Abstract: Hybrid particles having improved electrical conductivity and thermal and chemical stabilities are disclosed. The hybrid particles are for use in conductive pastes. The hybrid particles include a nanoparticle selected from a graphene-containing material, a dichalcogenide material, a conducting polymer, or a combination thereof encapsulated in a conducting metal. The hybrid particles include a nanoparticle selected from a graphene-containing material, a dichalcogenide material, or a combination thereof encapsulated in a conducting polymer, and optionally further in a conducting metal. Suitable conducting metals include nickel or silver. Suitable conducting polymers include polyaniline, polypyrrole, or polythiophene. Suitable dichalcogenide materials include MoS2 or MoSe2. The hybrid particles can further include a conducting polymer layer on an outer surface of the conducting metal. Methods of making the hybrid particles are also disclosed.
Abstract: A variety of compositions and materials are provided for water purification and remediation. The compositions including multiple functionalities for treating a variety of pollutants or contaminants. The compositions can include a porous organic polymer with one or more of a variety of functional groups for binding the contaminants and with a hierarchical pore size distribution over a range of pore sizes to facilitate enhanced removal of the contaminants. Functional groups can include one, two, or more different functional groups such as amines, halides, ammoniums, pyridiuiums, thiols, imidazoliums, salts thereof, or others. The range of pore sizes can be about 1 nm to 10 nm or more. Contaminants can include antimony, arsenic, barium, beryllium, cadmium, chromium, copper, lead, mercury, selenium, technetium, thallium, uranium, radium, urea, and phosphate. Methods of removing the contaminants from water using the compositions are also provided.
Abstract: The present disclosure is directed to compositions, methods of use, and methods of making, wherein the compositions contain one or more galloylated procyanidins having between two and five epicatechin monomers, wherein the one or more galloylated procyanidins include epicatechin-(4-8)-epicatechin-(4-8)-epicatechin-gallate, catechin trimer gallate, catechin dimer digallate, or combinations thereof.
Type:
Grant
Filed:
March 14, 2019
Date of Patent:
September 26, 2023
Assignees:
University of South Florida, Encore IP Management, LLC
Inventors:
Michael Louis Sperduti, Matthew Cleary Nickerson, Jimmy Roy Huddleston, Leigh Anthony West
Abstract: Methods of treating anxiety disorders or reducing anxiety-related behaviors. The methods include administering a therapeutically effective amount of ketone supplementation, such as butanediol, ketone esters (e.g., 1,3-butanediol-acetoacetate diester) and/or ketone salts (e.g., beta-hydroxybutyrate-mineral salt), chronically, sub-chronically, or acutely, with or without admixture with a medium chain triglyceride or in combination. It was determined herein that ketone supplementation reduced anxiety in rats on elevated plus maze as measured by less entries to closed arms, more time spent in open arms, more distance travelled in open arms, and delayed latency to entrance to closed arms, when compared to control. Along with reducing anxiety-related behavior, the chronic, sub-chronic, and acute ketone supplements also caused significant elevation of blood ?HB levels and changed blood glucose levels.
Type:
Grant
Filed:
April 19, 2021
Date of Patent:
September 26, 2023
Assignee:
UNIVERSITY OF SOUTH FLORIDA
Inventors:
Csilla Ari D'Agostino, Dominic Paul D'Agostino
Abstract: A method of treating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), otherwise known as COVID-19, infection by administering nicotinic receptor antagonists and/or PPAR-? agonists is presented. A combination of mecamylamine, or an isomer thereof, and pioglitazone synergistically reduces replication of SARS-CoV-2 in virus-infected cells and also synergistically reduces inflammatory cytokines such as IL-6, IL-?, and TNF?, which have been associated with SARS-CoV-2 infection.
