Patents Assigned to University of South Florida
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Patent number: 11851707Abstract: A method of predicting the development of chronic lung allograft dysfunction (CLAD) in lung transplant patients using N-myc-interactor (NMI) as a biomarker and associated treatment thereof is presented. Also presented is a method of reducing the risk of CLAD by administering a therapeutic agent capable of increasing NMI in the patient. NMI is a critical regulator of epithelial-to-mesenchymal transition (EMT) and an important precursor to development of CLAD. NMI expression is reduced in CLAD patients and can be used as an early diagnostic biomarker to predict the development of CLAD. NMI can also be used as a drug target for a therapeutic to increase expression of NMI and treat chronic lung disease such as CLAD. Therapeutics comprising NMI protein or NMI gene can be used as potential treatments for chronic lung diseases such as CLAD.Type: GrantFiled: March 29, 2021Date of Patent: December 26, 2023Assignee: University of South FloridaInventors: Nirmal S. Sharma, Mudassir Banday, Andreas Seyfang
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Patent number: 11846920Abstract: Disclosed are various embodiments for integrated diffuse correlation spectroscopy. A first control signal can be sent to a switch to cause an integrator to integrate a current from a photodiode. An integrated current can be received from the integrator, and a data signal can be sent to a computing device based at least in part on the integrated current. A second control signal can be sent to a switch to cause the integrator to cease integrating the current from the photodiode.Type: GrantFiled: November 1, 2022Date of Patent: December 19, 2023Assignee: UNIVERSITY OF SOUTH FLORIDAInventors: Ashwin Bharadwaj Parthasarathy, Arindam Biswas, Arash Takshi
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Patent number: 11844779Abstract: Provided herein are formulations that can contain an effective amount of a PKC? inhibitor. Also provided herein are methods of inhibiting a PKC? in a subject in need thereof, that can include the step of administering an effective amount of a compound that is capable of inhibiting a PKC?.Type: GrantFiled: September 13, 2021Date of Patent: December 19, 2023Assignees: UNIVERSITY OF SOUTH FLORIDA, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Niketa A. Patel, Rekha S. Patel, Robert Pleasants Sparks, Wayne Charles Guida
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Patent number: 11844809Abstract: Disclosed herein are compositions and methods for inducing, promoting, or enhancing an immune response in a subject. For example, the disclosed compositions and methods can be used prophylactically to prevent viral/microbial infections or therapeutically to treat acute infections. In some embodiments, the disclosed method involves administering to the subject a composition comprising in vitro transcribed (IVT) RNA comprising short interspersed nuclear elements (SINEs), such as Alu repeats. In some embodiments, the disclosed compositions and methods can be used to induce, promote, or enhance any immune response in a subject, including an anti-viral, anti-microbial, anti-fungal, or anti-parasite response. In some embodiments, the disclosed compositions can be administered to any mucosal barrier, such as lungs or intestines, e.g. to enhance an innate immune response against a virus or pathogen.Type: GrantFiled: June 7, 2022Date of Patent: December 19, 2023Assignee: UNIVERSITY OF SOUTH FLORIDAInventor: Hana Totary-Jain
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Patent number: 11844966Abstract: A breathing system for removing harmful contaminants, such as microbes and volatile organic compounds, is provided. The breathing system includes a face mask, an inhalation limb, and a plasmonic device. As a contaminated gas flows through an internal chamber of the plasmonic device, the contaminates are oxidized. Specifically, the internal chamber includes a source of photons spaced apart from the nanostructure. The nanostructure is coated in a plasmonic layer, including noble metal nanoparticles. The plasmonic layer is protected from oxidation through a photocatalyst layer disposed thereon.Type: GrantFiled: March 3, 2021Date of Patent: December 19, 2023Assignees: University of South Florida, MOLEKULE, INC.Inventors: Dharendra Yogi Goswami, Dilip Neeraj Goswami
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Patent number: 11840107Abstract: A method for generating three dimensional indicators for the visually impaired. The method includes selecting one or more pre-designed symbols from a plurality of pre-designed symbols. The pre-designed symbols represent standard building layout features and are sized to be readable via a physical touch. The method further includes inserting the one or more selected symbols into a two dimensional digital layout, and generating one or more of an orientation object and a legend object into the two dimensional digital layout. The method further includes converting the two dimensional digital layout into a three dimensional digital model, and generating an output file including the three dimensional model in a format compatible with a three dimensional printing device.Type: GrantFiled: March 15, 2021Date of Patent: December 12, 2023Assignee: UNIVERSITY OF SOUTH FLORIDAInventors: Howard David Kaplan, Spenser Fox Mason
