Abstract: Alzheimer's disease is treated using THC (alone, or in combination with melatonin) administered in an ultra-low dose amount sufficient to (i)reduce A? expression; (ii) reduce A? aggregation: (iii) maintain APP expression; (iv) enhance mitochondrial functioning; (v) decrease phosphorylation of GSK3? protein; (vi) decrease the expression of GSK3? protein; (vii) decrease phosphorylation of Tau protein; and/or (viii) maintain Tau protein expression, in said patient without severe psychological impairments and side effects associated with higher doses of THC.

Abstract: Described herein are compositions composed of frustrated Lewis pairs impregnated in porous materials such as, for example, metal-organic frameworks, and their uses thereof. These compositions may allow new applications of frustrated Lewis pairs in catalysis by sequestering and protecting the frustrated Lewis pair within the nanospace of the porous material. Also provided are methods of hydrogenating an organic compound having at least one unsaturated functional group comprising using the compositions described herein.

Abstract: The present invention concerns nanoparticles useful for treating posterior segment ocular diseases or conditions, such as macular degeneration and diabetic retinopathy; compositions comprising the nanoparticles; methods for producing the nanoparticles; and methods for treating posterior segment ocular diseases or conditions, comprising administering the nanoparticles or compositions to the ocular posterior segment of an afflicted eye.

Abstract: Disclosed are monoacylated Toll-like receptor 2 ligands which can be used in both the development of targeted agents for the imaging and treatment of pancreatic cancer as well as other cancers, and as an adjuvant for cancer immunotherapy. The monoacylated compounds disclosed herein have a higher binding affinity for TLR2 relative to a known potent diacylated agonists, but only ?½ the bioactivity. Competition of the monoacylated compound with the diacylated compound for binding TLR2 was confirmed. Hence, the reported monoacylated compounds are inhibitors/antagonists of TLR2 activation.

Abstract: A variety of amphiphobic porous materials are provided. The materials can include a variety of porous frameworks that have an outer surface functionalized by a plurality of perfluoroalkyl moieties. By careful selection of appropriate perfluoralkyl moieties, hydrophobic properties can be imparted to the exterior surface of the porous materials without significantly impacting the wetting properties of the porous interior. This can be used to create a variety of highly amphiphobic porous materials. Methods of making and using the amphiphobic porous materials are also provided.

Abstract: The centralized control capability of Software Defined Networking (SDN) presents a unique opportunity for enabling Quality of Service (QoS) routing. For delay sensitive traffic flows, a QoS mechanism efficiently computes path latency and minimizes a controller's response time. At the core of the challenges is how to handle short term network state fluctuations in terms of congestion and latency while guaranteeing the end-to-end latency performance of networking services. The disclosed technology provides a systematic framework that considers active link latency measurements, efficient statistic estimate of network states, and fast adaptive path computation. The disclosed technology can be implemented, for example, as an SDN controller application, and can find optimal end-to-end paths with minimum latency and significantly reduce the control overhead.

Abstract: In one embodiment, a flexible composite conducting polymer film includes a composite conducting polymer including a conducting polymer and one or more water-soluble polyanions, wherein the film is approximately 20 nanometers to 10 microns thick.

Abstract: Systems and methods are described for estimating a state of a process and an input to the process using a sensor network. Each sensor node in the sensor network is directly to one or more adjacent sensor nodes and indirectly coupled to the remaining sensor nodes through the one or more adjacent sensor nodes. Each sensor node iteratively calculates a new estimated state based on estimations of the state and the input to the process calculated by the sensor node in a previous iteration. The new estimated state is then adjusted based on a difference between a predicted and actual output of a sensor and is further adjusted based on differences between a previous estimated state calculated by the sensor node and estimated states calculated by adjacent sensor nodes.

Abstract: In one embodiment, a chromatic device includes a transparent conductive substrate, an active layer provided on the conductive substrate, the active layer comprising a conducting polymer, an electrolyte layer in contact with the conductive substrate and the active layer, the electrolyte comprising an oxidant and a salt but not comprising an acid, and a metal element configured to be selectively placed in and out of direct electrical contact with the conductive substrate or the active layer, wherein the active layer has a color that blocks light when the metal element is not in electrical contact with the conductive substrate but changes to a translucent color that transmits light when the metal element is placed in electrical contact with the conductive substrate or the active layer, wherein the active layer changes color without applying external energy to the active layer.

Abstract: Disclosed are various embodiments for batched query processing and optimization in database management systems. A single algebraic expression is generated based at least in part on applying equivalence rules to algebraic expressions for a plurality of database queries of a database comprising a set of relations. The equivalence rules involve relational operators comprising Psi (?) operators. The database can be queried using a single database query to create a result that is equivalent to the plurality of database queries.