Type:
Grant
Filed:
August 26, 2021
Date of Patent:
September 26, 2023
Assignee:
University of South Florida
Inventors:
Paul Ronald Sanberg, Christian Bernard Brechot, Shyam S. Mohapatra, Subhra Mohapatra
Abstract: A biosensor for an analyte monitoring system. In one embodiment, the biosensor includes a cascode common source transimpedance amplifier circuit, an analog to digital converter, and an output circuit. The cascode common source transimpedance amplifier circuit is configured to receive an electrical current generated by an electrochemical reaction of an analyte on a test strip. The cascode common source transimpedance amplifier circuit is also configured to convert the electrical current to an analog voltage signal. The analog to digital converter is configured to convert the analog voltage signal to a digital voltage signal. The output circuit is configured to transmit a signal indicating a measured level of the analyte based on the digital voltage signal.
Type:
Grant
Filed:
March 16, 2022
Date of Patent:
September 19, 2023
Assignee:
UNIVERSITY OF SOUTH FLORIDA
Inventors:
Kavyashree Puttananjegowda, Sylvia Thomas
Abstract: The present disclosure describes a multi-initialization ensemble-based defense strategy against an adversarial attack. In one embodiment, an exemplary method includes training a plurality of conventional neural networks (CNNs) with a training set of images, wherein the images include original images and images modified by an adversarial attack; after training of the plurality of conventional neural networks, providing an input image to the plurality of conventional neural networks, wherein the input image has been modified by an adversarial attack; receiving a probability output for the input image from each of the plurality of conventional neural networks; producing an ensemble probability output for the input image by combining the probability outputs from each of the plurality of conventional neural networks; and labeling the input image as belonging to one of the one or more categories based on the ensemble probability output.
Type:
Grant
Filed:
November 16, 2020
Date of Patent:
September 19, 2023
Assignees:
UNIVERSITY OF SOUTH FLORIDA, H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
Inventors:
Rahul Paul, Dmitry Goldgof, Lawrence Hall, Matthew Schabath, Robert Gillies
Abstract: The present disclosure is directed to methods for the treatment of inflammation or pain, particularly methods using compositions containing a compound of formula (I).
Type:
Grant
Filed:
March 2, 2021
Date of Patent:
September 19, 2023
Assignees:
University of South Florida, SprainGo, LLC
Inventors:
Bill J. Baker, Sofia Kokkaliari, James Leahy, Wayne Caleb Williams
Abstract: A multifunctional dendrimer nanoparticle and method of treating diseases of the posterior segment of the eye is presented. The functionalized polyamidoamine (PAMAM) dendrimer effectively delivers drugs and/or genes to the posterior eye, thereby providing for the effective, non-invasive, and topical treatment of diseased in the posterior eye. The multifunctional dendrimer nanoparticle has shRNA-encoding DNA and small molecule drug encapsulated cyclodextrin complexed to the outer surface of the dendrimer for delivery to the posterior segment of the eye.
Type:
Grant
Filed:
August 6, 2021
Date of Patent:
September 12, 2023
Assignees:
The United States Government as Represented by the Department of Veterans Affair, University of South Florida
Inventors:
Shyam S. Mohapatra, Subhra Mohapatra, Eleni Markoutsa
Abstract: A system and method for assessing a supply chain for a perishable product. In various embodiments, the present invention provides a quality code for a perishable product which encodes a plurality of the most important performance metrics of the cold chain for the perishable product, including food quality oriented measures such as cut-to-cool time, transportation quality and accumulated shelf-life loss, and food safety oriented measures such as most probable number range for microorganism growth into a compact, modular and simple to read format.
Type:
Grant
Filed:
June 4, 2019
Date of Patent:
September 5, 2023
Assignees:
University of South Florida, DeltaTrak, Inc.
Abstract: A Pulsed Thermography (PT) system and method is provided utilizing a long duration pulse in combination with a radiant heat shield as a non-destructive testing method for quantitatively measuring defect depths within a 3D printed part and for characterizing layer-by-layer surface defects in the 3D printed part.
Type:
Grant
Filed:
November 8, 2021
Date of Patent:
August 29, 2023
Assignee:
University of South Florida
Inventors:
Nathan Brad Crane, James Randall Pierce, III
Abstract: Examples of determining electronic component authenticity via electronic signal signature measurement are discussed. Reference pin identifiers corresponding to pins of a known authentic electronic component are determined. Measurement values corresponding to characteristics of pins of an electronic component are obtained, and pin identifiers based on the measurement values are generated. Accordingly, an indication that the electronic component is authentic can be provided based at least in part on a comparison of the pin identifiers and the reference pin identifiers.