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Patent number: 11843364Abstract: An acoustic resonator includes a piezoelectric stack including a piezoelectric layer having a top surface and a bottom surface, a top electrode layer disposed above the top surface, and a bottom electrode layer disposed below the bottom surface. A number of acoustic wave reflectors are disposed on a side of the bottom electrode layer opposite the piezoelectric layer. Each acoustic wave reflector includes a high acoustic impedance layer and may include a low acoustic impedance layer. The acoustic resonator may include a tether that extends laterally to a stacking direction of the layers of the piezoelectric stack. A supporting structure may be coupled to the tether opposite the acoustic resonator for anchoring the acoustic resonator. A mirror, one or more phononic crystals, or both may be positioned on proximate the tether opposite the acoustic resonator to avoid resonant waves from exiting the acoustic resonator in use.Type: GrantFiled: November 26, 2021Date of Patent: December 12, 2023Assignees: II-VI DELAWARE, INC., UNIVERSITY OF SOUTH FLORIDAInventors: Wen-Qing Xu, Di Lan, Jing Wang, Weiqi Li, Xu Han, Chao Liu, Elgin Eissler, Giovanni Barbarossa
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Patent number: 11837988Abstract: A method and device to collect and convert thermal energy from the surrounding environments to produce usable electric power. The device includes a rectenna that is preferably a narrow bandwidth rectenna. In an embodiment, the rectenna comprises a rectenna complex, which is, in sequence, a high gain antenna, optional matching circuits, an optional narrow bandpass filter, and one or more rectifying diodes. An embodiment may include multiple arrays of linked nanoscale rectenna complexes. When linked in arrays using preselected bandwidths in the infrared and near infrared spectral regions, the rectenna complex acts as a thermally responsive collector capable of extracting heat energy from its surrounding environment to produce usable electric power.Type: GrantFiled: May 10, 2018Date of Patent: December 5, 2023Assignee: University of South FloridaInventors: Michael Wayne Fountain, Gabriel Lee Saffold
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Patent number: 11833137Abstract: The present invention includes substituted chromenones that are useful to inhibit the IRE1/XBP-1 pathway. In certain embodiments, the compounds of the invention inhibit IRE1's RNase activity. In other embodiments, the compounds of the invention are useful to treat or prevent a cancer that involve activation of the ER stress response. The invention also relates, in certain aspects, to the discovery that secretory IgM (sIgM) can orchestrate an immunosuppressive microenvironment by recruiting myeloid-derived suppressor cells (MDSCs) into different tumor models, such as but not limited to solid tumors (such as but not limited to lung cancer) and tumors that have high levels of secreted IgM. In certain embodiments, sIgM produced by B cells or CLL cells can contribute to the accumulation of MDSCs in a tumor. In other embodiments, inhibition of the IRE1/XBP-1 pathway can ablate, minimize, or reduce MDSC levels in a tumor.Type: GrantFiled: April 1, 2019Date of Patent: December 5, 2023Assignees: The Wistar Institute, University of South FloridaInventors: Chih-Chi Andrew Hu, Juan R. Del Valle
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Patent number: 11828726Abstract: Disclose herein is a portable platform based on a direct digital synthesizer (DDS) is investigated for the orthogonal SAW sensor, integrating signal synthesis, gain control, phase/amplitude measurement, and data processing in a small, portable electronic system. The disclosed platform allows for simultaneous removal of non-specific binding proteins, and mixing, as well as improved incubation time.Type: GrantFiled: November 14, 2022Date of Patent: November 28, 2023Assignee: UNIVERSITY OF SOUTH FLORIDAInventors: Venkat R. Bhethanabotla, Shuangming Li
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Patent number: 11815779Abstract: In one embodiment, an electrochromic device includes a single active layer configured to be alternately placed in a light-transmitting state in which relatively large amounts of light can be transmitted through the active layer and a light-blocking state in which relatively small amounts of light can be transmitted through the active layer, wherein the device comprises no other layers of material that contribute to transitioning between the two states.Type: GrantFiled: June 13, 2022Date of Patent: November 14, 2023Assignee: UNIVERSITY OF SOUTH FLORIDAInventors: Manoj Kumar Ram, Elias K. Stefanakos
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Patent number: 11814385Abstract: Disclosed herein are compounds that can prevent and treat C. difficile by inhibiting sporulation. Also disclosed herein are compositions and formulations comprising the compound disclosed herein. Methods of preventing and treating C. difficile comprising administering the compounds described herein are also disclosed.Type: GrantFiled: June 27, 2022Date of Patent: November 14, 2023Assignee: University of South FloridaInventors: Yu Chen, Michael Sacco, James Leahy, Elena Bray, Xingmin Sun, Xiujun Zhang
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Patent number: 11809475Abstract: In accordance with some embodiments, systems, methods, and media for processing and representing multivariate sensor information gathered from multiple sources are provided. In some embodiments, the method comprises: receiving a data sequences from respective sources; identifying a shortest data sequence that corresponds to a first interval; calculating, for pairs of data sequences, a similarity value over the first interval; forming a first segment of a representative data sequence that is a weighted combination of the data sequences over the first interval based on similarity values associated with the data sequences; truncating at least a subset of data sequences to exclude elements corresponding to the first interval; identifying a shortest data sequence corresponding to a second interval; forming a second segment of the representative data sequence based on similarity values associated with the data sequences; and concatenating the first segment and the second segment of the representative data sequence.Type: GrantFiled: December 14, 2021Date of Patent: November 7, 2023Assignee: UNIVERSITY OF SOUTH FLORIDAInventors: Ismail Uysal, Alla Abdella