Abstract: Disclosed herein is a solid touchchromic device. The solid touchchromic device may include a conducting polymer or a conducting polymer composite film, a conducting plate, and a solid layer of a polymer-based electrolyte, the conducting plate being at least partially coated by the conducting polymer or the conducting polymer composite film. The solid touchchromic device may further include an oxidant, a salt, an acid, or a metal. Also included are methods of producing a solid touchchromic device and articles including a solid touchchromic device.

Abstract: The disclosed subject matter relates to methods for monitoring or controlling a manufacturing process of a material by determining when a variation in surface characteristics takes place. Such surface characteristics correlates to the processing condition of the material and can include density, roughness, porosity, or planarity on a surface of the material. The methods can include herein can include directing a solvent or energy on a surface of the material to form an at least partially modified surface, directing light at an incident angle with respect to the at least partially modified surface, measuring one or more predetermined properties of light reflected from the at least partially modified surface, determining that the material is fully processed based on the measured predetermined property of the light reflected, and optionally adjusting a processing parameter of the manufacturing process in response to the measured predetermined property.

Abstract: In some embodiments, a bioelectronic device includes an electrode, target proteins, and attachment mechanisms that immobilize the target proteins on the electrode, the attachment mechanisms comprising linker proteins that interface with the target proteins and attach the target proteins to the electrode.

Abstract: A method for controlled tumoricidal radiation dose delivery is disclosed. The method includes obtaining an image of a body organ; diving the image into a plurality of voxels; determining a set of feasible actions for the body organ by identifying an upper bound and a lower bound for the body organ; determining a utility function for the body organ; determining a disagreement point by identifying an ideal fluency map and a worst fluency map; determining a negotiation power weight based on a type of the body organ; and optimizing the plurality of radiation dose levels to the plurality of voxels based on the set of feasible actions, the utility function, the disagreement point, and the negotiation power weight. Other aspects, embodiments, and features are also claimed and described.

Abstract: Disclosed herein are compositions and methods for inducing, promoting, or enhancing an immune response in a subject. For example, the disclosed compositions and methods can be used prophylactically to prevent viral/microbial infections or therapeutically to treat acute infections. In some embodiments, the disclosed method involves administering to the subject a composition comprising in vitro transcribed (IVT) RNA comprising short interspersed nuclear elements (SINEs), such as Alu repeats. In some embodiments, the disclosed compositions and methods can be used to induce, promote, or enhance any immune response in a subject, including an anti-viral, anti-microbial, anti-fungal, or anti-parasite response. In some embodiments, the disclosed compositions can be administered to any mucosal barrier, such as lungs or intestines, e.g. to enhance an innate immune response against a virus or pathogen.

Abstract: In one embodiment, a system for identifying a biomedical condition of a subject includes apparatus for collecting blood flow sounds from the subject and a computing device that stores computer-executable instructions that are configured to: receive the collected blood flow sounds, extract acoustic heart pulses from the collected blood flow sounds, segment the acoustic heart pulses to obtain acoustic heart pulse segments, compute a continuous time wavelet transform-based feature for each acoustic heart pulse segment, and perform clustering on the computed continuous time wavelet transform-based features to determine whether or not the subject is experiencing the biomedical condition.

Abstract: In one embodiment, an electrochromic device includes a single active layer configured to be alternately placed in a light-transmitting state in which relatively large amounts of light can be transmitted through the active layer and a light-blocking state in which relatively small amounts of light can be transmitted through the active layer, wherein the device comprises no other layers of material that contribute to transitioning between the two states.

Abstract: Disclosed are various embodiments for performing a join operation using a graphics processing unit (GPU). The GPU can receive input data including sequences or tuples. The GPU can initialize a histogram in a memory location shared by threads. The GPU can build the histogram of hash values for the sequences. The GPU can reorder the sequences based on the histogram. The GPU can probe partitions and store the results in a buffer pool. The GPU can output the results of the join.

Abstract: A variety of particles forming microencapsulated thermochromic materials are provided. The particles can include a thermochromic core and a metal oxide shell encapsulating the thermochromic core. The thermochromic core can include one or both of an organic thermochromic material and an inorganic salt thermochromic material. In some aspects, the particles include a dye selected from a crystal violet lactone dye, a fluoran dye, and a combination thereof. In still further aspects, the particles include a color developer selected from a hydroxybenzoate, a 4, 4?-dihydroxydiphenyl propane, a hydroxycoumarin derivative, a lauryl gallate, and a combination thereof. In some aspects, the metal oxide shell is a TiO2 shell. The particles can be used in cements and paints and for a variety of building materials. Methods of making the particles and building materials and methods of use, for example, for removing a volatile organic carbon from a building material, are also provided.

Abstract: A method of coating at least one silica capillary using a novel dual ligand sol-gel sorbent and method of manufacture of such sorbent is provided herein. The dual ligand sol-gel sorbent provides superior enrichment effects through simultaneous exploitation of superhydrophobicity of one of the ligands and the ability of the other ligand to undergo ?-? interaction with hydrophobic aromatic analytes. Sorbent performance is enhanced both in terms of analyte enrichment and sorbent stability, such as pH stability and solvent stability.