Type:
Grant
Filed:
April 2, 2021
Date of Patent:
August 22, 2023
Assignee:
UNIVERSITY OF SOUTH FLORIDA
Inventors:
Yunghsiao Chung, Feng Yu, Stephen Edward Saddow
Abstract: In one embodiment, a metal-plated polymer object includes a polymer surface, a first metal layer that has been applied to the polymer surface to render it electrically conductive, and a second metal layer that has been deposited on the first metal layer.
Type:
Grant
Filed:
December 10, 2019
Date of Patent:
August 22, 2023
Assignee:
UNIVERSITY OF SOUTH FLORIDA
Inventors:
Jaspreet Dhau, D. Yogi Goswami, Chand K. Jotshi, Elias K. Stefanakos
Abstract: Provided herein are systems and methods for automated identification of volumes of interest in volumetric brain images using artificial intelligence (AI) enhanced imaging to diagnose and treat acute stroke. The methods can include receiving image data of a brain having header data and voxel values that represent an interruption in blood supply of the brain when imaged, extracting the header data from the image data, populating an array of cells with the voxel values, applying a segmenting analysis to the array to generate a segmented array, applying a morphological neighborhood analysis to the segmented array to generate a features relationship array, where the features relationship array includes features of interest in the brain indicative of stroke, identifying three-dimensional (3D) connected volumes of interest in the features relationship array, and generating output, for display at a user device, indicating the identified 3D volumes of interest.
Type:
Grant
Filed:
August 23, 2021
Date of Patent:
August 22, 2023
Assignee:
University of South Florida
Inventors:
Karl A. Kasischke, William Scott Burgin
Abstract: The present invention concerns nanoparticles useful for treating posterior segment ocular diseases or conditions, such as macular degeneration and diabetic retinopathy; compositions comprising the nanoparticles; methods for producing the nanoparticles; and methods for treating posterior segment ocular diseases or conditions, comprising administering the nanoparticles or compositions to the ocular posterior segment of an afflicted eye.
Type:
Grant
Filed:
December 27, 2021
Date of Patent:
August 22, 2023
Assignee:
UNIVERSITY OF SOUTH FLORIDA
Inventors:
Kathleen Emily-Ann Halasz, Yashwant V. Pathak, Vijaykumar Bhadabhai Sutariya
Abstract: The present invention provides pharmaceutical compositions and methods for use and manufacture thereof. The pharmaceutical compositions comprise a therapeutically effective amount of a cannabinoid or a pharmaceutically acceptable salt or solvate thereof and an amphiphilic copolymer comprising at least one hydrophilic component and at least one hydrophobic component. The cannabinoid is encapsulated in the amphiphilic copolymer, and the composition is suitable for intranasal or inhalation delivery.
Type:
Application
Filed:
May 26, 2021
Publication date:
July 27, 2023
Applicants:
RHODES TECHNOLOGIES, UNIVERSITY OF SOUTH FLORIDA
Abstract: An apparatus measures the transverse profile of vectorial optical field beams, including both the phase and the polarization spatial profile. The apparatus contains a polarization separation module, a weak perturbation module, and a detection module. Characterizing the transverse profile of vector fields provides an optical metrology tool for both fundamental studies of vectorial optical fields and a wide spectrum of applications, including microscopy, surveillance, imaging, communication, material processing, and laser trapping.
Type:
Grant
Filed:
July 19, 2021
Date of Patent:
July 25, 2023
Assignee:
University of South Florida
Inventors:
Zhimin Shi, Darrick Hay, Ziyi Zhu, Yiyu Zhou, Robert W. Boyd
Abstract: Described herein are electrochemical cells that include composite gel positioned between the first electrode and second electrode, wherein the composite gel comprises an electrolyte, a polyaryl amine, and an oxidant. The composite gels described herein are easy to produce at a low-cost, which makes them suitable in a number of different applications electrochromic devices, supercapacitors, solar cells, and hybrid photoactive supercapacitors.