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Patent number: 11806328Abstract: Ketone supplementation, such as through use of precursors of beta-hydroxybutyrate (BHB) and acetoacetate (AcAc), increased blood levels of ketone bodies, increases blood flow and wound closure in ischemic young and aged fisher rats significantly earlier compared to standard diet in aged rats. In vitro experiments with ketone bodies demonstrate decreased mitochondrial and cytosolic ROS in young and aged primary human dermal fibroblasts (PHDF). Ketone bodies increased migration in young and aged PHDFs.Type: GrantFiled: December 15, 2020Date of Patent: November 7, 2023Assignee: UNIVERSITY OF SOUTH FLORIDAInventors: Dominic Paul D'Agostino, Shannon Kesl
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Patent number: 11806356Abstract: Disclosed are compositions and methods for delaying or preventing idiopathic preterm birth.Type: GrantFiled: September 20, 2021Date of Patent: November 7, 2023Assignee: University of South FloridaInventors: Charles Lockwood, Ozlem Guzeloglu-Kayisli, Umit Ali Kayisli, Frederick Schatz
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Patent number: 11806312Abstract: A medication adherence system and corresponding medication box for improving medication adherence. The system includes the medication box, which is transparent and has a machine-readable marker, such as a QR code, on or beneath the floor thereof. The marker is capable of being scanned and read through the transparent bottoms of individual chambers. Data embedded in the marker includes, but is not limited to, the user's medication plan, the date and time when the medication is to be ingested, and instructions for recording the date and time when the marker is scanned and read. The underlying software program/application processes this information and provides an indication as to the user's compliance with the medication plan.Type: GrantFiled: February 14, 2022Date of Patent: November 7, 2023Assignees: UNIVERSITY OF SOUTH FLORIDA, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: William Diehl Kearns, Kimberly Ann Crosland, Jeffrey D. Craighead, James Leonard Fozard
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Patent number: 11809597Abstract: A public key generated by each user of a plurality of users is used to encrypt the contacts for that user. The results are sent to a server by each user. The key generated by each user is then distributed to every other user in the system, and each recipient encrypts their contacts with the keys. The result of these encryptions for all contacts for all recipients is then received by the server, and the server computes an encrypted computation of equality of two contacts and sends all computations back to the original user. The user can use the homomorphic property of the crypto protocol (e.g., a private key) to determine a set of users that are matched as contacts with the other users. The binary results are returned to the server, and the server computes a graph using the results.Type: GrantFiled: March 26, 2021Date of Patent: November 7, 2023Assignee: University of South FloridaInventors: Jean-Francois Biasse, William Youmans, Sriram Chellappan, Nathan Fisk, Noyem Khan
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Patent number: 11809563Abstract: A system and method of protecting against control-flow attacks provides two complementary, transparent, and strong security policies for the RTL design at a hardware level. The approach performs static analysis of controller, followed by lightweight instrumentation, such that CFI is enforced in-place and at runtime. The modified controller follows conservative CFG with the help of a monitor.Type: GrantFiled: July 7, 2021Date of Patent: November 7, 2023Assignee: University of South FloridaInventors: Srinivas Katkoori, Sheikh Ariful Islam
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Patent number: 11808710Abstract: Disclosed herein are methods for measuring the ionic strengths of the natural water sources. Also disclosed herein are systems used to measure an ionic strength of the natural water sources. More specifically disclosed herein are methods and systems utilizing spectroscopic pH measurements and calculations of the ionic strength as a function of the measured pH.Type: GrantFiled: June 24, 2021Date of Patent: November 7, 2023Assignee: University of South FloridaInventor: Robert H. Byrne
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Patent number: 11808290Abstract: A fluid flow conditioning apparatus having self-adjusting tab members that reduce flow losses within a conduit. A plurality of tabular members is affixed to an insertion plate-type flow conditioner. Tabular members are cojoined in pairs at their leading edges. When the cojoined pair of the first tabular member and the second tabular member are placed into a fluid flow, an angle between the first tabular member and the second tabular member is configured to decrease in response to static and dynamic pressure exerted onto the outer surfaces of the tabular members by the fluid flow. The tabular members may be made of a hyperplastic material configured to undergo an elastic deformation and exhibit flapping due to the dynamic pressure of the fluid flow. Tabular members maybe cojoined by a hinge configured to partially close in response to pressure exerted by the fluid flow, decreasing the angle between the tabular members.Type: GrantFiled: December 20, 2021Date of Patent: November 7, 2023Assignee: University of South FloridaInventors: Rajat Mittal, Dharendra Yogi Goswami