infections or therapeutically to treat acute infections. In some embodiments, the disclosed method involves administering to the subject a composition comprising in vitro transcribed (IVT) RNA comprising short interspersed nuclear elements (SINEs), such as Alu repeats. In some embodiments, the disclosed compositions and methods can be used to induce, promote, or enhance any immune response in a subject, including an anti-viral, anti-microbial, anti-fungal, or anti-parasite response. In some embodiments, the disclosed compositions can be administered to any mucosal barrier, such as lungs or intestines, e.g. to enhance an innate immune response against a virus or pathogen.
    Type: Grant
    Filed: June 7, 2022
    Date of Patent: December 19, 2023
    Assignee: UNIVERSITY OF SOUTH FLORIDA
    Inventor: Hana Totary-Jain
  • Patent number: 11844779
    Abstract: Provided herein are formulations that can contain an effective amount of a PKC? inhibitor. Also provided herein are methods of inhibiting a PKC? in a subject in need thereof, that can include the step of administering an effective amount of a compound that is capable of inhibiting a PKC?.
    Type: Grant
    Filed: September 13, 2021
    Date of Patent: December 19, 2023
    Assignees: UNIVERSITY OF SOUTH FLORIDA, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Niketa A. Patel, Rekha S. Patel, Robert Pleasants Sparks, Wayne Charles Guida
  • Patent number: 11846920
    Abstract: Disclosed are various embodiments for integrated diffuse correlation spectroscopy. A first control signal can be sent to a switch to cause an integrator to integrate a current from a photodiode. An integrated current can be received from the integrator, and a data signal can be sent to a computing device based at least in part on the integrated current. A second control signal can be sent to a switch to cause the integrator to cease integrating the current from the photodiode.
    Type: Grant
    Filed: November 1, 2022
    Date of Patent: December 19, 2023
    Assignee: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Ashwin Bharadwaj Parthasarathy, Arindam Biswas, Arash Takshi
  • Patent number: 11844966
    Abstract: A breathing system for removing harmful contaminants, such as microbes and volatile organic compounds, is provided. The breathing system includes a face mask, an inhalation limb, and a plasmonic device. As a contaminated gas flows through an internal chamber of the plasmonic device, the contaminates are oxidized. Specifically, the internal chamber includes a source of photons spaced apart from the nanostructure. The nanostructure is coated in a plasmonic layer, including noble metal nanoparticles. The plasmonic layer is protected from oxidation through a photocatalyst layer disposed thereon.
    Type: Grant
    Filed: March 3, 2021
    Date of Patent: December 19, 2023
    Assignees: University of South Florida, MOLEKULE, INC.
    Inventors: Dharendra Yogi Goswami, Dilip Neeraj Goswami